27 results
Author's Reply. RE: Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study
- Noham Wolpe, Shanquan Chen, Brian Kirkpatrick, Peter B. Jones, Christopher Jenkins, Rudolf N. Cardinal, Emilio Fernandez-Egea
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- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 1 / July 2023
- Published online by Cambridge University Press:
- 10 July 2023, pp. 336-337
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- July 2023
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Efficacy of technology-based personalised feedback on diet quality in young Australian adults: results for the advice, ideas and motivation for my eating (Aim4Me) randomised controlled trial
- Rebecca L Haslam, Jennifer N Baldwin, Kristine Pezdirc, Helen Truby, John Attia, Melinda J Hutchesson, Tracy Burrows, Robin Callister, Leanne Hides, Billie Bonevski, Deborah A Kerr, Sharon I Kirkpatrick, Megan E Rollo, Tracy A McCaffrey, Clare E Collins
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- Journal:
- Public Health Nutrition / Volume 26 / Issue 6 / June 2023
- Published online by Cambridge University Press:
- 09 February 2023, pp. 1293-1305
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Objective:
Web-based dietary interventions could support healthy eating. The Advice, Ideas and Motivation for My Eating (Aim4Me) trial investigated the impact of three levels of personalised web-based dietary feedback on diet quality in young adults. Secondary aims were to investigate participant retention, engagement and satisfaction.
Design:Randomised controlled trial.
Setting:Web-based intervention for young adults living in Australia.
Participants:18–24-year-olds recruited across Australia were randomised to Group 1 (control: brief diet quality feedback), Group 2 (comprehensive feedback on nutritional adequacy + website nutrition resources) or Group 3 (30-min dietitian consultation + Group 2 elements). Australian Recommended Food Score (ARFS) was the primary outcome. The ARFS subscales and percentage energy from nutrient-rich foods (secondary outcomes) were analysed at 3, 6 and 12 months using generalised linear mixed models. Engagement was measured with usage statistics and satisfaction with a process evaluation questionnaire.
Results:Participants (n 1005, 85 % female, mean age 21·7 ± 2·0 years) were randomised to Group 1 (n 343), Group 2 (n 325) and Group 3 (n 337). Overall, 32 (3 %), 88 (9 %) and 141 (14 %) participants were retained at 3, 6 and 12 months, respectively. Only fifty-two participants (15 % of Group 3) completed the dietitian consultation. No significant group-by-time interactions were observed (P > 0·05). The proportion of participants who visited the thirteen website pages ranged from 0·6 % to 75 %. Half (Group 2 = 53 %, Group 3 = 52 %) of participants who completed the process evaluation (Group 2, n 111; Group 3, n 90) were satisfied with the programme.
Conclusion:Recruiting and retaining young adults in web-based dietary interventions are challenging. Future research should consider ways to optimise these interventions, including co-design methods.
Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study
- Noham Wolpe, Shanquan Chen, Brian Kirkpatrick, Peter B. Jones, Christopher Jenkins, Rudolf N. Cardinal, Emilio Fernandez-Egea
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- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 1 / July 2023
- Published online by Cambridge University Press:
- 10 January 2023, pp. 295-297
- Print publication:
- July 2023
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Negative symptoms of schizophrenia manifest as reduced motivation and pleasure (MAP) and impaired emotional expressivity (EXP). These can occur as primary phenomena, but have also been suggested to occur secondary to other clinical factors, including antipsychotic-induced sedation. However, this relationship has not been established formally. Here, we examined the effect of antipsychotic-induced sedation (assessed via the proxy of total daily sleep duration) on MAP and EXP in a cohort of 187 clozapine-treated patients with schizophrenia followed for over 2 years on average, using multilevel regression and mediation models. MAP, but not EXP, was adversely influenced by sedation, independently of the severity of psychosis or depression. Moreover, clozapine impaired MAP indirectly by worsening sedation, but after accounting for clozapine-induced sedation, clozapine improved MAP. Our results highlight the importance of addressing sedative side-effects of antipsychotics to improve clinical outcomes.
Characterising entrainment in fountains and negatively buoyant jets
- L. Milton-McGurk, N. Williamson, S.W. Armfield, M.P. Kirkpatrick
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- Journal:
- Journal of Fluid Mechanics / Volume 939 / 25 May 2022
- Published online by Cambridge University Press:
- 31 March 2022, A29
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Turbulent fountain flow consists of two distinct stages, the initial ‘negatively buoyant jet’ (NBJ) stage, and the fully developed ‘fountain’ stage. The present study investigates both stages of the flow using particle image velocimetry and planar laser-induced fluorescence, over a range of source Froude numbers, $10\lesssim Fr_o\lesssim 30$, and Reynolds numbers, $5500\lesssim Re_o\lesssim 7700$. While the velocity and buoyancy profiles in NBJs take similar Gaussian shapes over a wide range of axial locations, this was not observed in fountains. The changing profile shape is most evident in the outer flow (OF) region, while there is a degree of similarity in the inner flow (IF). Entrainment between IF and OF is shown to depend on the local Richardson number, $Ri$. The fountains are found to have a negative entrainment coefficient, $\alpha <0$, for the majority of their height, implying a net radial outflow of fluid from the IF to the OF. An alternative description of entrainment is considered, the ‘decomposed top-hat’ model, where the radial flow is separated into inflow and outflow components that are then estimated using the present experimental data. The inflow component was found to be proportional to the axial IF velocity, which is similar to the classical description of entrainment in pure jets/plumes, while the outflow depends on the local $Ri$. Entrainment in NBJs may also be described by this framework, which, despite not having an OF, is still subject to an $Ri$-dependent radial outflow.
Entrainment and structure of negatively buoyant jets
- L. Milton-McGurk, N. Williamson, S.W. Armfield, M.P. Kirkpatrick, K.M. Talluru
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- Journal:
- Journal of Fluid Mechanics / Volume 911 / 25 March 2021
- Published online by Cambridge University Press:
- 25 January 2021, A21
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Turbulent negatively buoyant jets occur when the buoyancy of a jet directly opposes its momentum, and will decelerate until its mean momentum is reduced to zero. Here, the flow reverses direction and, for an axisymmetric flow originating from a round inlet, returns annularly towards the source, mixing with the opposing fluid and forming a fountain. This investigation focuses on the initial stage of the flow, before the return flow is established. Data are obtained experimentally using two-dimensional particle image velocimetry and planar laser induced fluorescence for saline/freshwater negatively buoyant jets with source Froude number $Fr_o=30$ and Reynolds numbers $5500\lesssim Re_o\lesssim 5900$ at axial locations $18\lesssim z/D\lesssim 30$, and compared to a neutral jet. The development of the mean and turbulence profiles with local $Fr$ are investigated, and it is found that, unlike neutral jets and plumes, the turbulence intensity in negatively buoyant jets does not scale with the mean flow. Additionally, the ratio of widths of the buoyancy and velocity profiles, $\lambda$, increases along the jet. The entrainment coefficient, $\alpha$, was estimated for a negatively buoyant jet, and was found to decrease with local $Fr$, eventually becoming negative, indicating fluid is being ejected from the jet. These observations differ to neutral or buoyant jets and plumes, which approach a constant $\lambda$ and $\alpha$ in the far field. This different behaviour in negatively buoyant jets is a natural consequence of the strongly decelerating mean flow as a result of opposing buoyancy, which is demonstrated in the context of the integral model framework developed by Morton et al. (Proc. R. Soc. Lond. A, vol. 234, no. 1196, 1956, pp. 1–23).
Turbulence structure of neutral and negatively buoyant jets
- K. M. Talluru, S. Armfield, N. Williamson, M. P. Kirkpatrick, L. Milton-McGurk
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- Journal:
- Journal of Fluid Mechanics / Volume 909 / 25 February 2021
- Published online by Cambridge University Press:
- 29 December 2020, A14
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High-fidelity measurements of velocity and concentration are carried out in a neutral jet (NJ) and a negatively buoyant jet (NBJ) by injecting a jet of fresh water vertically downwards into ambient fresh and saline water, respectively. The Reynolds number ($Re$) based on the pipe inlet diameter ($d$) and the source velocity ($W_o$) is approximately 5900 in all the experiments, while the source Froude number based on density difference is approximately 30 in the NBJ experiments. Velocity and concentration measurements are obtained in the region $17 \leq z/d \leq 40$ ($z$ being the axial coordinate) using particle image velocimetry and planar laser induced fluorescence techniques, respectively. Consistent with the literature on jets, the centreline velocity ($W_c$) decays as $z^{-1}$ in the NJ, but in the NBJ, $W_c$ decays faster along $z$ due to the action of negative buoyancy. Nonetheless, the mean velocity ($W$) and concentration ($C$) profiles in both the flows exhibit self-similar Gaussian form, when scaled by the local centreline parameters ($W_c,C_c$) and the jet half-widths ($r^\ast _{W},r^\ast _{C}$). On the other hand, the turbulence statistics and Reynolds stress in the NBJ do not scale with $W_c$. The results of autocorrelation functions, integral length scales and two-dimensional correlation maps show the similarity of turbulence structure in the NJ and the NBJ when the axial and radial distances are normalised by the local jet half-width. Further, the spectra and probability density functions are similar on the axis and only minor differences are seen near the jet interface. The above findings are fundamentally consistent with our recent analysis (Milton-McGurk et al., J. Fluid Mech., 2020b), where we observed that the mean and turbulence statistics in the NBJ have different development characteristics. Overall, we find that the turbulence structure of the NBJ (when scaled by local velocity and length scales) is very similar to the momentum-driven NJ, and the differences (e.g. spreading rate, scaling of turbulence intensities, etc.) between the NJ and the NBJ seem to be of secondary importance.
Destratification of thermally stratified turbulent open-channel flow by surface cooling
- Michael P. Kirkpatrick, N. Williamson, S. W. Armfield, V. Zecevic
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- Journal:
- Journal of Fluid Mechanics / Volume 899 / 25 September 2020
- Published online by Cambridge University Press:
- 28 July 2020, A29
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Destratification of thermally stratified open-channel flow by surface cooling is investigated using direct numerical simulation. The initial states are the equilibrium states resulting from radiative heating. Using these states as initial conditions, a series of direct numerical simulations was run with radiative heating removed and a constant, uniform cooling flux applied at the upper surface. The flow evolves until the initial stable stratification is broken down and replaced by unstable stratification driven by surface cooling. The destratification process is described with reference to the evolution of the internal structure of the turbulent flow field. Based on these observations, we conclude that the dominant time scales in the flow from the perspective of destratification are the time scales associated with shear ${t}_{\tau }$, convection ${t}_*$ and stable density stratification ${t}_N$. Scaling arguments are then used to derive a scaling relationship for destratification rate as a function of a friction Richardson number $Ri_{\tau } = ( {t}_{\tau }/ {t}_N)^2$ and a convection Richardson number $Ri_* = ( {t}_*/ {t}_N)^2$. The relationship takes the form ${\mathcal {D}}_N = C_1Ri_{\tau }^{-1} + C_2Ri_*^{-1}$, where ${\mathcal {D}}_N$ is the destratification rate non-dimensionalised with respect to $ {t}_N$ and $C_1$ and $C_2$ are model coefficients. The relationship is compared with simulation results and is shown to accurately predict the destratification rate in the simulations across a range of parameters. This relationship is then integrated to give a formula for the time taken for the flow to destratify.
Advance care planning and palliative care in ACHD: the healthcare providers’ perspective
- Jill M. Steiner, Erwin N. Oechslin, Gruschen Veldtman, Craig S. Broberg, Karen Stout, James Kirkpatrick, Adrienne H. Kovacs
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- Journal:
- Cardiology in the Young / Volume 30 / Issue 3 / March 2020
- Published online by Cambridge University Press:
- 14 February 2020, pp. 402-408
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Background:
Advance care planning and palliative care are gaining recognition as critical care components for adults with CHD, yet these often do not occur. Study objectives were to evaluate ACHD providers’ 1) comfort managing patients’ physical symptoms and psychosocial needs and 2) perspectives on the decision/timing of advance care planning initiation and palliative care referral.
Methods:Cross-sectional study of ACHD providers. Six hypothetical patients were described in case format, followed by questions regarding provider comfort managing symptoms, initiating advance care planning, and palliative care referral.
Results:Fifty providers (72% physicians) completed surveys. Participants reported low levels of personal palliative care knowledge, without variation by gender, years in practice, or prior palliative care training. Providers appeared more comfortable managing physical symptoms and discussing prognosis than addressing psychosocial needs. Providers recognised advance directives as important, although the percentage who would initiate advance care planning ranged from 18 to 67% and referral to palliative care from 14 to 32%. Barriers and facilitators to discussing advance care planning with patients were identified. Over 20% indicated that advance care planning and end-of-life discussions are best initiated with the development of at least one life-threatening complication/hospitalisation.
Conclusions:Providers noted high value in advance directives yet were themselves less likely to initiate advance care planning or refer to palliative care. This raises the critical questions of when, how, and by whom discussion of these important matters should be initiated and how best to support ACHD providers in these endeavours.
Evolution of thermally stratified turbulent open channel flow after removal of the heat source
- Michael P. Kirkpatrick, N. Williamson, S. W. Armfield, V. Zecevic
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- Journal:
- Journal of Fluid Mechanics / Volume 876 / 10 October 2019
- Published online by Cambridge University Press:
- 01 August 2019, pp. 356-412
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Evolution of thermally stratified open channel flow after removal of a volumetric heat source is investigated using direct numerical simulation. The heat source models radiative heating from above and varies with height due to progressive absorption. After removal of the heat source the initial stable stratification breaks down and the channel approaches a fully mixed isothermal state. The initial state consists of three distinct regions: a near-wall region where stratification plays only a minor role, a central region where stratification has a significant effect on flow dynamics and a near-surface region where buoyancy effects dominate. We find that a state of local energetic equilibrium observed in the central region of the channel in the initial state persists until the late stages of the destratification process. In this region local turbulence parameters such as eddy diffusivity $k_{h}$ and flux Richardson number $R_{f}$ are found to be functions only of the Prandtl number $Pr$ and a mixed parameter ${\mathcal{Q}}$, which is equal to the ratio of the local buoyancy Reynolds number $Re_{b}$ and the friction Reynolds number $Re_{\unicode[STIX]{x1D70F}}$. Close to the top and bottom boundaries turbulence is also affected by $Re_{\unicode[STIX]{x1D70F}}$ and vertical position $z$. In the initial heated equilibrium state the laminar surface layer is stabilised by the heat source, which acts as a potential energy sink. Removal of the heat source allows Kelvin–Helmholtz-like shear instabilities to form that lead to a rapid transition to turbulence and significantly enhance the mixing process. The destratifying flow is found to be governed by bulk parameters $Re_{\unicode[STIX]{x1D70F}}$, $Pr$ and the friction Richardson number $Ri_{\unicode[STIX]{x1D70F}}$. The overall destratification rate ${\mathcal{D}}$ is found to be a function of $Ri_{\unicode[STIX]{x1D70F}}$ and $Pr$.
Price Determinants of Performance-Tested Bulls over Time
- Christopher N. Boyer, Kelsey Campbell, Andrew P. Griffith, Karen L. DeLong, Justin Rhinehart, David Kirkpatrick
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- Journal:
- Journal of Agricultural and Applied Economics / Volume 51 / Issue 2 / May 2019
- Published online by Cambridge University Press:
- 25 March 2019, pp. 304-314
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We estimate the values of bull phenotypic traits, performance measurements, and expected progeny differences (EPDs) over time using bull sale data from an auction in Tennessee from 2006 to 2016. Moreover, we determine how a state partial-cost reimbursement program for bulls with certain EPDs affects bull sale price. Purebred seed stock producers in this region should focus on selling large, fast-growing, mature bulls that produce lighter calves for reduced calving stress. The state cost-share payment did not significantly increase bull prices in most years, meaning this payment was retained by cow-calf producers in most years.
Cost-utility analysis of antiviral use under pandemic influenza using a novel approach – linking pharmacology, epidemiology and heath economics
- D. B. C. Wu, N. Chaiyakunapruk, C. Pratoomsoot, K. K. C. Lee, H. Y. Chong, R. E. Nelson, P. F. Smith, C.M. Kirkpatrick, M. A. Kamal, K. Nieforth, G. Dall, S. Toovey, D. C. M. Kong, A. Kamauu, C. R. Rayner
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- Journal:
- Epidemiology & Infection / Volume 146 / Issue 4 / March 2018
- Published online by Cambridge University Press:
- 15 February 2018, pp. 496-507
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Simulation models are used widely in pharmacology, epidemiology and health economics (HEs). However, there have been no attempts to incorporate models from these disciplines into a single integrated model. Accordingly, we explored this linkage to evaluate the epidemiological and economic impact of oseltamivir dose optimisation in supporting pandemic influenza planning in the USA. An HE decision analytic model was linked to a pharmacokinetic/pharmacodynamics (PK/PD) – dynamic transmission model simulating the impact of pandemic influenza with low virulence and low transmissibility and, high virulence and high transmissibility. The cost-utility analysis was from the payer and societal perspectives, comparing oseltamivir 75 and 150 mg twice daily (BID) to no treatment over a 1-year time horizon. Model parameters were derived from published studies. Outcomes were measured as cost per quality-adjusted life year (QALY) gained. Sensitivity analyses were performed to examine the integrated model's robustness. Under both pandemic scenarios, compared to no treatment, the use of oseltamivir 75 or 150 mg BID led to a significant reduction of influenza episodes and influenza-related deaths, translating to substantial savings of QALYs. Overall drug costs were offset by the reduction of both direct and indirect costs, making these two interventions cost-saving from both perspectives. The results were sensitive to the proportion of inpatient presentation at the emergency visit and patients’ quality of life. Integrating PK/PD–EPI/HE models is achievable. Whilst further refinement of this novel linkage model to more closely mimic the reality is needed, the current study has generated useful insights to support influenza pandemic planning.
Entrainment across a sheared density interface in a cavity flow
- N. Williamson, M. P. Kirkpatrick, S. W. Armfield
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- Journal:
- Journal of Fluid Mechanics / Volume 835 / 25 January 2018
- Published online by Cambridge University Press:
- 29 November 2017, pp. 999-1021
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The entrainment of fluid across a sheared density interface has been examined experimentally in a purging cavity flow. In this flow, a long straight cavity with sloped entry and exit boundaries is located in the base of a straight open channel. Dense cavity fluid is entrained from the cavity into the turbulent overflow. The cavity geometry has been designed to ensure there is no separation of the overflow in the cavity region, with the goal of avoiding cavity-specific entrainment mechanisms as have been encountered in most previous experiments using similar arrangements. Results are obtained over a bulk Richardson number range $Ri_{b}=g\unicode[STIX]{x0394}\unicode[STIX]{x1D70C}D/\unicode[STIX]{x1D70C}_{0}U_{b}^{2}=1$ to 19, where $D$ and $U_{b}$ are the depth of the mixed layer and bulk velocity in the cavity, respectively. The experiments cover the Reynolds number range $Re=U_{b}D/\unicode[STIX]{x1D708}=7100$ to 15 100 and interface length to mixed layer depth ratios of 2.4 to 16. Particle image velocimetry and laser induced fluorescence measurements indicate the flow regime over this entire range is one dominated by the Holmboe wave instability. The non-dimensional entrainment rate, $E=u_{e}/U_{b}$, is shown to scale with the bulk Richardson number. We find that the entrainment scaling $E=CRi_{b}^{-1.38}$ applies over the entire experimental range, with no apparent dependence on interface length. The exponent in the scaling is similar to previous non-cavity-based sheared interface flows, however, the constant $C$ is up to an order of magnitude smaller. Close agreement is, however, obtained by instead correlating entrainment with the local gradient Richardson number centred on the interface, rather than bulk quantities. We obtain $E=0.0021Ri_{g}^{-0.63}$ for data over $10<Ri_{g}<50$, where $Ri_{g}=\langle g\unicode[STIX]{x2202}\unicode[STIX]{x1D70C}/\unicode[STIX]{x1D70C}_{0}\unicode[STIX]{x2202}z\rangle /\langle (\unicode[STIX]{x2202}U/\unicode[STIX]{x2202}z)^{2}\rangle$. The density interface is much thinner and therefore more stable in the present flow configuration compared with other published results for the same bulk Richardson number. We suggest that our configuration ensures a sharp mixing layer profile at the upstream end of the cavity even at relatively low bulk Richardson numbers of $Ri_{b}=1$ and that the reduced mixing in the Holmboe wave regime allows the interface to retain its sharp character over the cavity length, resulting in weak sensitivity to cavity length.
F68 New levels of performance in benchtop EDPXRF
- N. Kirkpatrick, J. Heckel, D. Wissmann
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- Journal:
- Powder Diffraction / Volume 21 / Issue 2 / June 2006
- Published online by Cambridge University Press:
- 20 May 2016, p. 170
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Transition to stably stratified states in open channel flow with radiative surface heating
- N. Williamson, S. W. Armfield, M. P. Kirkpatrick, S. E. Norris
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- Journal of Fluid Mechanics / Volume 766 / 10 March 2015
- Published online by Cambridge University Press:
- 09 February 2015, pp. 528-555
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Direct numerical simulations (DNS) of turbulent stratified flow in an open channel with an internal heat source following the Beer–Lambert law from the surface are used to investigate the transition from neutral to strongly stable flow. Our buoyancy bulk parameter is defined through the ratio of the domain height ${\it\delta}$ to $\mathscr{L}$ , a bulk Obukhov length scale for the flow. We cover the range ${\it\lambda}={\it\delta}/\mathscr{L}=0{-}2.0$ , from neutral conditions to the onset of the stable regime, with the Reynolds number range $Re_{{\it\tau}}=200{-}800$ , at a Prandtl number of 0.71. The result is a boundary layer flow where the effects of stratification are weak in the wall region but progressively stronger in the outer layer up to the free surface. At ${\it\lambda}\simeq 1$ the turbulent kinetic energy (TKE) budget is in local equilibrium over a region extending from the near-wall region to a free-surface affected region a distance $l_{{\it\nu}}$ from the surface, with $l_{{\it\nu}}/{\it\delta}\sim Re^{-1/2}$ . In this equilibrium region the flow can be characterised by the flux Richardson number $R_{f}$ and the local Obukhov length scale ${\it\Lambda}$ . At higher ${\it\lambda}$ local mixing limit conditions are observed over an extended region. At ${\it\lambda}=2$ the flux Richardson number approaches critical limit values of $R_{f,c}\simeq 0.18$ and gradient Richardson number $Ri_{c}\simeq 0.2$ . At high ${\it\lambda}$ , we obtain a flow field where buoyancy interacts with the smallest scales of motion and the turbulent shear stress and buoyancy flux are suppressed to molecular levels. We find that this regime can be identified in terms of the parameter $Re_{\mathscr{L},c}=\mathscr{L}u_{{\it\tau}}/{\it\nu}\lesssim 200{-}400$ (where $u_{{\it\tau}}$ is the friction velocity and ${\it\nu}$ the kinematic viscosity), which is related to the $L_{\ast }$ parameter of Flores and Riley (Boundary-Layer Meteorol., vol. 139 (2), 2011, pp. 241–259) and buoyancy Reynolds number $\mathscr{R}$ . With energetic equilibrium attained, the local buoyancy Reynolds number, $Re_{{\it\Lambda}}={\it\Lambda}\langle u^{\prime }w^{\prime }\rangle ^{1/2}/{\it\nu}$ , is directly related to the separation of the Ozmidov ( $l_{O}$ ) and Kolmogorov ( ${\it\eta}$ ) length scales in the outer boundary layer by $Re_{{\it\Lambda}}\simeq \mathscr{R}\equiv (l_{O}/{\it\eta})^{4/3}$ . The inner wall region has the behaviour $\mathscr{R}\sim Re_{\mathscr{L}}Re_{{\it\tau}}$ , in contrast to stratified boundary layer flows where the buoyancy flux is non-zero at the wall and $\mathscr{R}\sim Re_{\mathscr{L}}$ .
Optimizing Hospital Infection Control: The Role of Mathematical Modeling
- Tan N. Doan, David C. M. Kong, Carl M. J. Kirkpatrick, Emma S. McBryde
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 35 / Issue 12 / December 2014
- Published online by Cambridge University Press:
- 10 May 2016, pp. 1521-1530
- Print publication:
- December 2014
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Multidrug-resistant bacteria are major causes of nosocomial infections and are associated with considerable morbidity, mortality, and healthcare costs. Preventive strategies have therefore become increasingly important. Mathematical modeling has been widely used to understand the transmission dynamics of nosocomial infections and the quantitative effects of infection control measures. This review will explore the principles of mathematical modeling used in nosocomial infections and discuss the effectiveness of infection control measures investigated using mathematical modeling.
Infect Control Hosp Epidemiol 2014;35(12):1521–1530
Contributors
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- By Venkataraman Anantharaman, Philip D. Anderson, Christopher W. Baugh, J. Stephen Bohan, Kirsten Boyd, Matthias Brachmann, Peter R. Brown, Shelley Calder, David Callaway, Peter Cameron, Jody Crane, Meaghan Cussen, Christina Dempsey, Jonathan A. Edlow, Thomas Fleischmann, Robert L. Freitas, John D. Halamka, Manuel Hernandez, Cherri Hobgood, Jock Hoffman, Steven Horng, Kirk B. Jensen, Jennifer R. Johnson, Stephanie Kayden, Tasnim Khan, Daniel G. Kirkpatrick, James Lennon, Mary Leupold, Thom Mayer, J. Lawrence Mottley, Scott B. Murray, Deirdre Mylod, Larry A. Nathanson, Michael P. Pietrzak, Elke Platz, Nadeem Qureshi, Matthew M. Rice, Andrew Schenkel, Chet Schrader, Puneet Seth, Richard B. Siegrist, David Smith, Robert E. Suter, Carrie Tibbles, Sebastian N. Walker, Lee A. Wallis, Julie Welch, Leana S. Wen
- Edited by Stephanie Kayden, Philip D. Anderson, Robert Freitas, Elke Platz
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- Book:
- Emergency Department Leadership and Management
- Published online:
- 05 December 2014
- Print publication:
- 27 November 2014, pp ix-xii
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Effect of voltage waveform on dielectric barrier discharge ozone production efficiency
- N. Mericam-Bourdet, M.J. Kirkpatrick, F. Tuvache, D. Frochot, E. Odic
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- Journal:
- The European Physical Journal - Applied Physics / Volume 57 / Issue 3 / February 2012
- Published online by Cambridge University Press:
- 01 March 2012, 30801
- Print publication:
- February 2012
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Dielectric barrier discharges (DBDs) are commonly used for gas effluent cleanup and ozone generation. For these applications, the energy efficiency of the discharge is a major concern. This paper reports on investigations carried out on the voltage shape applied to DBD reactor electrodes, aiming to evaluate a possible energy efficiency improvement for ozone production. Two DBD reactor geometries were used: pin-to-pin and cylinder-to-cylinder, both driven either by a bi-directional power supply (voltage rise rate 1 kV/μs) or by a pulsed power supply (voltage rise rate 1 kV/ns). Ozone formed in dry air was measured at the reactor outlet. Special attention was paid to discharge input power evaluation using different methods including instantaneous current-voltage product and transferred charge-applied voltage figures. The charge transferred by the discharges was also correlated to the ozone production. It is shown that, in the case of the DBD reactors under investigation, the applied voltage shape has no influence on the ozone production efficiency. For the considered voltage rise rate, the charge deposit on the dielectric inserted inside the discharge gap is the important factor (as opposed to the voltage shape) governing the efficiency of the discharge – it does this by tailoring the duration of the current peak into the tens of nanosecond range.
Transition to oscillatory flow in a differentially heated cavity with a conducting partition
- N. Williamson, S. W. Armfield, M. P. Kirkpatrick
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- Journal:
- Journal of Fluid Mechanics / Volume 693 / 25 February 2012
- Published online by Cambridge University Press:
- 28 November 2011, pp. 93-114
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Numerical evidence is presented for previously unreported flow behaviour in a two-dimensional rectangular side-heated cavity partitioned in the centre by vertical wall with an infinite conductivity. In this flow heat is transferred between both sides of the cavity through the conducting wall with natural convection boundary layers forming on all vertical surfaces. Simulations have been conducted over the range of Rayleigh numbers at Prandtl number and at aspect ratios of where and are the height and width of the cavity. It was found that the thermal coupling of the boundary layers on either side of the conducting partition causes the cavity flow to become absolutely unstable for a Rayleigh number at which otherwise similar non-partitioned cavity flow is steady but convectively unstable. Additionally, unlike the non-partitioned cavity, which eventually bifurcates to a multi-modal oscillatory regime, this bifurcation is manifested as a single mode oscillation with , where is the temperature difference between the hot and cold walls, is the gravitational acceleration, is the oscillation frequency and and are the fluid viscosity and coefficient of thermal expansion respectively. The critical Rayleigh number for this transition occurs between for and for , indicating that the instability has an aspect ratio dependence.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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Death Is Just Not What It Used to Be
- JAMES N. KIRKPATRICK, KARA D. BEASLEY, ARTHUR CAPLAN
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- Journal:
- Cambridge Quarterly of Healthcare Ethics / Volume 19 / Issue 1 / January 2010
- Published online by Cambridge University Press:
- 22 December 2009, pp. 7-16
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It is said there are only two things in life that are certain: death and taxes … maybe only taxes.