17 results
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial
- Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Célia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. McDonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
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- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 6 / December 2023
- Published online by Cambridge University Press:
- 14 July 2023, pp. 533-541
- Print publication:
- December 2023
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Background
Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed.
AimsTo assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au.
MethodThis phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4.
ResultsThe final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h.
ConclusionsAdequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible.
Effectiveness and cost-effectiveness of psychiatric mother and baby units: quasi-experimental study – CORRIGENDUM
- Louise M. Howard, Kylee Trevillion, Laura Potts, Margaret Heslin, Andrew Pickles, Sarah Byford, Lauren E. Carson, Clare Dolman, Stacey Jennings, Sonia Johnson, Ian Jones, Rebecca McDonald, Susan Pawlby, Claire Powell, Gertrude Seneviratne, Rebekah Shallcross, Nicky Stanley, Angelika Wieck, Kathryn M. Abel
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- Journal:
- The British Journal of Psychiatry / Volume 221 / Issue 5 / November 2022
- Published online by Cambridge University Press:
- 03 August 2022, p. 704
- Print publication:
- November 2022
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Effectiveness and cost-effectiveness of psychiatric mother and baby units: quasi-experimental study
- Louise M. Howard, Kylee Trevillion, Laura Potts, Margaret Heslin, Andrew Pickles, Sarah Byford, Lauren E. Carson, Clare Dolman, Stacey Jennings, Sonia Johnson, Ian Jones, Rebecca McDonald, Susan Pawlby, Claire Powell, Gertrude Seneviratne, Rebekah Shallcross, Nicky Stanley, Angelika Wieck, Kathryn M. Abel
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- Journal:
- The British Journal of Psychiatry / Volume 221 / Issue 4 / October 2022
- Published online by Cambridge University Press:
- 04 May 2022, pp. 628-636
- Print publication:
- October 2022
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Background
Psychiatric mother and baby units (MBUs) are recommended for severe perinatal mental illness, but effectiveness compared with other forms of acute care remains unknown.
AimsWe hypothesised that women admitted to MBUs would be less likely to be readmitted to acute care in the 12 months following discharge, compared with women admitted to non-MBU acute care (generic psychiatric wards or crisis resolution teams (CRTs)).
MethodQuasi-experimental cohort study of women accessing acute psychiatric care up to 1 year postpartum in 42 healthcare organisations across England and Wales. Primary outcome was readmission within 12 months post-discharge. Propensity scores were used to account for systematic differences between MBU and non-MBU participants. Secondary outcomes included assessment of cost-effectiveness, experience of services, unmet needs, perceived bonding, observed mother–infant interaction quality and safeguarding outcome.
ResultsOf 279 women, 108 (39%) received MBU care, 62 (22%) generic ward care and 109 (39%) CRT care only. The MBU group (n = 105) had similar readmission rates to the non-MBU group (n = 158) (aOR = 0.95, 95% CI 0.86–1.04, P = 0.29; an absolute difference of −5%, 95% CI −14 to 4%). Service satisfaction was significantly higher among women accessing MBUs compared with non-MBUs; no significant differences were observed for any other secondary outcomes.
ConclusionsWe found no significant differences in rates of readmission, but MBU advantage might have been masked by residual confounders; readmission will also depend on quality of care after discharge and type of illness. Future studies should attempt to identify the effective ingredients of specialist perinatal in-patient and community care to improve outcomes.
Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
- Maria Stella Calafato, Johan H. Thygesen, Siri Ranlund, Eirini Zartaloudi, Wiepke Cahn, Benedicto Crespo-Facorro, Álvaro Díez-Revuelta, Marta Di Forti, Genetic Risk and Outcome of Psychosis (GROUP) consortium, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Kuang Lin, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Psychosis Endophenotypes International Consortium (PEIC), Marco Picchioni, Dan Rujescu, Madiha Shaikh, Timothea Toulopoulou, Jim Van Os, Evangelos Vassos, Muriel Walshe, John Powell, Cathryn M. Lewis, Robin M. Murray, Elvira Bramon, Wellcome Trust Case Control Consortium 2 (WTCCC2)
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- Journal:
- The British Journal of Psychiatry / Volume 213 / Issue 3 / September 2018
- Published online by Cambridge University Press:
- 16 August 2018, pp. 535-541
- Print publication:
- September 2018
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Background
There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.
AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.
MethodUsing the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.
ResultsPatients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.
ConclusionsAlthough polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.
Declaration of interestR.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
Managing Herbicide Resistance: Listening to the Perspectives of Practitioners. Procedures for Conducting Listening Sessions and an Evaluation of the Process
- Jill Schroeder, Michael Barrett, David R. Shaw, Amy B. Asmus, Harold Coble, David Ervin, Raymond A. Jussaume, Jr., Micheal D. K. Owen, Ian Burke, Cody F. Creech, A. Stanley Culpepper, William S. Curran, Darrin M. Dodds, Todd A. Gaines, Jeffrey L. Gunsolus, Bradley D. Hanson, Prashant Jha, Annie E. Klodd, Andrew R. Kniss, Ramon G. Leon, Sandra McDonald, Don W. Morishita, Brian J. Schutte, Christy L. Sprague, Phillip W. Stahlman, Larry E. Steckel, Mark J. VanGessel
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- Journal:
- Weed Technology / Volume 32 / Issue 4 / August 2018
- Published online by Cambridge University Press:
- 09 August 2018, pp. 489-497
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Seven half-day regional listening sessions were held between December 2016 and April 2017 with groups of diverse stakeholders on the issues and potential solutions for herbicide-resistance management. The objective of the listening sessions was to connect with stakeholders and hear their challenges and recommendations for addressing herbicide resistance. The coordinating team hired Strategic Conservation Solutions, LLC, to facilitate all the sessions. They and the coordinating team used in-person meetings, teleconferences, and email to communicate and coordinate the activities leading up to each regional listening session. The agenda was the same across all sessions and included small-group discussions followed by reporting to the full group for discussion. The planning process was the same across all the sessions, although the selection of venue, time of day, and stakeholder participants differed to accommodate the differences among regions. The listening-session format required a great deal of work and flexibility on the part of the coordinating team and regional coordinators. Overall, the participant evaluations from the sessions were positive, with participants expressing appreciation that they were asked for their thoughts on the subject of herbicide resistance. This paper details the methods and processes used to conduct these regional listening sessions and provides an assessment of the strengths and limitations of those processes.
Managing Wicked Herbicide-Resistance: Lessons from the Field
- Jill Schroeder, Michael Barrett, David R. Shaw, Amy B. Asmus, Harold Coble, David Ervin, Raymond A. Jussaume, Jr., Micheal D. K. Owen, Ian Burke, Cody F. Creech, A. Stanley Culpepper, William S. Curran, Darrin M. Dodds, Todd A. Gaines, Jeffrey L. Gunsolus, Bradley D. Hanson, Prashant Jha, Annie E. Klodd, Andrew R. Kniss, Ramon G. Leon, Sandra McDonald, Don W. Morishita, Brian J. Schutte, Christy L. Sprague, Phillip W. Stahlman, Larry E. Steckel, Mark J. VanGessel
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- Journal:
- Weed Technology / Volume 32 / Issue 4 / August 2018
- Published online by Cambridge University Press:
- 09 August 2018, pp. 475-488
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Herbicide resistance is ‘wicked’ in nature; therefore, results of the many educational efforts to encourage diversification of weed control practices in the United States have been mixed. It is clear that we do not sufficiently understand the totality of the grassroots obstacles, concerns, challenges, and specific solutions needed for varied crop production systems. Weed management issues and solutions vary with such variables as management styles, regions, cropping systems, and available or affordable technologies. Therefore, to help the weed science community better understand the needs and ideas of those directly dealing with herbicide resistance, seven half-day regional listening sessions were held across the United States between December 2016 and April 2017 with groups of diverse stakeholders on the issues and potential solutions for herbicide resistance management. The major goals of the sessions were to gain an understanding of stakeholders and their goals and concerns related to herbicide resistance management, to become familiar with regional differences, and to identify decision maker needs to address herbicide resistance. The messages shared by listening-session participants could be summarized by six themes: we need new herbicides; there is no need for more regulation; there is a need for more education, especially for others who were not present; diversity is hard; the agricultural economy makes it difficult to make changes; and we are aware of herbicide resistance but are managing it. The authors concluded that more work is needed to bring a community-wide, interdisciplinary approach to understanding the complexity of managing weeds within the context of the whole farm operation and for communicating the need to address herbicide resistance.
Extreme enrichment of selenium in the Apliki Cyprus-type VMS deposit, Troodos, Cyprus
- Andrew J. Martin, Iain McDonald, Christopher J. MacLeod, Hazel M. Prichard, Katie McFall
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- Mineralogical Magazine / Volume 82 / Issue 3 / June 2018
- Published online by Cambridge University Press:
- 15 April 2018, pp. 697-724
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The Troodos ophiolite Cyprus hosts the type locality for Cyprus-type, mafic volcanogenic massive sulfide (VMS) deposits. Regional soil geochemical data for Troodos are highly variable with the Solea graben, one of three regional graben structures on Cyprus, showing enrichment in Te and Se. Of the three VMS sampled within the Solea graben, Apliki exhibits the most significant enrichment in Se. Samples from the South Apliki Breccia Zone; a zone of hematite-rich breccia containing euhedral pyrite and chalcopyrite, contain up to 4953 and 3956 ppm Se in pyrite and chalcopyrite, respectively. Four paragenetic stages are identified at Apliki and different generations of pyrite are distinguishable using trace-element chemistry analysed via laser ablation inductively coupled plasma mass spectrometry. Results indicate stage I pyrite formed under reduced conditions at high temperatures >280°C and contains 182 ppm (n = 22 σ = 253) Se. Late stage III pyrite which is euhedral and overprints chalcopyrite and hematite is enriched in Se (averaging 1862 ppm; n = 23 σ = 1394). Sulfide dissolution and hematite formation displaced large amounts of Se as hematite cannot accommodate high concentrations of Se in its crystal structure. The mechanisms proposed to explain the pronounced change in redox are twofold. Fault movement leading to localized seawater ingress coupled with a decreasing magmatic flux that generated locally oxidizing conditions and promoted sulfide dissolution. A Se/S ratio of 9280 indicates a probable magmatic component for late stage III pyrite, which is suggested as a mechanism explaining the transition from oxidizing back to reduced conditions. This study highlights the significance of changes in redox which promote sulfide dissolution, mobilization and enrichment of Se.
Nolzeite, Na(Mn,□)2[Si3(B,Si)O9(OH)2]·2H2O, a new pyroxenoid mineral from Mont Saint-Hilaire, Québec, Canada
- Monika M. M. Haring, Andrew M. McDonald
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- Journal:
- Mineralogical Magazine / Volume 81 / Issue 1 / February 2017
- Published online by Cambridge University Press:
- 02 January 2018, pp. 183-197
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Nolzeite, Na(Mn,□)2[Si3(B,Si)O9(OH)2]·2H2O, is a new mineral found in altered sodalite syenite at the Poudrette quarry, La Vallée-du-Richelieu, Montérégie (formerly Rouville County), Québec, Canada. Crystals are colourless to pale green and are acicular with average dimensions of 5 μm × 8 μm × 55 μm. They occur as radiating to loose, randomly oriented groupings within vugs associated with aegirine, nepheline, sodalite, eudialyte-group minerals, analcime, natron, pyrrhotite, catapleiite, steedeite and the unidentified mineral, UK80. Nolzeite is non-pleochroic, biaxial, with nmin = 1.616(2) and nmax = 1.636(2) and has a positive elongation. The average of six chemical analyses gave the empirical formula: Na1.04(Mn1.69□0.24Fe0.05Ca0.02)∑=2.00(Si2.96S0.04)∑=3.00(B0.70Si0.30)∑=1.00O9(OH)2·2H2O based on 13 anions. The Raman spectrum shows six distinct bands occurring at ∼3600–3300 cm–1 and 1600–1500 cm–1 (O–H and H–O–H bending), 1300–1200 cm–1 (B–OH bending), 1030–800 cm–1 (Si–O–Si stretching) as well as 700–500 cm–1 and 400–50 cm–1 (Mn–O and Na–O bonding, respectively). The FTIR spectrum for nolzeite shows bands at ∼2800 –3600 cm–1(O–H) stretching, a moderately sharp band at 1631 cm –1(H–O–H) bending, strong, sharp bands at ∼650 –700 cm–1, ∼800 –840 cm–1, and ∼900–1100 cm–1(Si–O and B –O) bonds. Nolzeite is triclinic, crystallizing in space group P with a = 6.894(1), b = 7.632(2), c = 11.017(2) Å, α= 108.39(3), β= 99.03, γ = 103.05(3)°, V = 519.27 Å3, and Z = 2. The crystal structure was refined to R = 12.37% and wR2 = 31.07% for 1361 reflections (Fo > 4σFo). It is based on chains of tetrahedra with a periodicity of three (i.e. a dreier chain) consisting of three symmetrically independent SiO4 tetrahedra forming C-shaped clusters closed by BO2(OH)2 tetrahedra, producing single loop-branched dreier borosilicate chains. The chains are linked through shared corners to double chains of edge-sharing MnO5(OH) octahedra. Nolzeite is a chain silicate closely related to steedeite and members of the sérandite–pectolite series. Paragenetically, nolzeite is late-stage, probably forming under alkaline conditions and over a narrow range of low pressures and temperatures.
17 - Visualizing Macromolecules in Liquid at the Nanoscale
- from Part II - Applications
- Edited by Frances M. Ross, IBM T. J. Watson Research Center, New York
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- Liquid Cell Electron Microscopy
- Published online:
- 22 December 2016
- Print publication:
- 24 November 2016, pp 356-370
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An empirical assessment of two-dimensional (2D) Debye–Scherrer-type image-plate X-ray diffraction data collapsed into a 1D diffractogram
- Kirk C. Ross, Joseph A. Petrus, Andrew M. McDonald
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- Powder Diffraction / Volume 29 / Issue 4 / December 2014
- Published online by Cambridge University Press:
- 16 December 2014, pp. 337-345
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X-ray diffraction (XRD) has been routinely employed in the Earth sciences to characterize the crystallography of rocks and minerals. Routine characterization of samples too small for analysis by classic automated powder diffraction methods becomes challenging without access to single crystal or micro-diffraction equipment. Here, we show that a traditional Gandolfi camera lined with an image-plate (IP) as the detection medium can return a fully quantitative diffraction pattern from a sub-milligram single grain specimen in a simple and straightforward manner. Data pertaining to peak positions (d-spacings) were assessed using SRM640c Si powder, while intensity data were compared to the certified values for intensity standard SRM676a alumina powder. The refined unit-cell dimension of Si powder differed from the certified value of 5.4312 Å by no more than 0.0003 Å with a standard deviation (σ) of 0.0002 Å among the three experiments. For intensity, the σ and disparity from the certified values of three diffraction experiments on SRM676a were both <2%. The results of a comparative study of the crystallographic parameters determined for a naturally occurring garnet and clinopyroxene given through the refinement of their crystal structure by single-crystal XRD method are presented. These show through Rietveld refinement of X-ray data obtained by the Gandolfi–IP method outlined here that both accurate and precise XRD data can be produced in a timely and cost-effective manner using only an IP, Gandolfi camera, and software freely available on the internet.
Contributors
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- By Pascale Aebischer, K. E. Attar, Laura Aydelotte, Helen Barr, Sibylle Baumbach, Robert Bearman, Jacquelyn Bessell, Todd Borlik, Charlotte Brewer, Henry Buchanan, Hal Cobb, Brian Cummings, Paul Edmondson, Andrew James Hartley, Michael Hattaway, Andreas Höfele, Russell Jackson, Michael P. Jensen, John Jowett, Matt Kozusko, Jesse M. Lander, Laura Levine, Toby Malone, Russ McDonald, Carol Thomas Neely, Eric Rasmussen, Carol Chillington Rutter, Michael Saenger, Charlotte Scott, James Shaw, Margaret Shewring, Stuart Sillars, Holger Schott Syme, Curt L. Tofteland, Margaret Tudeau-Clayton, Roger Warren, Robert N. Watson, Stanley Wells
- Edited by Peter Holland, University of Notre Dame, Indiana
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- Shakespeare Survey
- Published online:
- 05 December 2012
- Print publication:
- 08 November 2012, pp vi-vii
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Evaluation of Organizational Culture among Different Levels of Healthcare Staff Participating in the Institute for Healthcare Improvement's 100,000 Lives Campaign
- Ronda L. Sinkowitz-Cochran, Amanda Garcia-Williams, Andrew D. Hackbarth, Bonnie Zell, G. Ross Baker, C. Joseph McCannon, Elise M. Beltrami, John A. Jernigan, L. Clifford McDonald, Donald A. Goldmann
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 33 / Issue 2 / February 2012
- Published online by Cambridge University Press:
- 02 January 2015, pp. 135-143
- Print publication:
- February 2012
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Background.
Little is known about how hospital organizational and cultural factors associated with implementation of quality initiatives such as the Institute for Healthcare Improvement's (IHI) 100,000 Lives Campaign differ among levels of healthcare staff.
Design.Evaluation of a mixed qualitative and quantitative methodology (“trilogic evaluation model”).
Setting.Six hospitals that joined the campaign before June 2006.
Participants.Three strata of staff (executive leadership, midlevel, and frontline) at each hospital.
Results.Surveys were completed in 2008 by 135 hospital personnel (midlevel, 43.7%; frontline, 38.5%; executive, 17.8%) who also participated in 20 focus groups. Overall, 93% of participants were aware of the IHI campaign in their hospital and perceived that 58% (standard deviation, 22.7%) of improvements in quality at their hospital were a direct result of the campaign. There were significant differences between staff levels on the organizational culture (OC) items, with executive-level staff having higher scores than midlevel and frontline staff. All 20 focus groups perceived that the campaign interventions were sustainable and that data feedback, buy-in, hardwiring (into daily activities), and leadership support were essential to sustainability.
Conclusions.The trilogic model demonstrated that the 3 levels of staff had markedly different perceptions regarding the IHI campaign and OC. A framework in which frontline, midlevel, and leadership staff are simultaneously assessed may be a useful tool for future evaluations of OC and quality initiatives such as the IHI campaign.
Infect Control Hosp Epidemiol 2012;33(2):135-143
Contributors
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- By Patrick Bélisle, Alisa Chalmers, Constance Dubuc, Linda M. Fedigan, Mariko Fujimoto, Noëlle Gunst, Michael A. Huffman, Eiji Inoue, Katharine M. Jack, Masao Kawai, Naoki Koyama, Jean-Baptiste Leca, Andrew J. J. MacIntosh, Yukiyo Maekawa, Eiji Ohta, Ann C. O’Neill, Mary S. McDonald, Sergio M. Pellis, Vivien C. Pellis, Jean Prud’homme, Anne E. Russon, Masaki Shimada, Keiko Shimizu, Yukimaru Sugiyama, Yukio Takahata, Yuji Takenoshita, Doug P. VanderLaan, Paul L. Vasey
- Edited by Jean-Baptiste Leca, University of Lethbridge, Alberta, Michael A. Huffman, Kyoto University, Japan, Paul L. Vasey, University of Lethbridge, Alberta
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- The Monkeys of Stormy Mountain
- Published online:
- 05 March 2012
- Print publication:
- 19 January 2012, pp x-xi
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Contributors
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- By Hideki Azuma, Susan Mary Benbow, Bettina Heike Bewernick, T. K. Birkenhäger, Hal Blumenfeld, Tom G. Bolwig, Stanley N. Caroff, Sidney S. Chang, Pinhas N. Dannon, Renana Eitan, Alan R. Felthous, Felipe Fregni, Gabor Gazdag, Nataliya Giagou, Mustafa M. Husain, Charles H. Kellner, Barry Alan Kramer, Galit Landshut, James Stuart Lawson, Bernard Lerer, Jerry Lewis, Dongchen Li, Colleen Loo, Michelle Magid, Stephan C. Mann, Limore Maron, W. Vaughn McCall, Shawn M. McClintock, Niall McCrae, Andrew McDonald, Nikolaus Michael, Paul S. Mueller, Alexander I. Nelson, Unnati D. Patel, Kathy Peng, Keith G. Rasmussen, William H. Reid, Joseph M. Rey, Barbara M. Rohland, Marina Odebrecht Rosa, Moacyr Alexandro Rosa, Oded Rosenberg, Peter B. Rosenquist, Thomas E. Schläpfer, Edward Shorter, Pascal Sienaert, Conrad M. Swartz, Kenneth Trevino, Gabor S. Ungvari, Walter W. van den Broek, Garry Walter, Julie A. Williams
- Edited by Conrad M. Swartz
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- Book:
- Electroconvulsive and Neuromodulation Therapies
- Published online:
- 15 July 2009
- Print publication:
- 02 March 2009, pp ix-xiv
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The dynamic nature of group A streptococcal epidemiology in tropical communities with high rates of rheumatic heart disease
- M. I. McDONALD, R. J. TOWERS, R. ANDREWS, N. BENGER, P. FAGAN, B. J. CURRIE, J. R. CARAPETIS
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- Epidemiology & Infection / Volume 136 / Issue 4 / April 2008
- Published online by Cambridge University Press:
- 31 May 2007, pp. 529-539
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Prospective surveillance was conducted in three remote Aboriginal communities with high rates of rheumatic heart disease in order to investigate the epidemiology of group A β-haemolytic streptococci (GAS). At each household visit, participants were asked about sore throat. Swabs were taken from all throats and any skin sores. GAS isolates were emm sequence and pattern-typed using standard laboratory methods. There were 531 household visits; 43 different emm types and subtypes (emmST) were recovered. Four epidemiological patterns were observed. Multiple emmST were present in the population at any one time and household acquisition rates were high. Household acquisition was most commonly via 5- to 9-year-olds. Following acquisition, there was a 1 in 5 chance of secondary detection in the household. Throat detection of emmST was brief, usually <2 months. The epidemiology of GAS in these remote Aboriginal communities is a highly dynamic process characterized by emmST diversity and turnover.
Fracture prevalence in Duchenne muscular dystrophy
- Denise G M McDonald, Maria Kinali, Andrew C Gallagher, Eugenio Mercuri, Francesco Muntoni, Helen Roper, Philip Jardine, David Hilton Jones, MG Pike
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- Journal:
- Developmental Medicine and Child Neurology / Volume 44 / Issue 10 / October 2002
- Published online by Cambridge University Press:
- 10 October 2002, pp. 695-698
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- October 2002
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The objective of this study was to determine the prevalence, circumstances, and outcome of fractures in males with Duchenne muscular dystrophy (DMD) attending neuromuscular clinics. Three hundred and seventy-eight males (median age 12 years, range 1 to 25 years) attending four neuromuscular centres were studied by case-note review supplemented by GP letter or by interview at the time of clinic attendance. Seventy-nine (20.9%) of these patients had experienced fractures. Forty-one percent of fractures were in patients aged 8 to 11 years and 48% in independently ambulant patients. Falling was the most common mechanism of fracture. Upper-limb fractures were most common in males using knee–ankle–foot orthoses (65%) while lower-limb fractures predominated in independently mobile and wheelchair dependent males (54% and 68% respectively). Twenty percent of ambulant males and 27% of those using orthoses lost mobility permanently as a result of the fracture. In a substantial proportion of males, the occurrence of a fracture had a significant impact on subsequent mobility.