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Excessive car ownership in cities has led to issues including congestion, air pollution and resource consumption. This paper investigates the impact of rail transit openings on automobile purchases in China based on detailed car sales data during 2013–2015 and using two-way fixed effects panel models. Our study reveals an average decrease of 2.27 per cent in car sales due to rail transit openings. Further analyses of cars with different fuel economy reveal stronger effects on fuel-efficient cars, indicating larger substitution elasticity between public transportation and driving for people with less income. Results also show the negative impact of rail transit openings is larger in cities with more developed economies, higher public revenue, larger population, bigger area and fewer buses. The decline in car sales translates into savings of 7.9 billion liters of gasoline and a reduction of about 20.3 million tons in life-cycle carbon emissions.
Overnutrition during before and pregnancy can cause maternal obesity and raise the risk of maternal metabolic diseases during pregnancy, and in offspring. Lentinus edodes may prevent or reduce obesity. This study aimed to to assess Lentinus edodes fermented products effects on insulin sensitivity, glucose and lipid metabolism in maternal and offspring, and explore its action mechanism. A model of overnutrition during pregnancy and lactation was developed using a 60 % kcal high-fat diet in C57BL6/J female mice. Fermented Lentinus edodes (FLE) was added to the diet at concentrations of 1 %, 3 %, and 5 %. The results demonstrated that FLE to the gestation diet significantly reduced serum insulin levels and homeostatic model assessment for insulin resistance (HOMA-IR) in pregnant mice. FLE can regulate maternal lipid metabolism and reduce fat deposition. Meanwhile, the hepatic phosphoinositide-3-kinase-protein kinase (PI3K/AKT) signaling pathway was significantly activated in the maternal mice. There is a significant negative correlation between maternal FLE supplementation doses and offspring body fat percentage and visceral fat content. Furthermore, FLE supplementation significantly increased offspring weaning litter weight, significantly reduced fasting glucose level, serum insulin level, HOMA-IR and serum glucose level, significantly activated liver PI3K/AKT signaling pathway in offspring, and upregulated the expression of liver lipolytic genes adipose triglyceride lipase, hormone-sensitive lipase and carnitine palmitoyltransferase 1 mRNA. Overall, FLE supplementation can regulate maternal lipid metabolism and reduce fat deposition during pregnancy and lactation, and it may improve insulin sensitivity in pregnant mothers and offspring at weaning through activation of the PI3K/AKT signaling pathway.
The extracellular matrices, such as the haemolymph, in insects are at the centre of most physiological processes and are protected from oxidative stress by the extracellular antioxidant enzymes. In this study, we identified two secreted superoxide dismutase genes (PxSOD3 and PxSOD5) and investigated the oxidative stress induced by chlorpyrifos (CPF) in the aquatic insect Protohermes xanthodes (Megaloptera: Corydalidae). PxSOD3 and PxSOD5 contain the signal peptides at the N-terminus. Structure analysis revealed that PxSOD3 and PxSOD5 contain the conserved CuZn-SOD domain, which is mainly composed of β-sheets and has conserved copper and zinc binding sites. Both PxSOD3 and PxSOD5 are predicted to be soluble proteins located in the extracellular space. After exposure to different concentrations of sublethal CPF, MDA content in P. xanthodes larvae were increased in a dose-dependent manner; SOD and CAT activities were also higher in CPF-treated groups than that in the no CPF control, indicating that sublethal CPF induces oxidative stress in P. xanthodes larvae. Furthermore, PxSOD3 and PxSOD5 expression levels and haemolymph SOD activity in the larvae were downregulated by sublethal CPF at different concentrations. Our results suggest that the PxSOD3 and PxSOD5 are putative extracellular antioxidant enzymes that may play a role in maintaining the oxidative balance in the extracellular space. Sublethal CPF may induce oxidative stress in the extracellular space of P. xanthodes by reducing the gene expression and catalytic activity of extracellular SODs.
The fate of deformable buoyancy-driven bubbles rising near a vertical wall under highly inertial conditions is investigated numerically. In the absence of path instability, simulations reveal that, when the Galilei number, $Ga$, which represents the buoyancy-to-viscous force ratio, exceeds a critical value, bubbles escape from the near-wall region after one to two bounces, while at smaller $Ga$ they perform periodic bounces without escaping. The escape mechanism is rooted in the vigorous rotational flow that forms around a bubble during its bounce at high enough $Ga$, resulting in a Magnus-like repulsive force capable of driving it away from the wall. Path instability takes place with bubbles whose Bond number, the buoyancy-to-capillary force ratio, exceeds a critical $Ga$-dependent value. Such bubbles may or may not escape from the wall region, depending on the competition between the classical repulsive wake–wall interaction mechanism and a specific wall-ward trapping mechanism. The latter results from the reduction of the bubble oblateness caused by the abrupt drop of the rise speed when the bubble–wall gap becomes very thin. Owing to this transient shape variation, bubbles exhibiting zigzagging motions with a large enough amplitude experience larger transverse drag and virtual mass forces when departing from the wall than when returning to it. With moderately oblate bubbles, i.e. in an intermediate Bond number range, this effect is large enough to counteract the repulsive interaction force, forcing such bubbles to perform a periodic zigzagging-like motion at a constant distance from the wall.
This paper focuses on the feature-based visual-inertial odometry (VIO) in dynamic illumination environments. While the performance of most existing feature-based VIO methods is degraded by the dynamic illumination, which leads to unstable feature association, we propose a tightly-coupled VIO algorithm termed RAFT-VINS, integrating a Lite-RAFT tracker into the visual inertial navigation system (VINS). The key module of this odometry algorithm is a lightweight optical flow network designed for accurate feature tracking with real-time operation. It guarantees robust feature association in dynamic illumination environments and thereby ensures the performance of the odometry. Besides, to further improve the accuracy of the pose estimation, a moving consistency check strategy is developed in RAFT-VINS to identify and remove the outlier feature points. Meanwhile, a tightly-coupled optimization-based framework is employed to fuse IMU and visual measurements in the sliding window for efficient and accurate pose estimation. Through comprehensive experiments in the public datasets and real-world scenarios, the proposed RAFT-VINS is validated for its capacity to provide trustable pose estimates in challenging dynamic illumination environments. Our codes are open-sourced on https://github.com/USTC-AIS-Lab/RAFT-VINS.
We consider a superprocess $\{X_t\colon t\geq 0\}$ in a random environment described by a Gaussian field $\{W(t,x)\colon t\geq 0,x\in \mathbb{R}^d\}$. First, we set up a representation of $\mathbb{E}[\langle g, X_t\rangle\mathrm{e}^{-\langle \,f,X_t\rangle }\mid\sigma(W)\vee\sigma(X_r,0\leq r\leq s)]$ for $0\leq s < t$ and some functions f,g, which generalizes the result in Mytnik and Xiong (2007, Theorem 2.15). Next, we give a uniform upper bound for the conditional log-Laplace equation with unbounded initial values. We then use this to establish the corresponding conditional entrance law. Finally, the excursion representation of $\{X_t\colon t\geq 0\}$ is given.
We presented an attosecond-precision timing detector based on linear optics. The minimum measurement floor is 1×10–10 fs2/Hz with only 1 mW input optical power. With this novel technique, the residual dispersion of a 5.2 km fiber link is characterized and precisely compensated. Finally, a comprehensive feedback model has been developed to analyze the noise coupling in a long-distance link stabilization system. The simulation results demonstrate an out-of-loop jitter of merely 359 as, integrated at [1 Hz, 1 MHz], at 1 mW input power per photodetector of our timing detector. Remarkably, the system is capable of maintaining sub-femtosecond precision even at optical power levels as low as 240 nW (for a 5.2 km link length), or link lengths as long as 20 km (with 1 μW optical power), respectively.
This paper presents an investigation of the secondary saturation characteristics of a HfTe2 saturable absorber. Pulse energies of 5.85 and 7.4 mJ were demonstrated with a high-order Hermite–Gaussian (HG) laser and a vortex laser, respectively, using alexandrite as the gain medium. To the best of our knowledge, these are the highest pulse energies directly generated with HG and vortex lasers. To broaden the applications of high-energy pulsed HG and vortex lasers, wavelength tuning in the region of 40 nm was achieved using an etalon.
This study was designed to explore the mediating role of serum 25-hydroxyvitamin D (25(OH) D) in Triglyceride–glucose (TyG) index and hypertension (HTN). Study participants were selected from the 2001 to 2018 National Health and Nutrition Examination Survey. Firstly, we estimated the association between TyG index and serum 25(OH)D with HTN using a weighted multivariable logistic regression model and restricted cubic spline. Secondly, we used a generalised additive model to investigate the correlation between TyG index and serum 25(OH)D. Lastly, serum 25(OH)D was investigated as a mediator in the association between TyG index and HTN. There were 14 099 subjects in total. TyG index was positively and linearly associated with HTN risk, while serum 25(OH)D had a U-shaped relationship with the prevalence of HTN. When the serum 25(OH)D levels were lower than 57·464 mmol/l, the prevalence of HTN decreased with the increase of serum 25(OH)D levels. When serum 25(OH)D levels rise above 57·464 mmol/l, the risk of HTN increases rapidly. Based on the U-shaped curve, serum 25(OH)D concentrations were divided into two groups: < 57·464 and ≥57·464 mmol/l. According to the mediation analysis, when serum 25(OH)D levels reached < 57·464 mmol/l, the positive association between the TyG index and incident HTN was increased by 25(OH)D. When serum 25(OH)D levels reached ≥ 57·464 mmol/l, the negative association between the TyG index and incident HTN was increased by 25(OH)D. There was a mediation effect between the TyG index and HTN, which was mediated by 25(OH)D. Therefore, we found that the association between serum 25(OH)D levels and TyG index may influence the prevalence of HTN.
When an oblate droplet translates through a viscous fluid under linear shear, it experiences a lateral lift force whose direction and magnitude are influenced by the Reynolds number, the droplet’s viscosity and its aspect ratio. Using a recently developed sharp interface method, we perform three-dimensional direct numerical simulations to explore the evolution of lift forces on oblate droplets across a broad range of these parameters. Our findings reveal that in the low-but-finite Reynolds number regime, the Saffman mechanism consistently governs the lift force. The lift increases with the droplet’s viscosity, aligning with the analytical solution derived by Legendre & Magnaudet (Phys. Fluids, vol. 9, 1997, p. 3572), and also rises with the droplet’s aspect ratio. We propose a semi-analytical correlation to predict this lift force. In the moderate- to high-Reynolds-number regime, distinct behaviours emerge: the $L\hbox{-}$ and $S\hbox{-}$mechanisms, arising from the vorticity contained in the upstream shear flow and the vorticity produced at the droplet surface, dominate for weakly and highly viscous droplets, respectively. Both mechanisms generate counter-rotating streamwise vortices of opposite signs, leading to observed lift reversals with increasing droplet viscosity. Detailed force decomposition based on vorticity moments indicates that in the $L\hbox{-}$mechanism-dominated regime for weakly to moderately viscous droplets, the streamwise vorticity-induced lift approximates the total lift. Conversely, in the $S\hbox{-}$mechanism-dominated regime, for moderately to highly viscous droplets, the streamwise vorticity-induced lift constitutes only a portion of the total lift, with the asymmetric advection of azimuthal vorticity at the droplet interface contributing additional positive lift to counterbalance the $S\hbox{-}$mechanism’s effects. These insights bridge the understanding between inviscid bubbles and rigid particles, enhancing our comprehension of the lift force experienced by droplets in different flow regimes.
This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.
When a droplet impacts onto a superheated liquid pool, vapour generation and drainage within the gas cushion play a crucial role in postponing or even preventing contact between the droplet and the pool surface. Through direct numerical simulations, we closely examine the transient dynamics of vapour flow confined within the thin film, with a particular focus on the minimum thickness of this film under a range of impact conditions. Our numerical findings manifest the significant influence of evaporation on the vertical motion of the liquid–vapour interface, revealing how the minimum film thickness evolves in response to variations in impact velocity and degree of superheat. In our numerical simulations, we have identified two distinct evolution laws for the minimum film thickness, corresponding to moderate and high superheat regimes, respectively. These regimes are differentiated by the dominance of evaporation effects within the vapour film during the early falling stage. Subsequently, we establish scaling relations to characterize these regimes by carefully balancing inertial, pressure and evaporation effects within the thin vapour film. Furthermore, we observe that the vapour pressure eventually reaches equilibrium with the rapid increase in capillary pressure at the spreading front, thereby controlling the minimum thickness of the vapour layer in both moderate and high superheat regimes. We derive self-similar solutions based on this equilibrium, and the predicted minimum film thickness aligns remarkably well with our numerical results. This provides compelling evidence that evaporation alone is insufficient to prevent droplet–pool coalescence.
Rhopalosiphum padi is an important grain pest, causing severe losses during crop production. As a systemic insecticide, flonicamid can control piercing-sucking pests efficiently. In our study, the lethal effects of flonicamid on the biological traits of R. padi were investigated via a life table approach. Flonicamid is highly efficiently toxic to R. padi, with an LC50 of 9.068 mg L−1. The adult longevity and fecundity of the R. padi F0 generation were markedly reduced under the LC25 and LC50 concentrations of flonicamid exposure. In addition, negative transgenerational effects on R. padi were observed under exposure to lethal concentrations of flonicamid, with noticeable decreases in the reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation under the LC25 concentration of flonicamid. Furthermore, the third nymph stage (N3), preadult stage, duration of the adult pre-reproductive period, duration of the total pre-reproductive period, reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation were significantly lower under treatment with the LC50 concentration of flonicamid. The life table parameters were subsequently analysed, revealing that the intrinsic rate of increase (rm) and the net reproductive rate (R0) were significantly lower but that the finite rate of increase (λ) and the mean generation time (T) were not significantly different under the LC25 and LC50 concentrations of flonicamid. These data are beneficial for grain aphid control and are critical for exploring the role of flonicamid in the integrated management of this key pest.
The ubiquitous marine radiocarbon reservoir effect (MRE) constrains the construction of reliable chronologies for marine sediments and the further comparison of paleoclimate records. Different reference values were suggested from various archives. However, it remains unclear how climate and MREs interact. Here we studied two pre-bomb corals from the Hainan Island and Xisha Island in the northern South China Sea (SCS), to examine the relationship between MRE and regional climate change. We find that the MRE from east of Hainan Island is mainly modulated by the Southern Asian Summer Monsoon-induced precipitation (with 11.4% contributed to seawater), rather than wind induced upwelling. In contrast, in the relatively open seawater of Xisha Island, the MRE is dominated by the East Asian Winter Monsoon, with relatively more negative (lower) ΔR values associated with high wind speeds, implying horizontal transport of seawater. The average SCS ΔR value relative to the Marine20 curve is –161±39 14C years. Our finding highlights the essential role of monsoon in regulating the MRE in the northern SCS, in particularly the tight bond between east Asian winter monsoon and regional MRE.
The double-cone ignition scheme is a promising novel ignition method, which is expected to greatly save the driver energy and enhance the robustness of the implosion process. In this paper, ablation of the inner surface of the cone by the hard X-ray from coronal Au plasma is studied via radiation hydrodynamics simulations. It is found that the X-ray ablation of the inner wall will form strong pre-plasma, which will significantly affect the implosion process and cause the Au plasma to mix with the fuel, leading to ignition failure. The radiation and pre-ablation intensities in the system are estimated, and the evolutions of areal density, ion temperature and the distribution of Au ions are analysed. In addition, the mixing of Au in CH at collision is quantified. Then, a scheme to reduce the X-ray pre-ablation by replacing the gold cone with a tungsten cone is proposed, showing that it is effective in reducing high-Z mixing and improving collision results.
Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.
Aims
Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.
Method
We examined average and modal controllability of the brain's functional connectome in 161 patients with schizophrenia, 37 unaffected siblings and 96 healthy controls during a two-back task. We use one-way analysis of variance to detect the regions with group differences, and correlated aberrant controllability to task performance and clinical characteristics. Regions affected in both unaffected siblings and patients were selected for gene and functional annotation analysis.
Results
Both average and modal controllability during the two-back task are reduced in patients compared to healthy controls and siblings, indicating a disruption in both proximal and distal state transitions. Among patients, reduced average controllability was prominent in auditory, visual and sensorimotor networks. Reduced modal controllability was prominent in default mode, frontoparietal and salience networks. Lower modal controllability in the affected networks correlated with worse task performance and higher antipsychotic dose in schizophrenia (uncorrected). Both siblings and patients had reduced average controllability in the paracentral lobule and Rolandic operculum. Subsequent out-of-sample gene analysis revealed that these two regions had preferential expression of genes relevant to bioenergetic pathways (calmodulin binding and insulin secretion).
Conclusions
Aberrant control of brain state transitions during task execution marks working memory deficits in patients and their siblings.
Stimulated Raman scattering is a third-order nonlinear optical effect that is not only effective for wavelength converting laser output, but also for single longitudinal-mode output due to the absence of spatial hole burning. Diamond is a prominent Raman-active medium that has significant potential for linewidth narrowing and wavelength converting lasers at high power levels due to its high thermal conductivity, long Raman frequency shift and wide spectral transmission range. In this work we utilize diamond in a resonantly mode-matched external cavity to achieve cascaded Raman conversion of a 1064 nm laser. By fine-tuning the length of this external cavity, we can obtain narrow linewidth emission at 1240 and 1485 nm. When operating at maximum power, the measured linewidths were more than twofold narrower than the linewidth of the fundamental field. In addition, the noise levels of the Stokes fields are lower than that of the fundamental field throughout the entire noise frequency range, and the intrinsic linewidth of the second Stokes field, which is expressed at the hertz level (~3.6 Hz), is decreased by approximately three orders of magnitude compared to that of the pump. This work represents the first measurement and analysis of the linewidth and noise characteristics of cascaded diamond Raman lasers and, significantly, offers a new means by which high-power, narrow linewidth laser output can be produced from wavelength-converted laser systems.
An optical spectrometer system based on 60 channels of fibers has been designed and employed to diagnose light emissions from laser–plasma interactions. The 60 fiber collectors cover an integrated solid angle of $\pi$, enabling the measurement of global energy losses in a symmetrical configuration. A detecting spectral range from ultraviolet to near-infrared, with angular distribution, allows for the understanding of the physical mechanisms involving various plasma modes. Experimental measurements of scattered lights from a conical implosion driven by high-energy nanosecond laser beams at the Shenguang-II Upgrade facility have been demonstrated, serving as reliable diagnostics to characterize laser absorption and energy losses from laser–plasma instabilities. This compact diagnostic system can provide comprehensive insights into laser energy coupling in direct-drive inertial confinement fusion research, which are essential for studying the driving asymmetry and improving the implosion efficiencies.