Chondrichthyan teeth from a new locality in the Scottish Borders supply additional evidence of Early Carboniferous chondrichthyans in the UK. The interbedded dolostones and siltstones of the Ballagan Formation exposed along Whitrope Burn are interpreted as representing a restricted lagoonal environment that received significant amounts of land-derived sediment. This site is palynologically dated to the latest Tournaisian–early Viséan. The diverse dental fauna documented here is dominated by large crushing holocephalan toothplates, with very few, small non-crushing chondrichthyan teeth. Two new taxa are named and described. Our samples are consistent with worldwide evidence that chondrichthyan crushing faunas are common following the Hangenberg extinction event. The lagoonal habitat represented by Whitrope Burn may represent a temporary refugium that was host to a near-relict fauna dominated by large holocephalan chondrichthyans with crushing dentitions. Many of these had already become scarce in other localities by the Viséan and become extinct later in the Carboniferous. This fauna provides evidence of early endemism or niche separation within European chondrichthyan faunas at this time. This evidence points to a complex picture in which the diversity of durophagous chondrichthyans is controlled by narrow spatial shifts in niche availability over time.

Canadian hospitals were made aware of the risk of Mycobacterium chimaera infection associated with heater-cooler units (HCUs) through alerts issued by the US food and Drug Administration (FDA) and the US Centers for Disease Control and Prevention (CDC). In response, most hospitals conducted retrospective reviews for infections, informed exposed patients, and initiated a requirement for informed consent with HCU use.

Infect Control Hosp Epidemiol 2018;39:482–484

The far-reaching impact of post-traumatic stress disorder (PTSD) on a person's life is well documented, yet PTSD often goes undetected and untreated. Previous literature suggests that there may be particular challenges in assessing PTSD in children and adolescents. There is evidence that once PTSD has been identified, a trauma-focused cognitive behavioural therapy (TF-CBT) approach is effective at treating PTSD in young people. Where PTSD in adolescents presents in response to multiple traumas it may be necessary to make some modifications to treatment protocols. This might include offering more sessions, extending the stabilization period, addressing common trauma themes, and tackling additional issues that may arise beyond a simple PTSD presentation. This single-case quasi-experimental design (n = 1) details the assessment (phase A) and treatment with individualized TF-CBT (phase B) of previously undiagnosed PTSD in response to multiple events in an adolescent girl who had been seen by several mental health professionals previously. The paper is also a clinical case report, paying particular attention to how PTSD was assessed and what other factors, for example emotion regulation, self-esteem and relationships, were found to be important. Trauma, anxiety and depression were measured with the Child PTSD Symptom Scale and the Revised Children's Anxiety and Depression Scale. Scores reduced from clinically significant to non-clinical levels by the end of treatment, with these gains being maintained at 3-month follow-up. Suggestions are made around assessing and treating trauma responses in young people, especially where PTSD exists in response to multiple traumas.

Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.

U–Pb ages of zircon from bentonites within the upper Cretaceous Bastion Ridge and Kanguk formations, Sverdrup Basin, provide constraints on sedimentation rates, biostratigraphic correlations, timing of Oceanic Anoxic Event 2 (OAE2) in the High Arctic, and the late magmatic history of the High Arctic Large Igneous Province (HALIP). A late Cenomanian to early Turonian age for the base of the Kanguk Formation is confirmed that supports correlations of the global OAE2 in the High Arctic. Sedimentation rates varied from 19 m Ma−1 between 93 and 91 Ma to 26 m Ma−1 between 91 and 83 Ma at Axel Heiberg Island. At Ellef Ringnes Island, the lower Kanguk Formation records high rates of ~70 m Ma−1 between 94 and 93 Ma, which decrease to rates comparable to those of the upper Axel Heiberg section. Differences in sedimentation rates may reflect differences in setting prior to the major transgression in the latest Cenomanian to early Turonian. The timing of Arctic occurrences of the Scaphites nigricollensis and Scaphites depressus ammonite zones is shown to be broadly comparable to that of lower-latitude occurrences within the Western Interior Seaway. An eruption frequency of 0.5–2.5 Ma characterizes the late alkaline phase of HALIP magmatism. Volcanic bed thicknesses of 10–50 cm suggest ash transport distances of less than 1000 km. Long-lived volcanic centres, in the area of the Alpha Ridge, northern Ellesmere Island or northern Greenland, were the likely source of volcanic ash over a period of 10–15 Ma.

“From a tiny stream grows a mighty flood ...”

At the end of 1966 U.S. direct investment in South Africa was $490 million. Ten years later the dollar value of U.S. direct investment had more than trebled, reaching a figure of at least $1.67 billion by 1976.

One of the major problems for anyone trying to understand United States-South Africa policy and relationships is the long established tradition of double talking. To find the truth it is necessary to penetrate behind the coded language and to recognize a series of myths which serve to cloak a far more unpleasant reality.

Background: Few studies have examined the acceptability and usefulness of enhanced cognitive behavioural therapy (CBT-E) for adolescents with eating disorders (EDs). Aim: To investigate whether CBT-E was an acceptable and efficacious treatment for an adolescent presenting to a routine clinical service with an ED. Method: Daily self-monitoring records were completed during a baseline (A) and intervention (B) phase in addition to routine outcome measures. Results: There were reductions in both ED behaviours and “feeling fat”, and increases in weight after 11 CBT-E sessions. Progress was only partially maintained at 8-month follow-up. Conclusion: CBT-E may be an acceptable and useful intervention for adolescents with EDs.