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In this paper, we study generalized versions of Poisson-type processes obtained by time-changing them with the geometric counting process (GCP). Our work generalizes the results of Meoli (2023). We introduce the geometric time-changed Poisson processes of Type I (GTCPP-I) and Type II (GTCPP-II), the geometric generalized compound, and multiplicative Poisson processes for both types. We derive several distributional properties for the above-mentioned processes and study special cases, including the geometric space-fractional Poisson process, the geometric tempered space-fractional Poisson process, and the geometric time-fractional Poisson process. We also analyze the asymptotic behavior of the correlation structure. Finally, we discuss applications in shock models in reliability theory, deriving explicit reliability functions and failure rates under both the extreme shock model and the cumulative shock model.
The proliferation of information and communication technologies in US archaeology has created myriad expectations for professional labor throughout the life cycle of data. Technological adoption has outpaced the development of professional and ethical frameworks, leaving archaeological data labor unsustainable in our under-resourced discipline. This article reviews traditional Western paradigms underpinning legal and intellectual property models that have shaped archaeological data standards and contribute to problematic outcomes for archaeological data labor, alienate publics from primary data of publicly mandated heritage preservation, disregard Indigenous Data Sovereignty, and enable the extractive commodification of heritage for AI enterprises. To address these tensions, archaeologists must reshape data labor and its products by centering public goods and Indigenous rights in all aspects of their work. As scientific and cultural professionals, archaeologists should embrace best practices in data ecosystems to create, guide, and enforce governance principles that inform and promote labor sustainability and accountability. This article illuminates the current state of archaeological data labor across the discipline through a critical review of policies, legislation, and ethics surrounding data governance (e.g., CARE, FAIR, and the US OPEN Government Data Act) and describes how archaeologists can integrate these efforts into technological initiatives across the full spectrum of archaeological practice.
Residual blood specimens collected at health facilities may be a source of samples for serosurveys of adults, a population often neglected in community-based serosurveys. Anonymized residual blood specimens were collected from individuals 15 – 49 years of age attending two sub-district hospitals in Palghar District, Maharashtra, from November 2018 to March 2019. Specimens also were collected from women 15 – 49 years of age enrolled in a cross-sectional, community-based serosurvey representative at the district level that was conducted 2 – 7 months after the residual specimen collection. Specimens were tested for IgG antibodies to measles and rubella viruses. Measles and rubella seroprevalence estimates using facility-based specimens were 99% and 92%, respectively, with men having significantly lower rubella seropositivity than women. Age-specific measles and rubella seroprevalence estimates were similar between the two specimen sources. Although measles seropositivity was slightly higher among adults attending the facilities, both facility and community measles seroprevalence estimates were 95% or higher. The similarity in measles and rubella seroprevalence estimates between the community-based and facility serosurveys highlights the potential value of residual specimens to approximate community seroprevalence.
Residual blood specimens provide a sample repository that could be analyzed to estimate and track changes in seroprevalence with fewer resources than household-based surveys. We conducted parallel facility and community-based cross-sectional serological surveys in two districts in India, Kanpur Nagar District, Uttar Pradesh, and Palghar District, Maharashtra, before and after a measles-rubella supplemental immunization activity (MR-SIA) from 2018 to 2019. Anonymized residual specimens from children 9 months to younger than 15 years of age were collected from public and private diagnostic laboratories and public hospitals and tested for IgG antibodies to measles and rubella viruses. Significant increases in seroprevalence were observed following the MR SIA using the facility-based specimens. Younger children whose specimens were tested at a public facility in Kanpur Nagar District had significantly lower rubella seroprevalence prior to the SIA compared to those attending a private hospital, but this difference was not observed following the SIA. Similar increases in rubella seroprevalence were observed in facility-based and community-based serosurveys following the MR SIA, but trends in measles seroprevalence were inconsistent between the two specimen sources. Despite challenges with representativeness and limited metadata, residual specimens can be useful in estimating seroprevalence and assessing trends through facility-based sentinel surveillance.
We give an explicit formula for the Frobenius number of triples associated with the Diophantine equation $x^2+y^2=z^3$, that is, the largest positive integer that can only be represented in p ways by combining the three integers of the solutions of $x^2+y^2=z^3$. For the equation $x^2+y^2=z^2$, the Frobenius number has already been given. Our approach can be extended to the general equation $x^2+y^2=z^r$ for $r>3$.
This study investigates the inheritance pattern of petalous and apetalous traits in yellow sarson (Brassica rapa var yellow sarson) and its significance for breeding efforts. Utilizing three crucial crosses between petalous (Pant Sweta, Pant Girija, YSH0401) and ‘apetalous’ parents, we observed the absence of apetalous plants in the F1 generation, indicating dominant inheritance of petalous plants. The F2 generation consistently displayed a 3:1 ratio of petalous to apetalous plants, confirming the dominance of the petalous trait. Chi-squared tests on each generation supported this conclusion. Backcrosses with petalous parents yielded no fruit, reinforcing the dominance of the petalous trait. Chi-squared tests on these backcrosses further confirmed the dominance inheritance pattern. Conversely, backcrosses with apetalous parents consistently exhibited a 1:1 ratio, highlighting the recessive nature of the apetalous trait. The study underscores the importance of understanding the inheritance pattern of petalous and apetalous traits in B. rapa var yellow sarson crop, as it has implications for breeding goals. Knowledge on trait inheritance can guide future breeding strategies, facilitating the transfer of the apetalous trait as needed. This study provides valuable insights for genetic investigations and breeding initiatives in B. rapa var yellow sarson.
Archaeology in the United States is caught in a “curation crisis” (Childs 1995; Childs and Warner 2019; Marquardt et al. 1982; SAA Advisory Committee on Curation 2003; Trimble and Marino 2003) and a “digital data crisis” (or “deluge”) more specifically (Bevan 2015; Clarke 2015; Kansa and Kansa 2021; Katsianis et al. 2022; Kersel 2015; McManamon et al. 2017:239–240; Rivers Cofield et al. 2024). Recent estimates suggest that, collectively, over 1.4 billion dollars are spent annually to support archaeological work that is mandated by federal law (SRI Foundation 2020). Although substantial efforts are underway to generate and provide mechanisms for managing, curating, and sharing the resultant digital data, we suggest that a critical step that has yet to be taken is to describe and visualize the components, connections, and causal dynamics of the US digital data system as it currently functions. Here, we specifically apply a “systems thinking” approach to produce such a high-level model of this system. We argue that understanding and visualizing this system will help us all “think bigger” (Heilen and Manney 2023); identify sources of knowledge, opportunities for critical analysis, collaboration, and capacity building; and increase much-needed archaeological digital literacy (Kansa and Kansa 2022). We conceptualize this as bringing “equilibrium” to the system, and in this article, we make several suggestions on how to bring this about. These insights can enable practitioners to better understand their roles in and contributions to the overall system and to evaluate efforts to improve data sharing, management, and curation practices not only within their organizations and departments but beyond.
Seizure freedom without deficits is the primary goal for epilepsy surgery. However, patients with medically refractory epilepsy commonly suffer from many co-morbidities related to mood, cognition, and sleep as well as social problems and resultant stigma. While epilepsy surgery literature does describe quality of life (QOL) and neuropsychological outcomes, there is a paucity of information on various common non-seizure outcomes, especially pertaining to mood, sleep, cognition, and social aspects. The objective of this study was to evaluate the role of various non-seizure parameters on post-epilepsy surgery QOL.
Methods:
Consecutive adult patients operated for refractory epilepsy at least 1 year prior to initiation of this study were included and classified as seizure-free (group 1) or non-seizure-free (group 2). QOL was assessed using the QOLIE-31 instrument; patients with a T score less than 40 were categorized as “poor QOL.” Non-seizure parameters assessed were cognition, mood disturbances, social improvement, social stigma, and sleep disturbances. Categorization into “good” and “poor” outcome subgroups on each item was carried out by dichotomization of scores.
Results:
Thirty-seven patients (16 F) [mean age 23.5 ± 5.6 years] were evaluated; 26 were seizure-free (group 1). In this group, impaired memory, lower language scores, depression, not having been employed, not receiving education prior to surgery, and experiencing social stigma were factors significantly associated with poor QOL. In group 2, all patients had poor QOL scores.
Conclusion:
Non-seizure factors related to common epilepsy co-morbidities and social issues are highly prevalent among seizure-free patients reporting poor QOL after epilepsy surgery.
Metallic nanoparticles from different natural sources exhibit superior therapeutic options as compared to the conventional methods. Selaginella species have attracted special attention of researchers worldwide due to the presence of bioactive molecules such as flavonoids, biflavonoids, triterpenes, steroids, saponins, tannins and other secondary metabolites that exhibit antimicrobial, antiplasmodial, anticancer and anti-inflammatory activities. Environment friendly green synthesised silver nanoparticles from Selaginella species provide viable, safe and efficient treatment against different fungal pathogens.
Objective
This systematic review aims to summarise the literature pertaining to superior antifungal ability of green synthesised silver nanoparticles using plant extracts of Selaginella spp. in comparison to both aqueous and ethanolic raw plant extracts by electronically collecting articles from databases.
Methods
The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis were taken into consideration while preparing this review. The titles and abstracts of the collected data were stored in Endnote20 based on the inclusion and exclusion criteria. The search strategy included literature from established sources like PubMed, Google Scholar and Retrieval System Online using subject descriptors.
Results
The search yielded 60 articles with unique hits. After removal of duplications, 46 articles were identified, 40 were assessed and only seven articles were chosen and included in this review based on our eligibility criteria.
Conclusion
The physicochemical and preliminary phytochemical investigations of Selaginella suggest higher drug potency of nanoparticles synthesised from plant extract against different diseases as compared to aqueous and ethanolic plant extracts. The study holds great promise as the synthesis of nanoparticles involves low energy consumption, minimal technology and least toxic effects.
Reuse and sharing of archaeological data are tied to ethics in data practice, research design, and the rights of Indigenous peoples in decision-making about their heritage. In this article, the authors discuss how the CARE (Collective benefit, Authority to control, Responsibility, and Ethics) principles and Indigenous data governance create intellectual space for archaeological research. We show how archaeologists can use this framework to highlight hidden costs and labor associated with the “data ecosystem,” which are often borne by Indigenous nations and communities. The CARE framework gives voice to Indigenous peoples’ concerns around data sharing, curation, and reuse; ways we can redress these issues; and strategies that facilitate Indigenous nations and communities in deriving collective benefit from research. In archaeology, these efforts include greater work on heritage legislation and policy, repositioning Indigenous peoples as active stewards of their data, and building capacity in digital methods and ethical data practice. Each Indigenous nation and community has its own interests, values, and protocols, and we suggest paths to bring data practice into alignment with the CARE framework.
A fundamental task of archaeology is to address challenging scientific questions related to the complexity of human societies. If we are to systematically understand the processes that affect human societies on multiple spatial and temporal scales, research leveraging existing archaeological data is essential. However, only a fraction of the data from archaeological projects are publicly findable or accessible, let alone interoperable or reusable. This is the case despite statements of disciplinary ethics, availability of capable technologies for data stewardship, publications providing guidance, and legal mandates. This article introduces the FAIR principles for data stewardship in North American archaeology, which state that data should be Findable, Accessible, Interoperable, and Reusable. We call for efforts to promote widespread adoption of the FAIR and CARE (Collective benefit, Authority to control, Responsibility, and Ethics) principles among professional organizations, publishers, data repositories, and researchers. We also call for adoption and implementation of requirements to adhere to these principles by governmental agencies, funding bodies, and other regulators of archaeological research. Ultimately, adoption of the FAIR principles in an ethical framework contributes to our understanding of our human experience and can lead to greater integration and reuse of research results, fostering increased partnerships between academia and industry.
Resistance to colistin, a last resort antibiotic, has emerged in India. We investigated colistin-resistant Klebsiella pneumoniae(ColR-KP) in a hospital in India to describe infections, characterize resistance of isolates, compare concordance of detection methods, and identify transmission events.
Design:
Retrospective observational study.
Methods:
Case-patients were defined as individuals from whom ColR-KP was isolated from a clinical specimen between January 2016 and October 2017. Isolates resistant to colistin by Vitek 2 were confirmed by broth microdilution (BMD). Isolates underwent colistin susceptibility testing by disk diffusion and whole-genome sequencing. Medical records were reviewed.
Results:
Of 846 K. pneumoniae isolates, 34 (4%) were colistin resistant. In total, 22 case-patients were identified. Most (90%) were male; their median age was 33 years. Half were transferred from another hospital; 45% died. Case-patients were admitted for a median of 14 days before detection of ColR-KP. Also, 7 case-patients (32%) received colistin before detection of ColR-KP. All isolates were resistant to carbapenems and susceptible to tigecycline. Isolates resistant to colistin by Vitek 2 were also resistant by BMD; 2 ColR-KP isolates were resistant by disk diffusion. Moreover, 8 multilocus sequence types were identified. Isolates were negative for mobile colistin resistance (mcr) genes. Based on sequencing analysis, in-hospital transmission may have occurred with 8 case-patients (38%).
Conclusions:
Multiple infections caused by highly resistant, mcr-negative ColR-KP with substantial mortality were identified. Disk diffusion correlated poorly with Vitek 2 and BMD for detection of ColR-KP. Sequencing indicated multiple importation and in-hospital transmission events. Enhanced detection for ColR-KP may be warranted in India.
(i) To assess diagnostic accuracy of mid-upper arm circumference (MUAC) for screening thinness and severe thinness in Indian adolescent girls aged 10–14 and 15–19 years compared with BMI-for-age Z-score (BAZ) <−2 and <−3 as the gold standard and (ii) to identify appropriate MUAC cut-offs for screening thinness and severe thinness in Indian girls aged 10–14 and 15–19 years.
Design:
Cross-sectional, conducted October 2016–April 2017.
Setting:
Four tribal blocks of two eastern India states, Chhattisgarh and Odisha.
Participants:
Girls (n 4628) aged 10–19 years. Measurements included height, weight and MUAC to calculate BAZ. Standard diagnostic accuracy tests, receiver–operating characteristic curves and Youden index helped arrive at MUAC cut-offs at BAZ < −2 and <−3, as gold standard.
Results:
Mean MUAC and BMI correlation was positive (0·78, P = 0·001 and r2 = 0·61). Among 10–14 years, MUAC cut-off corresponding to BAZ < −2 and BAZ < −3 was ≤19·4 and ≤18·9 cm. Among 15–19 years, corresponding values were ≤21·6 and ≤20·7 cm. For both BAZ < −2 and BAZ < −3, specificity was higher in 15–19 v. 10–14 years. State-wise variations existed. MUAC cut-offs ranged from 17·7 cm (10 years) to 22·5 cm (19 years) for BAZ < −2, and from 17·0 cm (10 years) to 21·5 cm (19 years) for BAZ < −3. Single-age area under the curve range was 0·82–0·97.
Conclusions:
Study provides a case for use of year-wise and sex-wise context-specific MUAC-cut-offs for screening thinness/severe thinness in adolescents, rather than one MUAC cut-off across 10–19 years, depending on purpose and logistic constraints.
To assess the prevalence and risk factors of underweight, overweight and obesity among a geriatric population living in a high-altitude region of India.
Design
Community-based cross-sectional study. Data were collected on sociodemographic profile and anthropometric parameters. Weight and height measurements were utilized for calculation of BMI. Nutrient intake data were collected using 24 h dietary recall.
Setting
High-altitude region of Nainital District, Uttarakhand State, North India.
Subjects
Community-dwelling geriatric subjects (n 981) aged 60 years or above.
Results
We found that 26·6 % of the elderly subjects were underweight (BMI<18·5 kg/m2). Overweight (BMI 25·0–29·9 kg/m2) and obesity (BMI≥30·0 kg/m2) was seen among 18·0 % and 4·6 %, respectively. After controlling for potential cofounders, risk factors such as low level of education and income, chewing problems and lower number of daily meals were found to be associated with underweight. On the other hand, risk factors for overweight/obesity were lower age, high income and unskilled work.
Conclusions
There is a need to develop and implement intervention strategies to prevent underweight, overweight and obesity among the geriatric population of India.
Motivated by the results of Scott and Patel about “untangling” closed geodesics in finite covers of hyperbolic surfaces, we introduce and study primitivity, simplicity and non-filling index functions for finitely generated free groups. We obtain lower bounds for these functions and relate these free group results back to the setting of hyperbolic surfaces. An appendix by Khalid Bou–Rabee connects the primitivity index function fprim(n, FN) to the residual finiteness growth function for FN.
Zinc oxide (ZnO) thin film deposited onto indium tin oxide (ITO) coated Corning glass substrates using pulsed laser deposition (PLD) technique has been used as a matrix for realization of an efficient urea biosensor after immobilization of urease (Urs) enzyme onto the surface of ZnO. The bioelectrode (Urs/ZnO/ITO/glass) is found to be exhibiting an enhanced sensitivity of 22μΑmΜ−1cm−2 towards urea over a wide detection range of 5-200 mg/dl. The relatively low value of Michaelis menten constant (Km= 0.94mM) indicates high affinity of the immobilized urease towards the analyte (urea). The prepared biosensor retains 90% of its activity for more than 10 weeks. The observed enhanced response characteristics of bioelectrode are attributed to the growth of the matrix (highly c-axis oriented ZnO thin film) with desired surface morphology and high electron communication feature. The results confirm the promising application of PLD grown ZnO thin film as an efficient matrix for urea detection.
SnO2 based sensor structures prepared by rf magnetron sputtering technique have been studied for detecting H2 gas. Pd catalyst was integrated onto the SnO2 thin film in the form of clusters and nano-particles to obtain enhanced sensing response characteristics. The prepared sensor structures have been studied over a temperature range of 50-250°C for sensing response towards 500 ppm H2 gas. The sensor with Pd catalyst dispersed in the form of nanoparticles was found to exhibit an enhanced sensing response of 1.9×103 at a relatively low operating temperature of 150°C with a fast response time of 2 s and recovery time of 65 s towards 500 ppm H2 gas. The origin of enhanced sensing response is identified in the light of the enhanced spill over of H2 gas molecules on the uncovered surface of SnO2 thin film.
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