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Debate 30A - Molecular Profiling Should be Done to Guide the Management of Endometrial Cancer?

Yes

from Section IV - Endometrial Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Both the National Comprehensive Cancer Network (NCCN) and the Society for Gynecologic Oncology (SGO) support the use of sentinel lymph node biopsy (SLNB) in the staging of apparent uterine-confined endometrial cancer. However, these recommendations are largely informed by retrospective and limited prospective studies performed in women with low-grade endometrial cancer (LGEC). The use of SLNB in women with high-grade endometrial cancers (HGEC), which are more biologically aggressive, have a higher risk of lymphatic spread, and poorer survival outcomes than those with LGEC, remains a matter of debate.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

de Boer, SM, et al; for PORTEC Study Group. Clinical consequences of upfront pathology review in the randomised PORTEC-3 trial for high-risk endometrial cancer. Ann Oncol 2018;29(2):424430. https://doi.org/10.1093/annonc/mdx753CrossRefGoogle Scholar
Cancer Genome Atlas Research Network, Kandoth, C, et al. Integrated genomic characterization of endometrial carcinoma. Nature 2013;497(7447):6773. https://doi.org/10.1038/nature12113. Erratum in: Nature 2013;500(7461):242.Google ScholarPubMed
DeLair, DF, et al. The genetic landscape of endometrial clear cell carcinomas. J Pathol 2017;243(2):230241. https://doi.org/10.1002/path.4947CrossRefGoogle ScholarPubMed
Stelloo, E, et al. Improved risk assessment by integrating molecular and clinicopathological factors in early-stage endometrial cancer: combined analysis of the PORTEC cohorts. Clin Cancer Res 2016;22(16):42154224. https://doi.org/10.1158/1078-0432.CCR-15-2878CrossRefGoogle ScholarPubMed
Salvador, MU, et al. Comprehensive paired tumor/germline testing for lynch syndrome: bringing resolution to the diagnostic process. J Clin Oncol 2019;37(8):647657. https://doi.org/10.1200/JCO.18.00696CrossRefGoogle Scholar

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