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The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia
- Błażej Misiak, Jerzy Samochowiec, Krzysztof Kowalski, Wolfgang Gaebel, Claudio L. A. Bassetti, Andrew Chan, Philip Gorwood, Sergi Papiol, Geert Dom, Umberto Volpe, Agata Szulc, Tamas Kurimay, Hilkka Kärkkäinen, Andre Decraene, Jan Wisse, Andrea Fiorillo, Peter Falkai
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- Journal:
- European Psychiatry / Volume 66 / Issue 1 / 2023
- Published online by Cambridge University Press:
- 21 July 2023, e58
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The ongoing developments of psychiatric classification systems have largely improved reliability of diagnosis, including that of schizophrenia. However, with an unknown pathophysiology and lacking biomarkers, its validity still remains low, requiring further advancements. Research has helped establish multiple sclerosis (MS) as the central nervous system (CNS) disorder with an established pathophysiology, defined biomarkers and therefore good validity and significantly improved treatment options. Before proposing next steps in research that aim to improve the diagnostic process of schizophrenia, it is imperative to recognize its clinical heterogeneity. Indeed, individuals with schizophrenia show high interindividual variability in terms of symptomatic manifestation, response to treatment, course of illness and functional outcomes. There is also a multiplicity of risk factors that contribute to the development of schizophrenia. Moreover, accumulating evidence indicates that several dimensions of psychopathology and risk factors cross current diagnostic categorizations. Schizophrenia shares a number of similarities with MS, which is a demyelinating disease of the CNS. These similarities appear in the context of age of onset, geographical distribution, involvement of immune-inflammatory processes, neurocognitive impairment and various trajectories of illness course. This article provides a critical appraisal of diagnostic process in schizophrenia, taking into consideration advancements that have been made in the diagnosis and management of MS. Based on the comparison between the two disorders, key directions for studies that aim to improve diagnostic process in schizophrenia are formulated. All of them converge on the necessity to deconstruct the psychosis spectrum and adopt dimensional approaches with deep phenotyping to refine current diagnostic boundaries.
3 - Strategies for Recovery of the Hainan Gibbon (Nomascus hainanus)
- Edited by Susan M. Cheyne, Borneo Nature Foundation, Carolyn Thompson, University College London, Peng-Fei Fan, Sun Yat-Sen University, China, Helen J. Chatterjee, University College London
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- Gibbon Conservation in the Anthropocene
- Published online:
- 13 April 2023
- Print publication:
- 20 April 2023, pp 40-56
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Summary
The Hainan gibbon (Nomascus hainanus) is endemic to China’s Hainan Island, and is the world’s rarest primate species. With rampant deforestation and hunting, by 1980 less than 10 individuals reportedly survived at Bawangling National Nature Reserve. A systematic population census in 2003 confirmed only 13 individuals and it was feared that it would be the first modern primate species to go extinct. In 2003, Kadoorie Farm and Botanic Garden was invited by the local conservation authority to take an active role in saving the species from extinction. Together with relevant government agencies and other stakeholders, a conservation strategy with prioritised conservation actions were devised and implemented; these ranged from reforestation of prime lowland habitat, establishment of gibbon monitoring teams, scientific research, awareness-raising and provision of alternative livelihoods to surrounding communities. With years of continuous presence and open dialogue, the local authorities and communities embraced the suite of conservation actions, and the species is on a slow but steady recovery pathway. The population is expanding its range and currently stands at five family groups of at least 34 gibbons.
Particle transport in a turbulent pipe flow: direct numerical simulations, phenomenological modelling and physical mechanisms
- T. Zahtila, L. Chan, A. Ooi, J. Philip
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- Journal:
- Journal of Fluid Mechanics / Volume 957 / 25 February 2023
- Published online by Cambridge University Press:
- 09 February 2023, A1
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In particle-laden turbulent wall flows, transport of particles towards solid walls is phenomenologically thought to be governed by the wall-normal turbulence intensity supporting the underlying particle–eddy interactions that are usually modelled by a combination of turbophoresis and turbulent diffusion. We estimate the turbophoretic and turbulent diffusive coefficients as a function of wall-normal coordinate directly from a generated direct numerical simulation (DNS) database of low volume fraction point particles in a turbulent pipe flow. These coefficients are then used in an advection–diffusion equation to estimate the particle concentration as a function of wall-normal distance and time, with favourable comparison against DNS for smaller Stokes number ($St^+$) particles suggesting a limitation of the common gradient diffusion hypothesis for larger $St^+$ particles. Using DNS we explore the non-trivial effects of $St^+$, pipe wall condition (particle absorbing or elastic) as well as the influence of drag and lift force on the velocity and particle statistics giving rise to different particle concentrations. We then appraise various Eulerian-based models of turbophoretic and turbulent diffusive coefficients and, finally, use physical insights from Lagrangian correlation times, conditional quadrant analysis and flow topology to shed further light on the particle transport as a function of various parameters and the limits of gradient diffusion hypothesis.
Trends in hospital antibiotic utilization during the coronavirus disease 2019 (COVID-19) pandemic: A multicenter interrupted time-series analysis
- Marion Elligsen, Michael Wan, Philip W. Lam, Jennifer Lo, Linda R. Taggart, April J. Chan, Mark Downing, Kevin Gough, Jenny Seah, Elizabeth Leung
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- Journal:
- Antimicrobial Stewardship & Healthcare Epidemiology / Volume 2 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 28 July 2022, e128
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Objective:
To describe the evolution of respiratory antibiotic prescribing during the coronavirus disease 2019 (COVID-19) pandemic across 3 large hospitals that maintained antimicrobial stewardship services throughout the pandemic.
Design:Retrospective interrupted time-series analysis.
Setting:A multicenter study was conducted including medical and intensive care units (ICUs) from 3 hospitals within a Canadian epicenter for COVID-19.
Methods:Interrupted time-series analysis was used to analyze rates of respiratory antibiotic utilization measured in days of therapy per 1,000 patient days (DOT/1,000 PD) in medical units and ICUs. Each of the first 3 waves of the pandemic were compared to the baseline.
Results:Within the medical units, use of respiratory antibiotics increased during the first wave of the pandemic (rate ratio [RR], 1.76; 95% CI, 1.38–2.25) but returned to the baseline in waves 2 and 3 despite more COVID-19 admissions. In ICU, the use of respiratory antibiotics increased in wave 1 (RR, 1.30; 95% CI, 1.16–1.46) and wave 2 of the pandemic (RR, 1.21; 95% CI, 1.11–1.33) and returned to the baseline in the third wave, which had the most COVID-19 admissions.
Conclusions:After an initial surge in respiratory antibiotic prescribing, we observed the normalization of prescribing trends at 3 large hospitals throughout the COVID-19 pandemic. This trend may have been due to the timely generation of new research and guidelines developed with frontline clinicians, allowing for the active application of new research to clinical practice.
Linking sporadic hospital clusters during a community surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) B.1.617.2 delta variant: The utility of whole-genome sequencing
- Liang En Wee, Karrie Kwan-Ki Ko, Edwin Philip Conceicao, Jean Xiang-Ying Sim, Nurdyana Abdul Rahman, Shireen Yan-Ling Tan, Delphine Yan-Hong Cao, Kenneth Xing-Long Chan, May Kyawt Aung, Myat Oo Aung, Yang Yong, Shalvi Arora, Molly Kue Bien How, Kwee Yuen Tan, Lai Chee Lee, Thuan Tong Tan, Limin Wijaya, James Heng Chiak Sim, Chayaporn Suphavilai, Indumathi Venkatachalam, Moi Lin Ling
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 44 / Issue 6 / June 2023
- Published online by Cambridge University Press:
- 27 April 2022, pp. 1014-1018
- Print publication:
- June 2023
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Sporadic clusters of healthcare-associated coronavirus disease 2019 (COVID-19) occurred despite intense rostered routine surveillance and a highly vaccinated healthcare worker (HCW) population, during a community surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) B.1.617.2 δ (delta) variant. Genomic analysis facilitated timely cluster detection and uncovered additional linkages via HCWs moving between clinical areas and among HCWs sharing a common lunch area, enabling early intervention.
Simulation and flow physics of a shocked and reshocked high-energy-density mixing layer
- Jason D. Bender, Oleg Schilling, Kumar S. Raman, Robert A. Managan, Britton J. Olson, Sean R. Copeland, C. Leland Ellison, David J. Erskine, Channing M. Huntington, Brandon E. Morgan, Sabrina R. Nagel, Shon T. Prisbrey, Brian S. Pudliner, Philip A. Sterne, Christopher E. Wehrenberg, Ye Zhou
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- Journal of Fluid Mechanics / Volume 915 / 25 May 2021
- Published online by Cambridge University Press:
- 22 March 2021, A84
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This paper describes a computational investigation of multimode instability growth and multimaterial mixing induced by multiple shock waves in a high-energy-density (HED) environment, where pressures exceed 1 Mbar. The simulations are based on a series of experiments performed at the National Ignition Facility (NIF) and designed as an HED analogue of non-HED shock-tube studies of the Richtmyer–Meshkov instability and turbulent mixing. A three-dimensional computational modelling framework is presented. It treats many complications absent from canonical non-HED shock-tube flows, including distinct ion and free-electron internal energies, non-ideal equations of state, radiation transport and plasma-state mass diffusivities, viscosities and thermal conductivities. The simulations are tuned to the available NIF data, and traditional statistical quantities of turbulence are analysed. Integrated measures of turbulent kinetic energy and enstrophy both increase by over an order of magnitude due to reshock. Large contributions to enstrophy production during reshock are seen from both the baroclinic source and enstrophy–dilatation terms, highlighting the significance of fluid compressibility in the HED regime. Dimensional analysis reveals that Reynolds numbers and diffusive Péclet numbers in the HED flow are similar to those in a canonical non-HED analogue, but conductive Péclet numbers are much smaller in the HED flow due to efficient thermal conduction by free electrons. It is shown that the mechanism of electron thermal conduction significantly softens local spanwise gradients of both temperature and density, which causes a minor but non-negligible decrease in enstrophy production and small-scale mixing relative to a flow without this mechanism.
Persistently high SARS-CoV-2 positivity rate and incidence for Hispanic/Latinos during state reopening in an urban setting: a retrospective cohort study
- Chien-Hsiang Weng, Andrew Saal, Daniel C. McGuire, Philip A. Chan
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- Journal:
- Epidemiology & Infection / Volume 149 / 2021
- Published online by Cambridge University Press:
- 18 January 2021, e25
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Hispanic/Latino populations are disproportionately impacted by coronavirus disease 2019 (COVID-19) in the United States. The impact of state reopening on COVID-19 in this population after stay-at-home orders is unknown. We evaluated the incidence, prevalence and trends during reopening of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) at a major federally qualified health centre in Providence, Rhode Island. A total of 14 505 patients were tested for SARS-CoV-2 from 19 March to 18 August 2020, of which, data on 13 318 (91.8%) patients were available; 70.0% were Hispanic/Latino, and 2905 were positive for SARS-CoV-2 infection. The urban Hispanic/Latino population was almost five times more likely to test positive for SARS-CoV-2 (risk ratio 4.97, 95% CI 2.59–9.53, P < 0.001) compared to non-Hispanic White. The positivity rates among the urban Hispanic/Latino population remained >10% during all phases of reopening. The trends of the incidence rates showed similar associations to those we observed for positivity rates. Public health interventions to address SARS-CoV-2 in Hispanic/Latino communities are urgently needed, even in latter phases of state reopening.
Risk of mortality and complications in patients with schizophrenia and diabetes mellitus: population-based cohort study
- Joe Kwun Nam Chan, Corine Sau Man Wong, Philip Chi Fai Or, Eric Yu Hai Chen, Wing Chung Chang
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 1 / July 2021
- Published online by Cambridge University Press:
- 07 January 2021, pp. 375-382
- Print publication:
- July 2021
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Background
Schizophrenia patients have markedly elevated prevalence of diabetes compared with the general population. However, risk of mortality and diabetes-related complications among schizophrenia patients with co-occurring diabetes is understudied.
AimsWe investigated whether schizophrenia increased the risk of overall mortality, complications and post-complication mortality in people with diabetes.
MethodThis population-based, propensity-score matched (1:10) cohort study identified 6991 patients with incident diabetes and pre-existing schizophrenia and 68 682 patients with incident diabetes only between 2001 and 2016 in Hong Kong using a medical record database of public healthcare services. Association between schizophrenia and all-cause mortality was examined with a Cox proportional hazards model. Effect of schizophrenia on first-year complication occurrence following diabetes diagnosis and post-complication mortality rates were evaluated.
ResultsSchizophrenia was associated with increased all-cause mortality (adjusted hazards ratio [aHR] 1.11, 95% CI 1.05–1.18), particularly among men and older age groups. Schizophrenia patients with diabetes had higher metabolic complication rate (aHR 1.99, 95% CI 1.63–2.42), lower microvascular complication rate (aHR 0.75, 95% CI 0.65–0.86) and comparable macrovascular complication rate (aHR 0.93, 95% CI 0.85–1.03), relative to patients with diabetes only. Among patients with diabetes complications, schizophrenia was associated with elevated all-cause mortality after macrovascular (aHR 1.19, 95% CI 1.04–1.37) and microvascular (aHR 1.33, 95% CI 1.08–1.64) complications. Gender-stratified analyses revealed that a significant effect of schizophrenia on heightened post-complication mortality was observed in men only.
ConclusionsSchizophrenia patients with co-occurring diabetes are at increased risk of excess mortality, including post-complication mortality. Further research identifying effective interventions is warranted to optimise diabetes-related outcomes in this vulnerable population.
Transport of particles in a turbulent rough-wall pipe flow
- L. Chan, T. Zahtila, A. Ooi, J. Philip
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- Journal:
- Journal of Fluid Mechanics / Volume 908 / 10 February 2021
- Published online by Cambridge University Press:
- 02 December 2020, A1
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Dense, small particles suspended in turbulent smooth-wall flow are known to migrate towards the wall. It is, however, not clear if the particle migration continues in a rough-wall flow and what the responsible mechanism is, especially with changing roughness parameters. Here, we address this using direct numerical simulation of a turbulent pipe flow of a fixed friction Reynolds numbers and changing the roughness size as well as the Stokes number of the particles. The transport and deposition mechanisms of particles are segregated into three different regimes dictated by the Stokes number. Particles with small Stokes number follow the carrier fluid and are affected by the turbulent structures of the rough wall. Flow separation in the wake of the roughness and stagnant flow in the trough of the roughness causes these particles to be trapped in the roughness canopy. Particles with very large Stokes number, on the other hand, are attracted to the wall due to turbophoresis and collide with the rough wall where the frequency of wall collision increases with increasing Stokes number. These ballistic particles are unaffected by the turbulent fluctuations of the flow and their trajectory is determined by the roughness topography. At intermediate Stokes numbers, the transport of the particles is influenced by both the wall collisions and also the turbulent flow. Particles in this range of Stokes number occasionally collide with the wall and are entrained by the turbulent flow. In this regime, the particles may have a mean streamwise velocity that is larger than the bulk flow rate of the fluid. Finally, we observe that bulk particle velocity scale better with a time scale based on the roughness elements rather than the usual viscous time scale.
New hope for the Hainan gibbon: formation of a new group outside its known range
- Bosco Pui Lok Chan, Yik Fui Philip Lo, Yanni Mo
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9 - Digital controllers for switching power converters
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- By Man Pun Chan, Marvell Hong Kong Ltd., Kowloon Bay, Hong Kong, China, Philip K. T. Mok, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
- Edited by Xicheng Jiang
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- Book:
- Digitally-Assisted Analog and Analog-Assisted Digital IC Design
- Published online:
- 05 August 2015
- Print publication:
- 23 July 2015, pp 323-391
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Maternal PUFA status and offspring allergic diseases up to the age of 18 months
- Ya-Mei Yu, Yiong-Huak Chan, Philip C. Calder, Antony Hardjojo, Shu-E Soh, Ai Lin Lim, Helena L. Fisk, Oon Hoe Teoh, Anne Goh, Seang-Mei Saw, Kenneth Kwek, Peter D. Gluckman, Keith M. Godfrey, Yap-Seng Chong, Lynette Pei-Chi Shek, An Pan, Mary Foong Fong Chong, Hugo P. S. van Bever
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- Journal:
- British Journal of Nutrition / Volume 113 / Issue 6 / 28 March 2015
- Published online by Cambridge University Press:
- 09 March 2015, pp. 975-983
- Print publication:
- 28 March 2015
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Studies have suggested that maternal PUFA status during pregnancy may influence early childhood allergic diseases, although findings are inconsistent. We examined the relationship between maternal PUFA status and risk of allergic diseases in early childhood in an Asian cohort. Maternal plasma samples from the Growing Up in Singapore Towards Healthy Outcomes mother–offspring cohort were assayed at 26–28 weeks of gestation for relative abundance of PUFA. Offspring (n 960) were followed up from 3 weeks to 18 months of age, and clinical outcomes of potential allergic diseases (rhinitis, eczema and wheezing) were assessed by repeated questionnaires. Skin prick testing (SPT) was also performed at the age of 18 months. Any allergic disease with positive SPT was defined as having any one of the clinical outcomes plus a positive SPT. The prevalence of a positive SPT, rhinitis, eczema, wheezing and any allergic disease with positive SPT was 14·1 % (103/728), 26·5 % (214/808), 17·6 % (147/833), 10·9 % (94/859) and 9·4 % (62/657), respectively. After adjustment for confounders, maternal total n-3, n-6 PUFA status and the n-6:n-3 PUFA ratio were not significantly associated with offspring rhinitis, eczema, wheezing, a positive SPT and having any allergic disease with positive SPT in the offspring (P>0·01 for all). A weak trend of higher maternal n-3 PUFA being associated with higher risk of allergic diseases with positive SPT in offspring was observed. These findings do not support the hypothesis that the risk of early childhood allergic diseases is modified by variation in maternal n-3 and n-6 PUFA status during pregnancy in an Asian population.
Contributors
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- By Dor Abrahamson, Jerry Andriessen, Roger Azevedo, Michael Baker, Ryan Baker, Sasha Barab, Carl Bereiter, Susan Bridges, Mario Carretero, Carol K. K. Chan, Clark A. Chinn, Paul Cobb, Allan Collins, Kevin Crowley, Elizabeth A. Davis, Chris Dede, Sharon J. Derry, Andrea A. diSessa, Michael Eisenberg, Yrjö Engeström, Noel Enyedy, Barry J. Fishman, Ricki Goldman, James G. Greeno, Erica Rosenfeld Halverson, Cindy E. Hmelo-Silver, Michael J. Jacobson, Sanna Järvelä, Yasmin B. Kafai, Yael Kali, Manu Kapur, Paul A. Kirschner, Karen Knutson, Timothy Koschmann, Joseph S. Krajcik, Carol D. Lee, Peter Lee, Robb Lindgren, Jingyan Lu, Richard E. Mayer, Naomi Miyake, Na’ilah Suad Nasir, Mitchell J. Nathan, Narcis Pares, Roy Pea, James W. Pellegrino, William R. Penuel, Palmyre Pierroux, Brian J. Reiser, K. Ann Renninger, Ann S. Rosebery, R. Keith Sawyer, Marlene Scardamalia, Anna Sfard, Mike Sharples, Kimberly M. Sheridan, Bruce L. Sherin, Namsoo Shin, George Siemens, Peter Smagorinsky, Nancy Butler Songer, James P. Spillane, Kurt Squire, Gerry Stahl, Constance Steinkuehler, Reed Stevens, Daniel Suthers, Iris Tabak, Beth Warren, Uri Wilensky, Philip H. Winne, Carmen Zahn
- Edited by R. Keith Sawyer, University of North Carolina, Chapel Hill
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- Book:
- The Cambridge Handbook of the Learning Sciences
- Published online:
- 05 November 2014
- Print publication:
- 17 November 2014, pp xv-xviii
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Contact line dynamics and boundary layer flow during reflection of a solitary wave
- Yong Sung Park, Philip L.-F. Liu, I-Chi Chan
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- Journal:
- Journal of Fluid Mechanics / Volume 707 / 25 September 2012
- Published online by Cambridge University Press:
- 13 July 2012, pp. 307-330
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In this paper we present a set of wave flume experiments for a solitary wave reflecting off a vertical wall. A particle tracking velocimetry (PTV) technique is used to measure free-surface velocity and the velocity field in the vicinity of the moving contact line. We observe that the free surface undergoes the so-called rolling motion as the contact line moves up and down the vertical wall, and fluid particles on the free surface almost always flow toward the wall except at the end of the reflection process. As the contact line descends along the wall, wall boundary layer flows move in a downward direction and therefore the boundary layer acts like a conduit through which the surface-rolling-induced flow escapes from the meniscus. However, during the last phase of the reflection process flow reversal occurs inside the wall boundary layer. An approximate analytical solution is developed to explain the flow reversal feature. Very good agreement between the approximate theory and measured data is obtained. Because of the flow reversal, boundary layer flows collide with the surface-rolling-induced flows. The collision gives rise to a jet ejecting from the meniscus into the water body, which later evolves into a small eddy. It is noticed that the fluid particles in different regions such as the free stream, the free-surface boundary layer and the wall boundary layer, can be transported to other regions by passing through the meniscus.
Long waves through emergent coastal vegetation
- Chiang C. Mei, I-Chi Chan, Philip L.-F. Liu, Zhenhua Huang, Wenbin Zhang
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- Journal:
- Journal of Fluid Mechanics / Volume 687 / 25 November 2011
- Published online by Cambridge University Press:
- 14 October 2011, pp. 461-491
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We study the effects of emergent coastal forests on the propagation of long surface waves of small amplitude. The forest is idealized by an array of vertical cylinders. Simple models are employed to represent bed friction and to simulate turbulence generated by flow through the tree trunks. A multi-scale (homogenization) analysis similar to that for seepage flows is carried out to deduce the effective equations on the macro-scale. The effective coefficients are calculated by numerically solving the micro-scale problem in a unit cell surrounding one or several cylinders. Analytical and numerical solutions for wave attenuation on the macro-scale for different bathymetries and coastal forest configurations are presented. For a transient incident wave, analytical results are discussed for the damping of a leading tsunami. For comparison series of laboratory data for periodic and transient incident waves are also presented. Good agreement is found even though some of the measured waves are short or nonlinear.
Contributors
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- By Aakash Agarwala, Linda S. Aglio, Rae M. Allain, Paul D. Allen, Houman Amirfarzan, Yasodananda Kumar Areti, Amit Asopa, Edwin G. Avery, Patricia R. Bachiller, Angela M. Bader, Rana Badr, Sibinka Bajic, David J. Baker, Sheila R. Barnett, Rena Beckerly, Lorenzo Berra, Walter Bethune, Sascha S. Beutler, Tarun Bhalla, Edward A. Bittner, Jonathan D. Bloom, Alina V. Bodas, Lina M. Bolanos-Diaz, Ruma R. Bose, Jan Boublik, John P. Broadnax, Jason C. Brookman, Meredith R. Brooks, Roland Brusseau, Ethan O. Bryson, Linda A. Bulich, Kenji Butterfield, William R. Camann, Denise M. Chan, Theresa S. Chang, Jonathan E. Charnin, Mark Chrostowski, Fred Cobey, Adam B. Collins, Mercedes A. Concepcion, Christopher W. Connor, Bronwyn Cooper, Jeffrey B. Cooper, Martha Cordoba-Amorocho, Stephen B. Corn, Darin J. Correll, Gregory J. Crosby, Lisa J. Crossley, Deborah J. Culley, Tomas Cvrk, Michael N. D'Ambra, Michael Decker, Daniel F. Dedrick, Mark Dershwitz, Francis X. Dillon, Pradeep Dinakar, Alimorad G. Djalali, D. John Doyle, Lambertus Drop, Ian F. Dunn, Theodore E. Dushane, Sunil Eappen, Thomas Edrich, Jesse M. Ehrenfeld, Jason M. Erlich, Lucinda L. Everett, Elliott S. Farber, Khaldoun Faris, Eddy M. Feliz, Massimo Ferrigno, Richard S. Field, Michael G. Fitzsimons, Hugh L. Flanagan Jr., Vladimir Formanek, Amanda A. Fox, John A. Fox, Gyorgy Frendl, Tanja S. Frey, Samuel M. Galvagno Jr., Edward R. Garcia, Jonathan D. Gates, Cosmin Gauran, Brian J. Gelfand, Simon Gelman, Alexander C. Gerhart, Peter Gerner, Omid Ghalambor, Christopher J. Gilligan, Christian D. Gonzalez, Noah E. Gordon, William B. Gormley, Thomas J. Graetz, Wendy L. Gross, Amit Gupta, James P. Hardy, Seetharaman Hariharan, Miriam Harnett, Philip M. Hartigan, Joaquim M. Havens, Bishr Haydar, Stephen O. Heard, James L. Helstrom, David L. Hepner, McCallum R. Hoyt, Robert N. Jamison, Karinne Jervis, Stephanie B. Jones, Swaminathan Karthik, Richard M. Kaufman, Shubjeet Kaur, Lee A. Kearse Jr., John C. Keel, Scott D. Kelley, Albert H. Kim, Amy L. Kim, Grace Y. Kim, Robert J. Klickovich, Robert M. Knapp, Bhavani S. Kodali, Rahul Koka, Alina Lazar, Laura H. Leduc, Stanley Leeson, Lisa R. Leffert, Scott A. LeGrand, Patricio Leyton, J. Lance Lichtor, John Lin, Alvaro A. Macias, Karan Madan, Sohail K. Mahboobi, Devi Mahendran, Christine Mai, Sayeed Malek, S. Rao Mallampati, Thomas J. Mancuso, Ramon Martin, Matthew C. Martinez, J. A. Jeevendra Martyn, Kai Matthes, Tommaso Mauri, Mary Ellen McCann, Shannon S. McKenna, Dennis J. McNicholl, Abdel-Kader Mehio, Thor C. Milland, Tonya L. K. Miller, John D. Mitchell, K. Annette Mizuguchi, Naila Moghul, David R. Moss, Ross J. Musumeci, Naveen Nathan, Ju-Mei Ng, Liem C. Nguyen, Ervant Nishanian, Martina Nowak, Ala Nozari, Michael Nurok, Arti Ori, Rafael A. Ortega, Amy J. Ortman, David Oxman, Arvind Palanisamy, Carlo Pancaro, Lisbeth Lopez Pappas, Benjamin Parish, Samuel Park, Deborah S. Pederson, Beverly K. Philip, James H. Philip, Silvia Pivi, Stephen D. Pratt, Douglas E. Raines, Stephen L. Ratcliff, James P. Rathmell, J. Taylor Reed, Elizabeth M. Rickerson, Selwyn O. Rogers Jr., Thomas M. Romanelli, William H. Rosenblatt, Carl E. Rosow, Edgar L. Ross, J. Victor Ryckman, Mônica M. Sá Rêgo, Nicholas Sadovnikoff, Warren S. Sandberg, Annette Y. Schure, B. Scott Segal, Navil F. Sethna, Swapneel K. Shah, Shaheen F. Shaikh, Fred E. Shapiro, Torin D. Shear, Prem S. Shekar, Stanton K. Shernan, Naomi Shimizu, Douglas C. Shook, Kamal K. Sikka, Pankaj K. Sikka, David A. Silver, Jeffrey H. Silverstein, Emily A. Singer, Ken Solt, Spiro G. Spanakis, Wolfgang Steudel, Matthias Stopfkuchen-Evans, Michael P. Storey, Gary R. Strichartz, Balachundhar Subramaniam, Wariya Sukhupragarn, John Summers, Shine Sun, Eswar Sundar, Sugantha Sundar, Neelakantan Sunder, Faraz Syed, Usha B. Tedrow, Nelson L. Thaemert, George P. Topulos, Lawrence C. Tsen, Richard D. Urman, Charles A. Vacanti, Francis X. Vacanti, Joshua C. Vacanti, Assia Valovska, Ivan T. Valovski, Mary Ann Vann, Susan Vassallo, Anasuya Vasudevan, Kamen V. Vlassakov, Gian Paolo Volpato, Essi M. Vulli, J. Matthias Walz, Jingping Wang, James F. Watkins, Maxwell Weinmann, Sharon L. Wetherall, Mallory Williams, Sarah H. Wiser, Zhiling Xiong, Warren M. Zapol, Jie Zhou
- Edited by Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman
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- Book:
- Essential Clinical Anesthesia
- Published online:
- 05 January 2012
- Print publication:
- 11 July 2011, pp xv-xxviii
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Peripheral Venous Catheter-Related Staphylococcus aureus Bacteremia
- T. Tony Trinh, Philip A. Chan, Omega Edwards, Brian Hollenbeck, Brian Huang, Nancy Burdick, Julie A. Jefferson, Leonard A. Mermel
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 32 / Issue 6 / June 2011
- Published online by Cambridge University Press:
- 02 January 2015, pp. 579-583
- Print publication:
- June 2011
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Objective.
Better understand the incidence, risk factors, and outcomes of peripheral venous catheter (PVC)-related Staphylococcus aureus bacteremia.
Design.Retrospective study of PVC-related S. aureus bacteremias in adult patients from July 2005 through March 2008. A point-prevalence survey was performed January 9, 2008, on adult inpatients to determine PVC utilization; patients with a PVC served as a cohort to assess risk factors for PVC-related S. aureus bacteremia.
Setting.Tertiary care teaching hospital.
Results.Twenty-four (18 definite and 6 probable) PVC-related S. aureus bacteremias were identified (estimated incidence density, 0.07 per 1,000 catheter-days), with a median duration of catheterization of 3 days (interquartile range, 2-6). Patients with PVC-related S. aureus bacteremia were significantly more likely to have a PVC in the antecubital fossa (odds ratio [OR], 6.5), a PVC placed in the emergency department (OR, 6.0), or a PVC placed at an outside hospital (P = .005), with a longer duration of catheterization (P < .001). These PVCs were significantly less likely to have been inserted in the hand (OR, 0.23) or placed on an inpatient medical unit (OR, 0.17). Mean duration of antibiotic treatment was 19 days (95% confidence interval, 15-23 days); 42% (10/24) of cases encountered complications. We estimate that there may be as many as 10,028 PVC-related S. aureus bacteremias yearly in US adult hospitalized inpatients.
Conclusion.PVC-related S. aureus bacteremia is an underrecognized complication. PVCs inserted in the emergency department or at outside institutions, PVCs placed in the antecubital fossa, and those with prolonged dwell times are associated with such infections.
Responses of Bingham-plastic muddy seabed to a surface solitary wave
- I-CHI CHAN, PHILIP L.-F. LIU
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- Journal:
- Journal of Fluid Mechanics / Volume 618 / 10 January 2009
- Published online by Cambridge University Press:
- 10 January 2009, pp. 155-180
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In this paper, we investigate the dynamics of muddy-seabed motions induced by a surface solitary wave. The muddy seabed is characterized as Bingham-plastic mud. We focus our attention on the situations where the horizontal scale of the wave-induced mud flow is much larger than the vertical scale. The thickness of the mud layer is also assumed to be much smaller than the water depth above. With these simplifications, the dynamic pressure in the mud column remains a constant and the vertical displacement of the water–mud interface is negligible. The horizontal gradient of the wave-induced dynamic pressure along the water–seabed interface drives the motions in the mud bed. For a Bingham-plastic muddy seafloor, the mud moves either like a solid (plug flow) or like a viscous fluid (shear flow) depending on whether the magnitude of shear stress is in excess of the yield stress. Velocities inside these two different flow regimes and the location(s) of the yield surface(s) vary in time as functions of water–mud interfacial pressure gradient and the properties of the Bingham-plastic mud. A semi-analytical approach is developed in this paper to analyse the motions inside the mud bed under a surface solitary wave loading. Three possible scenarios are discussed to illustrate the complexity of the seafloor responses. The formula for the damping rate caused by the energy dissipation inside the muddy seabed is also derived. Using realistic values of the physical parameters, the present results for damping rate agree qualitatively with the available field observations.
On long-wave propagation over a fluid-mud seabed
- PHILIP L.-F. LIU, I-CHI CHAN
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- Journal:
- Journal of Fluid Mechanics / Volume 579 / 25 May 2007
- Published online by Cambridge University Press:
- 02 May 2007, pp. 467-480
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Using the Boussinesq approximation, a set of depth-integrated wave equations for long-wave propagation over a mud bed is derived. The wave motions above the mud bed are assumed to be irrotational and the mud bed is modelled as a highly viscous fluid. The pressure and velocity are required to be continuous across the water–mud interface. The resulting governing equations are differential–integral equations in terms of the depth-integrated horizontal velocity and the free-surface displacement. The effects of the mud bed appear in the continuity equation in the form of a time integral of weighted divergence of the depth-averaged velocity. Damping rates for periodic waves and solitary waves are calculated. For the solitary wave case, the velocity profiles in the water column and the mud bed at different phases are discussed. The effects of the viscous boundary layer above the mud–water interface are also examined.