Dunbar proposes strategies to solve the fragmentation problem experienced by group-living animals. We highlight that bondedness not only mitigates stress but also provides structural scaffolding for group stability. Furthermore, we posit tolerance as a complementary mechanism smoothing social interactions and argue that variation in cohesion-promoting traits reflects context-dependent socio-ecological pressures, challenging static models linking sociality to cognition. Finally, we propose two further mechanisms—cultural transmission and dominance dynamics—that can enhance social cohesion by aligning behaviour and reducing uncertainty.

Humans show remarkable differences in social behaviour between families, groups, communities and cultures, whereas such group-level within-species variation in socio-behavioural propensities is typically overlooked in other species. Studies on intraspecific variation in animal social structures are needed to inform an evolutionary account of human sociality. Here, we study multiple independent bonobo populations (n = 6) in zoological settings to investigate if and how bonobos (n = 70) show group-specific signatures in sociality. By applying tailored Bayesian statistical methods, we find that beyond individual and dyadic variation, the groups substantially differ from each other in core dimensions of great ape sociality: social proximity, grooming and play. Moreover, the groups’ network structures are distinct regarding cohesiveness and clustering, with some groups forming cohesive wholes, while others showcasing high levels of sub-grouping. Overall, while there is consistent evidence of differences in sociality between the groups, the patterns of cohesiveness and clustering are not consistent across the networks. This suggests that rather than groups having different levels of sociality, different patterns of sociality exist in each group. These findings warrant caution with characterising bonobos’ behavioural phenotype at the species level, and identify an essential source of variation that needs to be integrated in phylogenetic analyses.

The opportunity to perform play behaviour may be an important ontogenic activity that stimulates behavioural variability and may enhance an individual's coping capacity later in life. Play behaviour in juveniles may be enhanced by the presence of cage enrichments relevant to the animal's motivations and natural behavioural repertoire. The present study aimed to investigate play behaviour in juvenile farmed mink reared and housed with the cage enrichments standard for the Dutch housing system (ie a cylinder and platform) and in an experimental group of animals with the same standard enrichments but with additional access to swimming water. Juvenile mink with access to swimming water played significantly more in the main cage than mink reared and housed with the cylinder and platform but without swimming water. The results suggest that swimming water presents the animals with biologically relevant stimuli that directly or indirectly influence the development of play behaviour. Specific implications for the animals' long-term welfare are discussed. Future studies should elucidate the effects of juvenile play on the occurrence of abnormal behavioural patterns in adulthood more precisely and more thoroughly.

We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain (${\sim}2.8\,\mbox{K Jy}^{-1}$) low-system temperature (${\sim}18\,\mbox{K at }20\,\mbox{cm}$) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar $\mbox{J}0737{-}3039\mbox{A}$, pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR $\mbox{J}0540{-}6919$, and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR $\mbox{J}2241{-}5236$ exhibits a jitter limit of $<4\,\mbox{ns h}^{-1}$ whilst timing of PSR $\mbox{J}1909{-}3744$ over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities.

Gaia DR2 was released in April 2018 and contains a photometric catalogue of more than 1 billion sources. This release contains colour information in the form of integrated BP and RP photometry in addition to the latest G-band photometry. The level of uncertainty can be as good as 2 mmag with some residual systematics at the 10 mmag level. The addition of colour information greatly enhances the value of the photometric data for the scientific community. A high level overview of the photometric processing, with a focus on the improvements with respect to Gaia DR1, was given. The definition of the Gaia photometric system, a crucial part of the calibration of the photometry, was also explained. Finally, some of the photometric improvements expected for the next data release were described.

PSR B1828–11 is a young pulsar once thought to be undergoing free precession and recently found instead to be switching magnetospheric states in tandem with spin-down changes. Here we show the two extreme states of the mode-changing found for this pulsar and comment briefly on its interpretation.

Humans colonized the Balearic Islands 5–4 ka ago. They arrived in a uniquely adapted ecosystem with the Balearic mountain goat Myotragus balearicus (Bovidae, Antilopinae, Caprini) as the only large mammal. This mammal went extinct rapidly after human arrival. Several hypotheses have been proposed to explain the extinction of M. balearicus. For the present study ancient DNA analysis (Sanger sequencing, Roche-454, Ion Torrent), and pollen and macrofossil analyses were performed on preserved coprolites from M. balearicus, providing information on its diet and paleo-environment. The information retrieved shows that M. balearicus was heavily dependent on the Balearic box species Buxus balearica during at least part of the year, and that it was most probably a browser. Hindcast ecological niche modelling of B. balearica shows that local distribution of this plant species was affected by climate changes. This suggests that the extinction of M. balearicus can be related to the decline and regional extinction of a plant species that formed a major component of its diet. The vegetation change is thought to be caused by increased aridity occurring throughout the Mediterranean. Previous hypotheses relating the extinction of M. balearicus directly to the arrival of humans on the islands must therefore be adjusted.

Time-stratigraphic interpretations of Late Pliocene to Early Pleistocene sediments from onshore locations and from marginal marine settings of the North Sea Basin often refer to the subdivision of the Dutch and British ’Quaternary’ regional stratigraphic stages. Since age control for these stages and their stage boundaries are based on relative dating methods, in this study pollen, dinoflagellate cysts and foraminiferal assemblages were investigated to correlate the regional stratigraphic stages independently to the global chronostratigraphy and the paleomagnetic timescale. The data were obtained from eight boreholes located in the depocentre setting of the Late Pliocene North Sea Basin comprising a 1000 m thick sedimentary succession. The British Gedgravian and Waltonian stages, the Dutch Reuverian to Brunssumian as well as published foraminiferal zones (NSB 14, FB and the lower part of the FA2 zone) fall within the Zanclean and Piacenzian. The lower boundaries of the Pre-Ludhamian and Pretiglian stages and of the NSB 14 to 15 zones are close to the paleomagnetic Gauss-Matuyama boundary. The Pre-Ludhamian, Ludhamian, Thurnian and the Pretiglian, Tiglian A and Tiglian B stages presumably cover the marine isotope stages 103 to 95. It is proposed that the Ludhamian, Thurnian and the Tiglian A were short lasting, warm, periods during which sea level highstand facilitated sedimentary deposition at the marginal areas of the North Sea Basin. The lower boundary of the paleomagnetic Olduvai subchron is situated in the Tiglian Cl-4b stage while the TC4c stage is found within the Olduvai subchron. Foraminiferal NSB 15 and NSB 16 zone as well as the upper part of the FA2 and FA1 zone fall within the Gelasian and cover the Matuyama chron as well as the lower part of the Olduvai subchron. Comparison with formerly dated North Sea sediments shows a good agreement between foraminiferal zonations on a broader scale but significant differences in absolute ages occur. Strontium isotope values indicate approximately 1 Ma younger ages as expected from our chronostratigraphic model. This discrepancy is explained by the dominance of freshwater from river discharge contributing high amounts of eroded material to the basin, leading to an increase of the 87Sr/86Sr ratio in the shelf-sea water.

The Amsterdam glacial basin was a major sedimentary sink from late Saalian until late Eemian (Picea zone, E6) times. The basin’s exemplary record makes it a potential reference area for the last interglacial stage. The cored Amsterdam-Terminal borehole was drilled in 1997 to provide a record throughout the Eemian interglacial. Integrated facies analysis has resulted in a detailed reconstruction of the sedimentary history.

After the Saalian ice mass had disappeared from the area, a large, deep lake had come into being, fed by the Rhine river. At the end of the glacial, the lake became smaller because it was cut off from the river-water supply, and eventually only a number of shallow pools remained in the Amsterdam basin. During the early Eemian (Betula zone, El), a seepage lake existed at the site. The lake deepened under the influence of a steadily rising sea level and finally evolved into a silled lagoon (late Quercus zone, E3). Initially, the lagoon water had fairly stable stratification, but as the sea level continued to rise the sill lost its significance, the lagoon becoming well mixed by the middle of the Corylus/Taxus zone (E4b). The phase of free exchange with the open sea ended in the early Carpinus zone (E5), when barriers developed in the sill area causing the lagoon to become stratified again. During the Late Eemian (late E5), a more dynamic system developed. The sandy barriers that had obstructed exchange with the open sea were no longer effective, and a tidally-influenced coastal lagoon formed.

The Eemian sedimentary history shown in the Amsterdam-Terminal borehole is intimately connected with the sea-level history. Because the site includes both a high-resolution pollen signal and a record of sea-level change, it has potential for correlation on various scales. Palaeomagnetic results show that the sediments predate the Blake Event, which confirms that this reversal excursion is relatively young. The U/Th age of the uppermost part of the Eemian sequence is 118.2±6.3 ka.

Over the last ten to twenty years, geological surveys all over the world have been entangled in a process of digitisation. Their paper archives, built over many decades, have largely been replaced by electronic databases. The systematic production of geological map sheets is being replaced by 3D subsurface modelling, the results of which are distributed electronically. In the Netherlands, this transition is both being accelerated and concluded by a new law that will govern management and utilisation of subsurface information. Under this law, the Geological Survey of the Netherlands has been commissioned to build a key register for the subsurface: a single national database for subsurface data and information, which Dutch government bodies are obliged to use when making policies or decisions that pertain to, or can be affected by the subsurface. This requires the Survey to rethink and redesign a substantial part of its operation: from data acquisition and interpretation to delivery. It has also helped shape our view on geological surveying in the future.

The key register, which is expected to start becoming operational in 2015, will contain vast quantities of subsurface data, as well as their interpretation into 3D models. The obligatory consultation of the register will raise user expectations of the reliability of all information it contains, and requires a strong focus on confidence issues. Building the necessary systems and meeting quality requirements is our biggest challenge in the upcoming years. The next step change will be towards building 4D models, which represent not only geological conditions in space, but also processes in time such as subsidence, anthropogenic effects, and those associated with global change.

The prevalence of Chlamydia trachomatis varies between ethnic groups in The Netherlands. It is, however, unknown whether this is associated with specific serogroups. The objective of this study was to determine whether serogroup distribution is associated with ethnic origin in the region of The Hague, The Netherlands. Serogroups of 370 microbiologically confirmed C. trachomatis-positive samples were analysed. The samples were obtained from 247 women and 123 men between January and October 2008, of self-reported Dutch Caucasian, Dutch Antillean, Surinamese, N. African/Turkish or other descent. We observed a difference in serogroup distribution comparing Dutch Caucasian women to Dutch Antillean women (χ2 for distribution P = 0·035). Serogroup C was more common in Dutch Antillean women, whereas serogroup B was less common (P = 0·03). This difference was not observed for Dutch Antillean men. The observed difference in distribution of C. trachomatis serogroups between ethnic groups is relevant for further transmission studies.

Pharmaco-nutrients have beneficial effects on protective and immunological mechanisms in patients undergoing surgery, which are important for recovery after injury and in combating infectious agents. The aim of this review article was to outline the potential of the administration of nutritional substrates to surgical patients and the underlying mechanisms that make them particularly important in peri-operative care. Surgery causes a stress response, which has catabolic effects on the body's substrate stores. The amino acid glutamine is a stimulating agent for immune cells. It activates protective mechanisms through its role as a precursor for antioxidants and it improves the barrier function of the gut. Arginine also enhances the function of the immune system, since it is the substrate for T-lymphocytes. Furthermore, n-3 PUFA stabilise surgery-induced hyper-inflammation. Taurine is another substrate that may counteract the negative effects of surgical injury on acid–base balance and osmotic balance. These pharmaco-nutrients rapidly become deficient under the influence of surgical stress. Supplementation of these nutrients in surgical patients may restore their protective and immune-enhancing actions and improve clinical outcome. Moreover, pre-operative fasting is still common practice in the Western world, although fasting has a negative effect on the patient's condition and the recovery after surgery. This may be counteracted by a simple intervention such as administering a carbohydrate-rich supplement just before surgery. In conclusion, there are various nutritional substrates that may be of great value in improving the condition of the surgical patient, which may be beneficial for post-operative recovery.

In an extended twin study we estimated the heritability of fasting HbA1c and blood glucose levels. Blood glucose was assessed in different settings (at home and in the clinic). We tested whether the genetic factors influencing fasting blood glucose levels overlapped with those influencing HbA1c and whether the same genetic factors were expressed across different settings. Fasting blood glucose was measured at home and during two visits to the clinic in 77 healthy families with same-sex twins and siblings, aged 20 to 45 years. HbA1c was measured during the first clinic visit. A 4-variate genetic structural equation model was used that estimated the heritability of each trait and the genetic correlations among traits. Heritability explained 75% of the variance in HbA1c. The heritability of fasting blood glucose was estimated at 66% at home and lower in the clinic (57% and 38%). Fasting blood glucose levels were significantly correlated across settings (0.34 < r < 0.54), mostly due to a common set of genes that explained between 53% and 95% of these correlations. Correlations between HbA1c and fasting blood glucoses were low (0.11 < r < 0.23) and genetic factors influencing HbA1c and fasting glucose were uncorrelated. These results suggest that in healthy adults the genes influencing HbA1c and fasting blood glucose reflect different aspects of the glucose metabolism. As a consequence these two glycemic parameters can not be used interchangeably in diagnostic procedures or in studies attempting to find genes for diabetes. Both contribute unique (genetic) information.

In shock, organ perfusion is of vital importance because organ oxygenation is at risk. NO, the main endothelial-derived vasodilator, is crucial for organ perfusion and coronary patency. The availability of NO might depend on the balance between a substrate (arginine) and an inhibitor (asymmetric dimethylarginine; ADMA) of NO synthase. Therefore, we investigated the relationship of arginine, ADMA and their ratio with circulatory markers, disease severity, organ failure and mortality in shock patients. In forty-four patients with shock (cardiogenic n 17, septic n 27), we prospectively measured plasma arginine and ADMA at intensive care unit admission, Acute Physiology and Chronic Health Evaluation (APACHE) II-(predicted mortality) and Sequential Organ Failure Assessment (SOFA) score, and circulatory markers to investigate their relationship. Arginine concentration was decreased (34·6 (sd 17·9) μmol/l) while ADMA concentration was within the normal range (0·46 (sd 0·18) μmol/l), resulting in a decrease in the arginine:ADMA ratio. The ratio correlated with several circulatory markers (cardiac index, disseminated intravascular coagulation, bicarbonate, lactate and pH), APACHE II and SOFA score, creatine kinase and glucose. The arginine:ADMA ratio showed an association (OR 0·976, 95 % CI 0·963, 0·997, P = 0·025) and a diagnostic accuracy (area under the curve 0·721, 95 % CI 0·560, 0·882, P = 0·016) for hospital mortality, whereas the arginine or ADMA concentration alone or APACHE II-predicted mortality failed to do so. In conclusion, in shock patients, the imbalance of arginine and ADMA is related to circulatory failure, organ failure and disease severity, and predicts mortality. We propose a pathophysiological mechanism in shock: the imbalance of arginine and ADMA contributes to endothelial and cardiac dysfunction resulting in poor organ perfusion and organ failure, thereby increasing the risk of death.