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Detecting schizophrenia at the level of the individual: relative diagnostic value of whole-brain images, connectome-wide functional connectivity and graph-based metrics
- Du Lei, Walter H. L. Pinaya, Therese van Amelsvoort, Machteld Marcelis, Gary Donohoe, David O. Mothersill, Aiden Corvin, Michael Gill, Sandra Vieira, Xiaoqi Huang, Su Lui, Cristina Scarpazza, Jonathan Young, Celso Arango, Edward Bullmore, Gong Qiyong, Philip McGuire, Andrea Mechelli
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- Journal:
- Psychological Medicine / Volume 50 / Issue 11 / August 2020
- Published online by Cambridge University Press:
- 08 August 2019, pp. 1852-1861
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Background
Previous studies using resting-state functional neuroimaging have revealed alterations in whole-brain images, connectome-wide functional connectivity and graph-based metrics in groups of patients with schizophrenia relative to groups of healthy controls. However, it is unclear which of these measures best captures the neural correlates of this disorder at the level of the individual patient.
MethodsHere we investigated the relative diagnostic value of these measures. A total of 295 patients with schizophrenia and 452 healthy controls were investigated using resting-state functional Magnetic Resonance Imaging at five research centres. Connectome-wide functional networks were constructed by thresholding correlation matrices of 90 brain regions, and their topological properties were analyzed using graph theory-based methods. Single-subject classification was performed using three machine learning (ML) approaches associated with varying degrees of complexity and abstraction, namely logistic regression, support vector machine and deep learning technology.
ResultsConnectome-wide functional connectivity allowed single-subject classification of patients and controls with higher accuracy (average: 81%) than both whole-brain images (average: 53%) and graph-based metrics (average: 69%). Classification based on connectome-wide functional connectivity was driven by a distributed bilateral network including the thalamus and temporal regions.
ConclusionThese results were replicated across the three employed ML approaches. Connectome-wide functional connectivity permits differentiation of patients with schizophrenia from healthy controls at single-subject level with greater accuracy; this pattern of results is consistent with the ‘dysconnectivity hypothesis’ of schizophrenia, which states that the neural basis of the disorder is best understood in terms of system-level functional connectivity alterations.
2356 The nasopharyngeal microbiome is perturbed and associated with increased clinical severity during acute respiratory viral infection
- Darrell Dinwiddie, Ashlee K. Bradley, Jesse L. Denson, Joshua L. Kennedy, Walter N. Dehority, Kurt C. Schwalm, Stephen A. Young
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- Journal:
- Journal of Clinical and Translational Science / Volume 2 / Issue S1 / June 2018
- Published online by Cambridge University Press:
- 21 November 2018, p. 32
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OBJECTIVES/SPECIFIC AIMS: We sought to investigate the role of the host microbiome during severe, acute respiratory infection (ARI) to understand the drivers of both acute clinical pathogenesis. METHODS/STUDY POPULATION: Nasopharyngeal swabs comprised of mixed cell populations at the active site of infection were collected from 192 hospitalized pediatric patients with ARI. We combined comprehensive respiratory virus detection and virus genome sequencing with 16S rRNA gene sequencing to evaluate the microbial content of the airway during ARI. This data was coupled with 11 clinical parameters, which were compiled to create a clinical severity score. The microbiome profiles were assessed to determine if clinical severity of infection, and/or specific virus was associated with increased clinical severity. RESULTS/ANTICIPATED RESULTS: We identified 8 major microbiome profiles classified by dominant bacterial genus, Moraxella, Corynebacterium, Staphylococcus, Haemophilus, Streptococcus, Alloiococcus, Schlegelella, and Diverse. Increased clinical severity was significantly associated with microbiome profiles dominated by Haemophilus, Streptococcus, and Schlegelella, whereas Corynebacterium and Alloiococcus were more prevalent in children with less severe disease. Independent of the microbial community, more than 60% of patients with the highest clinical severity were infected with either respiratory syncytial virus or rhinovirus. DISCUSSION/SIGNIFICANCE OF IMPACT: Our results indicate that individually and in combination, both virus and microbial composition may drive clinical severity during acute respiratory viral infections. It is still unclear how the complex interplay between virus, bacterial community, and the host response influence long-term respiratory impacts, such as the development of asthma. Nonetheless, during ARIs therapeutic interventions such as antibiotics and probiotics may be warranted in a subset of patients that are identified to have both a virus and microbiome profile that is associated with increased pathogenesis to limit both acute and long-term phenotypes.
2249: Gene expression signatures of acute respiratory syncytial virus infection in pediatric patients reveals insight into clinical pathogenesis
- Darrell Dinwiddie, Walter Dehority, Kurt C. Schwalm, Raymond J. Langley, Stephen A. Young, Joshua L. Kennedy
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- Journal:
- Journal of Clinical and Translational Science / Volume 1 / Issue S1 / September 2017
- Published online by Cambridge University Press:
- 10 May 2018, p. 59
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OBJECTIVES/SPECIFIC AIMS: Respiratory viruses cause enormous medical burden, yet many of the specific virus and host genetic factors that impact pathogenesis are still largely unknown or poorly understood. To better understand the drivers of both acute clinical pathogenesis and long-term impacts, such as the development of asthma, we investigated the host response to respiratory syncytial virus (RSV) infections in pediatric patients. METHODS/STUDY POPULATION: We collected nasopharyngeal swabs from 32 pediatric patients with acute RSV infection. The swabs represented a mixed cell population including epithelial and immune cells at the active site of infection. Unbiased RNA sequencing with ribosomal RNA depletion allowed the simultaneous detection of host gene expression and RSV infection. We sequenced samples 2×75 bp on an Illumina NextSeq 500. Sequences were mapped to the human genome using the TopHat 2 aligner and FPKM estimation of reference genes and transcripts and assembly of novel transcripts were conducted with Cufflinks 2. RESULTS/ANTICIPATED RESULTS: During acute RSV infection we identified 7343 genes that were significantly expressed. Pathway analysis using KEGG revealed significant upregulation of pathways involved in innate immune response infection, ribosome function, oxidative phosphorylation, spliceosome and autoimmune disorders. We found high levels of innate immune response genes including CXCL8, IFITM1, IFITM2, IFITM3, IL1RN, and ISG15. In comparing RSV subtype A to RSV B we found significant differential expression of multiple noncoding RNAs. DISCUSSION/SIGNIFICANCE OF IMPACT: Examination of the host gene response during acute RSV infections, yielded important insight into the mechanisms that cause clinical pathogenesis and may provide understanding of the mechanisms that lead to known long-term impacts, such as the development of asthma. Together, this data may be used to guide clinical treatment and management decisions for children with severe RSV infections.
Utility of Winter Rye Living Mulch for Weed Management in Zucchini Squash Production
- S. Alan Walters, Bryan G. Young
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- Journal:
- Weed Technology / Volume 22 / Issue 4 / December 2008
- Published online by Cambridge University Press:
- 20 January 2017, pp. 724-728
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The extended production of allelochemicals from a living mulch cover crop may potentially enhance weed management and crop productivity compared with traditional zucchini squash production systems. However, the efficacy of a living mulch cover crop in no-tillage (NT) systems with herbicides has not been determined for many vegetable crops. The objective of this research was to evaluate weed management and zucchini squash production using the combination of NT and a herbicide-suppressed winter rye cover crop with or without PRE herbicides. When used in combination with herbicides, the winter rye living mulch reduced the biomass of redroot pigweed compared to the herbicides applied alone, but did not influence the biomass of smooth crabgrass for any herbicide treatment. Visual estimates of weed control were similar for each herbicide treatment with and without the winter rye living mulch. The herbicide-suppressed winter rye resulted in excessive stunting of zucchini squash at 56 d after treatment which correlated with 20 and 50% squash yield reductions for the 2004 and 2005 growing seasons, respectively. Although some squash yield loss may have resulted from direct competition with the winter rye living mulch, yield reductions most likely resulted from allelopathy. The winter rye living mulch was the primary contributing factor for reduced squash yield and did not interact with herbicide treatment. All treatments containing herbicides resulted in yields similar to the weed-free treatment. Because of excessive zucchini injury, this research suggests that the use of herbicide-suppressed winter rye living mulch does not appear to be a feasible option for increased weed control in zucchini squash production regardless of the herbicide treatment.
Herbicides for Control of Volunteer Horseradish (Armoracia rusticana) and Potential Carryover to Subsequent Horseradish Production
- Nathan R. Johanning, S. Alan Walters, Bryan G. Young
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- Journal:
- Weed Technology / Volume 30 / Issue 1 / March 2016
- Published online by Cambridge University Press:
- 20 January 2017, pp. 181-189
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Volunteer horseradish plants that emerged from root segments remaining after harvest can reduce yields of rotational crops as well as provide a host for pathogens and insects, thus reducing the benefits of crop rotation. POST applications of halosulfuron in corn can be an effective component to improve management of volunteer horseradish, but the replant interval from application to safe planting of commercial horseradish has not been determined. Fall herbicide applications are another possible volunteer horseradish management strategy than can be implemented once crops are harvested. Therefore, field experiments were conducted to evaluate the safe replant interval of horseradish following halosulfuron applications and to determine the efficacy of fall herbicide applications for volunteer horseradish control. Visual estimates of horseradish injury were greatest (85%) in plantings made zero months after halosulfuron applied at two times the approved rate; moreover, for all rates, injury decreased as the time after halosulfuron application increased. No herbicide injury or root biomass reduction occurred on horseradish at any halosulfuron rate from replanting beyond 4 mo after halosulfuron application. Control of volunteer horseradish was 91% or greater for all fall herbicide applications that included 2,4-D. Furthermore, volunteer horseradish shoot density was the lowest following combinations of 2,4-D tank-mixed with halosulfuron or rimsulfuron : thifensulfuron (0.2 and 0.4 shoots m−2, respectively) compared with the nontreated control (5.1 shoots m−2). This research demonstrates the effectiveness of both halosulfuron and 2,4-D as components of an integrated management strategy for volunteer horseradish control and the potential for halosulfuron applications without soil persistence beyond 4 mo affecting subsequent commercial horseradish production.
Effects of Adjuvants, Halosulfuron, and Grass Herbicides on Cucurbita spp. Injury and Grass Control
- Kate J. Kammler, S. Alan Walters, Bryan G. Young
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- Journal:
- Weed Technology / Volume 24 / Issue 2 / June 2010
- Published online by Cambridge University Press:
- 20 January 2017, pp. 147-152
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Greenhouse experiments were conducted to evaluate pumpkin cultivar injury and control of three grass species from tank-mixtures of halosulfuron with either clethodim or sethoxydim in combination with nonionic surfactant (NIS), crop-oil concentrate (COC), methylated seed oil (MSO), and high-surfactant oil concentrate (HSOC). Pumpkin injury, in the form of chlorosis and visual growth reduction, was 13 to 21% by 7 d after treatment (DAT) for all pumpkin cultivars. The specific adjuvant used with halosulfuron did not influence pumpkin injury or final plant dry weight. Pumpkin growth reduction at 21 DAT from halosulfuron was less than 9% for all pumpkin cultivars with the least growth reduction (5% or less) observed with Cucurbita pepo ‘Howden’, C. pepo ‘Appalachian’, and Cucurbita moschata ‘Libby's Select’. The efficacy of sethoxydim or clethodim on large crabgrass was antagonized by the addition of halosulfuron with NIS or COC. However, only combinations of sethoxydim and halosulfuron with COC or MSO were antagonistic on smooth crabgrass. Giant foxtail dry weight reduction was decreased 4 to 24% by the addition of halosulfuron to sethoxydim with NIS and clethodim regardless of adjuvant. Although the frequency and magnitude of grass antagonism was variable, the use of clethodim and MSO with halosulfuron most often provided the greatest level of grass control compared with sethoxydim or other adjuvants.
Efficacy of Postemergence Corn and Soybean Herbicides on Volunteer Horseradish (Armoracia rusticana)
- Mark F. Rundle, S. Alan Walters, Bryan G. Young
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- Journal:
- Weed Technology / Volume 21 / Issue 2 / June 2007
- Published online by Cambridge University Press:
- 20 January 2017, pp. 501-505
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Viable horseradish roots of various sizes remain in the soil after harvest and can develop into volunteer plants in subsequent crops. Experiments were conducted to evaluate POST herbicides on volunteer horseradish control and to determine if efficacy is dependent upon horseradish root segment size, herbicide rate, horseradish cultivar, or horseradish shoot size at application. In the greenhouse, horseradish root segment size did not affect herbicide efficacy. Chlorimuron, cloransulam, imazamox, (2,4-dichlorophenoxy)acetic acid (2,4-D) amine, halosulfuron, and imazethapyr plus imazapyr provided greater than 95% foliar control of volunteer horseradish. Chlorimuron, halosulfuron, and 2,4-D amine were also among the herbicides that provided the greatest reduction in horseradish root biomass (69% or greater). Glyphosate provided little foliar control (76%) and root biomass reduction (57%) after one application. The efficacy of 2,4-D amine on horseradish foliage and root biomass increased with increasing herbicide rate; however, the response of horseradish to halosulfuron was similar for all rates evaluated. Root biomass reduction of the horseradish cultivar ‘1573’ was less responsive to 2,4-D amine and halosulfuron applications compared with ‘1038’ and ‘1722’. However, foliar injury from 2,4-D amine and halosulfuron was less for the horseradish cultivar ‘1038’ compared with ‘1573’ and ‘1722’. In field studies, 2,4-D amine applied to 15- and 30-cm-tall horseradish and halosulfuron applied to 15-cm-tall horseradish resulted in the greatest foliar and root biomass reduction. This study indicated that in-season control of volunteer horseradish in rotational crops may be achieved through proper herbicide selection.
Honeyvine Milkweed (Cynanchum laeve) Control in Plasticulture Bell Pepper Production
- Joseph G. Masabni, S. Alan Walters, Bryan G. Young, Timothy Coolong
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- Journal:
- Weed Technology / Volume 27 / Issue 4 / December 2013
- Published online by Cambridge University Press:
- 20 January 2017, pp. 671-674
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A 2-yr study was conducted to evaluate bell pepper response and honeyvine milkweed control from PRE herbicides, clomazone and trifluralin, applied under polyethylene mulch. Clomazone (0.8 and 1.4 kg ai ha−1) and trifluralin (0.7 and 1.1 kg ai ha−1) were applied alone or in combination. Herbicides were applied after beds were made and before polyethylene mulch was laid, followed by transplanting pepper within hours of herbicide application. In both years, initial bleaching of lower leaves was observed; the injury was observed in some treatments, but not others. Honeyvine milkweed, growing in the planting hole, exhibited significant bleaching and stunting in most herbicide treatments. Both clomazone and trifluralin resulted in season-long honeyvine milkweed control in both years. However, the use of clomazone and trifluralin together for control of honeyvine milkweed does not seem justified due to the potential for herbicide antagonism, as indicated in this study. The total number and fresh weight of harvested bell pepper were not affected by the herbicides or rates. All herbicide treatments resulted in about twice the yield (average of 8.8 kg) of the hand-weeded control (4.6 kg) in both years. This study strongly supports the safety and effectiveness of clomazone and/or trifluralin applied pretransplant under polyethylene mulch in bell pepper production for control of honeyvine milkweed.
Underweight and mortality
- Joo Young Lee, Hyeon Chang Kim, Changsoo Kim, Keeho Park, Song Vogue Ahn, Dae Ryong Kang, Kay-Tee Khaw, Walter C Willett, Il Suh
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- Journal:
- Public Health Nutrition / Volume 19 / Issue 10 / July 2016
- Published online by Cambridge University Press:
- 15 October 2015, pp. 1751-1756
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Objective
According to most prospective studies, being underweight (BMI<18·5 kg/m2) is associated with significantly higher mortality than being of normal weight, especially among smokers. We aimed to explore in a generally lean population whether being underweight is significantly associated with increased all-cause mortality.
DesignProspective cohort study.
SettingKorea Medical Insurance Corporation study with 14 years of follow-up.
SubjectsAfter excluding deaths within the first 5 years of follow-up (1993–1997) to minimize reverse causation and excluding participants without information about smoking and health status, 94 133 men and 48 496 women aged 35–59 years in 1990 were included.
ResultsWe documented 5411 (5·7 %) deaths in men and 762 (1·6 %) in women. Among never smokers, hazard ratios (HR) for underweight individuals were not significantly higher than those for normal-weight individuals (BMI=18·5–22·9 kg/m2): HR=0·87 (95 % CI 0·41, 1·84, P=0·72) for underweight men and HR=1·12 (95 % CI 0·76, 1·65, P=0·58) for underweight women. Among ex-smokers, HR=0·86 (95 % CI 0·38, 1·93, P=0·72) for underweight men and HR=3·77 (95 % CI 0·42, 32·29, P=0·24) for underweight women. Among current smokers, HR=1·60 (95 % CI 1·28, 2·01, P<0·001) for underweight men and HR=2·07 (95 % CI 0·43, 9·94, P=0·36) for underweight women.
ConclusionsThe present study does not support that being underweight per se is associated with increased all-cause mortality in Korean men and women.
Contributors
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- By Federica Agosta, Alberto Albanese, Timothy J. Amrhein, A. M. Barrett, Walter S. Bartynski, Felix Benninger, Thomas Brandt, Andrew G. Burke, Michelle Cameron, Elisa Canu, Louis R. Caplan, Christine M. Carr, Daniel J. A. Connolly, Firouz Daneshgari, John DeLuca, Marianne de Visser, Marianne Dieterich, Antonio E. Elia, Joseph H. Feinberg, Massimo Filippi, Lauren C. Frey, Gaëtan Garraux, Andrea Ginestroni, Peter J. Goadsby, Bronwyn E. Hamilton, Simon J. Hickman, Holly E. Hinson, Jon P. Jennings, Jan Kassubek, Horacio Kaufmann, David M. Kaylie, Joanna Kitley, Vladimir S. Kostic, C. T. Paul Krediet, Megan C. Leary, Farooq H. Maniyar, Ken R. Maravilla, Mario Mascalchi, Rajarshi Mazumder, Priyesh Mehta, Jacqueline A. Palace, Raj M. Paspulati, Christopher A. Potter, Angelo Quattrini, Louis P. Riccelli, Nilo Riva, Maria A. Rocca, Mirabelle B. Sajisevi, Richard Salazar-Montero, Nicholas D. Schiff, Jack H. Simon, Israel Steiner, Carl D. Stevens, Bart P. van de Warrenburg, Judith van Gaalen, William J. Weiner, Jane L. Weissman, Jay Yao, G. Bryan Young
- Edited by Massimo Filippi, Jack H. Simon
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- Book:
- Imaging Acute Neurologic Disease
- Published online:
- 05 October 2014
- Print publication:
- 11 September 2014, pp vi-viii
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- By Lenard A. Adler, Pinky Agarwal, Rehan Ahmed, Jagga Rao Alluri, Fawaz Al-Mufti, Samuel Alperin, Michael Amoashiy, Michael Andary, David J. Anschel, Padmaja Aradhya, Vandana Aspen, Esther Baldinger, Jee Bang, George D. Baquis, John J. Barry, Jason J. S. Barton, Julius Bazan, Amanda R. Bedford, Marlene Behrmann, Lourdes Bello-Espinosa, Ajay Berdia, Alan R. Berger, Mark Beyer, Don C. Bienfang, Kevin M. Biglan, Thomas M. Boes, Paul W. Brazis, Jonathan L. Brisman, Jeffrey A. Brown, Scott E. Brown, Ryan R. Byrne, Rina Caprarella, Casey A. Chamberlain, Wan-Tsu W. Chang, Grace M. Charles, Jasvinder Chawla, David Clark, Todd J. Cohen, Joe Colombo, Howard Crystal, Vladimir Dadashev, Sarita B. Dave, Jean Robert Desrouleaux, Richard L. Doty, Robert Duarte, Jeffrey S. Durmer, Christyn M. Edmundson, Eric R. Eggenberger, Steven Ender, Noam Epstein, Alberto J. Espay, Alan B. Ettinger, Niloofar (Nelly) Faghani, Amtul Farheen, Edward Firouztale, Rod Foroozan, Anne L. Foundas, David Elliot Friedman, Deborah I. Friedman, Steven J. Frucht, Oded Gerber, Tal Gilboa, Martin Gizzi, Teneille G. Gofton, Louis J. Goodrich, Malcolm H. Gottesman, Varda Gross-Tsur, Deepak Grover, David A. Gudis, John J. Halperin, Maxim D. Hammer, Andrew R. Harrison, L. Anne Hayman, Galen V. Henderson, Steven Herskovitz, Caitlin Hoffman, Laryssa A. Huryn, Andres M. Kanner, Gary P. Kaplan, Bashar Katirji, Kenneth R. Kaufman, Annie Killoran, Nina Kirz, Gad E. Klein, Danielle G. Koby, Christopher P. Kogut, W. Curt LaFrance, Patrick J.M. Lavin, Susan W. Law, James L. Levenson, Richard B. Lipton, Glenn Lopate, Daniel J. Luciano, Reema Maindiratta, Robert M. Mallery, Georgios Manousakis, Alan Mazurek, Luis J. Mejico, Dragana Micic, Ali Mokhtarzadeh, Walter J. Molofsky, Heather E. Moss, Mark L. Moster, Manpreet Multani, Siddhartha Nadkarni, George C. Newman, Rolla Nuoman, Paul A. Nyquist, Gaia Donata Oggioni, Odi Oguh, Denis Ostrovskiy, Kristina Y. Pao, Juwen Park, Anastas F. Pass, Victoria S. Pelak, Jeffrey Peterson, John Pile-Spellman, Misha L. Pless, Gregory M. Pontone, Aparna M. Prabhu, Michael T. Pulley, Philip Ragone, Prajwal Rajappa, Venkat Ramani, Sindhu Ramchandren, Ritesh A. Ramdhani, Ramses Ribot, Heidi D. Riney, Diana Rojas-Soto, Michael Ronthal, Daniel M. Rosenbaum, David B. Rosenfield, Durga Roy, Michael J. Ruckenstein, Max C. Rudansky, Eva Sahay, Friedhelm Sandbrink, Jade S. Schiffman, Angela Scicutella, Maroun T. Semaan, Robert C. Sergott, Aashit K. Shah, David M. Shaw, Amit M. Shelat, Claire A. Sheldon, Anant M. Shenoy, Yelizaveta Sher, Jessica A. Shields, Tanya Simuni, Rajpaul Singh, Eric E. Smouha, David Solomon, Mehri Songhorian, Steven A. Sparr, Egilius L. H. Spierings, Eve G. Spratt, Beth Stein, S.H. Subramony, Rosa Ana Tang, Cara Tannenbaum, Hakan Tekeli, Amanda J. Thompson, Michael J. Thorpy, Matthew J. Thurtell, Pedro J. Torrico, Ira M. Turner, Scott Uretsky, Ruth H. Walker, Deborah M. Weisbrot, Michael A. Williams, Jacques Winter, Randall J. Wright, Jay Elliot Yasen, Shicong Ye, G. Bryan Young, Huiying Yu, Ryan J. Zehnder
- Edited by Alan B. Ettinger, Albert Einstein College of Medicine, New York, Deborah M. Weisbrot, State University of New York, Stony Brook
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- Book:
- Neurologic Differential Diagnosis
- Published online:
- 05 June 2014
- Print publication:
- 17 April 2014, pp xi-xx
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- By Ghazi Al-Rawas, Vazken Andréassian, Tianqi Ao, Stacey A. Archfield, Berit Arheimer, András Bárdossy, Trent Biggs, Günter Blöschl, Theresa Blume, Marco Borga, Helge Bormann, Gianluca Botter, Tom Brown, Donald H. Burn, Sean K. Carey, Attilio Castellarin, Francis Chiew, François Colin, Paulin Coulibaly, Armand Crabit, Barry Croke, Siegfried Demuth, Qingyun Duan, Giuliano Di Baldassarre, Thomas Dunne, Ying Fan, Xing Fang, Boris Gartsman, Alexander Gelfan, Mikhail Georgievski, Nick van de Giesen, David C. Goodrich, Hoshin V. Gupta, Khaled Haddad, David M. Hannah, H. A. P. Hapuarachchi, Hege Hisdal, Kamila Hlavčová, Markus Hrachowitz, Denis A. Hughes, Günter Humer, Ruud Hurkmans, Vito Iacobellis, Elena Ilyichyova, Hiroshi Ishidaira, Graham Jewitt, Shaofeng Jia, Jeffrey R. Kennedy, Anthony S. Kiem, Robert Kirnbauer, Thomas R. Kjeldsen, Jürgen Komma, Leonid M. Korytny, Charles N. Kroll, George Kuczera, Gregor Laaha, Henny A. J. van Lanen, Hjalmar Laudon, Jens Liebe, Shijun Lin, Göran Lindström, Suxia Liu, Jun Magome, Danny G. Marks, Dominic Mazvimavi, Jeffrey J. McDonnell, Brian L. McGlynn, Kevin J. McGuire, Neil McIntyre, Thomas A. McMahon, Ralf Merz, Robert A. Metcalfe, Alberto Montanari, David Morris, Roger Moussa, Lakshman Nandagiri, Thomas Nester, Taha B. M. J. Ouarda, Ludovic Oudin, Juraj Parajka, Charles S. Pearson, Murray C. Peel, Charles Perrin, John W. Pomeroy, David A. Post, Ataur Rahman, Liliang Ren, Magdalena Rogger, Dan Rosbjerg, José Luis Salinas, Jos Samuel, Eric Sauquet, Hubert H. G. Savenije, Takahiro Sayama, John C. Schaake, Kevin Shook, Murugesu Sivapalan, Jon Olav Skøien, Chris Soulsby, Christopher Spence, R. ‘Sri’ Srikanthan, Tammo S. Steenhuis, Jan Szolgay, Yasuto Tachikawa, Kuniyoshi Takeuchi, Lena M. Tallaksen, Dörthe Tetzlaff, Sally E. Thompson, Elena Toth, Peter A. Troch, Remko Uijlenhoet, Carl L. Unkrich, Alberto Viglione, Neil R. Viney, Richard M. Vogel, Thorsten Wagener, M. Todd Walter, Guoqiang Wang, Markus Weiler, Rolf Weingartner, Erwin Weinmann, Hessel Winsemius, Ross A. Woods, Dawen Yang, Chihiro Yoshimura, Andy Young, Gordon Young, Erwin Zehe, Yongqiang Zhang, Maichun C. Zhou
- Edited by Günter Blöschl, Technische Universität Wien, Austria, Murugesu Sivapalan, University of Illinois, Urbana-Champaign, Thorsten Wagener, University of Bristol, Alberto Viglione, Technische Universität Wien, Austria, Hubert Savenije, Technische Universiteit Delft, The Netherlands
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- Book:
- Runoff Prediction in Ungauged Basins
- Published online:
- 05 April 2013
- Print publication:
- 18 April 2013, pp ix-xiv
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17 - Incorporating predicted species distribution in adaptive and conventional sampling designs
- Edited by Robert A. Gitzen , University of Missouri, Columbia, Joshua J. Millspaugh, University of Missouri, Columbia, Andrew B. Cooper, Simon Fraser University, British Columbia, Daniel S. Licht
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- Book:
- Design and Analysis of Long-term Ecological Monitoring Studies
- Published online:
- 05 July 2012
- Print publication:
- 07 June 2012, pp 381-396
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Summary
Introduction
Monitoring rare and clustered populations is challenging because of the large effort required to encounter occupied habitat and yield precise population estimates (McDonald 2004). Sampling designs are available to help reduce the effort required to encounter occupied habitat and increase precision, including stratified sampling, probability proportional to size (PPS) sampling, and various adaptive sampling designs (Thompson 2002). Use of these designs is motivated, in an intuitive sense, by each design's ability to allocate more sampling effort where target species are (or are likely to be) and less where they are not. This intuitive approach to allocation of effort can lead to increased precision when variability in the population tends to be higher in areas of high species density or abundance (Box 17.1). Conventional designs, such as stratified and PPS sampling, rely on prior information to allocate effort. For example, prior information could come from predicted species or habitat distributions (Guisan and Zimmermann 2000, Le Lay et al. 2010). Use of prior information is not a basic property of adaptive sampling designs, but these designs could use such information when available.
In this chapter, we demonstrate how prior information on species distribution can be incorporated into adaptive and conventional sampling designs. We start the chapter by introducing adaptive sampling, which remains a somewhat novel sampling design even though it was introduced by Thompson (1990) over 20 years ago. We then present a case study illustrating and evaluating the performance of conventional and adaptive sampling designs that either incorporate or ignore predicted species distributions. We examine how these designs compare in terms of efficiency, probability of sampling occupied habitat, and robustness to model inaccuracy. We end the chapter with recommendations and a discussion of future research and developments.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Reproducibility and validity of bioimpedance spectroscopy for tracking changes in total body water: implications for repeated measurements
- Jordan R. Moon, Jeffrey R. Stout, Abbie E. Smith, Sarah E. Tobkin, Christopher M. Lockwood, Kristina L. Kendall, Jennifer L. Graef, David H. Fukuda, Pablo B. Costa, Matt S. Stock, Kaelin C. Young, Patrick S. Tucker, Eonho Kim, Trent J. Herda, Ashley A. Walter, Steven L. Ferguson, Vanessa D. Sherk, Joel T. Cramer
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- British Journal of Nutrition / Volume 104 / Issue 9 / 14 November 2010
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- 12 July 2010, pp. 1384-1394
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- 14 November 2010
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Bioimpedance spectroscopy (BIS) has been used to track changes in total body water (TBW). Accurate TBW estimations can be influenced by both methodological and biological factors. One methodological variation that contributes to BIS TBW errors is the electrode placement. The purpose of the present study was to compare the reproducibility and validity of fixed-distance electrode placements (5 cm) with the standard single-site electrode placements. Twenty-nine subjects (fifteen men and fourteen women) participated in the reproducibility study, while sixty-nine subjects (thirty-three men and thirty-six women) participated in the validity study. The reproducibility study included two measurements that were taken 24 h apart, while the validity study consisted of a 12-week exercise intervention with measurements taken at weeks 1 and 12. TBW was estimated using BIS and 2H techniques. Reproducibility results indicated that fixed-distance electrodes reduced the day-to-day standard error of the measurement in men (from 1·13 to 0·81 litres) but not in women (0·47 litres). sem values were lower for women than for men, suggesting that BIS TBW estimates are sex dependent. Validity results produced similar accurate findings (mean difference < 0·21 litres). However, fixed-distance electrodes improved delta TBW errors (mean difference improvements>0·04 litres in men, women, and men and women combined). When tracking changes in TBW, fixed-distance electrodes may reduce reproducibility errors and allow for smaller changes to be detected. However, the reduction of reproducibility errors may be greater for men than for women. Therefore, reproducibility calculations should be based on the sex of the sample population.
Culture, Communication, and Dependency: The Tradition of H. A. InnisWilliam H. Melody, Liora Salter and Paul Heyer, eds. Norwood, N.J.: Ablex Publishing, 1981, pp. xi, 263
- Walter Young
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 15 / Issue 3 / September 1982
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- 10 November 2009, pp. 611-612
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The Canadian Left: A Critical AnalysisNorman Penner Scarborough, Ontario: Prentice-Hall, 1977, pp. 287
- Walter D. Young
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 11 / Issue 1 / March 1978
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- 10 November 2009, pp. 182-183
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Richard Allen. The Social Passion: Religion and Social Reform in Canada 1914–28. Toronto: University of Toronto Press, 1971, pp. xxv, 385.
- Walter Young
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 6 / Issue 1 / March 1973
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- 10 November 2009, pp. 155-156
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Norman Penlington, ed., On Canada: Essays in Honour of Frank H. Underhill. Toronto: University of Toronto Press, 1971, pp. xvii, 196.
- Walter Young
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 4 / Issue 4 / December 1971
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- 10 November 2009, p. 575
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The Voices of Democracy: Politics and Communication in Canada*
- Walter D. Young
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- Canadian Journal of Political Science/Revue canadienne de science politique / Volume 14 / Issue 4 / December 1981
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- 10 November 2009, pp. 683-700
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