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Population-based surveillance of urinary Escherichia coli was conducted in three U.S. counties. Findings included high incidence among females and older adults, resistance to recommended urinary tract infection treatments, and O serotypes common among invasive disease. The study emphasizes the value of understanding the epidemiology and resistance profiles to guide treatment.
Colonoware, a hand-built, low-fired coarse earthenware, appears on archaeological sites occupied from the mid-seventeenth to the mid-nineteenth century throughout the southeastern United States. Although colonoware is highly variable in appearance and abundance, it is evident that subjugated and marginalized communities, including enslaved and free Africans and Indigenous people, produced, marketed, and used colonoware to contribute to, circumvent, and disrupt traditional European markets. Because of the lack of documentary evidence and definitive ethnic markers, fundamental information about colonoware—who made it and for whom it was made—remains elusive. Expecting that function was related to geographically and temporally contextual cultural practices, we adopt an attribute-level approach to identify patterns in the functional role of colonoware in two regions: Virginia and South Carolina. We analyzed data from the Digital Archaeological Archive of Comparative Slavery (DAACS; www.daacs.org), which contains fine-grained information on colonoware and other artifacts from 21 sites. We found significant regional variation in abundance, sherd attributes, and form. We interpret this as evidence that Virginia colonoware was primarily made for tableware functions, whereas South Carolina colonoware was more likely used for both cooking and serving. Our examination of interregional variation demonstrates that function is a useful lens for interpreting cultural differences in the development and retention of locally made earthenware traditions.
The Canadian Nosocomial Infection Surveillance Program piloted a study assessing inter-rater agreement among a point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use in acute care hospitals across Canada. Results of this study revealed areas for improvement to be considered in future PPS methodology.
Although Large Language Model (LLM) deployment in healthcare continues to advance, systematic measurements of their performance for clinical contexts and use-cases in psychiatry remains limited. OpenAI’s HealthBench framework comprises standardised evaluation metrics for its utility and efficacy in healthcare, yet whether these general benchmarks adequately assess psychiatric competencies remains empirically untested.
Objectives
This study sought to evaluate ChatGPT iterations (GPT-3.5 through to GPT-o3) on psychiatry-relevant conversations extracted from the HealthBench dataset, quantifying performance trajectories and identifying domain-specific limitations.
Methods
147 psychiatry-related dialogues with LLMs from 5,000 HealthBench conversations were systematically extracted using keyword taxonomy and a manual human review. Based off this, three evaluation datasets were analysed: HealthBench-Psychiatry (n=147), HealthBench-Psychiatry Consensus (n=104), HealthBench-Psychiatry Hard (n=38). A rubric-based assessment was conducted for five behavioral axes and seven psychiatrically-relevant themes using OpenAI’s evaluation framework.
Results
Overall, evaluative scores for psychiatric conversations scores increased between models from 0.15 (GPT-3.5) to 0.59 (GPT-o3), in line with general medical benchmarks for LLM performance (mean deficit: -0.03). However, importantly, the pre-defined HealthBench domains for “instruction following” and “context awareness” demonstrated a lack of statistically significant improvements across recent iterations (p>0.344).
Conclusions
This study demonstrates marked improvements in ChatGPT psychiatric performance between iterations, aligning with broader medical benchmarks. Yet, persistent plateaus highlight critical gaps in meeting the nuanced demands of psychiatric clinical tasks. Accordingly, these findings suggest that current LLMs remain limited in their suitability for direct clinical deployment in mental health settings. Future progress will require domain-specific fine-tuning, rigorous psychiatric benchmarking, and safeguards to ensure safe, contextually sensitive integration into psychiatric practice.
Evidence has highlighted sizeable prevalence rates for mental illnesses in men’s elite-level cycling, especially for eating disorders, depression, and other conditions. In these contexts, distinctive sport-specific risk factors linked to performance pressures, sociocultural determinants, and weight concerns can increase athlete vulnerabilities. However, the complexity of individual riders’ lived experiences, particularly regarding career transitions and team support systems, remains largely underexplored.
Objectives
This qualitative investigation aimed to address this gap by examining mental health experiences amongst former elite-level cyclists to identify potential stressors and the level of available support to inform evidence-based interventions.
Methods
Semi-structured interviews were conducted with thirteen former male professional cyclists (Pro Continental-World Tour level; ages 29-44; minimum seven years professional experience). Thematic analysis following was employed to identify recurring patterns and core themes across the participants’ responses.
Results
The analysis revealed five primary thematic domains: (1) persistent concerns associated with contract insecurity and short-term employment structures; (2) systematic pressures to maintain sub-optimal body weight; (3) inadequate mental health infrastructure within team environments compounded by confidentiality concerns that deterred help-seeking; (4) widespread use of sleep medications and benzodiazepines during competition; (5) potential psychological issues during career transition characterised by identity disruption, financial instability, and absence of structured support mechanisms.
Conclusions
These findings identify substantial mental health challenges embedded within the culture and structures of elite men’s cycling, which potentially affect rider wellbeing. The difficulties cyclists face during retirement further expose the absence of coordinated transition pathways. Addressing these gaps may require wider reforms, including independent and confidential mental health services, evidence-based guidelines on medication use, and structured transition programmes that extend beyond performance-oriented support.
Hypena opulenta (Lepidoptera: Erebidae) has been introduced to control invasive swallow-worts (Apocynaceae) in North America. However, population densities remain too low to suppress weed populations. We examined winter cold and soil moisture as potential factors limiting H. opulenta population growth in Canada. We characterised cold-tolerance strategy, susceptibility to inoculative freezing (freezing initiated by external ice formation at higher subzero temperatures), and examined the effects of prolonged cold exposures on H. opulenta survival. Finally, we conducted a laboratory experiment to determine whether soil moisture content affects the cold hardiness of H. opulenta pupae. Hypena opulenta pupae are freeze-tolerant, but only 22% survived prolonged exposure to –15 °C for 15 hours. After 1-hour cold exposures, survival of pupae in which freezing was inoculated at high temperatures (25%) was lower than that of untreated pupae (62%). After 15-hour cold exposures, however, there was no difference in survival between inoculated and untreated pupae. Pupal mortality was not affected by cold-exposure duration or inoculative freezing in soil, but male pupae had higher survival than females. These results suggest that H. opulenta has the potential to continue to survive, grow, and eventually impact swallow-wort populations in Canada without being limited by winter conditions.
Guided by a lifespan developmental perspective, using a network analysis approach, this study compared the structure of daily stress components in mothers of adolescents and adults with developmental disabilities (DD) and a matched sample of mothers of children without DD. We also examined whether components of daily stress were differentially associated with subsequent depression symptoms. Participants (N = 516; 100% female; M = 54.52 years, SD = 10.21; 94.2% White) were drawn from two cohorts: a DD cohort constructed from two linked longitudinal studies of families of adolescents and adults with autism and fragile X syndrome and a comparison group from the Midlife in United States study. Participants completed an 8-day daily telephone interview and reported depressive symptoms two years later. Findings demonstrated that the daily stress network of mothers of individuals with DD was significantly more interconnected than that of the comparison group. Stressor risk appraisal emerged as a central node in both groups, highlighting the role of cognitive appraisal in shaping stress responses. Negative affective reactivity linked daily stress components with later depressive symptoms, particularly in the DD group. Chronic caregiving stress may heighten interconnectivity within daily stress networks, reducing psychological flexibility and increasing vulnerability to daily stressors.
Comparing the redshifts of fast radio burst (FRB) host galaxies to FRB dispersion measures has unlocked a new probe of the cosmological distribution of ionised gas. However, the necessary optical observations to identify FRB hosts and measure their redshifts are becoming increasingly onerous. Here, we analyse the ability of the Legacy Survey of Space and Time (LSST), being conducted by the Vera C. Rubin Observatory, to identify FRB host galaxies, and the utility of LSST photometric redshifts for FRB cosmology. By combining a model of FRB host galaxy r-band magnitudes, $m_r$, with predictions for the FRB z–DM distribution, we create a method to predict the $m_r(z)$ distribution for the host galaxies of FRBs detected by radio surveys. We then predict these distributions for the coherent modes of the Australian Square Kilometre Array Pathfinder (ASKAP) and MeerKAT. We find that even a single visit with Rubin will be able to identify 65% of FRB host galaxies detected by ASKAP’s coherent upgrade, ‘CRACO’; while the final 10 year co-added images will identify 81% of those from MeerKAT’s tied array beams. We find that estimated photo-z errors result in a decreased precision of only 7% on $H_0$ for ASKAP’s CRACO system. The impact of missing faint FRB hosts, however, will degrade sensitivity to $H_0$ by 47% or 62% when combined with photo-z errors. All told, Rubin’s LSST will be an incredibly powerful survey for facilitating FRB cosmology, although supplemental observations may be useful for particularly faint and distant host galaxies.
Traditional marriage was a transaction between two families, negotiated by a matchmaker. Through the Mao era, marriage remained focused on reproducing the ancestral line, but new ideas of love and free choice of partner gained ground. The chapter examines the supernatural practices that established the compatibility of a potential couple, the transfer of the bride to her husband’s house, the bride’s laments, and other practices. The chapter analyses beliefs and practices around fertility, including taboos around female pollution. The 1950 Marriage Law sought to eliminate ‘feudal’ aspects of traditional marriage and there was resistance to it in rural areas, especially over its divorce provisions. Significant change took place, evinced in the rise in the average age of marriage and a decline in female infanticide. Marriage registration became the norm in towns and grew steadily in the countryside, providing something akin to a wedding ceremony. The chapter explores CCP efforts to promote companionate marriage whilst stressing the duties of a couple to the collective. It ends with the drive to eliminate extravagance from weddings.
This chapter examines what the authorities called ‘mass superstitious incidents’ that took place in the early 1950s. These involved the movement of large numbers of people in search of holy water and sacred medicine. They were inspired to travel by the belief that sacred medicine had been brought down to earth by gods who were exhibiting their spiritual efficacy. It was an opportunity to access healing without the mediation of ritual specialists. The chapter looks at the role of stories of miraculous cures in spreading the phenomenon. Those who partook of sacred medicine explained that they did so because the level of rural healthcare was so dismal. Local officials were disconcerted by these events, not least because Beijing emitted conflicting signals on how local officials should respond. In a handful of cases pilgrims, stood up to attempts to shut down the sacred sites. As rural healthcare improved, pilgrimage for sacred medicine declined.
The chapter examines how and why ordinary people petitioned gods and other non-visible entities, such as spirits, ‘immortals’ (仙 xian), protective saints, or ancestors, for favours of all kinds. In return for offerings of food and drink and the burning of ritual items, such as incense, oil, paper images, paper money, charms, or printed prayers, they asked for help, cures for illness, the birth of a son, protection against evil forces, or success in business or examinations.
China had a long tradition of religiously inspired rebellion, and this chapter explores the ways in which folk religion fed into different forms of resistance in the Mao era. Popular protest in the Mao era was greater than has been assumed, but it was socio-economic and small-scale in characters, which did not prevent participants from believing that their protests had the blessing of the gods. It begins by looking at very low-level forms of resistance such as jokes as a way of lampooning authority; it goes on to explore the efforts of spirit mediums and others to stand up to authority in defence of folk religion, especially following the famine (1959–61) when people blamed disaster on the fact that they had denied the change to make sacrifices to the gods. Planned, organized rebellion was rare and was closely tied to the remnants of the redemptive religious societies. The chapter ends by looking at attempts by ordinary people to make themselves emperors and at millenarian risings, notably the Catholic rebellion in the Taiyuan region in 1965.
From the Socialist Education Movement onwards, folk religion specialists – now classed as ‘superstition professionals’ (akin to ‘religious professionals’) -- were targeted for re-education. Spirit mediums were singled out because of their number and their central role in healing. This was the prelude to the Four Olds Campaign inaugurated by the Cultural Revolution in 1966, when religious sites were destroyed and religious specialists came under attack from Red Guards, despite the fact that ‘religion’ was never named as one of the ‘four olds’. Two features of Cultural Revolution politics are explored: the use of iconoclasm – especially in relation to the Confucius Temple in Qufu; and the attempt to ‘revolutionize the environment’, which entailed renaming streets, shops, and consumer items, and painting buildings red. It ends with the fitful Campaign to Criticize Confucius and Lin Biao (1973–6), which engaged the rural and urban populace in a polemical critique of some simple Confucian texts.
Chapter 8 explores specifically anti-religious propaganda, arguing that initially this was relatively unfocused. The Great Leap Forward saw an attempt to propagate atheism through peasant philosophy teams and a mass campaign to get workers, peasants, and soldiers to write poems and songs discrediting belief in supernatural agency. The chapter explores the CCP’s appropriation of traditional cultural forms to erode popular belief in the agency of non-visible entities, focusing on long-form storytelling, revolutionary opera, and use of cinema for the same end. It briefly explores the onset of the Mao cult and the turn to small groups as a way of undermining folk religion, concentrating on a discussion among women in industry and a discussion in a village, again largely involving women, and suggests how taken-for-granted knowledge had become a terrain for different views.
This chapter discusses ghosts and demons. Ghosts were a capacious and ill-defined category. People feared ghosts but might also pity them. The annual Ghost Festival on the fifteenth day of the seventh lunar month marks the moment when ghosts enter the yang world. Buddhist and sometimes Daoist priests perform pudu, the rite of universal salvation, and ordinary folk put out food for ghosts to eat. Demons are an altogether more chaotic and violent force. A major dimension of folk religion is concerned to protect communities against demonic attack. Ritual specialists, especially Daoist priests and yin-yang masters, devise complex liturgies to keep demon armies at bay. The chapter looks at the role of ghosts in folk entertainment, particularly ‘ghost opera’. It shows that the attitude of the CCP was contradictory. Mao Zedong, like many members of the educated classes, valued this art form and backed efforts to reform it. Much of the content of ghost opera, however, could not be reconciled with materialism and revolutionary values, and after an aborted effort at reform, Mao’s wife, Jiang Qing, succeeded in banning it (although in practice the ban was never completely effective).