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The development of the unsteady pressure field on the floor of a rectangular cavity was studied at Mach 0.9 using high-frequency pressure-sensitive paint. Power spectral amplitudes at each cavity resonance exhibit a spatial distribution with a streamwise-oscillatory pattern; additional maxima and minima appear as the mode number is increased. This spatial distribution also appears in the propagation velocity of modal pressure disturbances. This behaviour was tied to the superposition of a downstream-propagating shear-layer disturbance and an upstream-propagating acoustic wave of different amplitudes and convection velocities, consistent with the classical Rossiter model. The summation of these waves generates a net downstream-travelling wave whose amplitude and phase velocity are modulated by a fixed envelope within the cavity. This travelling-wave interpretation of the Rossiter model correctly predicts the instantaneous modal pressure behaviour in the cavity. Subtle spanwise variations in the modal pressure behaviour were also observed, which could be attributed to a shift in the resonance pattern as a result of spillage effects at the edges of the finite-width cavity.

Nitrate promotes seed germination at low concentrations in many plant species, and functions as both a nutrient and a signal. As a nutrient, it is assimilated via nitrite to ammonium, which is then incorporated into amino acids. Nitrate reductase (NR) catalyses the reduction of nitrate to nitrite, the committed step in the assimilation. Seed sensitivity to nitrate is affected by other environmental factors, such as light and after-ripening, and by genotypes. Mode of nitrate action in seed germination has been well documented in Arabidopsis thaliana and the hedge mustard Sisymbrium officinale. In these species nitrate promotes seed germination independent of its assimilation by NR, suggesting that it acts as a signal to stimulate germination. In Arabidopsis, maternally applied nitrate affects the degree of primary dormancy in both wild-type and mutants defective in NR. This indicates that nitrate acts not only during germination, but also during seed development to negatively regulate primary dormancy. Functional genomics studies in Arabidopsis have revealed that nitrate elicits downstream events similar to other germination stimulators, such as after-ripening, light and stratification, suggesting that these distinct environmental signals share the same target(s). In Arabidopsis, the NIN-like protein 8 (NLP8) transcription factor, which acts downstream of nitrate signalling, induces nitrate-dependent gene expression. In particular, a gene encoding the abscisic acid (ABA) catabolic enzyme CYP707A2 is directly regulated by NLP8. This regulation triggers a nitrate-induced ABA decrease that permits seed germination. This review article summarizes an update of our current understanding of the regulation of seed dormancy and germination by nitrate.

This paper presents a novel approach to sensor-based feature evaluation and selection using a self-organizing map and spatial statistics as a combined technique applied to tool condition monitoring of the turning process. This approach takes advantage of the unique features of unsupervised neural networks combined with spatial statistics to perform analyses into the contributions of the different sensor-based features, carrying large quantities of noise, to achieve a classification of tool wear and a quantitative measure of each feature's suitability. This method does not assume a prior direct correlation between features avoiding misconstructions inherent to common approaches that assume that only obviously correlated features should be considered for condition monitoring. Instead, and taking advantage of neural networks ability to perform non-linear modeling, it has allowed a prior modeling of the process and then analyzed each feature's contribution toward classification. It was found that some of the commonly used features have proven to have a significant contribution to the classification of cutting tool wear, whereas others adversely affect classification performance. Further, it is demonstrated that the proposed combined technique can be used extensively to quantitatively evaluate the contribution of different features toward system monitoring in the presence of noisy data.

Cardiomyopathy develops in >90% of Duchenne muscular dystrophy (DMD) patients by the second decade of life. We assessed the associations between DMD gene mutations, as well as Latent transforming growth factor-beta-binding protein 4 (LTBP4) haplotypes, and age at onset of myocardial dysfunction in DMD. DMD patients with baseline normal left ventricular systolic function and genotyping between 2004 and 2013 were included. Patients were grouped in multiple ways: specific DMD mutation domains, true loss-of-function mutations (group A) versus possible residual gene expression (group B), and LTBP4 haplotype. Age at onset of myocardial dysfunction was the first echocardiogram with an ejection fraction <55% and/or shortening fraction <28%. Of 101 DMD patients, 40 developed cardiomyopathy. There was no difference in age at onset of myocardial dysfunction among DMD genotype mutation domains (13.7±4.8 versus 14.3±1.0 versus 14.3±2.9 versus 13.8±2.5, p=0.97), groups A and B (14.4±2.8 versus 12.1±4.4, p=0.09), or LTBP4 haplotypes (14.5±3.2 versus 13.1±3.2 versus 11.0±2.8, p=0.18). DMD gene mutations involving the hinge 3 region, actin-binding domain, and exons 45–49, as well as the LTBP4 IAAM haplotype, were not associated with age of left ventricular dysfunction onset in DMD.

British Anglo-Catholic and high church Anglicans promoted a new set of foreign missionary initiatives in the Pacific and South and East Africa in the 1860s. Theorizing new indigenizing models for mission inspired by Tractarian medievalism, the initiatives envisioned a different and better engagement with ‘native’ cultures. Despite setbacks, the continued use of Anglican sisters in Hawai‘i and brothers in Melanesia, Africa and India created a potent new imaginative space for missionary endeavour, but one problematized by the uneven reach of empire: from contested, as in the Pacific, to normal and pervasive, as in India. Of particular relevance was the Sandwich Islands mission, invited by the Hawaiian crown, where Bishop T. N. Staley arrived in 1862, followed by Anglican missionary sisters in 1864. Immensely controversial in Britain and America, where among evangelicals in particular suspicion of ‘popish’ religious practice ran high, Anglo-Catholic methods and religious communities mobilized discussion, denunciation and reaction. Particularly in the contested imperial space of an independent indigenous monarchy, Anglo-Catholics criticized what they styled the cruel austerities of evangelical American ‘puritanism’ and the ambitions of American imperialists; in the process they catalyzed a reconceptualized imperial reformism with important implications for the shape of the late Victorian British empire.