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We report on frequency doubling of high-energy, high repetition rate ns pulses from a cryogenically gas cooled multi-slab ytterbium-doped yttrium aluminum garnet laser system, Bivoj/DiPOLE, using a type-I phase matched lithium triborate crystal. We achieved conversion to 515 nm with energy of 95 J at repetition rate of 10 Hz and conversion efficiency of 79%. High conversion efficiency was achieved due to successful depolarization compensation of the fundamental input beam.
To describe national antibiotic prescribing for acute gastroenteritis (AGE).
Setting:
Ambulatory care.
Methods:
We included visits with diagnoses for bacterial and viral gastrointestinal infections from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (NAMCS/NHAMCS; 2006–2015) and the IBM Watson 2014 MarketScan Commercial Claims and Encounters Database. For NAMCS/NHAMCS, we calculated annual percentage estimates and 99% confidence intervals (CIs) of visits with antibiotics prescribed; sample sizes were too small to calculate estimates by pathogen. For MarketScan, we used Poisson regression to calculate the percentage of visits with antibiotics prescribed and 95% CIs, including by pathogen.
Results:
We included 10,210 NAMCS/NHAMCS AGE visits; an estimated 13.3% (99% CI, 11.2%–15.4%) resulted in antibiotic prescriptions, most frequently fluoroquinolones (28.7%; 99% CI, 21.1%–36.3%), nitroimidazoles (20.2%; 99% CI, 14.0%–26.4%), and penicillins (18.9%; 99% CI, 11.6%–26.2%). In NAMCS/NHAMCS, antibiotic prescribing was least frequent in emergency departments (10.8%; 99% CI, 9.5%–12.1%). Among 1,868,465 MarketScan AGE visits, antibiotics were prescribed for 13.8% (95% CI, 13.7%−13.8%), most commonly for Yersinia (46.7%; 95% CI, 21.4%–71.9%), Campylobacter (44.8%; 95% CI, 41.5%–48.1%), Shigella (39.7%; 95% CI, 35.9%–43.6%), typhoid or paratyphoid fever (32.7%; (95% CI, 27.2%–38.3%), and nontyphoidal Salmonella (31.7%; 95% CI, 29.5%–33.9%). Antibiotics were prescribed for 12.3% (95% CI, 11.7%–13.0%) of visits for viral gastroenteritis.
Conclusions:
Overall, ∼13% of AGE visits resulted in antibiotic prescriptions. Antibiotics were unnecessarily prescribed for viral gastroenteritis and some bacterial infections for which antibiotics are not recommended. Antibiotic stewardship assessments and interventions for AGE are needed in ambulatory settings.
We present the data and initial results from the first pilot survey of the Evolutionary Map of the Universe (EMU), observed at 944 MHz with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope. The survey covers
$270 \,\mathrm{deg}^2$
of an area covered by the Dark Energy Survey, reaching a depth of 25–30
$\mu\mathrm{Jy\ beam}^{-1}$
rms at a spatial resolution of
$\sim$
11–18 arcsec, resulting in a catalogue of
$\sim$
220 000 sources, of which
$\sim$
180 000 are single-component sources. Here we present the catalogue of single-component sources, together with (where available) optical and infrared cross-identifications, classifications, and redshifts. This survey explores a new region of parameter space compared to previous surveys. Specifically, the EMU Pilot Survey has a high density of sources, and also a high sensitivity to low surface brightness emission. These properties result in the detection of types of sources that were rarely seen in or absent from previous surveys. We present some of these new results here.
The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with
$\sim$
15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination
$+41^\circ$
made over a 288-MHz band centred at 887.5 MHz.
We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled, diode-pumped multi-slab Yb:YAG laser operating at 1 Hz. To the best of our knowledge, this is the highest energy ever recorded for a diode-pumped laser system.
In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100X, being built at the Central Laser Facility (CLF). This 1 kW average power diode-pumped solid-state laser (DPSSL) is based on a master oscillator power amplifier (MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser (XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density (HED) instrument.
The editor and forger John Payne Collier (1789–1883) claimed to have discovered a Second Folio of Shakespeare which had been 'corrected' in a mid-seventeenth-century hand. He published this catalogue of the emendations, including his commentary on them, in 1852. Collier then presented the so-called 'Perkins Folio' to the Duke of Devonshire, whose successor allowed it to be loaned in 1859 to the British Museum, where a thorough examination exposed it as a forgery. A storm of controversy followed and three of the key documents in the debate, all published in 1860, are also reissued here: 'An Inquiry into the Genuineness of the Manuscript Corrections in Mr. J. Payne Collier's Annotated Shakspere Folio, 1632' by Nicholas Hamilton (d.1915), assistant keeper of manuscripts at the British Museum; Collier's attempt to refute Hamilton's findings; and 'A Review of the Present State of the Shakespearian Controversy' by Thomas Duffus Hardy (1804–78).
In this paper we review the provision of the laser diagnostics that are installed on the Vulcan laser facility. We will present strategies for dealing with the energy of high energy systems and with ways of handling the beam sizes of the lasers. We present data captured during typical experimental campaigns to demonstrate their reliability and variation in shot to shot values.
Vitamin D deficiency is emerging worldwide and many studies now suggest its role in the development of several chronic diseases. Due to the low level of vitamin D naturally occurring in food there is a need for supplementation and use of vitamin D-enhanced products. The aim of the present study was to determine if daily consumption of vitamin D2-enhanced mushrooms increased vitamin D status in free-living healthy adults or affected markers of the metabolic syndrome. A total of ninety volunteers (aged 40–65 years) were randomly assigned to one of two 4-week studies: mushroom study (15 µg vitamin D2 or placebo mushroom powder) and capsule study (15 µg vitamin D3 or placebo capsules). Consumption of vitamin D2-enhanced mushrooms increased serum 25-hydroxyvitamin D2 (25(OH)D2) by 128 % from baseline (3·9 (sd 1·9) nmol/l; P < 0·05). Serum 25(OH)D3 increased significantly in the vitamin D3 capsule group (a 55 % increase from a baseline of 44.0 (sd 17·1) nmol/l; P < 0·05). Vitamin D status (25(OH)D) was affected only in the vitamin D3 group. Plasminogen activator inhibitor-1 was lowered by vitamin D2 intake. Vitamin D2 from enhanced mushrooms was bioavailable and increased serum 25(OH)D2 concentration with no significant effect on 25(OH)D3 or total 25(OH)D.
The functional catechol-O-methyltransferase (COMT Val108/158Met) polymorphism has been shown to have an impact on tasks of executive function, memory and attention and recently, tasks with an affective component. As oestrogen reduces COMT activity, we focused on the interaction between gender and COMT genotype on brain activations during an affective processing task. We used functional MRI (fMRI) to record brain activations from 74 healthy subjects who engaged in a facial affect recognition task; subjects viewed and identified fearful compared to neutral faces. There was no main effect of the COMT polymorphism, gender or genotype×gender interaction on task performance. We found a significant effect of gender on brain activations in the left amygdala and right temporal pole, where females demonstrated increased activations over males. Within these regions, Val/Val carriers showed greater signal magnitude compared to Met/Met carriers, particularly in females. The COMT Val108/158Met polymorphism impacts on gender-related patterns of activation in limbic and paralimbic regions but the functional significance of any oestrogen-related COMT inhibition appears modest.
There is an extensive literature on the well-known longshot-favourite bias in the odds offered by bookmakers on horse-races, see Figgis (1951), Dowie (1976), Royal Commission on Gambling (1978), Tuckwell (1983), Crafts (1985), Henery (1985), Bird and McCrae (1987), Shin (1991, 1992, 1993), Jullien and Salanié (1994), Vaughan Williams and Paton (1997, 1998) and the authoritative survey by Vaughan Williams (1999). The motivation of this short chapter is to consider the empirical evidence and theory behind the proposition that the odds offered on a horse by bookmakers will depend on the other horses in the race. Past empirical evidence and theory appears not to have considered that the odds offered on a horse may depend on the other horses in the race.
Intuitively, one might expect that the most likely horse to affect the odds offered on other horses is the favourite. The odds on favourites vary from as little as 25 to 1 on to as much as 14 to 1 against. The bias in very short odds is minimal but for less strong favourites the bias is greater. It is suggested that strength of favourite may affect the degree of bias in the odds offered on other horses. On the basis of British flat horse-race statistics for 1993, it is shown that the degree of bias in odds offered on horses is positively related to the presence of strong favourites. Two possible explanations are proposed for this relation.
The target article proposes an error theory for religious belief. In contrast, moral beliefs are typically not counterintuitive, and some moral cognition and motivation is functional. Error theories for moral belief try to reduce morality to nonmoral psychological capacities because objective moral beliefs seem too fragile in a competitive environment. An error theory for religious belief makes this unnecessary.
After distinguishing reductive explanability in principle from ontological deflation, I give a case of an obviously physical property that is reductively inexplicable in principle. I argue that biological systems often have this character, and that, if we make certain assumptions about the cohesion and dynamics of the mind and its physical substrate, then it is emergent according to Broad's criteria.
Corporate governance is a complex and contested issue, and its ambiguities become even more problematic when ethical considerations are taken into account. This introduction attempts to address these complexities, to illuminate their ethical aspects, and to situate the eight papers presented here within what we believe to be an integrative heuristic framework.
The dominant theoretical perspective on governance relationships and their associated problems is to be found within economics, and in particular within agency theory. With the separation of ownership from control (Berle and Means 1932) a potential problem arises in the context of what is now constituted as a relationship between the owners (principals) and directors (their agents). How can the principals ensure that the agents are serving the owners’ interests rather than their own? Against the backdrop of the assumption of an essentially self-seeking, opportunistic human nature only market discipline, monitoring, and incentives can be used to align agent behavior with the interests of the distant and/or absent shareholder understood as the owner.
In recent years there has developed a perspective that runs counter to this theorization of the key governance relationship and its problem. The elaboration of so-called stakeholder views of the corporation (Freeman 1993, Blair 1995) argues both empirically and normatively that there is a wider range of relevant relationships, and thus a greater number of interests at stake in the governance of the corporation. It is not only shareholders who have made firm-specific investments in the organization, but also employees, suppliers, and customers, and their interests must therefore also be taken account of in the constitution and conduct of corporate governance. Associated with this view is a very different conception of the director as steward (Davis et al. 1997) or trustee of the corporation (Kay 1996), where the corporation is conceived, not as a set of ownership rights accruing to those who assume the residual risk of a business, but as a social institution. From this perspective the duties of directors lie in aligning and balancing a wide variety of potentially competitive interests within the corporation.