10 results
Cost–utility analysis of Social Stories™ for children with autism spectrum disorder in mainstream primary schools: results from a randomised controlled trial
- Han-I. Wang, Kerry Bell, Jane Blackwell, Charlie Welch, Laura Mandefield, Judith Watson, Emma Standley, Dean McMillan, Simon Gilbody, Barry Wright, Catherine Hewitt, Steve Parrott
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- Journal:
- BJPsych Open / Volume 10 / Issue 4 / July 2024
- Published online by Cambridge University Press:
- 03 June 2024, e123
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Background
One in 57 children are diagnosed with autism in the UK, and the estimated cost for supporting these children in education is substantial. Social Stories™ is a promising and widely used intervention for supporting children with autism in schools and families. It is believed that Social Stories™ can provide meaningful social information to children that can improve social understanding and may reduce anxiety. However, no economic evaluation of Social Stories has been conducted.
AimsTo assess the cost-effectiveness of Social Stories through Autism Spectrum Social Stories in Schools Trial 2, a multi-site, pragmatic, cluster-randomised controlled trial.
MethodChildren with autism who were aged 4–11 years were recruited and randomised (N = 249). Costs measured from the societal perspective and quality-adjusted life-years (QALYs) measured by the EQ-5D-Y-3L proxy were collected at baseline and at 6-month follow-up for primary analysis. The incremental cost-effectiveness ratio was calculated, and the uncertainty around incremental cost-effectiveness ratios was captured by non-parametric bootstrapping. Sensitivity analyses were performed to evaluate the robustness of the primary findings.
ResultsSocial Stories is likely to result in a small cost savings (–£191 per child, 95% CI −767.7 to 337.7) and maintain similar QALY improvements compared with usual care. The probability of Social Stories being a preferred option is 75% if society is willing to pay £20 000 per QALY gained. The sensitivity analysis results aligned with the main study outcomes.
ConclusionsCompared with usual care, Social Stories did not lead to an increase in costs and maintained similar QALY improvements for primary-aged children with autism.
An examination of health care efficiency in Canada: a two-stage semi-parametric approach
- Barry Watson, Gholam R. Amin
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- Journal:
- Health Economics, Policy and Law , First View
- Published online by Cambridge University Press:
- 03 June 2024, pp. 1-20
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Using data envelopment analysis, we examine the efficiency of Canada's universal health care system by considering a set of labour (physicians) and capital (beds) inputs, which produce a level of care (measured in terms of health quality and quantity) in a given region. Data from 2013–2015 were collected from the Canadian Institute for Health Information regarding inputs and from the Canadian Community Health Survey and Statistics Canada regarding our output variables, health utility (quality) and life expectancy (quantity). We posit that variation in efficiency scores across Canada is the result of regional heterogeneity regarding socioeconomic and demographic disparities. Regressing efficiency scores on such covariates suggests that regional unemployment and an older population are quite impactful and associated with less efficient health care production. Moreover, regional variation indicates the Atlantic provinces (Newfoundland, Prince Edward Island, Nova Scotia, New Brunswick) are quite inefficient, have poorer economic prospects, and tend to have an older population than the rest of Canada. Oaxaca-Blinder decompositions suggest that the latter two factors explain about one-third of this efficiency gap. Based on our two-stage semi-parametric analysis, we recommend Canada adjust their transfer payments to reflect these disparities, thereby potentially reducing inequality in regional efficiency.
A new approach to impact case study analytics
- Jiajie Zhang, Paul Watson, Barry Hodgson
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- Journal:
- Data & Policy / Volume 4 / 2022
- Published online by Cambridge University Press:
- 28 September 2022, e30
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The 2014 Research Excellence Framework (REF) assessed the quality of university research in the UK. 20% of the assessment was allocated according to peer review of the impact of research, reflecting the growing importance of impact in UK government policy. Beyond academia, impact is defined as a change or benefit to the economy, society, culture, public policy or services, health, the environment, or quality of life. Each institution submitted a set of four-page impact case studies. These are predominantly free-form descriptions and evidences of the impact of study. Numerous analyses of these case studies have been conducted, but they have utilised either qualitative methods or primary forms of text searching. These approaches have limitations, including the time required to manually analyse the data and the frequently inferior quality of the answers provided by applying computational analysis to unstructured, context-less free text data. This paper describes a new system to address these problems. At its core is a structured, queryable representation of the case study data. We describe the ontology design used to structure the information and how semantic web related technologies are used to store and query the data. Experiments show that this gives two significant advantages over existing techniques: improved accuracy in question answering and the capability to answer a broader range of questions, by integrating data from external sources. Then we investigate whether machine learning can predict each case study’s grade using this structured representation. The results provide accurate predictions for computer science impact case studies.
Limitations of wireless power transfer technologies for mobile robots
- Wei Chen Cheah, Simon Andrew Watson, Barry Lennox
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- Journal:
- Wireless Power Transfer / Volume 6 / Issue 2 / September 2019
- Published online by Cambridge University Press:
- 07 October 2019, pp. 175-189
- Print publication:
- September 2019
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Advances in technology have seen mobile robots becoming a viable solution to many global challenges. A key limitation for tetherless operation, however, is the energy density of batteries. Whilst significant research is being undertaken into new battery technologies, wireless power transfer may be an alternative solution. The majority of the available technologies are not targeted toward the medium power requirements of mobile robots; they are either for low powers (a few Watts) or very large powers (kW). This paper reviews existing wireless power transfer technologies and their applications on mobile robots. The challenges of using these technologies on mobile robots include delivering the power required, system efficiency, human safety, transmission medium, and distance, all of which are analyzed for robots operating in a hazardous environment. The limitations of current wireless power technologies to meet the challenges for mobile robots are discussed and scenarios which current wireless power technologies can be used on mobile robots are presented.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- Book:
- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Relative validity and reproducibility of an FFQ to determine nutrient intakes of New Zealand toddlers aged 12–24 months
- Emily O Watson, Anne-Louise M Heath, Rachael W Taylor, Virginia C Mills, Ashleigh C Barris, Paula ML Skidmore
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- Journal:
- Public Health Nutrition / Volume 18 / Issue 18 / December 2015
- Published online by Cambridge University Press:
- 31 March 2015, pp. 3265-3271
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Objective
The study objective was to determine the relative validity and reproducibility of a modified FFQ for ranking the nutrient intakes of New Zealand toddlers aged 12–24 months.
DesignCross-sectional study.
SettingDunedin, New Zealand.
SubjectsOne hundred and fifty-two participants completed a ninety-five-item FFQ twice, and five days of weighed diet recording (WDR), over one month. Validity and reproducibility were assessed for crude data and for data that were weighted for total fruit and vegetable intake (FV-adjusted).
ResultsDe-attenuated correlations between FV-adjusted FFQ data and WDR data ranged from 0·45 (Zn) to 0·77 (Ca). The percentage classified to the correct WDR quartile by the FV-adjusted FFQ data ranged from 34·6 % (total fat, Zn) to 50·3 % (Fe). Average gross misclassification was 3 %. Bland–Altman statistics showed crude data had a range of 128–178 % agreement with the WDR and mean FV-adjusted intakes had 112–160 % agreement. FV-adjusted intra-class correlations, assessing reproducibility, ranged from 0·65 (vitamin C) to 0·75 (Ca).
ConclusionsThe Eating Assessment in Toddlers (EAT) FFQ showed acceptable to good relative validity, and good reproducibility, for ranking participants’ nutrient intake and is able to identify toddlers at extremes of the nutrient intake distribution. It will be a useful tool for investigating toddlers’ nutrient intakes in studies that require a method of dietary assessment with low respondent burden.
Contributors
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- By Stéphane Audoin-Rouzeau, Jean-Jacques Becker, Richard Bessel, Ian M. Brown, Martin Ceadel, Dittmar Dahlmann, Stig Förster, Robert Gerwarth, Stefan Goebel, Frédéric Guelton, Heather Jones, Helmut Konrad, Alan Kramer, Samuël Kruizinga, Gerd Krumeich, Roy Macleod, Antoine Prost, Leonard V. Smith, Georges-Henri Soutou, David Stevenson, Barry Supple, Hans-Peter Ullmann, Alexander Watson, Arndt Weinrich, Jay Winter, Benjamin Ziemann
- Edited by Jay Winter, Yale University, Connecticut
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- Book:
- The Cambridge History of the First World War
- Published online:
- 05 December 2013
- Print publication:
- 09 January 2014, pp xiv-xv
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Analysis of a Safety Climate Measure for Occupational Vehicle Drivers and Implications for Safer Workplaces
- Andrew R. Wills, Herbert C. Biggs, Barry Watson
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- Journal:
- The Australian Journal of Rehabilitation Counselling / Volume 11 / Issue 1 / January 2005
- Published online by Cambridge University Press:
- 23 February 2012, pp. 8-21
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Safety climate, defined as workers' shared perceptions about the importance of safety to their organisation, has received increasing attention as a construct that is useful for benchmarking organisational safety and as a way of measuring the socio-organisational antecedents of safety performance. Few studies have utilised pre-existing safety climate measures and as a result of this, there is limited information about the generalisability of the construct and its underlying dimensions across organisations and industries. This is an important step towards establishing safety climate as a generic organisational construct which can be reliably measured. In those few cases where studies have used existing measures, results indicate inconsistencies in the underlying factor structures. Accordingly, using a sample of 321 employees from three separate organisations and industries, this study examined the factor structure of a modified version of an existing measure (the Safety Climate Questionnaire [SCQ]). Principal components factor analysis revealed that the original factor structure was upheld by the current sample (with the exception of two factors collapsing into one). This provides support for the generic nature of safety climate as it is operationalised by the SCQ. Additional items were included and emerged as two dimensions, providing support for the generalisability of these new factors across the organisations and industries employed. The results are of theoretical and practical significance as they provide evidence for the generic structure of the construct across organisations and industries, and exemplify how a measure of safety climate could be usefully employed in disability management planning and early intervention strategies.
Retrieval, reuse, revision and retention in case-based reasoning
- RAMON LOPEZ DE MANTARAS, DAVID MCSHERRY, DEREK BRIDGE, DAVID LEAKE, BARRY SMYTH, SUSAN CRAW, BOI FALTINGS, MARY LOU MAHER, MICHAEL T COX, KENNETH FORBUS, MARK KEANE, AGNAR AAMODT, IAN WATSON
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- Journal:
- The Knowledge Engineering Review / Volume 20 / Issue 3 / September 2005
- Published online by Cambridge University Press:
- 08 May 2006, pp. 215-240
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Case-based reasoning (CBR) is an approach to problem solving that emphasizes the role of prior experience during future problem solving (i.e., new problems are solved by reusing and if necessary adapting the solutions to similar problems that were solved in the past). It has enjoyed considerable success in a wide variety of problem solving tasks and domains. Following a brief overview of the traditional problem-solving cycle in CBR, we examine the cognitive science foundations of CBR and its relationship to analogical reasoning. We then review a representative selection of CBR research in the past few decades on aspects of retrieval, reuse, revision and retention.
9 - Bacterial quorum sensing signalling molecules as immune modulators
- from Part III - Evasion of cellular immunity
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- By David Pritchard, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Doreen Hooi, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Eleanor Watson, Sek Chow, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Gary Telford, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Barrie Bycroft, Immune Modulation Research Group, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Siri Ram Chhabra, Department of Medicinal Chemistry, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Christopher Harty, Department of Medicinal Chemistry, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Miguel Camara, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Stephen Diggle, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK, Paul Williams, Department of Molecular Microbiology, School of Pharmaceutical Sciences and Institute of Infection and Immunity, University of Nottingham, Nottingham NG7 2RD, UK
- Edited by Brian Henderson, University College London, Petra C. F. Oyston, Defence Science and Technology Laboratory, Salisbury
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- Book:
- Bacterial Evasion of Host Immune Responses
- Published online:
- 13 August 2009
- Print publication:
- 28 April 2003, pp 201-222
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Summary
INTRODUCTION
For many pathogens, the outcome of the interaction between host and bacterium is strongly influenced by bacterial population size. Coupling the production of virulence determinants with cell population density ensures that the host lacks sufficient time to mount an effective defence against consolidated attack. Such a strategy depends on the ability of an individual bacterial cell to sense other members of the same species and, in response, differentially express specific sets of genes. Such bacterial cell-to-cell communication or “quorum sensing” describes the phenomenon whereby the accumulation of a diffusible, low molecular weight signal molecule (sometimes referred to as a “pheromone” or “autoinducer”) enables individual bacterial cells to sense when the minimal population unit or “quorum” of bacteria has been achieved for a concerted population response to be initiated. Quorum sensing thus constitutes a mechanism for multicellular behaviour in prokaryotes and is now known to control many different aspects of bacterial physiology including the production of virulence determinants in animal, fish, and plant pathogens. A number of chemically distinct quorum sensing signal molecules (QSMs) have been described of which the N-acylhomoserine lactone (AHL) family in Gram-negative bacteria has been the most intensively investigated (for reviews see Salmond et al., 1995; Fuqua et al., 1996; Dunny and Winans, 1999; Williams et al., 2000; Withers et al., 2001). The acyl groups of the naturally occurring AHLs identified to date range from 4 to 14 carbons in length and may be saturated or unsaturated with or without a C3 substituent (usually hydroxy or oxo; see Fig. 9.1).
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