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338 The Alabama Genomic Health Initiative: Integrating Genomic Medicine into Primary Care
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- Nita A Limdi, Devin Absher, Irf Asif, Lori Bateman, Greg Barsh, Kevin M. Bowling, Gregory M. Cooper, Brittney H. Davis, Kelly M. East, Candice R. Finnila, Blake Goff, Susan Hiatt, Melissa Kelly, Whitley V. Kelley, Bruce R. Korf, Donald R. Latner, James Lawlor, Thomas May, Matt Might, Irene P. Moss, Mariko Nakano-Okuno, Tiffany Osborne, Stephen Sodeke, Adriana Stout, Michelle L. Thompson
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue s1 / April 2023
- Published online by Cambridge University Press:
- 24 April 2023, pp. 100-101
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OBJECTIVES/GOALS: Supported by the State of Alabama, the Alabama Genomic Health Initiative (AGHI) is aimed at preventing and treating common conditions with a genetic basis. This joint UAB Medicine-HudsonAlpha Institute for Biotechnology effort provides genomic testing, interpretation, and counseling free of charge to residents in each of Alabama’s 67 counties. METHODS/STUDY POPULATION: Launched in 2017, as a state-wide population cohort, AGHI (1.0) enrolled 6,331 Alabamians and returned individual risk of disease(s) related to the ACMG SF v2.0 medically actionable genes. In 2021, the cohort was expanded to include a primary care cohort. AGHI (2.0) has enrolled 750 primary care patients, returning individual risk of disease(s) related to the ACMG SF v3.1 gene list and pre-emptive pharmacogenetics (PGx) to guide medication therapy. Genotyping is done on the Illumina Global Diversity Array with Sanger sequencing to confirm likely pathogenic / pathogenic variants in medically actionable genes and CYP2D6 copy number variants using Taqman assays, resulting in a CLIA-grade report. Disease risk results are returned by genetic counselors and Pharmacogenetics results are returned by Pharmacists. RESULTS/ANTICIPATED RESULTS: We have engaged a statewide community (>7000 participants), returning 94 disease risk genetic reports and 500 PGx reports. Disease risk reports include increased predisposition to cancers (n=38), cardiac diseases (n=33), metabolic (n=12), other (n=11). 100% of participants harbor an actionable PGx variant, 70% are on medication with PGx guidance, 48% harbor PGx variants and are taking medications affected. In 10% of participants, pharmacists sent an active alert to the provider to consider/ recommend alternative medication. Most commonly impacted medications included antidepressants, NSAIDS, proton-pump inhibitors and tramadol. To enable the EMR integration of genomic information, we have developed an automated transfer of reports into the EMR with Genetics Reports and PGx reports viewable in Cerner. DISCUSSION/SIGNIFICANCE: We share our experience on pre-emptive implementation of genetic risk and pharmacogenetic actionability at a population and clinic level. Both patients and providers are actively engaged, providing feedback to refine the return of results. Real time alerts with guidance at the time of prescription are needed to ensure future actionability and value.
Development of the systematic observation of COVID-19 mitigation (SOCOM): Assessing face covering and distancing in schools
- Ricky Camplain, Nanette V. Lopez, Dan M. Cooper, Thomas L. McKenzie, Kai Zheng, Shlomit Radom-Aizik
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue 1 / 2021
- Published online by Cambridge University Press:
- 30 April 2021, e124
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Introduction:
During the COVID-19 pandemic, some K-12 schools resumed in-person classes with varying degrees of mitigation plans in the fall 2020. Physical distancing and face coverings can minimize SARS-CoV-2 spread, the virus that causes COVID-19. However, no research has focused on adherence to mitigation strategies during school days. Thus, we sought to develop a systematic observation protocol to capture COVID-19 mitigation strategy adherence in school environments: The Systematic Observation of COVID-19 Mitigation (SOCOM).
Methods:We extended previously validated and internationally used tools to develop the SOCOM training and implementation protocols to assess physical-distancing and face-covering behaviors. SOCOM was tested in diverse indoor and outdoor settings (classrooms, lunchrooms, physical education [PE], and recess) among diverse schools (elementary, secondary, and special needs).
Results:For the unique metrics of physical-distancing and face-covering behaviors, areas with less activity and a maximum of 10–15 students were more favorable for accurately capturing data. Overall proportion of agreement was high for physical distancing (90.9%), face covering (88.6%), activity type (89.2%), and physical activity level (87.9%). Agreement was lowest during active recess, PE, and observation areas with ≥20 students.
Conclusions:Millions of children throughout the USA are likely to return to school in the months ahead. SOCOM is a relatively inexpensive research tool that can be implemented by schools to determine mitigation strategy adherence and to assess protocols that allow students return to school safely and slow the spread of COVID-19.
Exploration of baseline and early changes in neurocognitive characteristics as predictors of treatment response to bupropion, sertraline, and placebo in the EMBARC clinical trial
- Yuen-Siang Ang, Gerard E. Bruder, John G. Keilp, Ashleigh Rutherford, Daniel M. Alschuler, Pia Pechtel, Christian A. Webb, Thomas Carmody, Maurizio Fava, Cristina Cusin, Patrick J. McGrath, Myrna Weissman, Ramin Parsey, Maria A. Oquendo, Melvin G. McInnis, Crystal M. Cooper, Patricia Deldin, Madhukar H. Trivedi, Diego A. Pizzagalli
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- Journal:
- Psychological Medicine / Volume 52 / Issue 13 / October 2022
- Published online by Cambridge University Press:
- 20 November 2020, pp. 2441-2449
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Background
Treatment for major depressive disorder (MDD) is imprecise and often involves trial-and-error to determine the most effective approach. To facilitate optimal treatment selection and inform timely adjustment, the current study investigated whether neurocognitive variables could predict an antidepressant response in a treatment-specific manner.
MethodsIn the two-stage Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC) trial, outpatients with non-psychotic recurrent MDD were first randomized to an 8-week course of sertraline selective serotonin reuptake inhibitor or placebo. Behavioral measures of reward responsiveness, cognitive control, verbal fluency, psychomotor, and cognitive processing speeds were collected at baseline and week 1. Treatment responders then continued on another 8-week course of the same medication, whereas non-responders to sertraline or placebo were crossed-over under double-blinded conditions to bupropion noradrenaline/dopamine reuptake inhibitor or sertraline, respectively. Hamilton Rating for Depression scores were also assessed at baseline, weeks 8, and 16.
ResultsGreater improvements in psychomotor and cognitive processing speeds within the first week, as well as better pretreatment performance in these domains, were specifically associated with higher likelihood of response to placebo. Moreover, better reward responsiveness, poorer cognitive control and greater verbal fluency were associated with greater likelihood of response to bupropion in patients who previously failed to respond to sertraline.
ConclusionThese exploratory results warrant further scrutiny, but demonstrate that quick and non-invasive behavioral tests may have substantial clinical value in predicting antidepressant treatment response.
Estimation of ice fabric within Whillans Ice Stream using polarimetric phase-sensitive radar sounding
- Thomas M. Jordan, Dustin M. Schroeder, Cooper W. Elsworth, Matthew R. Siegfried
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- Journal:
- Annals of Glaciology / Volume 61 / Issue 81 / April 2020
- Published online by Cambridge University Press:
- 03 February 2020, pp. 74-83
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Here we use polarimetric measurements from an Autonomous phase-sensitive Radio-Echo Sounder (ApRES) to investigate ice fabric within Whillans Ice Stream, West Antarctica. The survey traverse is bounded at one end by the suture zone with the Mercer Ice Stream and at the other end by a basal ‘sticky spot’. Our data analysis employs a phase-based polarimetric coherence method to estimate horizontal ice fabric properties: the fabric orientation and the magnitude of the horizontal fabric asymmetry. We infer an azimuthal rotation in the prevailing horizontal c-axis between the near-surface (z ≈ 10–50 m) and deeper ice (z ≈ 170–360 m), with the near-surface orientated closer to perpendicular to flow and deeper ice closer to parallel. In the near-surface, the fabric asymmetry increases toward the center of Whillans Ice Stream which is consistent with the surface compression direction. By contrast, the fabric orientation in deeper ice is not aligned with the surface compression direction but is consistent with englacial ice reacting to longitudinal compression associated with basal resistance from the nearby sticky spot.
Methiozolin Efficacy for Annual Bluegrass (Poa annua) Control on Sand- and Soil-Based Creeping Bentgrass Putting Greens
- James T. Brosnan, Gerald M. Henry, Gregory K. Breeden, Tyler Cooper, Thomas J. Serensits
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- Journal:
- Weed Technology / Volume 27 / Issue 2 / June 2013
- Published online by Cambridge University Press:
- 20 January 2017, pp. 310-316
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Methiozolin is a new isoxazoline herbicide being investigated for selective POST annual bluegrass control in creeping bentgrass putting greens. Glasshouse and field research was conducted from 2010 to 2012 in Tennessee and Texas to evaluate annual bluegrass control efficacy with methiozolin. Application placement experiments in the glasshouse illustrated that root absorption was required for POST annual bluegrass control with methiozolin at 1,000 g ai ha−1. Soil-plus-foliar and soil-only applications of methiozolin reduced annual bluegrass biomass greater than treatments applied foliar-only. Field experiments evaluated annual bluegrass control efficacy with two application rates (500 and 1,000 g ha−1) and six application regimes (October, November, December, October followed by [fb] November, November fb December, and October fb November fb December) on sand- and soil-based putting greens. Annual bluegrass control with methiozolin at 1,000 g ha−1 on sand-based greens ranged from 70 to 72% compared to 87 to 89% on soil-based greens. Treatment at 500 g ha−1 controlled annual bluegrass 57 to 64% on sand-based greens compared to 72 to 80% on soil-based greens. Most sequential methiozolin application regimes controlled annual bluegrass more than single applications. On sand-based greens, sequential application programs controlled annual bluegrass 70 to 79% compared to 85 to 92% on soil-based greens. Responses indicate that methiozolin is a root-absorbed herbicide with efficacy for selective control of annual bluegrass in both sand- and soil-based creeping bentgrass putting greens.
Optimizing postemergence herbicide deposition and efficacy through application variables in no-till systems
- Thomas M. Wolf, S. Kent Harrison, Franklin R. Hall, Jane Cooper
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- Journal:
- Weed Science / Volume 48 / Issue 6 / December 2000
- Published online by Cambridge University Press:
- 20 January 2017, pp. 761-768
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Laboratory experiments were conducted to determine the effects of application factors and standing Triticum aestivum stubble on herbicide spray deposition and efficacy in a simulated no-till environment. Spray deposition on weeds was reduced in the presence of stubble, and deposition losses on Amaranthus hybridus were greater than those on Setaria faberi. Spray penetration through stubble was significantly enhanced with electrostatic charging of a fine hydraulic spray. The combination of 45 kV electrostatic charge and 50 cm nozzle spacing produced maximum spray deposition on weeds and resulted in a 96% and 345% increase in deposition on A. hybridus and S. faberi, respectively, compared to the uncharged controls. Deposit reduction from standing stubble was greater at travel speeds of 16 km h−1 (36 to 52%) than 8 km h−1 (9 to 38%). On a dry weight and plant density basis, weeds retained more spray than was retained by stubble, yet stubble, at average densities, was capable of capturing 9 to 12% of total applied spray dose per unit area. Bounce studies of individual droplets of water or imazethapyr plus adjuvant mixture demonstrated that T. aestivum straw had a general affinity for all spray droplets, exhibiting no rebound even for 800-µm water droplets. Setaria faberi foliage exhibited poor retention of droplets: both 350- and 800-µm water droplets as well as 800-µm droplets of imazethapyr plus adjuvant mixture rebounded. Only 350-µm herbicide mixture droplets were retained by S. faberi. Amaranthus hybridus retained all droplets. In broadcast spraying, British Crop Protection Council “Medium” quality sprays were poorly retained by S. faberi compared to “Fine” sprays, whereas A. hybridus retained both sprays equally well. However, imazethapyr spray deposits resulting from coarser sprays were more efficacious on S. faberi than fine spray deposits, a difference that was not observed for A. hybridus.
Contributor affiliations
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- By Frank Andrasik, Melissa R. Andrews, Ana Inés Ansaldo, Evangelos G. Antzoulatos, Lianhua Bai, Ellen Barrett, Linamara Battistella, Nicolas Bayle, Michael S. Beattie, Peter J. Beek, Serafin Beer, Heinrich Binder, Claire Bindschaedler, Sarah Blanton, Tasia Bobish, Michael L. Boninger, Joseph F. Bonner, Chadwick B. Boulay, Vanessa S. Boyce, Anna-Katharine Brem, Jacqueline C. Bresnahan, Floor E. Buma, Mary Bartlett Bunge, John H. Byrne, Jeffrey R. Capadona, Stefano F. Cappa, Diana D. Cardenas, Leeanne M. Carey, S. Thomas Carmichael, Glauco A. P. Caurin, Pablo Celnik, Kimberly M. Christian, Stephanie Clarke, Leonardo G. Cohen, Adriana B. Conforto, Rory A. Cooper, Rosemarie Cooper, Steven C. Cramer, Armin Curt, Mark D’Esposito, Matthew B. Dalva, Gavriel David, Brandon Delia, Wenbin Deng, Volker Dietz, Bruce H. Dobkin, Marco Domeniconi, Edith Durand, Tracey Vause Earland, Georg Ebersbach, Jonathan J. Evans, James W. Fawcett, Uri Feintuch, Toby A. Ferguson, Marie T. Filbin, Diasinou Fioravante, Itzhak Fischer, Agnes Floel, Herta Flor, Karim Fouad, Richard S. J. Frackowiak, Peter H. Gorman, Thomas W. Gould, Jean-Michel Gracies, Amparo Gutierrez, Kurt Haas, C.D. Hall, Hans-Peter Hartung, Zhigang He, Jordan Hecker, Susan J. Herdman, Seth Herman, Leigh R. Hochberg, Ahmet Höke, Fay B. Horak, Jared C. Horvath, Richard L. Huganir, Friedhelm C. Hummel, Beata Jarosiewicz, Frances E. Jensen, Michael Jöbges, Larry M. Jordan, Jon H. Kaas, Andres M. Kanner, Noomi Katz, Matthew S. Kayser, Annmarie Kelleher, Gerd Kempermann, Timothy E. Kennedy, Jürg Kesselring, Fary Khan, Rachel Kizony, Jeffery D. Kocsis, Boudewijn J. Kollen, Hubertus Köller, John W. Krakauer, Hermano I. Krebs, Gert Kwakkel, Bradley Lang, Catherine E. Lang, Helmar C. Lehmann, Angelo C. Lepore, Glenn S. Le Prell, Mindy F. Levin, Joel M. Levine, David A. Low, Marilyn MacKay-Lyons, Jeffrey D. Macklis, Margaret Mak, Francine Malouin, William C. Mann, Paul D. Marasco, Christopher J. Mathias, Laura McClure, Jan Mehrholz, Lorne M. Mendell, Robert H. Miller, Carol Milligan, Beth Mineo, Simon W. Moore, Jennifer Morgan, Charbel E-H. Moussa, Martin Munz, Randolph J. Nudo, Joseph J. Pancrazio, Theresa Pape, Alvaro Pascual-Leone, Kristin M. Pearson-Fuhrhop, P. Hunter Peckham, Tamara L. Pelleshi, Catherine Verrier Piersol, Thomas Platz, Marcus Pohl, Dejan B. Popović, Andrew M. Poulos, Maulik Purohit, Hui-Xin Qi, Debbie Rand, Mahendra S. Rao, Josef P. Rauschecker, Aimee Reiss, Carol L. Richards, Keith M. Robinson, Melvyn Roerdink, John C. Rosenbek, Serge Rossignol, Edward S. Ruthazer, Arash Sahraie, Krishnankutty Sathian, Marc H. Schieber, Brian J. Schmidt, Michael E. Selzer, Mijail D. Serruya, Himanshu Sharma, Michael Shifman, Jerry Silver, Thomas Sinkjær, George M. Smith, Young-Jin Son, Tim Spencer, John D. Steeves, Oswald Steward, Sheela Stuart, Austin J. Sumner, Chin Lik Tan, Robert W. Teasell, Gareth Thomas, Aiko K. Thompson, Richard F. Thompson, Wesley J. Thompson, Erika Timar, Ceri T. Trevethan, Christopher Trimby, Gary R. Turner, Mark H. Tuszynski, Erna A. van Niekerk, Ricardo Viana, Difei Wang, Anthony B. Ward, Nick S. Ward, Stephen G. Waxman, Patrice L. Weiss, Jörg Wissel, Steven L. Wolf, Jonathan R. Wolpaw, Sharon Wood-Dauphinee, Ross D. Zafonte, Binhai Zheng, Richard D. Zorowitz
- Edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Gert Kwakkel, Robert Miller, Case Western Reserve University, Ohio
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- Book:
- Textbook of Neural Repair and Rehabilitation
- Published online:
- 05 May 2014
- Print publication:
- 24 April 2014, pp ix-xvi
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- By Frank Andrasik, Melissa R. Andrews, Ana Inés Ansaldo, Evangelos G. Antzoulatos, Lianhua Bai, Ellen Barrett, Linamara Battistella, Nicolas Bayle, Michael S. Beattie, Peter J. Beek, Serafin Beer, Heinrich Binder, Claire Bindschaedler, Sarah Blanton, Tasia Bobish, Michael L. Boninger, Joseph F. Bonner, Chadwick B. Boulay, Vanessa S. Boyce, Anna-Katharine Brem, Jacqueline C. Bresnahan, Floor E. Buma, Mary Bartlett Bunge, John H. Byrne, Jeffrey R. Capadona, Stefano F. Cappa, Diana D. Cardenas, Leeanne M. Carey, S. Thomas Carmichael, Glauco A. P. Caurin, Pablo Celnik, Kimberly M. Christian, Stephanie Clarke, Leonardo G. Cohen, Adriana B. Conforto, Rory A. Cooper, Rosemarie Cooper, Steven C. Cramer, Armin Curt, Mark D’Esposito, Matthew B. Dalva, Gavriel David, Brandon Delia, Wenbin Deng, Volker Dietz, Bruce H. Dobkin, Marco Domeniconi, Edith Durand, Tracey Vause Earland, Georg Ebersbach, Jonathan J. Evans, James W. Fawcett, Uri Feintuch, Toby A. Ferguson, Marie T. Filbin, Diasinou Fioravante, Itzhak Fischer, Agnes Floel, Herta Flor, Karim Fouad, Richard S. J. Frackowiak, Peter H. Gorman, Thomas W. Gould, Jean-Michel Gracies, Amparo Gutierrez, Kurt Haas, C.D. Hall, Hans-Peter Hartung, Zhigang He, Jordan Hecker, Susan J. Herdman, Seth Herman, Leigh R. Hochberg, Ahmet Höke, Fay B. Horak, Jared C. Horvath, Richard L. Huganir, Friedhelm C. Hummel, Beata Jarosiewicz, Frances E. Jensen, Michael Jöbges, Larry M. Jordan, Jon H. Kaas, Andres M. Kanner, Noomi Katz, Matthew S. Kayser, Annmarie Kelleher, Gerd Kempermann, Timothy E. Kennedy, Jürg Kesselring, Fary Khan, Rachel Kizony, Jeffery D. Kocsis, Boudewijn J. Kollen, Hubertus Köller, John W. Krakauer, Hermano I. Krebs, Gert Kwakkel, Bradley Lang, Catherine E. Lang, Helmar C. Lehmann, Angelo C. Lepore, Glenn S. Le Prell, Mindy F. Levin, Joel M. Levine, David A. Low, Marilyn MacKay-Lyons, Jeffrey D. Macklis, Margaret Mak, Francine Malouin, William C. Mann, Paul D. Marasco, Christopher J. Mathias, Laura McClure, Jan Mehrholz, Lorne M. Mendell, Robert H. Miller, Carol Milligan, Beth Mineo, Simon W. Moore, Jennifer Morgan, Charbel E-H. Moussa, Martin Munz, Randolph J. Nudo, Joseph J. Pancrazio, Theresa Pape, Alvaro Pascual-Leone, Kristin M. Pearson-Fuhrhop, P. Hunter Peckham, Tamara L. Pelleshi, Catherine Verrier Piersol, Thomas Platz, Marcus Pohl, Dejan B. Popović, Andrew M. Poulos, Maulik Purohit, Hui-Xin Qi, Debbie Rand, Mahendra S. Rao, Josef P. Rauschecker, Aimee Reiss, Carol L. Richards, Keith M. Robinson, Melvyn Roerdink, John C. Rosenbek, Serge Rossignol, Edward S. Ruthazer, Arash Sahraie, Krishnankutty Sathian, Marc H. Schieber, Brian J. Schmidt, Michael E. Selzer, Mijail D. Serruya, Himanshu Sharma, Michael Shifman, Jerry Silver, Thomas Sinkjær, George M. Smith, Young-Jin Son, Tim Spencer, John D. Steeves, Oswald Steward, Sheela Stuart, Austin J. Sumner, Chin Lik Tan, Robert W. Teasell, Gareth Thomas, Aiko K. Thompson, Richard F. Thompson, Wesley J. Thompson, Erika Timar, Ceri T. Trevethan, Christopher Trimby, Gary R. Turner, Mark H. Tuszynski, Erna A. van Niekerk, Ricardo Viana, Difei Wang, Anthony B. Ward, Nick S. Ward, Stephen G. Waxman, Patrice L. Weiss, Jörg Wissel, Steven L. Wolf, Jonathan R. Wolpaw, Sharon Wood-Dauphinee, Ross D. Zafonte, Binhai Zheng, Richard D. Zorowitz
- Edited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel, Robert H. Miller, Case Western Reserve University, Ohio
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- Textbook of Neural Repair and Rehabilitation
- Published online:
- 05 June 2014
- Print publication:
- 24 April 2014, pp ix-xvi
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- By Pat Alger, Eric Anderson, Henry Atmore, Steven Gould Axelrod, Thomas Bailey, Jonathan N. Barron, James Barszcz, David Chandler, John Xiros Cooper, David Evans, Robert Faggen, Lesley Lee Francis, Dana Gioia, Robert Bernard Hass, Tyler Hoffman, Tim Kendall, Karen L. Kilcup, Grzegorz Kosc, Jonathan Levin, Marit MacArthur, Alec Marsh, Paul Morrison, Paul Muldoon, Jay Parini, William Pritchard, Mark Richardson, Margery Sabin, Mark Scott, Lisa Seale, Donald G. Sheehy, Yasuko Shiojiri, Sean Street, Joseph M. Thomas, David Tutein
- Edited by Mark Richardson, Doshisha University, Kyoto
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- Book:
- Robert Frost in Context
- Published online:
- 05 April 2014
- Print publication:
- 14 April 2014, pp ix-xvi
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- By Zachary W. Adams, Margarita Alegría, Atalay Alem, Jordi Alonso, Victor Aparicio, Rifat Atun, Florence Baingana, Emily Baron, Marco Bertelli, Dinesh Bhugra, Sanchita Biswas, José Miguel Caldas de Almeida, Edwin Cameron, Somnath Chatterji, Erminia Colucci, Janice L. Cooper, Carla Kmett Danielson, Diego De Leo, Mary-Jo DelVecchio Good, Marten W. de Vries, Maureen S. Durkin, Xiangming Fang, Julia W. Felton, Sally Field, Andrea Fiorillo, Lance Gable, Teddy Gafna, Sandro Galea, Patrick Gatonga, Sofia Halperin-Goldstein, Yanling He, Grace A. Herbert, Sabrina Hermosilla, Simone Honikman, Takashi Izutsu, Ruwan M. Jayatunge, Janis H. Jenkins, Rachel Jenkins, Lynne Jones, Jayanthi Karunaratne, Ronald C. Kessler, Rob Keukens, Lincoln I. Khasakhala, Hanna Kienzler, Sarah Kippen Wood, M. Thomas Kishore, Robert Kohn, Natasja Koitzsch Jensen, Sheri Lapatin, Anna Lessios, Isabel Louro Bernal, Feijun Luo, Laura MacPherson, Matthew J. Maenner, Anne W. Mbwayo, David McDaid, Ingrid Meintjes, Victoria N. Mutiso, David M. Ndetei, Samuel O. Okpaku, Lijing Ouyang, Ramachandran Padmavati, Clare Pain, Duncan Pedersen, Jordan Pfau, Felipe Picon, Rodney D. Presley, Reima Pryor, Shoba Raja, Thara Rangaswamy, Jorge Rodriguez, Diana Rose, Moosa Salie, Norman Sartorius, Ester Shapiro, Manuela Silva, Daya Somasundaram, Katherine Sorsdahl, Dan J. Stein, Deborah M. Stone, Heather Stuart, Athula Sumathipala, Hema Tharoor, Rita Thom, Lay San Too, Atsuro Tsutsumi, Chris Underhill, Anne Valentine, Claire van der Westhuizen, Thandi van Heyningen, Robert van Voren, Inka Weissbecker, Gail Wyatt
- Edited by Samuel O. Okpaku
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- Book:
- Essentials of Global Mental Health
- Published online:
- 05 March 2014
- Print publication:
- 27 February 2014, pp x-xiv
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Cholesteric liquid crystal glass platinum acetylides
- Thomas M. Cooper, Aaron R. Burke, Douglas M. Krein, Ronald F. Ziolo, Eduardo Arias, Ivana Moggio, Albert Fratini, Yuriy Garbovskiy, Anatoliy V. Glushchenko
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- Journal:
- MRS Online Proceedings Library Archive / Volume 1698 / 2014
- Published online by Cambridge University Press:
- 21 August 2014, mrss14-1698-jj05-01
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- 2014
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To prepare cholesteric liquid crystalline nonlinear optical materials with ability to be vitrified on cooling and form long time stability cholesteric glasses at room temperature, a series of platinum acetylide complexes modified with cholesterol has been synthesized. The materials synthesized have the formula trans-Pt(PR3)(cholesterol (3 or 4)-ethynyl benzoate)(1-ethynyl-4-X-benzene), where R = Et, Bu or Oct and X = H, F, OCH3 and CN. A cholesteric liquid crystal phase was observed in the complexes R = Et, and X = F, OCH3 and CN but not in any of the other complexes. When X = CN, a cholesteric glass was observed at room temperature which remained stable up to 130 °C, then converted to a mixed crystalline/cholesteric phase and completely melted to an isotropic phase at 230 °C. When X = F or OCH3 the complexes were crystalline at room temperature with conversion to the cholesteric phase upon heating to 190 and 230 °C, respectively. In the series X = CN, OCH3 and F, the cholesteric pitch was determined to be 1.7, 3.4 and 9.0 µ, respectively.
Developing Consensus on Appropriate Standards of Disaster Care for Children
- Robert K. Kanter, John S. Andrake, Nancy M. Boeing, James Callahan, Arthur Cooper, Christine A. Lopez-Dwyer, James P. Marcin, Folafoluwa O. Odetola, Anne E. Ryan, Thomas E. Terndrup, Joseph R. Tobin
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- Journal:
- Disaster Medicine and Public Health Preparedness / Volume 3 / Issue 1 / March 2009
- Published online by Cambridge University Press:
- 08 April 2013, pp. 27-32
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Background: Neither professional consensus nor evidence exists to guide the choice of essential hospital disaster interventions. The objective of our study was to demonstrate a method for developing consensus on hospital disaster interventions that should be regarded as essential, quantitatively balancing needs and resources.
Methods: A panel of pediatric acute care practitioners developed consensus using a modified Delphi process. Interventions were chosen such that workload per staff member would not exceed the previously validated maximum according to the Therapeutic Intervention Scoring System. Based on published models, it was assumed that the usual numbers of staff would care for a disaster surge of 4 times the usual number of intensive care and non–intensive care hospital patients.
Results: Using a single set of assumptions on constrained resources and overwhelming needs, the panel ranked and agreed on essential interventions. A number of standard interventions would exceed crisis workload constraints, including detailed recording of vital signs and fluid balance, administration of vasoactive agents, invasive monitoring of pressures (central venous, intraarterial, intracranial), dialysis, and tube feedings.
Conclusions: The quantitative methodology and consensus development process described in the present report may have utility in future planning. Groups with appropriate expertise must develop action plans according to authority within each jurisdiction, addressing likely disaster scenarios, according to the needs in each medical service region, using available regional resources, and accounting for the capabilities of each institution. (Disaster Med Public Health Preparedness. 2009;3:27–32)
Contributors
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- By Basem Abdelmalak, Linda S. Aglio, Daniel Alam, Maged Argalious, Carlos A. Artime, Rahul G. Baijal, David Beebe, Michael S. Benninger, Carol R. Bradford, Paul C. Bryson, Brian Burkey, Richard M. Cooper, Jacek B. Cywinski, Onur Demirci, D. John Doyle, Thomas Edrich, Louise Ellard, Matthew R. Eng, Nicole M. Fowler, Ursula Galway, John George, Carin A. Hagberg, David W. Healy, Marshal B. Kaplan, Paul Kempen, Ashish Khanna, Alan Kominsky, Tatyana Kopyeva, Biao Lei, Emad B. Mossad, Vladimir Nekhendzy, Edward Noguera, Megan Nolan, Mauricio Perilla, Marc Popovich, Gazanfar Rahmathulla, Gail I. Randel, William H. Rosenblatt, Twain Russell, Mona Sarkiss, Joseph Scharpf, Tracey Straker, David E. Traul, Robert Weil, Sivan Wexler, David T. Wong, Benjamin Wood, Jie Zhou
- Edited by Basem Abdelmalak, John Doyle
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- Book:
- Anesthesia for Otolaryngologic Surgery
- Published online:
- 05 November 2012
- Print publication:
- 18 October 2012, pp xi-xiv
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- By Michael F. Azari, Michael S. Beattie, Michael J. Bell, David M. Benglis, Anat Biegon, Jacqueline C. Bresnahan, A. Ross Bullock, D. James Cooper, Frances Corrigan, Kallol K. Dey, W. Dalton Dietrich, Volker Dietz, Per Enblad, Michael G. Fehlings, Julio C. Furlan, John C. Gensel, Gerald A. Grant, Gopalakrishna Gururaj, Ronald L. Hayes, Lars T. Hillered, John Houle, Jimmy W. Huh, Pavla Jendelová, Theresa A. Jones, Patrick M. Kochanek, Thomas Kossmann, Dorothy A. Kozlowski, Laura Krisa, Andrew Maas, Lawrence F. Marshall, Ankit I. Mehta, David K. Menon, Cristina Morganti-Kossmann, Marion Murray, Virginia F.J. Newcombe, Alistair D. Nichol, Linda Papa, Steven Petratos, Jennie Ponsford, Phillip G. Popovich, Gourikumar K. Prusty, Ramesh Raghupathi, Ricky Rasschaert, Peter L. Reilly, Nataliya Romanyuk, Bob Roozenbeek, Jeffrey V. Rosenfeld, Kathryn E. Saatman, Bridgette D. Semple, Esther Shohami, Eva Syková, Charles H. Tator, Brett Trimble, Robert Vink, Kevin K.W. Wang, Jefferson R. Wilson, Wise Young, Jenna M. Ziebell
- Edited by Cristina Morganti-Kossmann, Ramesh Raghupathi, Andrew Maas
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- Book:
- Traumatic Brain and Spinal Cord Injury
- Published online:
- 05 August 2012
- Print publication:
- 19 July 2012, pp ix-xii
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Photophysical Properties of a Nonlinear Dye in PMMA at High Concentration
- Joy E. Haley, Jonathan L. Flikkema, Weijie Su, Douglas M. Krein, Thomas M. Cooper
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- MRS Online Proceedings Library Archive / Volume 1392 / 2012
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- 23 April 2012, mrsf11-1392-k04-02
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- 2012
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The effects of high concentration on the photophysical properties of a nonlinear material have been of interest for some time in our group. It is well known in the literature that for a nonlinear absorbing dye to be the most effective, high concentrations are needed. The problem is that most photophysical studies in solution are done at low concentration. These low concentration studies are important for understanding inherent materials properties but it is also important to understand what happens in a material at high concentration. In addition to this, efforts have been made to study the effects of incorporating a dye into a solid matrix environment to better understand the constraints this environment has to a given material. Preliminary results for a PMMA system reveal the formation of excimers (excited state dimers) with an increase in concentration. Excimers are forming from the triplet excited state of the E1-BTF. A rate constant for this formation is 2.3 x 106 M-1 s-1. While rather slow, at high concentration the excimer is readily formed. This must be considered when making nonlinear absorption measurements since the excimer will certainly contribute to the overall nonlinearity.
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- By Aakash Agarwala, Linda S. Aglio, Rae M. Allain, Paul D. Allen, Houman Amirfarzan, Yasodananda Kumar Areti, Amit Asopa, Edwin G. Avery, Patricia R. Bachiller, Angela M. Bader, Rana Badr, Sibinka Bajic, David J. Baker, Sheila R. Barnett, Rena Beckerly, Lorenzo Berra, Walter Bethune, Sascha S. Beutler, Tarun Bhalla, Edward A. Bittner, Jonathan D. Bloom, Alina V. Bodas, Lina M. Bolanos-Diaz, Ruma R. Bose, Jan Boublik, John P. Broadnax, Jason C. Brookman, Meredith R. Brooks, Roland Brusseau, Ethan O. Bryson, Linda A. Bulich, Kenji Butterfield, William R. Camann, Denise M. Chan, Theresa S. Chang, Jonathan E. Charnin, Mark Chrostowski, Fred Cobey, Adam B. Collins, Mercedes A. Concepcion, Christopher W. Connor, Bronwyn Cooper, Jeffrey B. Cooper, Martha Cordoba-Amorocho, Stephen B. Corn, Darin J. Correll, Gregory J. Crosby, Lisa J. Crossley, Deborah J. Culley, Tomas Cvrk, Michael N. D'Ambra, Michael Decker, Daniel F. Dedrick, Mark Dershwitz, Francis X. Dillon, Pradeep Dinakar, Alimorad G. Djalali, D. John Doyle, Lambertus Drop, Ian F. Dunn, Theodore E. Dushane, Sunil Eappen, Thomas Edrich, Jesse M. Ehrenfeld, Jason M. Erlich, Lucinda L. Everett, Elliott S. Farber, Khaldoun Faris, Eddy M. Feliz, Massimo Ferrigno, Richard S. Field, Michael G. Fitzsimons, Hugh L. Flanagan Jr., Vladimir Formanek, Amanda A. Fox, John A. Fox, Gyorgy Frendl, Tanja S. Frey, Samuel M. Galvagno Jr., Edward R. Garcia, Jonathan D. Gates, Cosmin Gauran, Brian J. Gelfand, Simon Gelman, Alexander C. Gerhart, Peter Gerner, Omid Ghalambor, Christopher J. Gilligan, Christian D. Gonzalez, Noah E. Gordon, William B. Gormley, Thomas J. Graetz, Wendy L. Gross, Amit Gupta, James P. Hardy, Seetharaman Hariharan, Miriam Harnett, Philip M. Hartigan, Joaquim M. Havens, Bishr Haydar, Stephen O. Heard, James L. Helstrom, David L. Hepner, McCallum R. Hoyt, Robert N. Jamison, Karinne Jervis, Stephanie B. Jones, Swaminathan Karthik, Richard M. Kaufman, Shubjeet Kaur, Lee A. Kearse Jr., John C. Keel, Scott D. Kelley, Albert H. Kim, Amy L. Kim, Grace Y. Kim, Robert J. Klickovich, Robert M. Knapp, Bhavani S. Kodali, Rahul Koka, Alina Lazar, Laura H. Leduc, Stanley Leeson, Lisa R. Leffert, Scott A. LeGrand, Patricio Leyton, J. Lance Lichtor, John Lin, Alvaro A. Macias, Karan Madan, Sohail K. Mahboobi, Devi Mahendran, Christine Mai, Sayeed Malek, S. Rao Mallampati, Thomas J. Mancuso, Ramon Martin, Matthew C. Martinez, J. A. Jeevendra Martyn, Kai Matthes, Tommaso Mauri, Mary Ellen McCann, Shannon S. McKenna, Dennis J. McNicholl, Abdel-Kader Mehio, Thor C. Milland, Tonya L. K. Miller, John D. Mitchell, K. Annette Mizuguchi, Naila Moghul, David R. Moss, Ross J. Musumeci, Naveen Nathan, Ju-Mei Ng, Liem C. Nguyen, Ervant Nishanian, Martina Nowak, Ala Nozari, Michael Nurok, Arti Ori, Rafael A. Ortega, Amy J. Ortman, David Oxman, Arvind Palanisamy, Carlo Pancaro, Lisbeth Lopez Pappas, Benjamin Parish, Samuel Park, Deborah S. Pederson, Beverly K. Philip, James H. Philip, Silvia Pivi, Stephen D. Pratt, Douglas E. Raines, Stephen L. Ratcliff, James P. Rathmell, J. Taylor Reed, Elizabeth M. Rickerson, Selwyn O. Rogers Jr., Thomas M. Romanelli, William H. Rosenblatt, Carl E. Rosow, Edgar L. Ross, J. Victor Ryckman, Mônica M. Sá Rêgo, Nicholas Sadovnikoff, Warren S. Sandberg, Annette Y. Schure, B. Scott Segal, Navil F. Sethna, Swapneel K. Shah, Shaheen F. Shaikh, Fred E. Shapiro, Torin D. Shear, Prem S. Shekar, Stanton K. Shernan, Naomi Shimizu, Douglas C. Shook, Kamal K. Sikka, Pankaj K. Sikka, David A. Silver, Jeffrey H. Silverstein, Emily A. Singer, Ken Solt, Spiro G. Spanakis, Wolfgang Steudel, Matthias Stopfkuchen-Evans, Michael P. Storey, Gary R. Strichartz, Balachundhar Subramaniam, Wariya Sukhupragarn, John Summers, Shine Sun, Eswar Sundar, Sugantha Sundar, Neelakantan Sunder, Faraz Syed, Usha B. Tedrow, Nelson L. Thaemert, George P. Topulos, Lawrence C. Tsen, Richard D. Urman, Charles A. Vacanti, Francis X. Vacanti, Joshua C. Vacanti, Assia Valovska, Ivan T. Valovski, Mary Ann Vann, Susan Vassallo, Anasuya Vasudevan, Kamen V. Vlassakov, Gian Paolo Volpato, Essi M. Vulli, J. Matthias Walz, Jingping Wang, James F. Watkins, Maxwell Weinmann, Sharon L. Wetherall, Mallory Williams, Sarah H. Wiser, Zhiling Xiong, Warren M. Zapol, Jie Zhou
- Edited by Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman
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- By Saleh H. Alwasel, Susan P. Bagby, David J. P Barker, Richard Boyd, Robert Boyd, Graham Burdge, Graham J Burton, Anthony M Carter, Irene Cetin, Zoe Cole, Cyrus Cooper, Hilary Critchley, Elaine Dennison, Susie Earl, Johan G Eriksson, Caroline H. D Fall, Anne C. Ferguson-Smith, Tom P. Fleming, Alison J. Forhead, Abigail L. Fowden, Dino Giussani, Laura Goodfellow, Nicholas Harvey, Christopher Holroyd, Joan Hunt, Alan A. Jackson, Thomas Jansson, Eric Jauniaux, Rosalind John, Eero Kajantie, Michelle Lampl, Karen Lillycrop, Charlie Loke, Samantha Louey, Per Magnus, Ashley Moffett, Lorna G. Moore, Terry Morgan, Clive Osmond, Perrie F. O'Tierney, Robert Pijnenborg, Lucilla Poston, Theresa L. Powell, Elizabeth J. Radford, Tessa J. Roseboom, Amanda Sferruzzi-Perri, Colin P. Sibley, Gordon C. S. Smith, Emanuela Taricco, Kent Thornburg, Benjamin Tycko, Owen R. Vaughan, Lisbeth Vercruysse
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. 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Assessing Quality through Measurement of Unmet Needs of Disaster Populations after the 2007 Southern California Wildfires
- Thomas D. Kirsch, Lauren M. Sauer, Yu-Hsiang Hsieh, Lauren E. Cooper, Jennifer L. Jenkins
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- Prehospital and Disaster Medicine / Volume 24 / Issue S1 / February 2009
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Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease – the perspective of critical care
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- Joan M. LaRovere, Howard E. Jeffries, Ramesh C. Sachdeva, Thomas B. Rice, Randall C. Wetzel, David S. Cooper, Geoffrey L. Bird, Nancy S. Ghanayem, Paul A. Checchia, Anthony C. Chang, David L. Wessel
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The development of databases to track the outcomes of children with cardiovascular disease has been ongoing for much of the last two decades, paralleled by the rise of databases in the intensive care unit. While the breadth of data available in national, regional and local databases has grown exponentially, the ability to identify meaningful measurements of outcomes for patients with cardiovascular disease is still in its early stages.
In the United States of America, the Virtual Pediatric Intensive Care Unit Performance System (VPS) is a clinically based database system for the paediatric intensive care unit that provides standardized high quality, comparative data to its participants [https://portal.myvps.org/]. All participants collect information on multiple parameters: (1) patients and their stay in the hospital, (2) diagnoses, (3) interventions, (4) discharge, (5) various measures of outcome, (6) organ donation, and (7) paediatric severity of illness scores. Because of the standards of quality within the database, through customizable interfaces, the database can also be used for several applications: (1) administrative purposes, such as assessing the utilization of resources and strategic planning, (2) multi-institutional research studies, and (3) additional internal projects of quality improvement or research.
In the United Kingdom, The Paediatric Intensive Care Audit Network is a database established in 2002 to record details of the treatment of all critically ill children in paediatric intensive care units of the National Health Service in England, Wales and Scotland. The Paediatric Intensive Care Audit Network was designed to develop and maintain a secure and confidential high quality clinical database of pediatric intensive care activity in order to meet the following objectives: (1) identify best clinical practice, (2) monitor supply and demand, (3) monitor and review outcomes of treatment episodes, (4) facilitate strategic healthcare planning, (5) quantify resource requirements, and (6) study the epidemiology of critical illness in children.
Two distinct physiologic risk adjustment methodologies are the Pediatric Risk of Mortality Scoring System (PRISM), and the Paediatric Index of Mortality Scoring System 2 (PIM 2). Both Pediatric Risk of Mortality (PRISM 2) and Pediatric Risk of Mortality (PRISM 3) are comprised of clinical variables that include physiological and laboratory measurements that are weighted on a logistic scale. The raw Pediatric Risk of Mortality (PRISM) score provides quantitative measures of severity of illness. The Pediatric Risk of Mortality (PRISM) score when used in a logistic regression model provides a probability of the predicted risk of mortality. This predicted risk of mortality can then be used along with the rates of observed mortality to provide a quantitative measurement of the Standardized Mortality Ratio (SMR). Similar to the Pediatric Risk of Mortality (PRISM) scoring system, the Paediatric Index of Mortality (PIM) score is comprised of physiological and laboratory values and provides a quantitative measurement to estimate the probability of death using a logistic regression model.
The primary use of national and international databases of patients with congenital cardiac disease should be to improve the quality of care for these patients. The utilization of common nomenclature and datasets by the various regional subspecialty databases will facilitate the eventual linking of these databases and the creation of a comprehensive database that spans conventional geographic and subspecialty boundaries.