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Interviews with 22 home-based primary care (HBPC) clinicians revealed that infectious disease physicians and clinical pharmacists facilitate infection management and antibiotic selection, respectively, and that local initiatives within programs support antibiotic prescribing decisions. Interventions that facilitate specialist engagement and tailored approaches that address the unique challenges of HBPC are needed.
The regent honeyeater Anthochaera phrygia is a Critically Endangered Australian songbird, with current population estimates of < 300 individuals remaining in the wild. Low nest success is a factor preventing the recovery of the population, and management remedies are needed. However, a lack of data on intervention success raises uncertainty and impedes planning. To identify management priorities under uncertainty, we engaged with conservation practitioners and key stakeholders to develop and evaluate potential nest protection interventions. Four categories of threats were considered: avian predators, mammalian predators, extreme weather events and avian competitors. The interventions with the highest predicted probabilities of nest success under each threat category were, respectively: lethal control of avian predators, the use of tree collars to control arboreal mammalian predators, the provisioning of supplementary food and nesting resources during extreme weather events, and control of the noisy miner Manorina melanocephala, a competitor species. Our analysis shows that by applying a combination of conservation actions alongside improvements in nest detection, it is possible, based on the opinion of experts, to provide a pathway for the recovery of the regent honeyeater.
Originating from a unique partnership between data scientists (datavaluepeople) and peacebuilders (Build Up), this commentary explores an innovative methodology to overcome key challenges in social media analysis by developing customized text classifiers through a participatory design approach, engaging both peace practitioners and data scientists. It advocates for researchers to focus on developing frameworks that prioritize being usable and participatory in field settings, rather than perfect in simulation. Focusing on a case study investigating the polarization within online Christian communities in the United States, we outline a testing process with a dataset consisting of 8954 tweets and 10,034 Facebook posts to experiment with active learning methodologies aimed at enhancing the efficiency and accuracy of text classification. This commentary demonstrates that the inclusion of domain expertise from peace practitioners significantly refines the design and performance of text classifiers, enabling a deeper comprehension of digital conflicts. This collaborative framework seeks to transition from a data-rich, analysis-poor scenario to one where data-driven insights robustly inform peacebuilding interventions.
With the decline of the Western framing of the war on terror (WoT) in security discourse, it has become commonplace to note the ‘return’ of great power politics. But under-analysed so far have been the nuclear dimensions of this trend. This is important because we are on the cusp of a multipolar order where the ‘poles of power’ are nuclear-armed. We outline the ways in which almost 30 years of perceptions of unipolarity, and particularly the focus on ‘rogue’ and non-state (nuclear) terrorism post 9/11 on the part of Western policy practitioners, analysts, and scholars, allowed for the previous focus on the threat of nuclear war to be supplanted by a wider ‘nuclear security’ agenda. We unpack the return of nuclear threats and risk-taking in the Euro-Atlantic, the nuclear deterrence balance in the Western Pacific, and the emergence of a non-aligned nuclear great power in the Global South. While we argue that managing the dangers of the return of nuclear great power politics will require a dual approach drawing lessons from both from the Cold War ‘balance of terror’ and from an earlier era of a multipolar ‘balance of power’, many key dynamics from the WoT years remain.
We present the Sydney Radio Star Catalogue, a new catalogue of stars detected at megahertz to gigahertz radio frequencies. It consists of 839 unique stars with 3 405 radio detections, more than doubling the previously known number of radio stars. We have included stars from large area searches for radio stars found using circular polarisation searches, cross-matching, variability searches, and proper motion searches as well as presenting hundreds of newly detected stars from our search of Australian SKA Pathfinder observations. The focus of this first version of the catalogue is on objects detected in surveys using SKA precursor and pathfinder instruments; however, we will expand this scope in future versions. The 839 objects in the Sydney Radio Star Catalogue are distributed across the whole sky and range from ultracool dwarfs to Wolf-Rayet stars. We demonstrate that the radio luminosities of cool dwarfs are lower than the radio luminosities of more evolved sub-giant and giant stars. We use X-ray detections of 530 radio stars by the eROSITA soft X-ray instrument onboard the Spectrum Roentgen Gamma spacecraft to show that almost all of the radio stars in the catalogue are over-luminous in the radio, indicating that the majority of stars at these radio frequencies are coherent radio emitters. The Sydney Radio Star Catalogue can be found in Vizier or at https://radiostars.org.
The early essay in English was a fluid and malleable form. It was thus ‘fugitive’: it could be deeply topical, fleeting, and perishable, taking up the ephemeral and the occasional, and could easily travel across media from reader to reader given its portability. This chapter studies how writers exploited the affordances of the essay, first in seventeenth-century newsbooks and pamphlets, and then in early eighteenth-century periodicals. It retraces the origins of the English newsbook in a highly regulated media ecology, and examines the essayistic writings of Marchamont Nedham as a case study in stylistic innovation and rhetorical self-fashioning. During the era of licensing (1662–95) and the first decades of the eighteenth century, essayists continued to adapt the form, finding in the emergent print media of this period a ready site for politics and polemic.
Type 2 diabetes (T2DM) poses a significant public health challenge, with pronounced disparities in control and outcomes. Social determinants of health (SDoH) significantly contribute to these disparities, affecting healthcare access, neighborhood environments, and social context. We discuss the design, development, and use of an innovative web-based application integrating real-world data (electronic health record and geospatial files), to enhance comprehension of the impact of SDoH on T2 DM health disparities.
Methods:
We identified a patient cohort with diabetes from the institutional Diabetes Registry (N = 67,699) within the Duke University Health System. Patient-level information (demographics, comorbidities, service utilization, laboratory results, and medications) was extracted to Tableau. Neighborhood-level socioeconomic status was assessed via the Area Deprivation Index (ADI), and geospatial files incorporated additional data related to points of interest (i.e., parks/green space). Interactive Tableau dashboards were developed to understand risk and contextual factors affecting diabetes management at the individual, group, neighborhood, and population levels.
Results:
The Tableau-powered digital health tool offers dynamic visualizations, identifying T2DM-related disparities. The dashboard allows for the exploration of contextual factors affecting diabetes management (e.g., food insecurity, built environment) and possesses capabilities to generate targeted patient lists for personalized diabetes care planning.
Conclusion:
As part of a broader health equity initiative, this application meets the needs of a diverse range of users. The interactive dashboard, incorporating clinical, sociodemographic, and environmental factors, enhances understanding at various levels and facilitates targeted interventions to address disparities in diabetes care and outcomes. Ultimately, this transformative approach aims to manage SDoH and improve patient care.
The world faces a forced displacement crisis. Tens of millions of individuals have been forced across international boundaries worldwide. Therefore, the causes and consequences of refugee flows are the subjects of significant social science inquiry. Unfortunately, the historical lack of reliable data on actual refugee flows, country-specific data reporting timelines, and more general pre-2000 data quality issues have significantly limited empirical inferences on these topics. We replicate 28 articles on these topics using data newly released after a multiyear collaboration with the United Nations on annual dyadic flows. We observe major inconsistencies between the newly released flow numbers and the stock-based flow estimates upon which decades of research are based; we also find widespread inappropriate treatment of missing historical values. When we replicate the existing literature using the newly introduced flow data, correcting the treatment of missing historical values, and temporally extending/restricting the study periods, we produce significantly different results.
Crimean–Congo haemorrhagic fever virus (CCHFV) is an emerging viral pathogen with pandemic potential that is often misdiagnosed. Case fatality in low-resource settings could be up to 40% due to close contact between animals and humans. A two-year cross-sectional study was conducted in Fagge abattoir, Kano State, Nigeria, to estimate the seropositivity of CCHFV in camels using a commercial multi-species competitive enzyme-linked immunosorbent assay (ELISA). A closed-ended questionnaire was administered to the abattoir workers to assess their awareness, mitigation, and behavioural practices associated with CCHF. Of the 184 camels tested, 179 (97%) were seropositive for CCHFV (95% confidence interval (CI): 93.77, 99.11). The median (interquartile range (IQR)) age of respondents was 41 (35–52), with 62% having no education. Respondents had little knowledge about CCHFV and the concept of zoonotic disease. In this study, the high estimated prevalence of antibodies to CCHFV in camels highlights the heightened risk of transmission of CCHFV in Nigeria. Similarly, a concerning lack of knowledge and inadequate preventive practices, alongside a prevalence of high-risk behaviours associated with CCHF among abattoir workers, were noted in this study. Thus, there is an urgent need for comprehensive public health education and collaborative One Health strategies to avert the threats of spillover events.
This study investigates the impact of primary care utilisation of a symptom-based head and neck cancer risk calculator (Head and Neck Cancer Risk Calculator version 2) in the post-coronavirus disease 2019 period on the number of primary care referrals and cancer diagnoses.
Methods
The number of referrals from April 2019 to August 2019 and from April 2020 to July 2020 (pre-calculator) was compared with the number from the period January 2021 to August 2022 (post-calculator) using the chi-square test. The patients’ characteristics, referral urgency, triage outcome, Head and Neck Cancer Risk Calculator version 2 score and cancer diagnosis were recorded.
Results
In total, 1110 referrals from the pre-calculator period were compared with 1559 from the post-calculator period. Patient characteristics were comparable for both cohorts. More patients were referred on the cancer pathway in the post-calculator cohort (pre-calculator patients 51.1 per cent vs post-calculator 64.0 per cent). The cancer diagnosis rate increased from 2.7 per cent in the pre-calculator cohort to 3.3 per cent in the post-calculator cohort. A lower rate of cancer diagnosis in the non-cancer pathway occurred in the cohort managed using the Head and Neck Cancer Risk Calculator version 2 (10 per cent vs 23 per cent, p = 0.10).
Conclusion
Head and Neck Cancer Risk Calculator version 2 demonstrated high sensitivity in cancer diagnosis. Further studies are required to improve the predictive strength of the calculator.
Whole-body tissue protein turnover is regulated, in part, by the postprandial rise in plasma amino acid concentrations, although minimal data exist on the amino acid response following non-animal-derived protein consumption. We hypothesised that the ingestion of novel plant- and algae-derived dietary protein sources would elicit divergent plasma amino acid responses when compared with vegan- and animal-derived control proteins. Twelve healthy young (male (m)/female (f): 6/6; age: 22 ± 1 years) and 10 healthy older (m/f: 5/5; age: 69 ± 2 years) adults participated in a randomised, double-blind, cross-over trial. During each visit, volunteers consumed 30 g of protein from milk, mycoprotein, pea, lupin, spirulina or chlorella. Repeated arterialised venous blood samples were collected at baseline and over a 5-h postprandial period to assess circulating amino acid, glucose and insulin concentrations. Protein ingestion increased plasma total and essential amino acid concentrations (P < 0·001), to differing degrees between sources (P < 0·001), and the increase was further modulated by age (P < 0·001). Postprandial maximal plasma total and essential amino acid concentrations were highest for pea (2828 ± 106 and 1480 ± 51 µmol·l−1) and spirulina (2809 ± 99 and 1455 ± 49 µmol·l−1) and lowest for chlorella (2053 ± 83 and 983 ± 35 µmol·l−1) (P < 0·001), but were not affected by age (P > 0·05). Postprandial total and essential amino acid availabilities were highest for pea, spirulina and mycoprotein and lowest for chlorella (all P < 0·05), but no effect of age was observed (P > 0·05). The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age.
What if the formulation Heidegger and Literature were turned into question? What if, rather than asking about an assumed relation, the relation was problematized? Rather than linking Heidegger to the proper names of literature – as though such names as Mann, Trakl, Hölderlin, Sophocles etc., had an assumed and already determined status – what would then endure in each moment would be the presence of that relation as a question. Retaining the question would open up fields of genuine investigation. Hence the point of departure would be less Heidegger and Literature and more Heidegger and Literature? A question to which responses were not just awaited, more significantly each response would have a transformative effect both on how ‘Heidegger’ then figured and ‘Literature’ was itself understood. In other words, allowing for the endurance of the question – Heidegger and Literature? – undoes the possibility that there is a singular Heidegger that is then connected and reconnected to differing instances of the literary. Part of the significance of the chapters comprising this volume is that not only does the question of literature (and its complex relation to poetry) continue to be reconfigured, it is also the case that those processes of reconfiguration reposition Heidegger; again, a repositioning that allows for a type of plurality to attend the proper name. A cautionary word needs to be introduced here. This is not a plurality that refuses the possibility of judgement. On the contrary, it is a conception of plurality that demands that the stakes of judgement be allocated an exacting precision.