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Debate 39A - What is the Best Management for Premenopausal Women with Early-stage Uterine Leiomyosarcoma Status Post Hysterectomy for Presumed Uterine Leiomyomas?

Oophorectomy

from Section IV - Endometrial Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Surgery represents the mainstay of treatment for uterine leiomyosarcomas (u-LMS) [1]. Resection of disease without fragmentation and with negative surgical margins seemingly provides survival advantage [1]. For macroscopically uterus-limited disease, total abdominal hysterectomy (TAH) should be considered as the standard management of choice [1]. Uterine leiomyosarcomas usually are discovered as incidental findings after hysterectomy or myomectomy for presumed benign pathology (e.g., fibroid uterus). For peri-menopausal or post-menopausal women, routine bilateral salpingo-oophorectomy (BSO) is usually performed; however, amongst pre-menopausal women with uterus-limited disease, the role of ovarian preservation (OP), as part of the staging process, remains to date a field of contention.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Hensley, ML, et al. Gynecologic Cancer InterGroup (GCIG) consensus review: uterine and ovarian leiomyosarcomas. Int J Gynecol Cancer 2014;9(Suppl. 3):S6166.CrossRefGoogle Scholar
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Nasioudis, D, et al. Safety of ovarian preservation in premenopausal women with stage I uterine sarcoma. J Gynecol Oncol 2017;28(4):e46.CrossRefGoogle ScholarPubMed

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