35 results
Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) outbreak investigation in a hospital emergency department—California, December 2020–January 2021
- Part of
- Ruoran Li, Elizabeth Beshearse, Deborah Malden, Holly Truong, Vit Kraushaar, Brandon J. Bonin, Janice Kim, Idamae Kennedy, Jennifer McNary, George S. Han, Sarah L. Rudman, Joseph F. Perz, Kiran M. Perkins, Janet Glowicz, Erin Epson, Isaac Benowitz, Elsa Villarino
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 44 / Issue 7 / July 2023
- Published online by Cambridge University Press:
- 20 May 2022, pp. 1187-1192
- Print publication:
- July 2023
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We describe a large outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) involving an acute-care hospital emergency department during December 2020 and January 2021, in which 27 healthcare personnel worked while infectious, resulting in multiple opportunities for SARS-CoV-2 transmission to patients and other healthcare personnel. We provide recommendations for improving infection prevention and control.
Characterisation of age and polarity at onset in bipolar disorder
- Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 25 August 2021, pp. 659-669
- Print publication:
- December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) Science and the CBRNE Science Medical Operations Science Support Expert (CMOSSE)
- C. Norman Coleman, Judith L. Bader, John F. Koerner, Chad Hrdina, Kenneth D. Cliffer, John L. Hick, James J. James, Monique K. Mansoura, Alicia A. Livinski, Scott V. Nystrom, Andrea DiCarlo-Cohen, Maria Julia Marinissen, Lynne Wathen, Jessica M. Appler, Brooke Buddemeier, Rocco Casagrande, Derek Estes, Patrick Byrne, Edward M. Kennedy, Ann A. Jakubowski, Cullen Case, Jr, David M. Weinstock, Nicholas Dainiak, Dan Hanfling, Andrew L. Garrett, Natalie N. Grant, Daniel Dodgen, Irwin Redlener, Thomas F. MacKAY, Meghan Treber, Mary J. Homer, Tammy P. Taylor, Aubrey Miller, George Korch, Richard Hatchett
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 13 / Issue 5-6 / December 2019
- Published online by Cambridge University Press:
- 17 June 2019, pp. 995-1010
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A national need is to prepare for and respond to accidental or intentional disasters categorized as chemical, biological, radiological, nuclear, or explosive (CBRNE). These incidents require specific subject-matter expertise, yet have commonalities. We identify 7 core elements comprising CBRNE science that require integration for effective preparedness planning and public health and medical response and recovery. These core elements are (1) basic and clinical sciences, (2) modeling and systems management, (3) planning, (4) response and incident management, (5) recovery and resilience, (6) lessons learned, and (7) continuous improvement. A key feature is the ability of relevant subject matter experts to integrate information into response operations. We propose the CBRNE medical operations science support expert as a professional who (1) understands that CBRNE incidents require an integrated systems approach, (2) understands the key functions and contributions of CBRNE science practitioners, (3) helps direct strategic and tactical CBRNE planning and responses through first-hand experience, and (4) provides advice to senior decision-makers managing response activities. Recognition of both CBRNE science as a distinct competency and the establishment of the CBRNE medical operations science support expert informs the public of the enormous progress made, broadcasts opportunities for new talent, and enhances the sophistication and analytic expertise of senior managers planning for and responding to CBRNE incidents.
Uranium-Series Ages of Marine Terrace Corals from the Pacific Coast of North America and Implications for Last-Interglacial Sea Level History
- Daniel R. Muhs, George L. Kennedy, Thomas K. Rockwell
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- Journal:
- Quaternary Research / Volume 42 / Issue 1 / July 1994
- Published online by Cambridge University Press:
- 20 January 2017, pp. 72-87
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Few of the marine terraces along the Pacific coast of North America have been dated using uranium-series techniques. Ten terrace sequences from southern Oregon to southern Baja California Sur have yielded fossil corals in quantities suitable for U-series dating by alpha spectrometry. U-series-dated terraces representing the ∼80,000 yr sea-level high stand are identified in five areas (Bandon, Oregon; Point Arena, San Nicolas Island, and Point Loma, California; and Punta Banda, Baja California); terraces representing the ∼125,000 yr sea-level high stand are identified in eight areas (Cayucos, San Luis Obispo Bay, San Nicolas Island, San Clemente Island, and Point Loma, California; Punta Bands and Isla Guadalupe, Baja California; and Cabo Pulmo, Baja California Sur). On San Nicolas Island, Point Loma, and Punta Bands, both the ∼80,000 and the ∼125,000 yr terraces are dated. Terraces that may represent the ∼105,000 sea-level high stand are rarely preserved and none has yielded corals for U-series dating. Similarity of coral ages from midlatitude, erosional marine terraces with coral ages from emergent, constructional reefs on tropical coastlines suggests a common forcing mechanism, namely glacioeustatically controlled fluctuations in sea level superimposed on steady tectonic uplift. The low marine terrace dated at ∼125,000 yr on Isla Guadalupe, Baja California, presumed to be tectonically stable, supports evidence from other localities for a +6-m sea level at that time. Data from the Pacific Coast and a compilation of data from other coasts indicate that sea levels at ∼80,000 and ∼105,000 yr may have been closer to present sea level (within a few meters) than previous studies have suggested.
New Cretaceous and Tertiary Pholadidae (Mollusca: Bivalvia) from California
- George L. Kennedy
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- Journal:
- Journal of Paleontology / Volume 67 / Issue 3 / May 1993
- Published online by Cambridge University Press:
- 20 May 2016, pp. 397-404
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Cretaceous and early Tertiary Pholadidae (Mollusca: Bivalvia) from the Pacific Slope of North America are rare and only poorly known. Three new species, each the earliest known Pacific Slope representative of its respective genus, are described: Barnea (Anchomasa) saulae n. sp. (Pholadinae) from the Upper Cretaceous (Coniacian and Santonian) Redding Formation near Redding, uppermost Sacramento Valley, Shasta County, northern California; Chaceia fulcherae n. sp. (Martesiinae) from three widely separated areas of outcrop represented by 1) the middle Miocene (“Temblor”) Temblor Formation near Oil City and in Jasper Canyon, western Fresno County, central California, 2) the middle Miocene (“Temblor”) Topanga(?) Group in the northern Santa Ana Mountains, Orange County, southern California, and 3) the upper Miocene (Wishkahan) Montesano Formation on the Middle Fork of the Satsop River, Mason County, western Washington; and Netastoma squiresi n. sp. (Jouannetiinae) from the lowest Eocene (uppermost “Meganos”) part of the Santa Susana Formation north of Simi Valley in the Santa Susana Mountains, Ventura County, southern California.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Quantitative DT-MRI Investigations of the Human Cingulum Bundle
- Nikos Makris, Deepak N. Pandya, Joseph J. Normandin, George M. Papadimitriou, Scott L. Rauch, Verne S. Caviness, David N. Kennedy
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- Journal:
- CNS Spectrums / Volume 7 / Issue 7 / July 2002
- Published online by Cambridge University Press:
- 07 November 2014, pp. 522-528
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White matter fiber pathways are key structural components of the brain and its functional organization. The limbic system carries a great deal of its anatomic connectivity via the cingulum bundle. By allowing the in vivo delineation of the stem of the major fiber pathway systems, diffusion tensor magnetic resonance imaging has opened a new window into the detailed structure of the white matter in health and disease. Topographic, biophysical, and volumetric information about fiber tracts will provide a more complete understanding of the brain. By appreciating its interconnections, the precise anatomical knowledge of the cingulum bundle will improve our understanding of the limbic system and may enable improvements in the assessment and treatment of neuropsychiatric disorders. In this study, the stem of the cingulum bundle was investigated and defined in terms of its trajectory, anisotropy, and volume, in four normal human subjects, using diffusion tensor imaging.
Contributor affiliations
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- By Frank Andrasik, Melissa R. Andrews, Ana Inés Ansaldo, Evangelos G. Antzoulatos, Lianhua Bai, Ellen Barrett, Linamara Battistella, Nicolas Bayle, Michael S. Beattie, Peter J. Beek, Serafin Beer, Heinrich Binder, Claire Bindschaedler, Sarah Blanton, Tasia Bobish, Michael L. Boninger, Joseph F. Bonner, Chadwick B. Boulay, Vanessa S. Boyce, Anna-Katharine Brem, Jacqueline C. Bresnahan, Floor E. Buma, Mary Bartlett Bunge, John H. Byrne, Jeffrey R. Capadona, Stefano F. Cappa, Diana D. Cardenas, Leeanne M. Carey, S. Thomas Carmichael, Glauco A. P. Caurin, Pablo Celnik, Kimberly M. Christian, Stephanie Clarke, Leonardo G. Cohen, Adriana B. Conforto, Rory A. Cooper, Rosemarie Cooper, Steven C. Cramer, Armin Curt, Mark D’Esposito, Matthew B. Dalva, Gavriel David, Brandon Delia, Wenbin Deng, Volker Dietz, Bruce H. Dobkin, Marco Domeniconi, Edith Durand, Tracey Vause Earland, Georg Ebersbach, Jonathan J. Evans, James W. Fawcett, Uri Feintuch, Toby A. Ferguson, Marie T. Filbin, Diasinou Fioravante, Itzhak Fischer, Agnes Floel, Herta Flor, Karim Fouad, Richard S. J. Frackowiak, Peter H. Gorman, Thomas W. Gould, Jean-Michel Gracies, Amparo Gutierrez, Kurt Haas, C.D. Hall, Hans-Peter Hartung, Zhigang He, Jordan Hecker, Susan J. Herdman, Seth Herman, Leigh R. Hochberg, Ahmet Höke, Fay B. Horak, Jared C. Horvath, Richard L. Huganir, Friedhelm C. Hummel, Beata Jarosiewicz, Frances E. Jensen, Michael Jöbges, Larry M. Jordan, Jon H. Kaas, Andres M. Kanner, Noomi Katz, Matthew S. Kayser, Annmarie Kelleher, Gerd Kempermann, Timothy E. Kennedy, Jürg Kesselring, Fary Khan, Rachel Kizony, Jeffery D. Kocsis, Boudewijn J. Kollen, Hubertus Köller, John W. Krakauer, Hermano I. Krebs, Gert Kwakkel, Bradley Lang, Catherine E. Lang, Helmar C. Lehmann, Angelo C. Lepore, Glenn S. Le Prell, Mindy F. Levin, Joel M. Levine, David A. Low, Marilyn MacKay-Lyons, Jeffrey D. Macklis, Margaret Mak, Francine Malouin, William C. Mann, Paul D. Marasco, Christopher J. Mathias, Laura McClure, Jan Mehrholz, Lorne M. Mendell, Robert H. Miller, Carol Milligan, Beth Mineo, Simon W. Moore, Jennifer Morgan, Charbel E-H. Moussa, Martin Munz, Randolph J. Nudo, Joseph J. Pancrazio, Theresa Pape, Alvaro Pascual-Leone, Kristin M. Pearson-Fuhrhop, P. Hunter Peckham, Tamara L. Pelleshi, Catherine Verrier Piersol, Thomas Platz, Marcus Pohl, Dejan B. Popović, Andrew M. Poulos, Maulik Purohit, Hui-Xin Qi, Debbie Rand, Mahendra S. Rao, Josef P. Rauschecker, Aimee Reiss, Carol L. Richards, Keith M. Robinson, Melvyn Roerdink, John C. Rosenbek, Serge Rossignol, Edward S. Ruthazer, Arash Sahraie, Krishnankutty Sathian, Marc H. Schieber, Brian J. Schmidt, Michael E. Selzer, Mijail D. Serruya, Himanshu Sharma, Michael Shifman, Jerry Silver, Thomas Sinkjær, George M. Smith, Young-Jin Son, Tim Spencer, John D. Steeves, Oswald Steward, Sheela Stuart, Austin J. Sumner, Chin Lik Tan, Robert W. Teasell, Gareth Thomas, Aiko K. Thompson, Richard F. Thompson, Wesley J. Thompson, Erika Timar, Ceri T. Trevethan, Christopher Trimby, Gary R. Turner, Mark H. Tuszynski, Erna A. van Niekerk, Ricardo Viana, Difei Wang, Anthony B. Ward, Nick S. Ward, Stephen G. Waxman, Patrice L. Weiss, Jörg Wissel, Steven L. Wolf, Jonathan R. Wolpaw, Sharon Wood-Dauphinee, Ross D. Zafonte, Binhai Zheng, Richard D. Zorowitz
- Edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Gert Kwakkel, Robert Miller, Case Western Reserve University, Ohio
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- Book:
- Textbook of Neural Repair and Rehabilitation
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- 05 May 2014
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- Textbook of Neural Repair and Rehabilitation
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Locating the Dust in A Star Debris Discs
- Mark Booth, Grant Kennedy, Bruce Sibthorpe, Brenda C. Matthews, Mark C. Wyatt, Gaspard Duchêne, J. J. Kavelaars, David Rodriguez, Jane S. Greaves, Alice Koning, Laura Vican, George H. Rieke, Kate Y. L. Su, Amaya Moro-Martín, Paul Kalas
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- Journal:
- Proceedings of the International Astronomical Union / Volume 8 / Issue S299 / June 2013
- Published online by Cambridge University Press:
- 06 January 2014, pp. 330-331
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- June 2013
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Using photometry at just two wavelengths it is possible to fit a blackbody to the spectrum of infrared excess that is the signature of a debris disc. From this the location of the dust can be inferred. However, it is well known that dust in debris discs is not a perfect blackbody. By resolving debris discs we can find the actual location of the dust and compare this to that inferred from the blackbody fit. Using the Herschel Space Observatory we resolved many systems as part of the DEBRIS survey. Here we discuss a sample of 9 discs surrounding A stars and find that the discs are actually located between 1 and 2.5 times further from their star than predicted by blackbody fits to the spectral energy distribution (SED). The variation in this ratio is due to differences in stellar luminosities, location of the dust, size distribution and composition of the dust.
Contributors
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- By Ghazi Al-Rawas, Vazken Andréassian, Tianqi Ao, Stacey A. Archfield, Berit Arheimer, András Bárdossy, Trent Biggs, Günter Blöschl, Theresa Blume, Marco Borga, Helge Bormann, Gianluca Botter, Tom Brown, Donald H. Burn, Sean K. Carey, Attilio Castellarin, Francis Chiew, François Colin, Paulin Coulibaly, Armand Crabit, Barry Croke, Siegfried Demuth, Qingyun Duan, Giuliano Di Baldassarre, Thomas Dunne, Ying Fan, Xing Fang, Boris Gartsman, Alexander Gelfan, Mikhail Georgievski, Nick van de Giesen, David C. Goodrich, Hoshin V. Gupta, Khaled Haddad, David M. Hannah, H. A. P. Hapuarachchi, Hege Hisdal, Kamila Hlavčová, Markus Hrachowitz, Denis A. Hughes, Günter Humer, Ruud Hurkmans, Vito Iacobellis, Elena Ilyichyova, Hiroshi Ishidaira, Graham Jewitt, Shaofeng Jia, Jeffrey R. Kennedy, Anthony S. Kiem, Robert Kirnbauer, Thomas R. Kjeldsen, Jürgen Komma, Leonid M. Korytny, Charles N. Kroll, George Kuczera, Gregor Laaha, Henny A. J. van Lanen, Hjalmar Laudon, Jens Liebe, Shijun Lin, Göran Lindström, Suxia Liu, Jun Magome, Danny G. Marks, Dominic Mazvimavi, Jeffrey J. McDonnell, Brian L. McGlynn, Kevin J. McGuire, Neil McIntyre, Thomas A. McMahon, Ralf Merz, Robert A. Metcalfe, Alberto Montanari, David Morris, Roger Moussa, Lakshman Nandagiri, Thomas Nester, Taha B. M. J. Ouarda, Ludovic Oudin, Juraj Parajka, Charles S. Pearson, Murray C. Peel, Charles Perrin, John W. Pomeroy, David A. Post, Ataur Rahman, Liliang Ren, Magdalena Rogger, Dan Rosbjerg, José Luis Salinas, Jos Samuel, Eric Sauquet, Hubert H. G. Savenije, Takahiro Sayama, John C. Schaake, Kevin Shook, Murugesu Sivapalan, Jon Olav Skøien, Chris Soulsby, Christopher Spence, R. ‘Sri’ Srikanthan, Tammo S. Steenhuis, Jan Szolgay, Yasuto Tachikawa, Kuniyoshi Takeuchi, Lena M. Tallaksen, Dörthe Tetzlaff, Sally E. Thompson, Elena Toth, Peter A. Troch, Remko Uijlenhoet, Carl L. Unkrich, Alberto Viglione, Neil R. Viney, Richard M. Vogel, Thorsten Wagener, M. Todd Walter, Guoqiang Wang, Markus Weiler, Rolf Weingartner, Erwin Weinmann, Hessel Winsemius, Ross A. Woods, Dawen Yang, Chihiro Yoshimura, Andy Young, Gordon Young, Erwin Zehe, Yongqiang Zhang, Maichun C. Zhou
- Edited by Günter Blöschl, Technische Universität Wien, Austria, Murugesu Sivapalan, University of Illinois, Urbana-Champaign, Thorsten Wagener, University of Bristol, Alberto Viglione, Technische Universität Wien, Austria, Hubert Savenije, Technische Universiteit Delft, The Netherlands
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- Runoff Prediction in Ungauged Basins
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- 05 April 2013
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- 18 April 2013, pp ix-xiv
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Carotenoids but not flavonoids are associated with improvements in spatial working memory in younger adults in a flavonoid-rich v. -poor fruit and vegetable intervention study
- A. L. Macready, L. T. Butler, O. B. Kennedy, T. W. George, M. F. Chong, J. A. Lovegrove, the Flavurs team
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- Proceedings of the Nutrition Society / Volume 70 / Issue OCE4 / 2011
- Published online by Cambridge University Press:
- 14 October 2011, E133
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Using the theory of planned behaviour to assess if psychosocial determinants of fruit and vegetable intake in a UK adult population change following a dietary intervention
- T. D. Eggers, G. Herbert, T. W. George, M. F. Chong, J. A. Lovegrove, L. Butler, O. B. Kennedy, the FLAVURS Team
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- Proceedings of the Nutrition Society / Volume 69 / Issue OCE6 / 2010
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- 19 November 2010, E421
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Rhetorical Exercises from Late Antiquity
- A Translation of Choricius of Gaza's Preliminary Talks and Declamations
- Choricius
- Edited by Robert J. Penella
- With Eugenio Amato, Malcolm Heath, George A. Kennedy, Terry L. Papillon, William R. Reader, D. A. Russell, Simon Swain
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- Published online:
- 29 January 2010
- Print publication:
- 10 September 2009
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The first translation, produced by a team of eight scholars, of the Declamations and Preliminary Talks of the sixth-century sophist Choricius of Gaza. Declamations, deliberative or judicial orations on fictitious themes, were the fundamental advanced exercises of the rhetorical schools of the Roman Empire, of interest also to audiences outside the schools. Some of Choricius' declamations are on generic themes (e.g. a tyrannicide, a war-hero), while others are based on specific motifs from Homeric times or from classical Greek history. The Preliminary Talks were typical prefaces to orations of all kinds. This volume also contains a detailed study of Choricius' reception in Byzantium and Renaissance Italy. It will be of interest to students of late antiquity, ancient rhetoric, and ancient education.
11 - Declamation 10 [XXXVIII]: <Patroclus>
- from II - CHORICIUS, DECLAMATIONS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
- Published online:
- 29 January 2010
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- 10 September 2009, pp 200-221
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Summary
[THEME]
After Achilles was deprived of Briseis he withdrew into his own hut enraged. Agamemnon sent ambassadors to him, offering him back the girl along with very many gifts. But his embassy, with Briseis and the gifts, proved unsuccessful. In the short intervening time there were also many further misfortunes for the Greeks. Patroclus took notice of this and shared in their suffering; and with both tears and admonitions he tries to reconcile Achilles with the Greeks. Let us take the part of Patroclus.
EXPLANATORY COMMENT
[1] For what reason is Patroclus now troubled along with the Greeks, though the Thessalian [Achilles] does not at all feel this way? For the two are intimates and friends, and the maxim does require that “friends have all things in common.” For what reason, although he had earlier shared Achilles' anger, did he not maintain with him to the end that partnership of wrath? The poet resolved the difficulty, I think, by presenting to us the one as mild and easily brought to compassion – for he calls him “gentle” – but the other as rough and violent and also “lion-hearted,” as he adds in his poetry. [2] Therefore, given this lack of humane feeling it was necessary for the gentle one to be a counselor to the one who was not so. Consequently he stands beside him, shedding tears before him like a fountain, but [Achilles], the son of Peleus, did not know the cause for the lamentation.
4 - Declamation 3 [XIV]: <The Lydians>
- from II - CHORICIUS, DECLAMATIONS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
- Published online:
- 29 January 2010
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- 10 September 2009, pp 87-95
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Summary
[THEME]
The Persian king Cyrus made a prisoner of the Lydian ruler Croesus. When he discovered that the Lydians were plotting to regain their kingdom, he ordered them to be stripped of their weapons, to put on women's clothing, and to sing and play music and teach such things to their children. He devised this as a means of curbing their pride. Later, when his expedition against the Massagetae was under way, he summoned the Lydians and offered them their former equipment; they opposed the offer. Let us take the part of the Lydians.
EXPLANATORY COMMENT
[1] At first sight it may be thought strange for the Lydians to object in favor of a form of dress which demeans their reputation and shames their masculinity. They should be absolutely delighted about Cyrus' order to take off those disgraceful clothes and take up their familiar armor. [2] This is actually what the Lydians want; but they want to appear otherwise. For if they were enticed by Cyrus' change of heart into letting their faces show their delight and ran to their weapons clapping their hands, they would startle him into suspecting a fresh uprising. [3] They anticipate such a reaction, and to suit their purpose they figure their speech as a rejection of Cyrus, pretending that their experiences have deprived them of their virility and considering his intention, in case he is simply devising a way of testing them.
9 - Declamation 8 [XXIX]: <A Spartan Citizen>
- from II - CHORICIUS, DECLAMATIONS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
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- 29 January 2010
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- 10 September 2009, pp 158-176
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Summary
[THEME]
When ugly girls were being born in Lacedaemon, Lacedaemonians came to Delphi to seek a cure for the affliction. The god [Apollo] proclaimed that the disease had fallen on Sparta because of the anger of Aphrodite, who was outraged at some recent event. The goddess would cease from her anger when honored by a statue. They commissioned the statue from Praxiteles, who practiced this art. Having completed a statue modeled on the courtesan Phryne, his paramour, he inscribed it with the name “Aphrodite.” An assembly convened to consider the matter. Praxiteles urges the statue to be accepted, while a certain Spartan citizen speaks against it. Let us declaim the part of the Spartan.
EXPLANATORY COMMENT
[1] Why on earth, they say, did the speech invent this theme with its Spartan setting, and why does it imagine convening a Laconian assembly and enjoy describing their customs? A statue of a lewd woman is being rejected, and the Spartans are the most modest of all Greeks; hence the speech blames all the more the lover of Phryne, comparing him to the decency of Lacedaemon. [2] In a similar spirit long ago, Demosthenes also elaborated a rather bitter attack on the licentiousness of Aeschines. For after gathering a tyrannical drinking party and introducing Aeschines to the feast and then making the man drunk and, while he was in a drunken state, inciting him to a passion for an Olynthian woman, Demosthenes' account brings Iatrocles to the party, a man devoted to self-control, providing proof of the shamelessness of Aeschines by introducing that man's decency; for to a temperate observer, drunkenness is a demonstration of extreme lack of self-control.
1 - Preliminary Talks
- from I - CHORICIUS, PRELIMINARY TALKS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
- Published online:
- 29 January 2010
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- 10 September 2009, pp 35-58
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Summary
[I]: THIS PRELIMINARY TALK, BOLDER THAN USUAL, OPPORTUNELY SEEKS THE GOODWILL OF THE AUDIENCE
[1] Since the occasion allows us to be somewhat playful – for we are having a festival, and a single pleasure and cheerfulness are diffused over the whole crowd – well, I myself shall make a display [of my oratory] before those I love. [2] Come, then, O eloquence, for splendor befits feasts: if you have ever taken pride in me at another contest, come forth all the more on this occasion, very well crowned, gracefully garbed, and ready to serve up a manifold feast. [3] For when it is not a public festivity that banqueters are attending, they tolerate even bad food, I think. If a host has been negligent, every guest keeps his criticisms to himself; those who eat the host's food do not show their disapproval. But as it is, this is a lavish [public] festival, and the tables everywhere are laden with delicacies, so we will need many cooks and many wine-pourers to pour the wine in a refined and elegant manner.
[4] Now at Sparta, when the Hyacinthia is celebrated – for the citizens of Sparta honor the youth [Hyacinthus] – a chorus of individuals of the same age as the honorand sing to the accompaniment of lyre and pipe, and maidens dance to the rhythm of the song; for people who live a martial life are not well versed in celebrating by means of oratory.
12 - Declamation 11 [XL]: <The War-Hero>
- from II - CHORICIUS, DECLAMATIONS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
- Published online:
- 29 January 2010
- Print publication:
- 10 September 2009, pp 222-240
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Summary
[THEME]
<There is a law that a war-hero be memorialized in a painting with the clothing he wore. A general who put on a woman's clothing and defeated his enemies during the night asked that he not be memorialized, even though the other general – the one who had already been defeated by them – speaks in opposition. Let us take on the role of the war-hero. >
<DECLAMATION>
[1] When they are defeated, freedom of speech usually leaves men…
[2] The whole world is a likeness of illustrious men…
[3] Without good planning, power is not naturally of any help; but good judgment, even if it is not accompanied by might, often contrives many things…
[4] Just as those bearing the heaviest loads are released from their burdens somehow by singing whatever comes to them, so even for those sick from envy argument and counterargument offer a brief comfort…
[5] <If someone asked him what> the aim of the law was that ordained that a war-hero be memorialized with the clothing he wore, he would have answered that a person is glad to see himself presented in the way he became famous. And suppose he asked him again: “If anyone were to turn aside such a commemorative painting – whether for putting on women's clothing or for some other reason – since it seemed best to him not to be memorialized, do you set down in the law that this man take the prize against his will?
3 - Declamation 2 [XII]: <Priam>
- from II - CHORICIUS, DECLAMATIONS
- Choricius
- Edited by Robert J. Penella, Fordham University, New York
- With Eugenio Amato, Université de Nantes, France, Malcolm Heath, University of Leeds, George A. Kennedy, University of North Carolina, Chapel Hill, Terry L. Papillon, Virginia Polytechnic Institute and State University, William R. Reader, Central Michigan University, D. A. Russell, University of Oxford, Simon Swain, University of Warwick
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- Rhetorical Exercises from Late Antiquity
- Published online:
- 29 January 2010
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- 10 September 2009, pp 74-86
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Summary
[THEME]
Let us now take the part of Priam. The preliminary explanatory comment is based on the fact that the audience, at the epilogue of the preceding speech, demanded a speech on the opposite side and cried out, “Don't let the old man be forced!”
EXPLANATORY COMMENT
[1] Like all of you, I sympathized with the old man and thought it scandalous to give the girl to Achilles, who “made Priam bereaved of many brave sons.” [2] So what shall I do? How shall I help the old man by putting the right issues at each point? The man with whom he is unwilling to make peace has acquired an almost invincible strength and is therefore much wanted by the Trojans. [3] Where shall we find an appropriate technique? The orator who is great in all things again serves us well: not being able to denigrate Philip's preparations, he finds fault with his way of life, adducing drunkenness, lewd dances, and other terms suggestive of incontinence. [4] Similarly, having no means of disparaging Achilles' power, we have collected material for an attack on his character: boastfulness, sexual exploits, instability, insolence to rulers, the overthrow of respect for the dead shown by his insulting treatment of Hector. [5] Since men do not care long about what is once done, however, but think more about their future safety, the Trojans therefore come rather to favor the son of Peleus for the sake of their future salvation than to hate him for his former wicked deeds.