Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 – 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 – 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 – 7 months after the residual specimen collection. Specimens were tested for IgG antibodies to measles and rubella viruses. Measles and rubella seroprevalence estimates using facility-based specimens were 99% and 92%, respectively, with men having significantly lower rubella seropositivity than women. Age-specific measles and rubella seroprevalence estimates were similar between the two specimen sources. Although measles seropositivity was slightly higher among adults attending the facilities, both facility and community measles seroprevalence estimates were 95% or higher. The similarity in measles and rubella seroprevalence estimates between the community-based and facility serosurveys highlights the potential value of residual specimens to approximate community seroprevalence.

Experiments were conducted to assess the impact of crown architecture on light availability beneath the trees, flowering, fruiting, yield and quality of jamun (Syzygium cumini [L.] Skeels). Trees were maintained as control, palmette and open centre crown. Impact was evaluated for three consecutive years, i.e. 2017–2019. Diffuse light beneath the trees ranged from 69.7 ± 2.22 to 45.9 ± 1.45%, whereas direct light varied from 30.4 ± 0.97 to 54.1 ± 1.78%. At flowering and fruit development stage (June), photosynthesis rate (A) in control trees was 12.5 ± 0.43 μmol CO2/m2/s; however, at fruit maturity and dormancy (August), it was only 9.5 ± 0.35 μmol CO2/m2/s. Similarly, in palmette and open centre trees, photosynthesis rate at flowering and fruit development stage was 13.5 ± 0.46 and 15.7 ± 0.54 μmol CO2/m2/s, respectively; whereas at fruit maturity and dormancy, photosynthesis rate dropped to 10.5 ± 0.39 and 11.7 ± 0.43 μmol CO2/m2/s, respectively. Substantial variation in stomatal conductance (gs), vapour pressure deficit (VPD) and transpiration rate (E) was also found. Days to start flowering ranged from 92 ± 0.33 to 98 ± 0.33. Similarly, days to end flowering varied from 99 ± 0.07 to 107 ± 0.36, days to fruit set 132 ± 0.33 to 139 ± 0.33 and days to fruit maturity 176 ± 0.48 to 184 ± 0.63. Significant variation in fruit length, fruit width and fruit weight was also found. Total soluble solids in fruit pulp varied from 9.0 ± 0.15 to 12.2 ± 0.149°Brix and fruit yield 62.3 ± 1.5 to 86.7 ± 1.33 kg per tree. Noteworthy variation in fruit quality traits was also recorded. This study illustrates that crown architecture has considerable impact on gas exchange parameters, flowering, fruiting, yield and quality of jamun.

Residual blood specimens provide a sample repository that could be analyzed to estimate and track changes in seroprevalence with fewer resources than household-based surveys. We conducted parallel facility and community-based cross-sectional serological surveys in two districts in India, Kanpur Nagar District, Uttar Pradesh, and Palghar District, Maharashtra, before and after a measles-rubella supplemental immunization activity (MR-SIA) from 2018 to 2019. Anonymized residual specimens from children 9 months to younger than 15 years of age were collected from public and private diagnostic laboratories and public hospitals and tested for IgG antibodies to measles and rubella viruses. Significant increases in seroprevalence were observed following the MR SIA using the facility-based specimens. Younger children whose specimens were tested at a public facility in Kanpur Nagar District had significantly lower rubella seroprevalence prior to the SIA compared to those attending a private hospital, but this difference was not observed following the SIA. Similar increases in rubella seroprevalence were observed in facility-based and community-based serosurveys following the MR SIA, but trends in measles seroprevalence were inconsistent between the two specimen sources. Despite challenges with representativeness and limited metadata, residual specimens can be useful in estimating seroprevalence and assessing trends through facility-based sentinel surveillance.

Face milling is performed on aluminum alloy A96061-T6 at diverse cutting parameters proposed by the design of experiments. Surface roughness is predicted by examining the effects of cutting parameters (CP), vibrations (Vib), and sound characteristics (SC). Sound characteristics based on surface roughness estimation determine the rarity of the work. In this study, a unique ANN-TLBO hybrid model (Artificial Neural Networks: Teaching Learning Based Algorithm) is created to predict the surface roughness from CP, Vib, and SC. To ascertain their correctness and efficacy in evaluating surface roughness, the performance of these models is evaluated. First off, the CP hybrid model demonstrated an amazing accuracy of 95.1%, demonstrating its capacity to offer trustworthy forecasts of surface roughness values. The Vib hybrid model, in addition, demonstrated a respectable accuracy of 85.4%. Although it was not as accurate as the CP model, it nevertheless showed promise in forecasting surface roughness. The SC-based hybrid model outperformed the other two models in terms of accuracy with a remarkable accuracy of 96.2%, making it the most trustworthy and efficient technique for assessing surface roughness in this investigation. An analysis of error percentages revealed the exceptional performance of SC-based Model-3, exhibiting an average error percentage of 3.77%. This outperformed Vib Model-2 (14.52%) and CP-based Model-1 (4.75%). The SC model is the best option, and given its outstanding accuracy, it may end up becoming the go-to technique for industrial applications needing accurate surface roughness measurement. The SC model’s exceptional performance highlights the importance of optimization strategies in improving the prediction capacities of ANN-based models, leading to significant advancements in the field of surface roughness assessment and related fields. An IoT platform is developed to link the model’s output with other systems. The system created eliminates the need for manual, physical surface roughness measurement and allows for the display of surface roughness data on the cloud and other platforms.

Nutmeg (Myristica fragrans Houtt; family: Myristicaceae) is an important tree spice of great export value due to the presence of secondary metabolites with scope in health, wellness and cosmetic industries. Its dioecious in nature due to which it is propagated by budding and grafting which requires specialised skill and as a result authentic planting material production is very expensive. Based on the constant demand from farmers and stakeholders for a suitable, fast and easy technique for determining the authenticity of nutmeg varieties, an attempt was made to develop morphological and molecular markers for the identification of three commercial varieties that are in high demand in India; viz. IISR Vishwashree, IISR Keralashree, Sindhushree and a monoecious nutmeg (MN) accession, along with their biochemical profiles. Among the various morphological characters as per distinctiveness, uniformity and stability guidelines, the varieties showed distinctness mainly in leaf shape, shape of female flowers, fruit shape and seed shape. Out of 35 ISSR primers screened, six primers viz., IS 02, ISSR 12, ISSR 05, ISSR 14, ISSR 01 and UBC 834 generated clear, unique reproducible polymorphic bands capable of distinguishing the varieties. Among the varieties analysed, MN was found to be superior in terms of seed butter and essential oil in nut, mace and leaves. IISR Vishwashree was on par with MN in nut essential oil content. IISR Keralashree was superior in terms of oleoresin in nuts and mace. The morphological and molecular markers identified may be used for effective checking of authenticity of planting materials of commercially grown nutmeg varieties.

In recent issues of the Journal of the Society for Cardiovascular Angiography and Interventions and the Journal of the American College of Cardiology: Cardiovascular Interventions, Holzer and colleagues presented an Expert Consensus Document titled: “PICS / AEPC / APPCS / CSANZ / SCAI / SOLACI: Expert consensus statement on cardiac catheterization for pediatric patients and adults with congenital heart disease.” This Expert Consensus Document is a massively important contribution to the community of paediatric and congenital cardiac care. This document was developed as an Expert Consensus Document by the Pediatric and Congenital Interventional Cardiovascular Society, the Association for European Paediatric and Congenital Cardiology, the Asia-Pacific Pediatric Cardiac Society, the Cardiac Society of Australia and New Zealand, the Society for Cardiovascular Angiography and Interventions, and the Latin American Society of Interventional Cardiology, as well as the Congenital Cardiac Anesthesia Society and the American Association of Physicists in Medicine.

As perfectly stated in the Preamble of this Expert Consensus Document, “This expert consensus document is intended to inform practitioners, payors, hospital administrators and other parties as to the opinion of the aforementioned societies about best practices for cardiac catheterisation and transcatheter management of paediatric and adult patients with congenital heart disease, with added accommodations for resource-limited environments.” And, the fact that the authorship of this Expert Consensus Document includes global representation is notable, commendable, and important.

This Expert Consensus Document has the potential to fill an important gap for this patient population. National guideline documents for specific aspects of interventions in patients with paediatric heart disease, including training guidelines, do exist. However, this current Expert Consensus Document authored by Holzer and colleagues provides truly globally applicable standards on cardiac catheterisation for both paediatric patients and adults with congenital heart disease (CHD).

Our current Editorial provides different regional perspectives from senior physicians dedicated to paediatric and congenital cardiac care who are practicing in Europe, the Asia-Pacific region, Latin America, Australia/New Zealand, and North America. Establishing worldwide standards for cardiac catheterisation laboratories for children and adults with CHD is a significant stride towards improving the quality and consistency of care. These standards should not only reflect the current state of medical knowledge but should also be adaptable to future advancements, ultimately fostering better outcomes and enhancing the lives of individuals affected by CHD worldwide.

Ensuring that these standards are accessible and adaptable across different healthcare settings globally is a critical step. Given the variability in resources and infrastructure globally, the need exists for flexibility and tailoring to implement recommendations.

The potential impact of the Expert Consensus Document and its recommendations is likely significant, but heterogeneity of healthcare systems will pose continuing challenges on healthcare professionals. Indeed, this heterogeneity of healthcare systems will challenge healthcare professionals to finally close the gap between acceptable and ideal in the catheterisation of patients with paediatric and/or congenital heart disease.

Heart University [https://www.heartuniversity.org/] is a free educational website providing structured training curricula with knowledge-based testing and access to webinars and conference recordings for practicing and in-training providers of paediatric and congenital cardiac care. To date, there are over 15,000 registered website users from over 140 countries on Heart University, with over 2,000 training modules and/or recorded educational videos. Heart University has developed an “asynchronous” educational lecture series entitled “Pediatric and Congenital Cardiac Care in Resource-Limited Settings.” This recorded lecture series is specifically focused on topics relevant to practicing paediatric and/or congenital cardiac care in low-resource settings.

A relatively new initiative, “Cardiology Across Continents,” supplements the existing educational resources for providers of paediatric and/or congenital cardiac care in low-income countries and lower-middle-income countries by providing an additional live, interactive, case-based forum. Sessions occur every 1–2 months and focus on challenging cases from diagnostic or management perspective with a view to promote collaboration between partnered institutions. “Cardiology Across Continents” is an expanding initiative that facilitates learning and collaboration between clinicians across varied practice settings via interactive case discussions. We welcome trainees and providers of paediatric and congenital cardiac care to join the sessions and invite any insight that can enhance learning for clinicians around the world. This manuscript describes “Cardiology Across Continents” and discusses the development, history, current status, and future plans of Heart University.

Exploring the nutritional potential of underutilized legumes such as Dolichos bean (Lablab purpureus L.) is of great significance, particularly, in view of accomplishing the United Nation's Sustainable Development Goal number two, which emphasizes on improving food and nutrition security by 2030. A thorough understanding of genetic variability is crucial for developing biofortified cultivars of Dolichos bean. In this study, the Dolichos bean genotypes represented by pole and bush types (28 bush and 19 pole types) were assessed for genetic variability for Cu, Mn, Fe and Zn contents. Pole type genotypes had higher average contents for all micronutrients except manganese. Among micronutrients, Cu, Fe, Mn and Zn, content ranged from 10.10–19.95, 77.13–331.93, 22.78–46.40 and 42.03–102.85 mg kg−1 in pole type, and 8.2–18.5, 50.8–99.3, 25.65–53.25 and 37.15–63.25 mg kg−1 in bush type beans, respectively. Strong positive correlations between Cu, Fe and Zn concentrations occurred, which indicates the possibility of simultaneous improvement of these nutrients. Pod pigmentation was positively correlated with contents of Fe and Zn. There was an association of micronutrients with yield. The pole genotypes VRSEM-1000, VRDB-01 and VRSEM 109 and bush type genotypes VRBSEM-3, VRBSEM-35 and VRBSEM- 200 are good source of microelements and high yielders. Gene sources with enhanced nutrients may be used as cultivated forms or as input material for breeding nutritionally rich biofortified varieties of bean.

Surgical repair of channels between the ventricles is enhanced when the surgeon knows precisely where to place a patch, or baffle, so as to restore septal integrity. The paediatric cardiologist should provide the necessary information. Communication will be enhanced if the same words are used to account for the structures in question. Currently, however, the same term, namely “ventricular septal defect,” is used to account for markedly different areas within the heart. Closure of perimembranous defects found in hearts with concordant or discordant ventriculo-arterial connections restores the integrity of the ventricular septum, at the same time separating the systemic and pulmonary blood streams. When both arterial trunks arise from the right ventricle, in contrast, the surgeon when placing a baffle so as to separate the blood streams, does not close the channel most frequently described as the “ventricular septal defect.” In this review, we show that the perimembranous lesions as found in hearts with concordant or discordant ventriculo-arterial connections are the right ventricular entrances to the areas subtended beneath the hinges of the leaflets of the aortic or pulmonary valves. When both arterial trunks arise from the right ventricle, and the channel between the ventricles is directly subaortic, then the channel termed the “ventricular septal defect” is the left ventricular entrance to the comparable space subtended beneath the aortic root. We argue that recognition of these fundamental anatomical differences enhances the appreciation of the underlying morphology of the various lesions that reflect transfer, during cardiac development, of the aortic root from the morphologically right to the morphologically left ventricle.

Mental disorders are the leading cause of disease burden, affecting 13% of all people globally in 2019. However, there is scarce evidence on the burden of mental disorders in Nepal. This study used the Global Burden of Disease Study 2019 data to assess the prevalence and disability-adjusted life-years (DALYs) of mental disorders in Nepal between 1990 and 2019. In 2019, there were 3.9 million (95% UI: 3.6–4.3) people with mental disorders in Nepal. Major depressive disorders (1.1 million; 95% UI: 0.9–1.2 million) and anxiety disorders (0.9 million; 95% UI: 0.8–1.2 million) were the most prevalent mental disorders in 2019. Attention deficit hyperactive disorder, conduct disorder, and autism spectrum disorders were present twice as high in males than in females. The proportional contribution of mental disorders to the total disease burden has tripled between 1990 (1.79% of all DALYs) and 2019 (5.5% of all DALYs). In conclusion, the proportional contribution of mental disorders to total disease burden has increased significantly in the last three decades in Nepal, with apparent sex and age differentials in prevalence and DALY rates. Effective program and policy responses are required to prepare the health system for reducing the growing burden of mental health disorders in Nepal.

The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery (WCPCCS) will be held in Washington DC, USA, from Saturday, 26 August, 2023 to Friday, 1 September, 2023, inclusive. The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery will be the largest and most comprehensive scientific meeting dedicated to paediatric and congenital cardiac care ever held. At the time of the writing of this manuscript, The Eighth World Congress of Pediatric Cardiology and Cardiac Surgery has 5,037 registered attendees (and rising) from 117 countries, a truly diverse and international faculty of over 925 individuals from 89 countries, over 2,000 individual abstracts and poster presenters from 101 countries, and a Best Abstract Competition featuring 153 oral abstracts from 34 countries. For information about the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery, please visit the following website: [www.WCPCCS2023.org]. The purpose of this manuscript is to review the activities related to global health and advocacy that will occur at the Eighth World Congress of Pediatric Cardiology and Cardiac Surgery.

Acknowledging the need for urgent change, we wanted to take the opportunity to bring a common voice to the global community and issue the Washington DC WCPCCS Call to Action on Addressing the Global Burden of Pediatric and Congenital Heart Diseases. A copy of this Washington DC WCPCCS Call to Action is provided in the Appendix of this manuscript. This Washington DC WCPCCS Call to Action is an initiative aimed at increasing awareness of the global burden, promoting the development of sustainable care systems, and improving access to high quality and equitable healthcare for children with heart disease as well as adults with congenital heart disease worldwide.

A subset ${\mathcal D}$ of a domain $\Omega \subset {\mathbb C}^d$ is determining for an analytic function $f:\Omega \to \overline {{\mathbb D}}$ if whenever an analytic function $g:\Omega \rightarrow \overline {{\mathbb D}}$ coincides with f on ${\mathcal D}$, equals to f on whole $\Omega $. This note finds several sufficient conditions for a subset of the symmetrized bidisk to be determining. For any $N\geq 1$, a set consisting of $N^2-N+1$ many points is constructed which is determining for any rational inner function with a degree constraint. We also investigate when the intersection of the symmetrized bidisk intersected with some special algebraic varieties can be determining for rational inner functions.

This paper presents an efficient water cycle algorithm based on the processes of water cycle with movement of streams and rivers in to the sea. This optimization algorithm is applied to obtain the optimal feasible path with minimum travel duration during motion planning of both single and multiple humanoid robots in both static and dynamic cluttered environments. This technique discards the rainfall process considering falling water droplets forming streams during raining and the process of flowing. The flowing process searches the solution space and finds the more accurate solution and represents the local search. Motion planning of humanoids is carried out in V-REP software. The performance of proposed algorithm is tested in experimental scenario under laboratory conditions and shows the developed algorithm performs well in terms of obtaining optimal path length and minimum time span of travel. Here, navigational analysis has been performed on both single as well as multiple humanoid robots. Statistical analysis of results obtained from both simulation and experimental environments is carried out for both single and multiple humanoids, along with the comparison with another existing optimization technique that indicate the strength and effectiveness of the proposed water cycle algorithm.

Despite enormous strides in our field with respect to patient care, there has been surprisingly limited dialogue on how to train and educate the next generation of congenital cardiologists. This paper reviews the current status of training and evolving developments in medical education pertinent to congenital cardiology. The adoption of competency-based medical education has been lauded as a robust framework for contemporary medical education over the last two decades. However, inconsistencies in frameworks across different jurisdictions remain, and bridging gaps between competency frameworks and clinical practice has proved challenging. Entrustable professional activities have been proposed as a solution, but integration of such activities into busy clinical cardiology practices will present its own challenges. Consequently, this pivot towards a more structured approach to medical education necessitates the widespread availability of appropriately trained medical educationalists, a development that will better inform curriculum development, instructional design, and assessment. Differentiation between superficial and deep learning, the vital role of rich formative feedback and coaching, should guide our trainees to become self-regulated learners, capable of critical reasoning yet retaining an awareness of uncertainty and ambiguity. Furthermore, disruptive innovations such as “technology enhanced learning” may be leveraged to improve education, especially for trainees from low- and middle-income countries. Each of these initiatives will require resources, widespread advocacy and raised awareness, and publication of supporting data, and so it is especially gratifying that Cardiology in the Young has fostered a progressive approach, agreeing to publish one or two articles in each journal issue in this domain.