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Relationship status in first onset schizophrenia
- G. Hutchinson, R. Burnett, M. Mallet, D. Bhugra, J. Leff
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- Journal:
- European Psychiatry / Volume 13 / Issue S4 / 1998
- Published online by Cambridge University Press:
- 16 April 2020, p. 289s
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Maternal Negative Affect and Infant Sleep: Investigating Bi-directional Relationships Using Structural Equation Modelling
- H. Fiedler, D. Hutchinson, R. Rapee
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- Journal:
- European Psychiatry / Volume 30 / Issue S1 / March 2015
- Published online by Cambridge University Press:
- 15 April 2020, p. 1
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It is well documented that problematic sleep patterns in children are related to maternal mental health issues, such as stress, depression and anxiety. Although it is not clear whether it is the sleep patterns that predict maternal mental health or vice versa. Studies have called for the use of transactional models to allow for the contextual representation of the complexities of the interaction between mother and child. The current paper examines the potential bi-directional relationship between infant sleep patterns and maternal negative affect. Maternal negative affect was measured using the Edinburgh Postnatal Depression Scale and the Depression Anxiety Stress Scales. Infant sleep was measured using the Brief Infant Sleep Questionnaire (BISQ) and maternal ratings of infant sleep.
Structural equation modeling suggests relationships are bi-directional but appear to weaken after 8 weeks, although there is some re-emergence of the relationship again at 9-12 months. Moreover, the results indicate poor maternal negative affect during pregnancy predicts poorer infant sleep at birth to eight weeks and two to six months, and poor infant sleep at birth to eight weeks predicts poorer maternal negative affect at 8 weeks old.
The results indicate the relationship between maternal negative affect and infant sleep is bi-directional. Clinically, this has important implications for assessment and treatment, advocating the need for both constructs to be considered in the context of each other. They also highlight the importance of screening and treatment for maternal mental health during pregnancy and potential intervention for infant sleep problems in the early postnatal period.
A novel approach to process brittle ice for continuous flow analysis of stable water isotopes
- REBECCA L. PYNE, ELIZABETH D. KELLER, SILVIA CANESSA, NANCY A. N. BERTLER, ALEX R. PYNE, DARCY MANDENO, PAUL VALLELONGA, STEFANIE SEMPER, HELLE A. KJÆR, ED HUTCHINSON, W. TROY BAISDEN
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- Journal:
- Journal of Glaciology / Volume 64 / Issue 244 / April 2018
- Published online by Cambridge University Press:
- 16 March 2018, pp. 289-299
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Brittle ice, which occurs in all intermediate-depth and deep ice cores retrieved from high-latitude regions, presents a challenge for high-resolution measurements of water isotopes, gases, ions and other quantities conducted with continuous flow analysis (CFA). We present a novel method of preserving brittle ice for CFA stable water isotope measurements using data from a new ice core recovered by the Roosevelt Island Climate Evolution (RICE) project. Modest modification of the drilling technique and the accommodation of non-horizontal fractures (‘slanted breaks’) in processing led to a substantial improvement in the percentage of brittle ice analyzed with CFA (87.8%). Whereas traditional processing methods remove entire fragmented pieces of ice, our method allowed the incorporation of a total of 3 m of ice (1% of the 261 m of brittle ice and ~1300 years of climate history) that otherwise would not have been available for CFA. Using the RICE stable water isotope CFA dataset, we demonstrate the effect of slanted breaks and analyze the resulting smoothing of the data with real and simulated examples. Our results suggest that retaining slanted breaks are a promising technique for preserving brittle ice material for CFA stable water isotope measurements.
The natural history of risky drinking and associated harms from adolescence to young adulthood: findings from the Australian Temperament Project
- K. S. Betts, R. Alati, P. Baker, P. Letcher, D. Hutchinson, G. Youssef, C. A. Olsson
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- Journal:
- Psychological Medicine / Volume 48 / Issue 1 / January 2018
- Published online by Cambridge University Press:
- 28 September 2017, pp. 23-32
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Background
We aimed to describe the natural history of heavy episodic drinking (HED) and associated harms from adolescence to young adulthood in a large Australian population cohort study.
MethodThe Australian Temperament Project consists of mothers and babies (4–8 months) recruited from Infant Welfare Centres and followed every 2 to 4 years until age 28 years. Analyses were based on data from 1156 young people (497 male; 659 female) surveyed repeatedly at ages 16, 18, 20, 24 and 28 years. We used dual processes latent class growth analysis to estimate trajectories of HED and associated harms, employing a piecewise approach to model the hypothesized rise and subsequent fall across adolescence and the late twenties, respectively.
ResultsWe identified four sex-specific trajectories and observed little evidence of maturing-out across the twenties. In males, a normative pattern of increasing HED across the twenties with little related harm was observed (40% of the male sample). Early and late starter groups that peaked in harms at age 20 years with only minor attenuation in binging thereafter were also observed (6.1% and 35%, respectively). In females, a normative pattern of increasing, but moderate, HED with little related harm was observed (44% of the female sample). Early and late starter groups were also identified (18% and 17%, respectively); however, unlike males, the female late starter group showed a pattern of increasing HED and related harms.
ConclusionsContinued patterns of risky alcohol use and related harms are apparent for both males and females across the twenties.
The Origin and Distribution of Subbottom Sediments in Southern Lake Champlain
- R. P. Freeman-Lynde, D. R. Hutchinson, D. W. Folger, B. H. Wiley, M. J. Hewett
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- Journal:
- Quaternary Research / Volume 14 / Issue 2 / September 1980
- Published online by Cambridge University Press:
- 20 January 2017, pp. 224-239
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Three units, correlatable with recent Lake Champlain, late-glacial marine Champlain Sea, and proglacial Lake Vermont sediments, have been identified from about 200 km of high-resolution seismic reflection profiles and eight piston cores collected in southern Lake Champlain. Lake Vermont deposits are nonfossiliferous and range from thin to absent nearshore and on bedrock highs to more than 126 m thick near Split Rock Point. Champlain Sea sediments contain marine foraminifers and ostracodes and are fairly uniform in thickness (20–30 m). Recent Lake Champlain sediments range in thickness from 0 to 25 m. Average sedimentation rates for Lake Vermont are considerably higher (4–8 cm/yr) than those for the Champlain Sea (0.8–1.2 cm/yr) and Lake Champlain (0.14–0.15 cm/yr). Bedrock, till, and deltaic and alluvial deposits were also identified on the acoustic records but were not sampled. An unconformity separating Champlain Sea deposits from Lake Champlain deposits is associated with numerous benches at water depths of 20–30 m. These benches, the alluvial deposits, and the onset of deltaic deposition are probably associated with a low water level stillstand at the close of the Champlain Sea episode.
Fracture and its Role in Determining Ice Forces on Offshore Structures
- A.C. Palmer, D. J. Goodman, M. F. Ashby, A. G. Evans, J.W. Hutchinson, A. R. S. Ponter
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- Journal:
- Annals of Glaciology / Volume 4 / 1983
- Published online by Cambridge University Press:
- 20 January 2017, pp. 216-221
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One of the most conspicuous phenomena in the Arctic Is the fracture of sea ice. It is scarcely possible to travel far without seeing a variety of fracture forms, produced both by natural processes and by human activity.
At strain-rates below about 10−4 s−1, deformation is dominated by creep, but at higher strain-rates fracture is much more important. One of the reasons for this is the very low fracture toughness of ice. The movements of ice in contact with offshore structures often induce strain-rates well beyond the level at which fracture begins, and so offshore structures will often operate in the fracture regime, and it is fracture processes which will determine the design loads. We consider the different modes of repeated fracture that will occur, and classify them into distinct mechanisms of crushing, spalling, and radial and circumferential cracking. Experimental and field observations are plotted on a deformation mode map. A theoretical treatment of radial cracking confirms that very low loads can propagate cracks to long distances; these loads are small by comparison with those calculated from theoretical models that treat ice as a plastically-deforming continuum.
Parental supply of alcohol and alcohol consumption in adolescence: prospective cohort study
- R. P. Mattick, M. Wadolowski, A. Aiken, P. J. Clare, D. Hutchinson, J. Najman, T. Slade, R. Bruno, N. McBride, L. Degenhardt, K. Kypri
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- Journal:
- Psychological Medicine / Volume 47 / Issue 2 / January 2017
- Published online by Cambridge University Press:
- 05 October 2016, pp. 267-278
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Background
Parents are a major supplier of alcohol to adolescents, yet there is limited research examining the impact of this on adolescent alcohol use. This study investigates associations between parental supply of alcohol, supply from other sources, and adolescent drinking, adjusting for child, parent, family and peer variables.
MethodA cohort of 1927 adolescents was surveyed annually from 2010 to 2014. Measures include: consumption of whole drinks; binge drinking (>4 standard drinks on any occasion); parental supply of alcohol; supply from other sources; child, parent, family and peer covariates.
ResultsAfter adjustment, adolescents supplied alcohol by parents had higher odds of drinking whole beverages [odds ratio (OR) 1.80, 95% confidence interval (CI) 1.33–2.45] than those not supplied by parents. However, parental supply was not associated with bingeing, and those supplied alcohol by parents typically consumed fewer drinks per occasion (incidence rate ratio 0.86, 95% CI 0.77–0.96) than adolescents supplied only from other sources. Adolescents obtaining alcohol from non-parental sources had increased odds of drinking whole beverages (OR 2.53, 95% CI 1.86–3.45) and bingeing (OR 3.51, 95% CI 2.53–4.87).
ConclusionsParental supply of alcohol to adolescents was associated with increased risk of drinking, but not bingeing. These parentally-supplied children also consumed fewer drinks on a typical drinking occasion. Adolescents supplied alcohol from non-parental sources had greater odds of drinking and bingeing. Further follow-up is necessary to determine whether these patterns continue, and to examine alcohol-related harm trajectories. Parents should be advised that supply of alcohol may increase children's drinking.
Use of laboratory-based surveillance data to estimate the number of people chronically infected with hepatitis B living in Scotland
- C. SCHNIER, L. WALLACE, K. TEMPELTON, C. AITKEN, R. N. GUNSON, P. MOLYNEAUX, P. McINTYRE, C. POVEY, D. GOLDBERG, S. HUTCHINSON
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- Journal:
- Epidemiology & Infection / Volume 142 / Issue 10 / October 2014
- Published online by Cambridge University Press:
- 17 December 2013, pp. 2121-2130
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It is paramount to understand the epidemiology of chronic hepatitis B to inform national policies on vaccination and screening/testing as well as cost-effectiveness studies. However, information on the national (Scottish) prevalence of chronic hepatitis B by ethnic group is lacking. To estimate the number of people with chronic hepatitis B in Scotland in 2009 by ethnicity, gender and age, the test data from virology laboratories in the four largest cities in Scotland were combined with estimates of the ethnic distribution of the Scottish population. Ethnicity in both the test data and the Scottish population was derived using a name-based ethnicity classification software (OnoMAP; Publicprofiler Ltd, UK). For 2009, we estimated 8720 [95% confidence interval (CI) 7490–10 230] people aged ⩾15 years were living with chronic hepatitis B infection in Scotland. This corresponds to 0·2% (95% CI 0·17–0·24) of the Scottish population aged ⩾15 years. Although East and South Asians make up a small proportion of the Scottish population, they make up 44% of the infected population. In addition, 75% of those infected were aged 15–44 years with almost 60% male. This study quantifies for the first time on a national level the burden of chronic hepatitis B infection by ethnicity, gender and age. It confirms the importance of promoting and targeting ethnic minority groups for hepatitis B testing.
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- By Yohance M. Allette, Christophe Altier, Charles E. Argoff, Nadine Attal, Paul J. Austin, Didier Bouhassira, Ian Carroll, Kristine M. Chapman, Stephen Coleman, Lynn Kerene Cooper, Michael R. Due, Mary-Ann Fitzcharles, Robyn Flynn, Andrea D. Furlan, Vishal Gupta, Maija Haanpää, Jennifer Hah, Steven H. Horowitz, John Hughes, Mark R. Hutchinson, Scott Jarvis, Maan Kattan, Manpreet Kaur, Bradley J. Kerr, Krishna Kumar, Yuen Hei Kwok, Wojciech Leppert, Liang Liu, Angela Mailis-Gagnon, Gila Moalem-Taylor, Dwight E. Moulin, Harsha Nagaraja, Dontese Nicholson, Lauren Nicotra, Anne Louise Oaklander, John Xavier Pereira, Syed Rizvi, Stephan A. Schug, Michael Serpell, Amanda Sherwin, Howard S. Smith, Peter A. Smith, Pam Squire, Peter A. Ste-Marie, Patrick L. Stemkowski, Nicole M. Sumracki, Cory Toth, Krista van Steeg, Jan H. Vranken, Bharati Vyawahare, Mark A. Ware, Linda R. Watkins, C. Peter N. Watson, Fletcher A. White
- Edited by Cory Toth, Dwight E. Moulin
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- Book:
- Neuropathic Pain
- Published online:
- 05 December 2013
- Print publication:
- 07 November 2013, pp vii-x
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- By Federico Agliardi, Andrea Alpiger, Gianluca Bianchi Fasani, Lars Harald Blikra, Brian D. Bornhold, Edward N. Bromhead, Marko H.K. Bulmer, D. Calvin Campbell, Marie Charrière, Masahiro Chigira, John J. Clague, John Coggan, Giovanni B. Crosta, Tim Davies, Marc-Henri Derron, Mark Diederichs, Erik Eberhardt, Carlo Esposito, Robin Fell, Paolo Frattini, Corey R. Froese, Monica Ghirotti, Valentin Gischig, James S. Griffiths, Stephen R. Hencher, Reginald L. Hermanns, Kris Holm, Seyyedmahdi Hosseyni, Niels Hovius, Christian Huggel, Florian Humair, Oldrich Hungr, D. Jean Hutchinson, Michel Jaboyedoff, Matthias Jakob, Julien Jakubowski, Randall W. Jibson, Katherine S. Kalenchuk, Nikolay Khabarov, Oliver Korup, Luca Lenti, Serge Leroueil, Simon Loew, Oddvar Longva, Patrick MacGregor, Andrew W. Malone, Salvatore Martino, Scott McDougall, Mika McKinnon, Mauri McSaveney, Patrick Meunier, Dennis Moore, Jeffrey R. Moore, David C. Mosher, Michael Obersteiner, Lucio Olivares, Thierry Oppikofer, Luca Pagano, Massimo Pecci, Andrea Pedrazzini, David Petley, Luciano Picarelli, David J.W. Piper, John Psutka, Nicholas J. Roberts, Gabriele Scarascia Mugnozza, David Stapledon, Douglas Stead, Richard E. Thomson, Paolo Tommasi, J. Kenneth Torrance, Nobuyuki Torii, Gianfranco Urciuoli, Gonghui Wang, Christopher F. Waythomas, Malcolm Whitworth, Heike Willenberg, Xiyong Wu
- Edited by John J. Clague, Simon Fraser University, British Columbia, Douglas Stead, Simon Fraser University, British Columbia
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- Book:
- Landslides
- Published online:
- 05 May 2013
- Print publication:
- 23 August 2012, pp vii-x
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Sources of uncertainty in the IPCC Tier 2 Canadian livestock model
- Y. KARIMI-ZINDASHTY, J. D. MACDONALD, R. L. DESJARDINS, D. E. WORTH, J. J. HUTCHINSON, X. P. C. VERGÉ
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- Journal:
- The Journal of Agricultural Science / Volume 150 / Issue 5 / October 2012
- Published online by Cambridge University Press:
- 19 December 2011, pp. 556-569
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Estimates of uncertainties are essential when comparing the greenhouse gas (GHG) emissions from a variety of sources. Monte Carlo Simulation (MCS) was applied to estimate the uncertainties in methane emissions and the methane emission intensities from livestock in Canada, calculated using the Intergovernmental Panel on Climate Change (IPCC) methodology. National methane emissions from enteric fermentation and manure management in 2008 were 21·2 and 4·3 Teragram CO2 equivalents (Tg CO2e) with uncertainties of 38 and 73%, respectively. The methane emission intensities (kg of CO2e per kg of live animal weight) were 5·9, 0·9 and 4·9 from Canadian beef, swine and lamb, respectively, with overall uncertainties of 44, 99 and 101%, defined as the 95% confidence interval relative to the mean. A sensitivity analysis demonstrated that IPCC default parameters such as the methane conversion rate (Ym), the coefficient for calculating net energy for maintenance (Cfi) and the methane conversion factor (MCF) were the greatest sources of uncertainty. Canadian agricultural methane emissions are usually calculated by province and by animal subcategories. However, the IPCC default parameters can be assumed to be correlated among regions and animal subcategories; therefore values are assigned at the national scale for the main cattle categories (dairy and non-dairy cattle). When it was assumed that these parameters were uncorrelated at the regional scale, the overall uncertainties were reduced to 20 and 48% for enteric fermentation and manure management, respectively, and assuming that parameters were uncorrelated at the animal subcategory scale reduced uncertainties to 13 and 41% for enteric fermentation and manure management, respectively. When the uncertainty is assigned at the most disaggregated level, even doubling the uncertainty of key parameters such as Ym and Cfi, only increased the national uncertainties to 22 and 52% for enteric fermentation and manure management, respectively. The current analysis demonstrated the importance of obtaining parameters specific to regions and animal subcategories in order to estimate GHG emissions more accurately and to reduce the uncertainties in agricultural GHG inventories. It also showed that assumptions made in the calculation of uncertainties can have a large influence on the uncertainty estimates.
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- By Antony R. Absalom, Lorenz Breuer, Christoph S. Burkhart, Rowan M. Burnstein, Ian Calder, Jonathan P. Coles, Amanda Cox, Marek Czosnyka, Armagan Dagal, Judith Dinsmore, Derek Duane, Kristin Engelhard, Ari Ercole, Rik Fox, Sabrina G. Galloway, Arnab Ghosh, Arun K. Gupta, Nicholas Hirsch, Robin Howard, Peter Hutchinson, Nicole C. Keong, Martin Köhrmann, Arthur M. Lam, Andrea Lavinio, Brian P. Lemkuil, Luca Longhi, Craig D. McClain, Robert Macfarlane, Basil F. Matta, Stephan A. Mayer, David K. Menon, Andrew W. Michell, Dick Moberg, Paul G. Murphy, Clara Poon, Amit Prakash, Frank Rasulo, Fred Rincon, Stefan Schwab, Martin Smith, Sulpicio G. Soriano, Luzius A. Steiner, Nino Stocchetti, Stephan P. Strebel, Jane Sturgess, Magnus Teig, Tonny Veenith, Christian Werner, Christian Zweifel
- Edited by Basil F. Matta, David K. Menon, Martin Smith
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- Book:
- Core Topics in Neuroanaesthesia and Neurointensive Care
- Published online:
- 05 December 2011
- Print publication:
- 13 October 2011, pp vii-x
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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Excess morbidity in the hepatitis C-diagnosed population in Scotland, 1991–2006
- S. A. McDONALD, S. J. HUTCHINSON, S. M. BIRD, P. R. MILLS, P. HAYES, J. F. DILLON, D. J. GOLDBERG
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- Journal:
- Epidemiology & Infection / Volume 139 / Issue 3 / March 2011
- Published online by Cambridge University Press:
- 29 June 2010, pp. 344-353
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We estimated the excess risk of in-patient hospitalization in a large cohort of persons diagnosed with hepatitis C virus (HCV) infection, controlling for social deprivation. A total of 20 749 individuals diagnosed with HCV in Scotland by 31 December 2006 were linked to the Scottish hospital discharge database, and indirectly standardized hospitalization rates, adjusting for sex, age, year and deprivation were calculated. We observed significant excess morbidity considering episodes for: any diagnosis [standardized morbidity ratio (SMR) 3·4, 95% CI 3·3–3·5]; liver-related diagnoses (SMR 41·3, 95% CI 39·6–43·0); and only non-liver-related diagnoses (SMR 2·14, 95% CI 2·08–2·19). Cox regression analyses of the 2000–2006 data indicated increased relative risks of hospitalization for males [hazard ratio (HR) 1·1, 95% CI 1·0–1·2], older age (per 10 years) (HR 1·55, 95% CI 1·5–1·6), and those testing HIV-positive (HR 1·6, 95% CI 1·3–1·8). This study has revealed substantial excess all-cause and liver-related morbidity in the Scottish HCV-diagnosed population, even after allowing for deprivation.
Are many women immunized against rubella unnecessarily?
- P. P. Mortimer, J. M. B. Edwards, A. D. Porter, R. S. Tedder, J. E. Mace, A. Hutchinson
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- Journal:
- Journal of Hygiene / Volume 87 / Issue 1 / August 1981
- Published online by Cambridge University Press:
- 25 March 2010, pp. 131-138
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Radial haemolysis (RH) was used to test sera for immunity to rubella from 1317 patients attending a general practice. One hundred and forty-one (10·7%) were treated as susceptible and offered an attenuated virus vaccine (RA 27/3). Pre-immunization sera from 43% of these patients were reactive at low levels in RH (< 15 international units rubella antibody per ml).
Pre- (S1) and post- (S2) immunization sera from 66 vaccinees were studied in detail. Antibody was detected by RH, haemagglutination inhibition (HI) and enzyme-linked immunosorbent assay (ELISA), and the specific IgM response was measured by a solid-phase M-antibody capture radioimmunoassay (MACRIA). The vaccine-induced IgM response was only detected if the S1 serum was non-reactive by all tests for rubella antibody. It was weaker than that seen following wild virus infection. It could be detected reliably for six weeks, and in most cases for nine weeks, after immunization. In contrast, patients with S1 specimens reactive by RH, HI or ELISA never showed an IgM response in the S2 specimen despite ‘significant’ antibody rises often being present.
It was considered that an IgM response to RA 27/3 was the best indicator of pre-immunization susceptibility to rubella. The failure of many vaccinees to make an IgM response implied that a significant proportion were already immune. It is suggested that the threshold for a report of immunity to rubella could be lowered from 15 i.u. antibody per ml and so fewer women immunized without vaccine being withheld from those who need it.
Differing patterns of brain structural abnormalities between black and white patients with their first episode of psychosis
- K. D. Morgan, P. Dazzan, C. Morgan, J. Lappin, G. Hutchinson, X. Chitnis, J. Suckling, P. Fearon, P. B. Jones, J. Leff, R. M. Murray
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- Journal:
- Psychological Medicine / Volume 40 / Issue 7 / July 2010
- Published online by Cambridge University Press:
- 06 November 2009, pp. 1137-1147
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Background
African-Caribbean and black African people living in the UK are reported to have a higher incidence of diagnosed psychosis compared with white British people. It has been argued that this may be a consequence of misdiagnosis. If this is true they might be less likely to show the patterns of structural brain abnormalities reported in white British patients. The aim of this study therefore was to investigate whether there are differences in the prevalence of structural brain abnormalities in white and black first-episode psychosis patients.
MethodWe obtained dual-echo (proton density/T2-weighted) images from a sample of 75 first-episode psychosis patients and 68 healthy controls. We used high resolution magnetic resonance imaging and voxel-based methods of image analysis. Two separate analyses were conducted: (1) 34 white British patients were compared with 33 white British controls; (2) 41 African-Caribbean and black African patients were compared with 35 African-Caribbean and black African controls.
ResultsWhite British patients and African-Caribbean/black African patients had ventricular enlargement and increased lenticular nucleus volume compared with their respective ethnic controls. The African-Caribbean/black African patients also showed reduced global grey matter and increased lingual gyrus grey-matter volume. The white British patients had no regional or global grey-matter loss compared with their normal ethnic counterparts but showed increased grey matter in the left superior temporal lobe and right parahippocampal gyrus.
ConclusionsWe found no evidence in support of our hypothesis. Indeed, the finding of reduced global grey-matter volume in the African-Caribbean/black African patients but not in the white British patients was contrary to our prediction.
Diagnosis of hepatitis C virus infection in Scotland's injecting drug user population
- S. A. McDONALD, S. J. HUTCHINSON, P. R. MILLS, S. M. BIRD, C. ROBERTSON, J. F. DILLON, A. SPRINGBETT, D. J. GOLDBERG
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- Journal:
- Epidemiology & Infection / Volume 138 / Issue 3 / March 2010
- Published online by Cambridge University Press:
- 02 September 2009, pp. 393-402
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We estimated the extent of undiagnosed hepatitis C virus (HCV) infection in injecting drug users (IDUs) in Scotland. We used record-linkage to determine HCV diagnosis status for 41 062 current/former IDUs attending drug treatment and support services between 1 April 1995 and 31 March 2006; the extent of undiagnosed HCV infection was estimated by comparing the number HCV-diagnosed to the number HCV-infected (estimated from an unlinked anonymous testing survey of 2141 current/former IDUs). In all, 9145 IDUs (22%) were diagnosed HCV antibody-positive since first attendance at drug services (diagnosis rate of 33·6/1000 person-years, 95% CI 32·7–34·4). By 31 March 2006, of the 19 632 current/former IDUs who had attended drug services and were determined to be living with HCV, an estimated 58% (95% CI 45–62) had not been HCV-diagnosed. It is essential that the deployment of resources for identifying at-risk IDUs with a view to offering antiviral therapy is guided by evidence.
The problems of tracing a geographically widespread outbreak of salmonellosis from a commonly eaten food: Salmonella typhimurium DT193 in North West England and North Wales in 1991
- L. Thornton, S. Gray, P. Bingham, R. L. Salmon, D. N. Hutchinson, B. Rowe, D. Newton, Q. U. Syed
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- Journal:
- Epidemiology & Infection / Volume 111 / Issue 3 / December 1993
- Published online by Cambridge University Press:
- 15 May 2009, pp. 465-472
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Geographically widespread outbreaks involving commonly isolated organisms and where the vehicles of infection are commonly eaten foodstuffs pose particular difficulties at a technical and organizational level.
An outbreak of Salmonella typhimurium infection, affecting 39 people, spread over a wide area in North West England and North Wales in April and May 1991, was detected thanks to the practice of sending specimens to the national reference laboratory where phage typing and characterizing of antibiotic resistance patterns enabled the identification of a cluster of distinctive isolates (S. typhimurium DT193 resistant to sulphonamides, trimethoprim and furazolidone). An investigation, involving twenty environmental health departments in addition to health authorities and the Public Health Laboratory Service, showed an association between the illness and eating loose sliced cooked ham (P = 0.004). Detailed tracing of the chain of supply of the ham showed this to be particularly cooked ham originating from a single small local producer (P = 0.00003). Further investigation of that producer revealed that a batch of ham distributed on one day in early April was undercooked due to a malfunction in cooking equipment.
An outbreak of foodborne botulism associated with contaminated hazelnut yoghurt
- M. O'Mahony, E. Mitchell, R. J. Gilbert, D. N. Hutchinson, N. T. Begg, J. C. Rodhouse, J. E. Morris
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- Journal:
- Epidemiology & Infection / Volume 104 / Issue 3 / June 1990
- Published online by Cambridge University Press:
- 15 May 2009, pp. 389-395
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The largest recorded outbreak of foodborne botulism in the United Kingdom occurred in June 1989. A total of 27 patients was affected; one patient died. Twenty-five of the patients had eaten one brand of hazelnut yoghurt in the week before the onset of symptoms. This yoghurt contained hazelnut conserve sweetened with aspartame rather than sugar. Clostridium botulinum type B toxin was detected in a blown can of hazelnut conserve, opened and unopened cartons of hazelnut yoghurt, and one faecal specimen. Cl. botulinum type B was subsequently cultured from both opened and unopened cartons of the hazelnut yoghurt and from one faecal specimen. Investigations indicated that the processing of the conserve was inadequate to destroy Cl. botulinum spores. Control measures included the cessation of all yoghurt production by the implicated producer, the withdrawal of the firm's yoghurts from sale, the recall of cans of the hazelnut conserve, and advice to the general public to avoid the consumption of all hazelnut yoghurts.
The safety of the Trexler isolator as judged by some physical and biological criteria: a report of experimental work at two centres
- J. G. P. Hutchinson, J. Gray, T. H. Flewett, R. T. D. Emond, Brandon Evans, P. C. Trexler
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- Journal:
- Journal of Hygiene / Volume 81 / Issue 2 / October 1978
- Published online by Cambridge University Press:
- 15 May 2009, pp. 311-319
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We have assessed the effectiveness of flexible-film negative-pressure isolators by physical and biological means. We have found that they afford a high degree of containment and therefore also of safety to hospital staff. We offer some recommendations on the operation of these isolators to ensure the optimum degree of protection.
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