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Synthetic Aperture Radar Interferometry (InSAR) is an active remote sensing method that uses repeated radar scans of the Earth's solid surface to measure relative deformation at centimeter precision over a wide swath. It has revolutionized our understanding of the earthquake cycle, volcanic eruptions, landslides, glacier flow, ice grounding lines, ground fluid injection/withdrawal, underground nuclear tests, and other applications requiring high spatial resolution measurements of ground deformation. This book examines the theory behind and the applications of InSAR for measuring surface deformation. The most recent generation of InSAR satellites have transformed the method from investigating 10's to 100's of SAR images to processing 1000's and 10,000's of images using a wide range of computer facilities. This book is intended for students and researchers in the physical sciences, particularly for those working in geophysics, natural hazards, space geodesy, and remote sensing. This title is also available as Open Access on Cambridge Core.
Objectives/Goals: Trainees in clinical and translational science (CTS) must learn to effectively communicate their research ideas and findings to a range of audiences. As part of our science communication curriculum, we developed ORAL and WRITTEN science communication rubrics for our trainees to use across their courses and research activities. Methods/Study Population: The Tufts CTS Graduate Program is the training core of the Tufts CTSI and its associated pre- and post-doctoral T32 awards. Approximately 10 trainees with a range of backgrounds (e.g., physicians, medical students, master’s-level researchers, and basic science PhDs) matriculate each year. Faculty members and staff with expertise in science communication and pedagogy formed a committee to develop the rubrics. Because oral and written communication require different skills, we developed separate rubrics for each. We reviewed our current science communication curriculum, reviewed existing communication rubrics, and identified common mistakes students make. Following pilot testing by students and faculty pilot for one semester, we modified the rubrics based on informal feedback. Results/Anticipated Results: Both rubrics include a section to identify the target audience and specific items organized by theme. Oral rubric themes include presentation content, slides, verbal communication, nonverbal communication, and following instructions. Written rubric themes include overall, manuscript/proposal sections, and following instructions. The rubrics serve as feedback tools for faculty and students to evaluate work others produce and as self-evaluation tools. Feedback elements include a 4-point rating for each rubric item, open text feedback for each theme, and an open text holistic assessment. We now use the rubrics in our study design course, which features student presentations of planned research, and in our writing course. We anticipate collecting formal student feedback to further evaluate the rubrics. Discussion/Significance of Impact: Our rubrics can supplement existing science communication training and can be integrated into all CTS coursework and research activities. For future clinical and translational scientists to have the greatest impact, they must learn to effectively communicate findings to multiple audiences, ranging from experts in their field to the general public.
Research faculty often experience poor mentoring, low vitality, and burnout. We report on our logic model inputs, activities, measurable outcomes, and impact of a novel mentoring intervention for biomedical research faculty: the C-Change Mentoring & Leadership Institute. We present a) a detailed description of the curriculum and process, b) evaluation of the program’s mentoring effectiveness from the perspective of participants, and c) documentation of mentoring correlated with key positive outcomes.
Methods:
A yearlong facilitated group peer mentoring program that convened quarterly in person was conducted twice (2020–2022) as part of an NIH-funded randomized controlled study. The culture change intervention aimed to increase faculty vitality, career advancement, and cross-cultural competence through structured career planning and learning of skills essential for advancement and leadership in academic medicine. Participants were 40 midcareer MD and PhD research faculty, half women, and half underrepresented by race or ethnicity from 27 US medical schools.
Results:
Participants highly rated their mentoring received at the Institute. Extent of effective mentoring experienced correlated strongly with the measurable outcomes of enhanced vitality, self-efficacy in career advancement, research and work-life integration, feelings of inclusion in the program, valuing diversity, and skills for addressing inequity.
Conclusions:
The mentoring model fully included men and women and historically underrepresented persons in medicine and minimized problems of power, gender, race, and ethnicity discordance. The intervention successfully addressed the urgencies of sustaining faculty vitality, developing faculty careers, facilitating cross-cultural engagement and inclusion, and contributing to cultivating cultures of inclusive excellence in academic medicine.
Tetralogy of Fallot is the most common cyanotic congenital malformation of the heart. The right ventricular outflow tract is of great interest in this setting, but most of the focus on this feature has been on the size of the so-called pulmonary valvar “annulus”. We aimed to characterise other aspects of the morphology of the pulmonary root in heart specimens with tetralogy of Fallot.
Methods:
We reviewed archived hearts with tetralogy of Fallot from four registries. The pulmonary root was examined with specific attention to the number of sinuses, the number of leaflets, presence of any fusion of leaflets, and the direction of the zone of apposition between the leaflets. Cluster analyses were then conducted to see if the features permitted segregation into groups.
Results:
We examined a total of 155 hearts. The pulmonary valve had two leaflets in 62%, three leaflets in 34%, and one leaflet in 3%. Irrespective of leaflet morphology, most hearts had two sinuses. Cluster analysis permitted segregation into three groups, with the direction of the zone of apposition being the most important feature for segregation.
Conclusion:
In two-thirds of our hearts with tetralogy of Fallot, the pulmonary valve had two leaflets. Most frequently there were three sinuses. In the setting of a valve with two sinuses, the zone of apposition between the leaflets pointing towards the aorta. Cluster analysis permitted statistically sound segregation of the heart and highlights the importance of delineating these features, specifically the leaflet and sinus morphology, with clinical imaging.
These are all very practical decisions, and the methods of analyzing them make use of Principle 1:A dollar today is not worth the same as a dollar tomorrow. Economists have considered the management of personal financial resources over a lifetime to be a central issue worthy of serious study, and several Nobel Prizes in economics have been awarded for contributions in this area. And, as Box 3.1 shows, financial literacy for a nation’s people is a goal being pursued by countries all over the world.
Most financial decisions boil down to figuring out how much an asset is worth. For example, in deciding whether to invest in a security such as a stock or a bond or in a business opportunity, you have to determine whether the price being asked is high or low relative to other investment opportunities available to you. In addition to investment decisions, there are many other situations in which one needs to determine the value of an asset. For example, suppose that the tax assessor in your town has assessed your house at $500,000 for property tax purposes. Is this value too high or too low? Or suppose you and your siblings inherit some property, and you decide to sell it and share the proceeds equally among yourselves. How do you decide how much it is worth?
In the previous chapters we introduced the concept of valuation, which involved converting cash flows that are expected to happen in the future into today’s terms, and we learned about the returns on various assets and how to analyze the past performance of financial instruments to inform investment decisions. However, the future is not known for sure. The cash flows that occur may be different from what we initially expect, and the value (and rates of return) of financial instruments change over time. In this chapter, we introduce a fundamental concept in finance: Uncertainty about the future can affect valuation and decision making.
We begin by defining what risk is in finance, and how it affects financial decisions. We then dive into how risk can be managed, which includes identifying relevant risks, assessing how they can affect one’s financial situation, and then determining appropriate techniques that can be used to reduce these risks.
Before proceeding with our first steps in valuation, we need to introduce some tools and define some notation that will be used here and throughout the book when valuing assets.
At a fundamental level, the value of an asset comes from the cash flows that are associated with it—that is, from the amounts of money that the owner either receives or pays at various points in time. An essential tool in analyzing cash flows from any financial decision is a diagram known as a timeline, a linear representation of cash outflows and inflows over a period of time. A negative sign in front of a cash flow means that you are paying that amount of money (it’s a cash outflow from you). No sign means that you are receiving an amount of money (it’s a cash inflow to you).
In the last few chapters we have considered financial and strategic decisions made within companies, and whether they improve the value of the company. In this chapter we continue examining company decisions, and focus on a particular financial decision—the payout decision, which considers whether a company keeps the cash it holds or gives it back to investors. As we will show, this decision is important because firms can potentially increase their value—and benefit their investors—through their choice of whether to pay out cash to investors. Furthermore, as we discussed in the previous chapter, agency problems may arise when companies hold onto large amounts of cash due to managerial conflicts of interest. Thus, payout can serve an important role in corporate governance.
In previous chapters we explored how to calculate the value of a company, given decisions that it had already made. In subsequent chapters we then focused on decisions that a manager within a company could make, and how they affect company value, such as project investment decisions. In this chapter we continue to examine decisions made by companies, and focus on a particularly important decision—the financing decision. Capital structure is the mix of financing sources that a firm uses to fund its operations, growth, and investment projects. A firm may choose to use internal funding from operations, or use external funding from issuing debt (bonds) or equity (stock), or other financing instruments.
In the previous chapter we discussed what risk is and how managing risk is an essential element of every financial decision. Risk stems from uncertainty about the future. In this chapter, we introduce and explain financial contracts—options—that help resolve uncertainty by allowing an asset to be traded at a fixed price in the future after observing outcomes. More specifically, put options allow the choice to sell or not sell an underlying asset in the future, while call options allow the choice to buy or not buy an underlying asset in the future. The owner does not have to sell (in the case of a put) or buy (in the case of a call) in the future if it is not beneficial to them. Thus, the value of option contracts is that they embed flexibility—the owner makes the decision after the market price of the underlying asset is observed.
In the previous chapter we went over the process by which investors form portfolios, how to measure the risk and return of a given portfolio, and how an optimal portfolio can be chosen from a riskless asset and a set of risky assets. We saw that the optimal portfolio consists of holding some portion of one’s money in the riskless asset and some portion in the tangency portfolio consisting of the optimal combination of risky assets (OCRA). In this chapter we introduce the capital asset pricing model (CAPM), which specifies exactly what the OCRA should be. The CAPM predicts, under a set of assumptions, that the OCRA consists of holding all assets in the market in proportion to their value. Thus, all investors should hold some combination of the market portfolio and the riskless asset because it is most efficient.