Traumatic Brain and Spinal Cord Injury: Challenges and Developments

doi:10.1017/CBO9781139030564

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury Overview of major pathophysiological changesThe development of animal models; successes and limitationsPast, current and future therapeutic strategies including rehabilitative opportunities.Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

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Traumatic Brain and Spinal Cord Injury - Half title page
pp i-ii
Challenges and Developments
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Traumatic Brain and Spinal Cord Injury - Title page
pp iii-iii
Challenges and Developments
- By Cristina Morganti-Kossmann, Ramesh Raghupathi, Andrew Maas
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Copyright page
pp iv-iv
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Dedication
pp v-vi
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Contents
pp vii-viii
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Contributors
pp ix-xii
- By Michael F. Azari, Michael S. Beattie, Michael J. Bell, David M. Benglis, Anat Biegon, Jacqueline C. Bresnahan, A. Ross Bullock, D. James Cooper, Frances Corrigan, Kallol K. Dey, W. Dalton Dietrich, Volker Dietz, Per Enblad, Michael G. Fehlings, Julio C. Furlan, John C. Gensel, Gerald A. Grant, Gopalakrishna Gururaj, Ronald L. Hayes, Lars T. Hillered, John Houle, Jimmy W. Huh, Pavla Jendelová, Theresa A. Jones, Patrick M. Kochanek, Thomas Kossmann, Dorothy A. Kozlowski, Laura Krisa, Andrew Maas, Lawrence F. Marshall, Ankit I. Mehta, David K. Menon, Cristina Morganti-Kossmann, Marion Murray, Virginia F.J. Newcombe, Alistair D. Nichol, Linda Papa, Steven Petratos, Jennie Ponsford, Phillip G. Popovich, Gourikumar K. Prusty, Ramesh Raghupathi, Ricky Rasschaert, Peter L. Reilly, Nataliya Romanyuk, Bob Roozenbeek, Jeffrey V. Rosenfeld, Kathryn E. Saatman, Bridgette D. Semple, Esther Shohami, Eva Syková, Charles H. Tator, Brett Trimble, Robert Vink, Kevin K.W. Wang, Jefferson R. Wilson, Wise Young, Jenna M. Ziebell
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Preface
pp xiii-xiv
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Section 1 - Traumatic Brain Injury
pp 1-215
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1 - Current evaluation of TBI epidemiologyin an ageing society with improved preventive measures
pp 1-16
- By Peter L. Reilly
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2 - Neurotrauma:an emerging epidemic in low- and middle-income countries
pp 17-29
- By Gourikumar K. Prusty, Gopalakrishna Gururaj, Kallol K. Dey
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3 - Blast-inducedtraumatic brain injury and post-traumatic stress disorder
pp 30-42
- By Ankit I. Mehta, Gerald A. Grant, Lawrence F. Marshall
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4 - Psychological effects of mild traumatic brain injury: their nature and treatment
pp 43-53
- By Jennie Ponsford
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5 - Developments of neuroimagingtechniques to diagnose and visualize white matter damage
pp 54-66
- By Virginia F.J. Newcombe, David K. Menon
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6 - New advances in monitoring the injuredbrain metabolism
pp 67-81
- By David M. Benglis, Brett Trimble, A. Ross Bullock
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7 - Potential use and limitations of microdialysisfor monitoring of neurochemical changes after TBI
pp 82-91
- By Lars Hillered, Per Enblad
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8 - Metabolic and therapeutic differences in pediatric and adult TBI: implications for clinical care and therapeutic hypothermia
pp 92-102
- By Michael J. Bell, Patrick M. Kochanek
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9 - Utility of biomarkersfor diagnosis and prognosis of traumatic brain injury
pp 103-113
- By Kevin K.W. Wang, Linda Papa, Ronald L. Hayes
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10 - Animal models of mild and severe TBI: what have we learned in the past 30 years?
pp 114-125
- By Jenna M. Ziebell, Frances Corrigan, Robert Vink
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11 - Pediatric brain trauma: what do age-appropriate animal models teach us about the age-at-injury effect?
pp 126-137
- By Ramesh Raghupathi, Jimmy W. Huh
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12 - The complexity of traumatic axonal injury
pp 138-154
- By Kathryn E. Saatman
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13 - Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both?
pp 155-168
- By Bridgette D. Semple, Cristina Morganti-Kossmann
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14 - Controversial findings on the role of NMDA receptors in traumatic brain injury
pp 169-179
- By Esther Shohami, Anat Biegon
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15 - Plasticity and recovery of the injured brain
pp 180-191
- By Dorothy A. Kozlowski, Theresa A. Jones
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16 - Design and analysis of clinical trialsin TBI
pp 192-204
- By Bob Roozenbeek, Andrew Maas
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17 - Future perspectives for the treatment of traumatic brain injury patients: decompressive craniectomy, hypothermia and erythropoietin
pp 205-215
- By Alistair D. Nichol, Jeffrey V. Rosenfeld, D. James Cooper
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Section 2 - Traumatic Spinal Injury
pp 216-333
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18 - Global epidemiologyof traumatic spinal cord injury
pp 216-228
- By Julio C. Furlan, Charles H. Tator
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19 - Classification and surgical stabilization of the injured spine
pp 229-241
- By Ricky Rasschaert, Thomas Kossmann
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20 - Spinal cord injury: pathophysiology and prospect of decompressive surgical treatment
pp 242-251
- By Jefferson R. Wilson, Michael G. Fehlings
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21 - Modeling the injured spinal cord to match the human condition
pp 252-263
- By Jacqueline C. Bresnahan, Michael S. Beattie
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Challenges and Developments

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