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Advocacy at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery
- Bistra Zheleva, Amy Verstappen, David M. Overman, Farhan Ahmad, Sulafa K.M. Ali, Zohair Y. Al Halees, Joumana Ghandour Atallah, Isabella E. Badhwar, Carissa Baker-Smith, Maria Balestrini, Amy Basken, Jonah S. Bassuk, Lee Benson, Horacio Capelli, Santo Carollo, Devyani Chowdhury, M. Sertaç Çiçek, Mitchell I. Cohen, David S. Cooper, John E. Deanfield, Joseph Dearani, Blanca del Valle, Kathryn M. Dodds, Junbao Du, Frank Edwin, Ekanem Ekure, Nurun Nahar Fatema, Anu Gomanju, Babar Hasan, Lewis Henry, Christopher Hugo-Hamman, Krishna S. Iyer, Marcelo B. Jatene, Kathy J. Jenkins, Tara Karamlou, Tom R. Karl, James K. Kirklin, Christián Kreutzer, Raman Krishna Kumar, Keila N. Lopez, Alexis Palacios Macedo, Bradley S. Marino, Eva M. Marwali, Folkert J. Meijboom, Sandra S. Mattos, Hani Najm, Dan Newlin, William M. Novick, Sir Shakeel A. Qureshi, Budi Rahmat, Robert Raylman, Irfan Levent Saltik, Craig Sable, Nestor Sandoval, Anita Saxena, Emma Scanlan, Gary F. Sholler, Jodi Smith, James D. St Louis, Christo I. Tchervenkov, Koh Ghee Tiong, Vladimiro Vida, Susan Vosloo, Douglas J. “DJ” Weinstein, James L. Wilkinson, Liesl Zuhlke, Jeffrey P. Jacobs
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- Journal:
- Cardiology in the Young / Volume 33 / Issue 8 / August 2023
- Published online by Cambridge University Press:
- 24 August 2023, pp. 1277-1287
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The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.
Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.
Affective wellbeing moderates the association between polygenic risk score for neuroticism and change in neuroticism
- J. Bahbouhová, M. V. Cade, A. T. De Sadeleer, C. Dibbets, L.-Q. Herrmann, P. O. F. Hovens, B. M. Jakson, R. C. Reising, C. Menne-Lothmann, J. Decoster, R. van Winkel, D. Collip, P. Delespaul, M. De Hert, C. Derom, E. Thiery, N. Jacobs, M. Wichers, J. van Os, B. P. F. Rutten, S. Gülöksüz, B. Klingenberg
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- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, p. S175
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Introduction
Neuroticism has societal, mental and physical health relevance, with an etiology involving genetic predisposition, psychological influence, and their interaction.
ObjectivesTo understand whether the association between polygenic risk score for neuroticism (PRS-N) and neuroticism is moderated by affective well-being.
MethodsData were derived from TwinssCan, a general population twin cohort (age range=15-35 years, 478 monozygotic twins). Self-report questionnaires were used to measure well-being and neuroticism. PRS-N was trained from the Genetics of Personality Consortium (GPC) and United Kingdom Biobank (UKB). Multilevel mixed-effects models were used to test baseline and changes in well-being and neuroticism.
ResultsBaseline wellbeing and neuroticism were associated (β=-1.35, p<0.001). PRSs-N were associated with baseline neuroticism (lowest p-value: 0.008 in GPC, 0.01 in UKB). In interaction models (PRS x wellbeing), GPC PRS-N (β=0.38, p=0.04) and UKB PRS-N (β=0.81, p<0.001) had significant interactions.
PRSs-N were associated with changes in neuroticism (lowest p-value: 0.03 in GPC, 0.3 in UKB). Furthermore, changes in wellbeing and neuroticism were associated (β =-0.66, p<0.001). In interaction models (PRS x change in wellbeing), only UKB PRS-N had a significant interaction (β=0.80, p<0.001).
ConclusionsInteraction between polygenic risk, wellbeing and neuroticism, were observed regarding baselines measures and change over time. Depending on the analysis step, the direction of the effect changed.
Disclosure of InterestNone Declared
The Parkes Pulsar Timing Array third data release
- Andrew Zic, Daniel J. Reardon, Agastya Kapur, George Hobbs, Rami Mandow, Małgorzata Curyło, Ryan M. Shannon, Jacob Askew, Matthew Bailes, N. D. Ramesh Bhat, Andrew Cameron, Zu-Cheng Chen, Shi Dai, Valentina Di Marco, Yi Feng, Matthew Kerr, Atharva Kulkarni, Marcus E. Lower, Rui Luo, Richard N. Manchester, Matthew T. Miles, Rowina S. Nathan, Stefan Osłowski, Axl F. Rogers, Christopher J. Russell, John M. Sarkissian, Mohsen Shamohammadi, Renée Spiewak, Nithyanandan Thyagarajan, Lawrence Toomey, Shuangqiang Wang, Lei Zhang, Songbo Zhang, Xing-Jiang Zhu
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 40 / 2023
- Published online by Cambridge University Press:
- 19 July 2023, e049
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We present the third data release from the Parkes Pulsar Timing Array (PPTA) project. The release contains observations of 32 pulsars obtained using the 64-m Parkes ‘Murriyang’ radio telescope. The data span is up to 18 yr with a typical cadence of 3 weeks. This data release is formed by combining an updated version of our second data release with $\sim$3 yr of more recent data primarily obtained using an ultra-wide-bandwidth receiver system that operates between 704 and 4032 MHz. We provide calibrated pulse profiles, flux density dynamic spectra, pulse times of arrival, and initial pulsar timing models. We describe methods for processing such wide-bandwidth observations and compare this data release with our previous release.
Differential associations of childhood adversity subtypes and psychopathology in men and women
- T. Prachason, I. Mutlu, L. Fusar-Poli, C. Menne-Lothmann, J. Decoster, R. van Winkel, D. Collip, P. Delespaul, M. De Hert, C. Derom, E. Thiery, N. Jacobs, M. Wichers, J. van Os, B. P. F. Rutten, L.-K. Pries, S. Gülöksüz
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- Journal:
- European Psychiatry / Volume 66 / Issue S1 / March 2023
- Published online by Cambridge University Press:
- 19 July 2023, pp. S80-S81
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Introduction
Prior evidence suggests that men and women might be differentially susceptible to distinct types of childhood adversity (CA), but research on gender-specific associations between CA subtypes and psychiatric symptoms is limited.
ObjectivesTo test the gender-specific associations of CA subtypes and psychiatric symptoms in the general population.
MethodsData from 791 twins and siblings from the TwinssCan project were used. Psychopathology and CA exposure were assessed using the Symptom Checklist-90 Revised (SCL-90) and the Childhood Trauma Questionnaire (CTQ), respectively. The associations between the total CTQ scores and SCL-90 scores (i.e. total SCL-90, psychoticism, paranoid ideation, anxiety, depression, somatization, obsessive-compulsive, interpersonal sensitivity, hostility, and phobic anxiety) were tested in men and women separately. The associations between the five CA subtypes (i.e. physical abuse, emotional abuse, sexual abuse, physical neglect, and emotional neglect) and total SCL-90 were tested in a mutually adjusted model. As exploratory analyses, the associations between all CA subtypes and the nine SCL-90 subdomain scores were similarly tested. The regression coefficients between men and women were compared using Chow’s test. All models were adjusted for age and family structure.
ResultsTotal CTQ was significantly associated with total SCL-90 in men (B = 0.013, SE = 0.003, P < .001) and women (B = 0.011, SE = 0.002, P < .001). The associations with the nine symptom domains were also significant in both genders (P < .001). No significant gender differences in the regression coefficients of total CTQ were detected. The analyses of CA subtypes showed a significant association between emotional abuse and total SCL-90 in women (B = 0.173, SE = 0.030, P < .001) and men (B = 0.080, SE = 0.035, P = .023), but the association was significantly stronger in women (ꭓ2(1) = 4.10, P = .043). The association of sexual abuse and total SCL-90 was only significant in women (B = 0.217, SE = 0.053, P < .001). The associations of emotional neglect (B = 0.061, SE = 0.027, P = .026) and physical neglect (B = 0.167, SE = 0.043, P < .001) with total SCL-90 were only significant in men. The explorative analyses of SCL-90 subdomains revealed significant associations of emotional abuse with all nine symptom domains and of sexual abuse with seven symptom domains in women. Significant associations of physical neglect with six symptom domains and of emotional neglect with depression were also detected in men. No other significant associations between CT subtypes and total SCL-90 or symptom domain scores were observed in men and women.
ConclusionsCA exposure was associated with diverse psychopathology similarly in both genders. However, women are more sensitive to abuse, but men are more sensitive to neglect. Gender-specific influences of CA subtypes on psychopathology should be considered in future studies.
Disclosure of InterestNone Declared
Chapter 14 - Visualizing Structural Underpinnings of DOHaD
- from Section IV - Mechanisms
- Edited by Lucilla Poston, King's College London, Keith M. Godfrey, University of Southampton, Peter D. Gluckman, University of Auckland, Mark A. Hanson, University of Southampton
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- Developmental Origins of Health and Disease
- Published online:
- 01 December 2022
- Print publication:
- 22 December 2022, pp 133-145
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Summary
Structural compromises are one of the important underpinnings of the developmental origins of health and disease. Quantifying anatomic changes during development is difficult but improved technology for clinical imaging has brought new research opportunities for visualizing such alterations. During prenatal life, maternal malnutrition, toxic social stress and exposure to toxic chemicals change fetal organ structures in specific ways. High placental resistance suppresses cardiomyocyte endowment. New imaging techniques allow quantification of nephrons in cadaverous kidneys without tedious dissection. High fat diets can lead to fatty liver and fibrosis. Pancreatic islet numbers and function are compromised by poor maternal diets. Both social and nutritional stressors change wiring and cellular composition of the brain for life. Advances in optical imaging also offer exciting new technologies for viewing structure and function in cells stressed during development.
Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults
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- Jacob J. Crouse, Nicholas Ho, Jan Scott, Richard Parker, Shin Ho Park, Baptiste Couvy-Duchesne, Brittany L. Mitchell, Enda M. Byrne, Daniel F. Hermens, Sarah E. Medland, Nicholas G. Martin, Nathan A. Gillespie, Ian B. Hickie
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- Journal:
- European Psychiatry / Volume 65 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 13 June 2022, e32
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Background
Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults.
MethodsWe modeled two dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal/lifestyle factors (role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal/lifestyle factors at 19Up were associated with (a) themselves or different items at 25Up, and (b) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome (STS) at 25Up.
ResultsThe first DBN identified 11 items that when endorsed at 19Up were more likely to be reendorsed at 25Up (e.g., hypersomnia, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory model with no threshold, >20 items at 19Up were associated with progression to an STS at 25Up (with lower statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like STS; increased activity and a later hypo-manic-like STS; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like STS.
ConclusionsThese probabilistic models identify symptoms and personal/lifestyle factors that might prove useful targets for indicated preventative strategies.
A New Radiocarbon Database for the Lower 48 States
- Robert L. Kelly, Madeline E. Mackie, Erick Robinson, Jack Meyer, Michael Berry, Matthew Boulanger, Brian F. Codding, Jacob Freeman, Carey James Garland, Joseph Gingerich, Robert Hard, James Haug, Andrew Martindale, Scott Meeks, Myles Miller, Shane Miller, Timothy Perttula, Jim A. Railey, Ken Reid, Ian Scharlotta, Jerry Spangler, David Hurst Thomas, Victor Thompson, Andrew White
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- Journal:
- American Antiquity / Volume 87 / Issue 3 / July 2022
- Published online by Cambridge University Press:
- 07 February 2022, pp. 581-590
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- July 2022
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From 2014 to 2020, we compiled radiocarbon ages from the lower 48 states, creating a database of more than 100,000 archaeological, geological, and paleontological ages that will be freely available to researchers through the Canadian Archaeological Radiocarbon Database. Here, we discuss the process used to compile ages, general characteristics of the database, and lessons learned from this exercise in “big data” compilation.
Outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in hospitalized hemodialysis patients: An epidemiologic and genomic investigation
- Part of
- Charles E. Marvil, Ahmed Babiker, Aaron Preston, Andrew S. Webster, Jeannette Guarner, Kari Love, Elham Ghonim, Paulina A. Rebolledo, Yun F. Wang, Robert A. Arthur, H. Richard Johnston, Jesse J. Waggoner, Anne Piantadosi, Jesse T. Jacob
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 44 / Issue 2 / February 2023
- Published online by Cambridge University Press:
- 06 December 2021, pp. 332-334
- Print publication:
- February 2023
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We performed an epidemiological investigation and genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) to define the source and scope of an outbreak in a cluster of hospitalized patients. Lack of appropriate respiratory hygiene led to SARS-CoV-2 transmission to patients and healthcare workers during a single hemodialysis session, highlighting the importance of infection prevention precautions.
Smoking ban in a psychiatry department: Are nonsmoking employees less exposed to environmental tobacco smoke?
- F. Vorspan, V. Bloch, E. Guillem, G. Dupuy, S. Pirnay, N. Jacob, J.-P. Lépine
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- European Psychiatry / Volume 24 / Issue 8 / December 2009
- Published online by Cambridge University Press:
- 16 April 2020, pp. 529-532
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Staff members of psychiatric facilities are at high risk of secondhand smoking. Smoking exposure was assessed in 41 nonsmoking employees of a psychiatry department before and after a ban. Subjective exposure measures decreased in 76% of the subjects. Salivary cotinine decreased in the subsample of seven subjects with high pre-ban levels (32 ±8 vs 40 ± 17 ng/ml, p = .045).
Science with the Murchison Widefield Array: Phase I results and Phase II opportunities – Corrigendum
- A. P. Beardsley, M. Johnston-Hollitt, C. M. Trott, J. C. Pober, J. Morgan, D. Oberoi, D. L. Kaplan, C. R. Lynch, G. E. Anderson, P. I. McCauley, S. Croft, C. W. James, O. I. Wong, C. D. Tremblay, R. P. Norris, I. H. Cairns, C. J. Lonsdale, P. J. Hancock, B. M. Gaensler, N. D. R. Bhat, W. Li, N. Hurley-Walker, J. R. Callingham, N. Seymour, S. Yoshiura, R. C. Joseph, K. Takahashi, M. Sokolowski, J. C. A. Miller-Jones, J. V. Chauhan, I. Bojičić, M. D. Filipović, D. Leahy, H. Su, W. W. Tian, S. J. McSweeney, B. W. Meyers, S. Kitaeff, T. Vernstrom, G. Gürkan, G. Heald, M. Xue, C. J. Riseley, S. W. Duchesne, J. D. Bowman, D. C. Jacobs, B. Crosse, D. Emrich, T. M. O. Franzen, L. Horsley, D. Kenney, M. F. Morales, D. Pallot, K. Steele, S. J. Tingay, M. Walker, R. B. Wayth, A. Williams, C. Wu
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- Publications of the Astronomical Society of Australia / Volume 37 / 2020
- Published online by Cambridge University Press:
- 23 March 2020, e014
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Science with the Murchison Widefield Array: Phase I results and Phase II opportunities
- A. P. Beardsley, M. Johnston-Hollitt, C. M. Trott, J. C. Pober, J. Morgan, D. Oberoi, D. L. Kaplan, C. R. Lynch, G. E. Anderson, P. I. McCauley, S. Croft, C. W. James, O. I. Wong, C. D. Tremblay, R. P. Norris, I. H. Cairns, C. J. Lonsdale, P. J. Hancock, B. M. Gaensler, N. D. R. Bhat, W. Li, N. Hurley-Walker, J. R. Callingham, N. Seymour, S. Yoshiura, R. C. Joseph, K. Takahashi, M. Sokolowski, J. C. A. Miller-Jones, J. V. Chauhan, I. Bojičić, M. D. Filipović, D. Leahy, H. Su, W. W. Tian, S. J. McSweeney, B. W. Meyers, S. Kitaeff, T. Vernstrom, G. Gürkan, G. Heald, M. Xue, C. J. Riseley, S. W. Duchesne, J. D. Bowman, D. C. Jacobs, B. Crosse, D. Emrich, T. M. O. Franzen, L. Horsley, D. Kenney, M. F. Morales, D. Pallot, K. Steele, S. J. Tingay, M. Walker, R. B. Wayth, A. Williams, C. Wu
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- Publications of the Astronomical Society of Australia / Volume 36 / 2019
- Published online by Cambridge University Press:
- 13 December 2019, e050
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The Murchison Widefield Array (MWA) is an open access telescope dedicated to studying the low-frequency (80–300 MHz) southern sky. Since beginning operations in mid-2013, the MWA has opened a new observational window in the southern hemisphere enabling many science areas. The driving science objectives of the original design were to observe 21 cm radiation from the Epoch of Reionisation (EoR), explore the radio time domain, perform Galactic and extragalactic surveys, and monitor solar, heliospheric, and ionospheric phenomena. All together $60+$ programs recorded 20 000 h producing 146 papers to date. In 2016, the telescope underwent a major upgrade resulting in alternating compact and extended configurations. Other upgrades, including digital back-ends and a rapid-response triggering system, have been developed since the original array was commissioned. In this paper, we review the major results from the prior operation of the MWA and then discuss the new science paths enabled by the improved capabilities. We group these science opportunities by the four original science themes but also include ideas for directions outside these categories.
The compositional variability of eudialyte-group minerals
- J. Schilling, F.-Y. Wu, C. McCammon, T. Wenzel, M. A. W. Marks, K. Pfaff, D. E. Jacob, G. Markl
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- Mineralogical Magazine / Volume 75 / Issue 1 / February 2011
- Published online by Cambridge University Press:
- 05 July 2018, pp. 87-115
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Eudialyte-group minerals (EGM) represent the most important index minerals of persodic agpaitic systems. Results are presented here of a combined EPMA, Mössbauer spectroscopy and LA-ICP-MS study and EGM which crystallized in various fractionation stages from different parental melts and mineral assemblages in silica over- and undersaturated systems are compared. Compositional variability is closely related to texture, allowing for reconstruction of locally acting magmatic to hydrothermal processes. Early-magmatic EGM are invariably dominated by Fe whereas hydrothermal EGM can be virtually Fe-free and form pure Mn end-members. Hence the Mn/Fe ratio is the most suitable fractionation indicator, although crystal chemistry effects and co-crystallizing phases play a secondary role in the incorporation of Fe and Mn into EGM. Mössbauer spectroscopy of EGM from three selected occurrences indicates the Fe3+/ΣFe ratio to be governed by the hydration state of EGM rather than by the oxygen fugacity of the coexisting melt. Negative Eu anomalies are restricted to EGM that crystallized from alkali basaltic parental melts while EGM from nephelinitic parental melts invariably lack negative Eu anomalies. Even after extensive differentiation intervals, EGM reflect properties of their respective parental melts and the fractionation of plagioclase and other minerals such as Fe-Ti oxides, amphibole and sulphides.
Effect of exercise on apparent total tract digestibility of nutrients and faecal recovery of ADL and TiO2 in ponies
- F. J. W. C. Schaafstra, D. A. van Doorn, J. T. Schonewille, E. Roelfsema, C. M. Westermann, O. Dansen, M. Jacobs, J.-Y. Lee, E. A. Spronck, M. C. Blok, W. H. Hendriks
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Exercise and physical training are known to affect gastrointestinal function and digestibility in horses and can lead to inaccurate estimates of nutrient and energy digestibility when markers are used. The effect of exercise on apparent nutrient digestibility and faecal recoveries of ADL and TiO2 was studied in six Welsh pony geldings subjected to either a low- (LI) or high-intensity (HI) exercise regime according to a cross-over design. Ponies performing LI exercise were walked once per day for 45 min in a horse walker (5 km/h) for 47 consecutive days. Ponies submitted to HI exercise were gradually trained for the same 47 days according a standardized protocol. Throughout the experiment, the ponies received a fixed level of feed and the daily rations consisted of 4.7 kg DM of grass hay and 0.95 kg DM of concentrate. The diet was supplemented with minerals, vitamins and TiO2 (3.0 g Ti/day). Total tract digestibility of DM, organic matter (OM), CP, crude fat, NDF, ADF, starch, sugar and energy was determined with the total faeces collection (TFC) method. In addition, DM and OM digestibility was estimated using internal ADL and the externally supplemented Ti as markers. Urine was collected on the final 2 days of each experimental period. Exercise did not affect apparent digestibility of CP, crude fat, starch and sugar. Digestibility of DM (DMD), OM (OMD), ADF and NDF tended to be lower and DE was decreased when ponies received the HI exercise regime. For all treatments combined, mean faecal recoveries of ADL and Ti were 87.8±1.7% and 99.3±1.7%, respectively. Ti was not detected in the urine, indicating that intestinal integrity was maintained with exercise. Dry matter digestibility estimated with the TFC, ADL and Ti for ponies subjected to LI exercise were 66.3%, 60.3% and 64.8%, respectively, while DMD for HI ponies were 64.2%, 60.3% and 65.2%, respectively. In conclusion, physical exercise has an influence on the GE digestibility of the feed in ponies provided with equivalent levels of feed intake. In addition, the two markers used for estimating apparent DMD and OMD indicate that externally supplemented Ti is a suitable marker to determine digestibility of nutrients in horses performing exercise unlike dietary ADL.
International quality improvement initiatives
- Patricia A. Hickey, Jean A. Connor, Kotturathu M. Cherian, Kathy Jenkins, Kaitlin Doherty, Haibo Zhang, Michael Gaies, Sara Pasquali, Sarah Tabbutt, James D. St. Louis, George E. Sarris, Hiromi Kurosawa, Richard A. Jonas, Nestor Sandoval, Christo I. Tchervenkov, Jeffery P. Jacobs, Giovanni Stellin, James K. Kirklin, Rajnish Garg, David F. Vener
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- Journal:
- Cardiology in the Young / Volume 27 / Issue S6 / December 2017
- Published online by Cambridge University Press:
- 04 December 2017, pp. S61-S68
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Across the globe, the implementation of quality improvement science and collaborative learning has positively affected the care and outcomes for children born with CHD. These efforts have advanced the collective expertise and performance of inter-professional healthcare teams. In this review, we highlight selected quality improvement initiatives and strategies impacting the field of cardiovascular care and describe implications for future practice and research. The continued leveraging of technology, commitment to data transparency, focus on team-based practice, and recognition of cultural norms and preferences ensure the success of sustainable models of global collaboration.
Wohlfahrtiimonas chitiniclastica: current insights into an emerging human pathogen
- P. SCHRÖTTNER, W. W. RUDOLPH, U. DAMME, C. LOTZ, E. JACOBS, F. GUNZER
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- Journal:
- Epidemiology & Infection / Volume 145 / Issue 7 / May 2017
- Published online by Cambridge University Press:
- 06 February 2017, pp. 1292-1303
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Since the first description of Wohlfahrtiimonas chitiniclastica in 2008, a number of well described case reports demonstrating its pathogenic role in humans have been published. Infections may be closely linked to flies, such as Wohlfahrtia magnifica, Lucilia sericata, Chrysomya megacephala or Musca domestica. These insects are potent vectors for the distribution of W. chitiniclastica causing local or systemic infections originating from wounds infested with fly larvae. However, other potential sources of transmission of W. chitiniclastica have been described such as soil or chicken meat. Infections in humans reported to date comprise wound infections, cellulitis, osteomyelitis and sepsis. This review summarizes all the literature available up to now and gives the current knowledge about this emerging human pathogen. Additionally, four patients with proven W. chitiniclastica infections treated at Dresden University Hospital between 2013 and 2015, are included. Special focus was placed on microbiological identification and antibiotic susceptibility testing of the pathogen.
Infrared Spectra of the Ices at ≈4 K and the Interpretation of the vOD(D2O) Bands of Ices II and IX
- F. E. Bates, S. M. Jacobs, J. E. Bertie
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- Journal of Glaciology / Volume 21 / Issue 85 / 1978
- Published online by Cambridge University Press:
- 30 January 2017, p. 694
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We have studied the infrared absorption by the OD stretching, vOD(D2O), and D2O rotational, vR(D2O), vibrations of fully deuterated ice II and ice IX at lo K, and the absorption by OD stretching vibrations, vOD (HDO), of HDO molecules isolated in ices Ih, II, and IX at 10 K. Calculations of the frequencies and relative intensities of the zero-wave-vector normal vOD(D2O) vibrations of ices II and IX have allowed the vOD(D2O) absorption to be assigned. Each component of the band is broad, even at 10 K, most probably because of Fermi resonance between the fundamental OD stretching vibrational states and the isoenergetic continuum of high-order overtone and combination states of the lattice modes. This work has yielded the most complete interpretation yet achieved of an infrared band due to the OH or OD stretching vibrations of a phase of ice.
The far-infrared absorption by the translational vibrations of H2O and D2O ices Ih and Ic at 4.3 K has been measured, and has revealed differences between the spectra of ices III and Ic for the first time.
Papers describing this work in full have been published in Journal of Chemical Physics, Vol. 67, No. 4, 1977, p. 1311-18, and Vol. 67, No. 6, 1977, p. 2445-48.
Infrared Spectra of the Clathrate Hydrates
- D. A. Othen, P. G. Wright, F. E. Bates, D. K. Hendricksen, S. M. Jacobs, J. E. Bertie
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- Journal of Glaciology / Volume 21 / Issue 85 / 1978
- Published online by Cambridge University Press:
- 30 January 2017, pp. 694-696
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Detailed mid- and far-infrared spectra have been recorded for authenticated samples of several clathrate hydrates with the two main structures, I and II, at temperatures between 150 and 4 K. The systems are complicated, yet a detailed analysis of the many interesting spectral features is required before reliable, detailed information can be obtained. Consequently only rather general conclusions can be drawn at present.
The mid-infrared spectra have been recorded for the structure I hydrates and deuterates of ethylene oxide, trimethylene oxide, and cyclopropane, and the structure II hydrate and deuterate of trimethylene oxide, all at 100 K. The OD stretching vibrations of isolated HDO molecules, vOD (HDO), and of the fully deuterated forms, vOD(D2O), have also been recorded for cyclopropane and trimethylene oxide structure I hydrates at 40 K, and the absorption by the guest molecules has been studied for all of the structure I hydrates at temperatures down to 40 K.
The absorption by the water molecules at 100 K is similar to that in ice, with frequencies that vary in the expected way with the lattice parameter and, hence, the hydrogen bond lengths. The shapes of the vOH(H2O)vOD(D2O), and vR(D2O) bands are essentially the same for structures I and II, while the vOD(D2O) band varies only slightly and depends more on the guest molecule than on the structure. The water absorption changed only slightly when the samples were cooled from 100 to 40 K.
The vOD(HDO) bands provide clear evidence that the distribution of hydrogen bond lengths in cyclopropane hydrate differs from those in ethylene oxide and trimethylene oxide structure I hydrates, even though powder X-ray methods indicate that the three hydrates are isostructural. The difference is attributed to an interaction between the hydrogen bonds and the dipole moment of the guest which is too irregular to be sensed by powder X-ray methods.
Some absorption bands of the guest molecules are visible in the spectra of structure I hydrates and, as expected, fewer are visible in the spectra of structure II hydrates, which have a higher water-to-guest ratio. For both structures more guest bands are visible in the spectra of deuterates since the D2O absorption is weaker than that of H2O. The guest bands are single in most cases, with half-widths of 1 to 5 cm-1 for ethylene oxide and cyclopropane and 5 to 15 cm-1 for trimethylene oxide in its deuterates of both structures. One band of ethylene oxide at 100 K and below is a doublet, and one degenerate and one non-degenerate vibration of cyclopropane yields a doublet at 40 K. This must mean that there are two non-equivalent positions for the guest molecule in the tetrakaidecahedral cage of the structure I hydrate at these temperatures.
Far infrared spectra have been recorded of the structure I hydrates of ethylene oxide, cyclopropane, trimethylene oxide, and xenon, and of the structure II hydrates of trimethylene oxide, cyclopropane, tetrahydrofuran, cyclobutanone, and 1,3-dioxolane, all at 4.3 K. The spectra of the hydrates and corresponding deuterates have enabled the absorption by the rotational vibrations of the guest molecules in the cage to be identified. The absorption above 100 cm-1 by the translational vibrations of the water molecules is significantly different for the two structures, but is rather insensitive to the guest molecule within one structure.
A careful search was made for evidence of the transition in trimethylene oxide structure I hydrate at which the guest molecules partly order, that was detected by Davidson from dielectric studies. No spectral changes due to the transition were detected.
Papers describing this work have been published in Canadian. Journal of Chemistry, Vol. 51, No. 8, 1973, p. 1159-68; Vol. 53, No. 1, 1975, p. 71-75; Vol. 55, No. 10, 1977, p. 1777-85. A further paper is accepted for publication in Journal of Chemical Physics and others arc in preparation.
Evaluating the Competitive Ability of Semileafless Field Pea Cultivars
- Cory E. Jacob, Eric N. Johnson, Miles F. Dyck, Christian J. Willenborg
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- Journal:
- Weed Science / Volume 64 / Issue 1 / March 2016
- Published online by Cambridge University Press:
- 20 January 2017, pp. 137-145
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The inclusion of competitive crop cultivars in crop rotations is an important integrated weed management (IWM) tool. However, competitiveness is often not considered a priority for breeding or cultivar selection by growers. Field pea (Pisum sativum L.) is often considered a poor competitor with weeds, but it is not known whether competitiveness varies among semileafless cultivars. The objectives of this study were to determine if semileafless field pea cultivars vary in their ability to compete and/or withstand competition, as well as to identify aboveground trait(s) that may be associated with increased competitive ability. Field experiments were conducted in 2012 and 2013 at three locations in western Canada. Fourteen semileafless field pea cultivars were included in the study representing four different market classes. Cultivars were grown either in the presence or absence of model weeds (wheat and canola), and competitive ability of the cultivars was determined based on their ability to withstand competition (AWC) and their ability to compete (AC). Crop yield, weed biomass and weed fecundity varied among sites but not years. Cultivars exhibited inconsistent differences in competitive ability, although cv. Reward consistently exhibited the lowest AC and AWC. None of the traits measured in this study correlated highly with competitive ability. However, the highest-yielding cultivars generally were those that had the highest AC, whereas cultivars that ranked highest for AWC were associated with lower weed fecundity. Ranking the competitive ability of field pea cultivars could be an important IWM tool for growers and agronomists.
Ionospheric Modelling using GPS to Calibrate the MWA. I: Comparison of First Order Ionospheric Effects between GPS Models and MWA Observations
- Part of
- B. S. Arora, J. Morgan, S. M. Ord, S. J. Tingay, N. Hurley-Walker, M. Bell, G. Bernardi, N. D. R. Bhat, F. Briggs, J. R. Callingham, A. A. Deshpande, K. S. Dwarakanath, A. Ewall-Wice, L. Feng, B.-Q. For, P. Hancock, B. J. Hazelton, L. Hindson, D. Jacobs, M. Johnston-Hollitt, A. D. Kapińska, N. Kudryavtseva, E. Lenc, B. McKinley, D. Mitchell, D. Oberoi, A. R. Offringa, B. Pindor, P. Procopio, J. Riding, L. Staveley-Smith, R. B. Wayth, C. Wu, Q. Zheng, J. D. Bowman, R. J. Cappallo, B. E. Corey, D. Emrich, R. Goeke, L. J. Greenhill, D. L. Kaplan, J. C. Kasper, E. Kratzenberg, C. J. Lonsdale, M. J. Lynch, S. R. McWhirter, M. F. Morales, E. Morgan, T. Prabu, A. E. E. Rogers, A. Roshi, N. Udaya Shankar, K. S. Srivani, R. Subrahmanyan, M. Waterson, R. L. Webster, A. R. Whitney, A. Williams, and C. L. Williams
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 32 / 2015
- Published online by Cambridge University Press:
- 10 August 2015, e029
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We compare first-order (refractive) ionospheric effects seen by the MWA with the ionosphere as inferred from GPS data. The first-order ionosphere manifests itself as a bulk position shift of the observed sources across an MWA field of view. These effects can be computed from global ionosphere maps provided by GPS analysis centres, namely the CODE. However, for precision radio astronomy applications, data from local GPS networks needs to be incorporated into ionospheric modelling. For GPS observations, the ionospheric parameters are biased by GPS receiver instrument delays, among other effects, also known as receiver DCBs. The receiver DCBs need to be estimated for any non-CODE GPS station used for ionosphere modelling. In this work, single GPS station-based ionospheric modelling is performed at a time resolution of 10 min. Also the receiver DCBs are estimated for selected Geoscience Australia GPS receivers, located at Murchison Radio Observatory, Yarragadee, Mount Magnet and Wiluna. The ionospheric gradients estimated from GPS are compared with that inferred from MWA. The ionospheric gradients at all the GPS stations show a correlation with the gradients observed with the MWA. The ionosphere estimates obtained using GPS measurements show promise in terms of providing calibration information for the MWA.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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