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1 Predictors of Neurocognitive Outcome in Pediatric Ischemic and Hemorrhagic Stroke
- Claire M Champigny, Samantha J Feldman, Nataly Beribisky, Mary Desrocher, Tamiko Isaacs, Pradeep Krishnan, Georges Monette, Nomazulu Dlamini, Peter Dirks, Robyn Westmacott
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- Journal:
- Journal of the International Neuropsychological Society / Volume 29 / Issue s1 / November 2023
- Published online by Cambridge University Press:
- 21 December 2023, pp. 93-94
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Objective:
Neurocognitive deficits commonly occur following pediatric stroke and can impact many neuropsychological domains. Despite awareness of these deleterious effects, neurocognitive outcome after pediatric stroke, especially hemorrhagic stroke, is understudied. This clinical study aimed to elucidate the impact of eight factors identified in the scientific literature as possible predictors of neurocognitive outcome following pediatric stroke: age at stroke, stroke type (i.e., ischemic vs. hemorrhagic), lesion size, lesion location (i.e., brain region, structures impacted, and laterality), time since stroke, neurologic severity, seizures post-stroke, and socioeconomic status.
Participants and Methods:Ninety-two patients, ages six to 25 and with a history of pediatric stroke, chose to participate in the study and were administered standardized neuropsychological tests assessing verbal reasoning, abstract reasoning, working memory, processing speed, attention, learning ability, long-term memory, and visuomotor integration. A standardized parent questionnaire provided an estimate of executive functioning. Statistical analyses included spline regressions to examine the impact of age at stroke and lesion size, further divided by stroke type; a series of one-way analysis of variance to examine differences in variables with three levels; Welch’s t-tests to examine dichotomous variables; and simple linear regressions for continuous variables.
Results:Lesion size, stroke type, age at stroke, and socioeconomic status were identified as predictors of neurocognitive outcome in our sample. Large lesions were associated with worse neurocognitive outcomes compared to small to medium lesions across neurocognitive domains. Exploratory spline regressions suggested that ischemic stroke was associated with worse neurocognitive outcomes than hemorrhagic stroke. Based on patterns shown in graphs, age at stroke appeared to have an impact on outcome depending on the neurocognitive domain and stroke type, with U-shaped trends suggesting worse outcome across most domains when stroke occurred at approximately 5 to 10 years of age. Socioeconomic status positively predicted outcomes across most neurocognitive domains. Participants with seizures had more severe executive functioning impairments than youth without seizures. Youth with combined cortical-subcortical lesions scored lower on abstract reasoning than youth with cortical and youth with subcortical lesions, and lower on attention than youth with cortical lesions. Neurologic severity predicted scores on abstract reasoning, attention, processing speed, and visuomotor integration, depending on stroke type. There was no evidence of differences on outcome measures based on time since stroke, lesion laterality, or lesion region defined as supra-versus infratentorial.
Conclusions:The current study contributed to the scientific literature by identifying lesion size, stroke type, age at stroke, and socioeconomic status as predictors of neurocognitive outcome following pediatric stroke. Future research should examine other possible predictors of neurocognitive outcome that remain unexplored. Multisite collaborations would provide larger sample sizes and allow teams to build models with better statistical power and more predictors. Enhancing understanding of neurocognitive outcomes following pediatric stroke is a first step towards improving appraisals of prognosis.
Findings are clinically applicable as they provide professionals with information that can help assess individual expected patterns of recovery and thus refer patients to appropriate support services.
Deepest far ultraviolet view of a central field in the Coma cluster by AstroSat UVIT
- Smriti Mahajan, Kulinder Pal Singh, Joseph E. Postma, Kala G. Pradeep, Koshy George, Patrick Côté
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 39 / 2022
- Published online by Cambridge University Press:
- 18 October 2022, e048
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We present analysis of the far ultraviolet (FUV) emission of sources in the central region of the Coma cluster ( $z=0.023$ ) using the data taken by the UVIT aboard the multi-wavelength satellite mission AstroSat. We find a good correlation between the UVIT FUV flux and the fluxes in both wavebands of the Galex mission, for the common sources. We detect stars and galaxies, amongst which the brightest ( $r \lesssim 17$ mag) galaxies in the field of view are mostly members of the Coma cluster. We also detect three quasars ( $z = 0.38, 0.51, 2.31$ ), one of which is likely the farthest object observed by the UVIT so far. In almost all the optical and UV colour-colour and colour-magnitude planes explored in this work, the Coma galaxies, other galaxies and bright stars could be separately identified, but the fainter stars and quasars often coincide with the faint galaxies. We have also investigated galaxies with unusual FUV morphology which are likely to be galaxies experiencing ram-pressure stripping in the cluster. Amongst others, two confirmed cluster members which were not investigated in the literature earlier, have been found to show unusual FUV emission. All the distorted sources are likely to have fallen into the cluster recently, and hence have not virialised yet. A subset of our data have optical spectroscopic information available from the archives. For these sources ( ${\sim} 10\%$ of the sample), we find that 17 galaxies identify as star-forming, 18 as composite and 13 as host galaxies for active galactic nuclei, respectively on the emission-line diagnostic diagram.
Fontan failure: phenotypes, evaluation, management, and future directions
- Ujjwal Kumar Chowdhury, Niwin George, Lakshmi Kumari Sankhyan, Doniparthi Pradeep, Chaitanya Chittimuri, Abhinavsingh Chauhan, Niraj Nirmal Pandey, Shikha Goja
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- Journal:
- Cardiology in the Young / Volume 32 / Issue 10 / October 2022
- Published online by Cambridge University Press:
- 22 June 2022, pp. 1554-1563
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Objectives:
Management of “failing” and “failed” Fontan circulation, particularly the indications, timing, and type of re-intervention, currently remains nebulous. Factors contributing to pathogenesis and mortality following Fontan procedure differ between children and adults.
Methods:Since organ systems in individual patients are affected differently, we searched the extant literature for a “failing” and “failed” Fontan reviewing the clinical phenotypes, diagnostic modalities, pharmacological, non-pharmacological, and surgical techniques employed, and their outcomes.
Results:A total of 410 investigations were synthesised. Although proper candidate selection, thoughtful technical modifications, timely deployment of mechanical support devices, tissue-engineered conduits, and Fontan takedown have decreased the peri-operative mortality from 9 to 15% and 1 to 3% per cent in recent series, pernicious changes in organ function are causing long-term patient attrition. In the setting of a failed Fontan circulation, literature documents three surgical options: Fontan revision, Fontan conversion, or cardiac transplantation. The reported morbidity of 25% and mortality of 8–10% among Fontan conversion continue to improve in select institutions. While operative mortality following cardiac transplantation for Fontan failure is 30% higher than for other CHDs, there is no difference in long-term survival with actuarial 10-year survival of around 54%. Mechanical circulatory assistance, stem cells, and tissue-engineered Fontan conduit for destination therapy or as a bridge to transplantation are in infancy for failing Fontan circulation.
Conclusions:An individualised management strategy according to clinical phenotypes may delay the organ damage in patients with a failing Fontan circulation. At present, cardiac transplantation remains the last stage of palliation with gradually improving outcomes.
Guidelines for Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD)
- Ari Ercole, Vibeke Brinck, Pradeep George, Ramona Hicks, Jilske Huijben, Michael Jarrett, Mary Vassar, Lindsay Wilson, the DAQCORD collaborators
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- Journal:
- Journal of Clinical and Translational Science / Volume 4 / Issue 4 / August 2020
- Published online by Cambridge University Press:
- 13 March 2020, pp. 354-359
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Background:
High-quality data are critical to the entire scientific enterprise, yet the complexity and effort involved in data curation are vastly under-appreciated. This is especially true for large observational, clinical studies because of the amount of multimodal data that is captured and the opportunity for addressing numerous research questions through analysis, either alone or in combination with other data sets. However, a lack of details concerning data curation methods can result in unresolved questions about the robustness of the data, its utility for addressing specific research questions or hypotheses and how to interpret the results. We aimed to develop a framework for the design, documentation and reporting of data curation methods in order to advance the scientific rigour, reproducibility and analysis of the data.
Methods:Forty-six experts participated in a modified Delphi process to reach consensus on indicators of data curation that could be used in the design and reporting of studies.
Results:We identified 46 indicators that are applicable to the design, training/testing, run time and post-collection phases of studies.
Conclusion:The Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD) Guidelines are the first comprehensive set of data quality indicators for large observational studies. They were developed around the needs of neuroscience projects, but we believe they are relevant and generalisable, in whole or in part, to other fields of health research, and also to smaller observational studies and preclinical research. The DAQCORD Guidelines provide a framework for achieving high-quality data; a cornerstone of health research.
The genus Relicinopsis is nested within Relicina (Parmeliaceae, Ascomycota)
- Paul M. KIRIKA, Pradeep K. DIVAKAR, Steven D. LEAVITT, Kawinnat BUARUANG, Ana CRESPO, George MUGAMBI, Grace W. GATHERI, H. Thorsten LUMBSCH
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- Journal:
- The Lichenologist / Volume 49 / Issue 3 / May 2017
- Published online by Cambridge University Press:
- 30 May 2017, pp. 189-197
- Print publication:
- May 2017
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Macro-morphological features traditionally used to segregate genera in Parmeliaceae have been shown to be highly plastic, placing limits on their taxonomic value. Here we aim to elucidate the evolutionary relationships of the genera Relicina and Relicinopsis and reassess the phenotypic features traditionally used to separate these genera. To this end, we gathered ribosomal DNA sequences of ITS, nuLSU and mtSSU and analyzed them in a phylogenetic framework. Relicina was recovered as paraphyletic, with Relicinopsis nested within, and three different clades were identified within Relicina. Alternative hypothesis tests significantly rejected the monophyly of Relicina. Our results indicate that the presence or absence of bulbate cilia is of limited taxonomic value in this clade. Based on differences in conidia, however, we propose to accept Relicinopsis as a subgenus within Relicina as Relicina subgen. Relicinopsis (Elix & Verdon) Kirika, Divakar & Lumbsch. It is proposed that five new combinations of species previously classified in Relicinopsis be placed in Relicina.
Depositional environment and OSL chronology of the Homeb silt deposits, Kuiseb River, Namibia
- Pradeep Srivastava, George A. Brook, Eugene Marais, P. Morthekai, Ashok K. Singhvi
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- Journal:
- Quaternary Research / Volume 65 / Issue 3 / May 2006
- Published online by Cambridge University Press:
- 20 January 2017, pp. 478-491
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Previous studies suggest that the Homeb silts of the Kuiseb valley, Namibia (i) accumulated in a dune-dammed lake, (ii) are end-point deposits, (iii) represent an aggrading river bed, and (iv) are slackwater deposits. Thus, they have been used alternatively as evidence of past drier conditions or past wetter conditions. Lithostratigraphic analysis of two sediment sequences at Homeb indicates sedimentation by aggradation of the Kuiseb River triggered by a transition from an arid to humid climate. OSL ages for the sequences were obtained by the SAR protocol on aliquots of 9.6-mm and 4.0-mm diameter and on single grains. Four-millimeter aliquot minimum ages closely approximate the single-grain minimum ages and are younger than 9.6-mm aliquot minimum and central ages. Based on these results, the small-aliquot (4-mm) approach appears to provide ages comparable to those obtained by the more laborious and time-consuming single-grain method. Minimum ages indicate rapid deposition of the Homeb Silts in at least two episodes centered at ∼15 ka and ∼6 ka during climate transitions from arid to humid. Flash floods eroded the valley fills during slightly more arid conditions.
Contributors
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- By Pierre Alexandre, Trevor Allen, Marcelo Assumpção, José Roberto Barbosa, Lucas Barros, Hilario Bezzera, Sanjib Kumar Biswas, Thierry Camelbeeck, Dan Clark, João Carlos Dourado, Joaquim Ferreira, David Garcia Moreno, Susan E. Hough, Cheng Jia, Aitaro Kato, Elisabeth Knuts, Maurice Lamontagne, Thomas Lecocq, Mian Liu, Prantik Mandal, Andrew McPherson, Eduardo Menezes, Aderson do Nascimento, Søren B. Nielsen, Marlon Pirchiner, Giorgio Ranalli, Bal Krishna Rastogi, Luís Carlos Ribotta, Alain Sabbe, George Sand França, Christian Schiffer, Randell Stephenson, Pradeep Talwani, Roy Van Arsdale, Hui Wang, Jiyang Ye
- Edited by Pradeep Talwani, University of South Carolina
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- Book:
- Intraplate Earthquakes
- Published online:
- 05 May 2014
- Print publication:
- 24 April 2014, pp vii-ix
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- By Aakash Agarwala, Linda S. Aglio, Rae M. Allain, Paul D. Allen, Houman Amirfarzan, Yasodananda Kumar Areti, Amit Asopa, Edwin G. Avery, Patricia R. Bachiller, Angela M. Bader, Rana Badr, Sibinka Bajic, David J. Baker, Sheila R. Barnett, Rena Beckerly, Lorenzo Berra, Walter Bethune, Sascha S. Beutler, Tarun Bhalla, Edward A. Bittner, Jonathan D. Bloom, Alina V. Bodas, Lina M. Bolanos-Diaz, Ruma R. Bose, Jan Boublik, John P. Broadnax, Jason C. Brookman, Meredith R. Brooks, Roland Brusseau, Ethan O. Bryson, Linda A. Bulich, Kenji Butterfield, William R. Camann, Denise M. Chan, Theresa S. Chang, Jonathan E. Charnin, Mark Chrostowski, Fred Cobey, Adam B. Collins, Mercedes A. Concepcion, Christopher W. Connor, Bronwyn Cooper, Jeffrey B. Cooper, Martha Cordoba-Amorocho, Stephen B. Corn, Darin J. Correll, Gregory J. Crosby, Lisa J. Crossley, Deborah J. Culley, Tomas Cvrk, Michael N. D'Ambra, Michael Decker, Daniel F. Dedrick, Mark Dershwitz, Francis X. Dillon, Pradeep Dinakar, Alimorad G. Djalali, D. John Doyle, Lambertus Drop, Ian F. Dunn, Theodore E. Dushane, Sunil Eappen, Thomas Edrich, Jesse M. Ehrenfeld, Jason M. Erlich, Lucinda L. Everett, Elliott S. Farber, Khaldoun Faris, Eddy M. Feliz, Massimo Ferrigno, Richard S. Field, Michael G. Fitzsimons, Hugh L. Flanagan Jr., Vladimir Formanek, Amanda A. Fox, John A. Fox, Gyorgy Frendl, Tanja S. Frey, Samuel M. Galvagno Jr., Edward R. Garcia, Jonathan D. Gates, Cosmin Gauran, Brian J. Gelfand, Simon Gelman, Alexander C. Gerhart, Peter Gerner, Omid Ghalambor, Christopher J. Gilligan, Christian D. Gonzalez, Noah E. Gordon, William B. Gormley, Thomas J. Graetz, Wendy L. Gross, Amit Gupta, James P. Hardy, Seetharaman Hariharan, Miriam Harnett, Philip M. Hartigan, Joaquim M. Havens, Bishr Haydar, Stephen O. Heard, James L. Helstrom, David L. Hepner, McCallum R. Hoyt, Robert N. Jamison, Karinne Jervis, Stephanie B. Jones, Swaminathan Karthik, Richard M. Kaufman, Shubjeet Kaur, Lee A. Kearse Jr., John C. Keel, Scott D. Kelley, Albert H. Kim, Amy L. Kim, Grace Y. Kim, Robert J. Klickovich, Robert M. Knapp, Bhavani S. Kodali, Rahul Koka, Alina Lazar, Laura H. Leduc, Stanley Leeson, Lisa R. Leffert, Scott A. LeGrand, Patricio Leyton, J. Lance Lichtor, John Lin, Alvaro A. Macias, Karan Madan, Sohail K. Mahboobi, Devi Mahendran, Christine Mai, Sayeed Malek, S. Rao Mallampati, Thomas J. Mancuso, Ramon Martin, Matthew C. Martinez, J. A. Jeevendra Martyn, Kai Matthes, Tommaso Mauri, Mary Ellen McCann, Shannon S. McKenna, Dennis J. McNicholl, Abdel-Kader Mehio, Thor C. Milland, Tonya L. K. Miller, John D. Mitchell, K. Annette Mizuguchi, Naila Moghul, David R. Moss, Ross J. Musumeci, Naveen Nathan, Ju-Mei Ng, Liem C. Nguyen, Ervant Nishanian, Martina Nowak, Ala Nozari, Michael Nurok, Arti Ori, Rafael A. Ortega, Amy J. Ortman, David Oxman, Arvind Palanisamy, Carlo Pancaro, Lisbeth Lopez Pappas, Benjamin Parish, Samuel Park, Deborah S. Pederson, Beverly K. Philip, James H. Philip, Silvia Pivi, Stephen D. Pratt, Douglas E. Raines, Stephen L. Ratcliff, James P. Rathmell, J. Taylor Reed, Elizabeth M. Rickerson, Selwyn O. Rogers Jr., Thomas M. Romanelli, William H. Rosenblatt, Carl E. Rosow, Edgar L. Ross, J. Victor Ryckman, Mônica M. Sá Rêgo, Nicholas Sadovnikoff, Warren S. Sandberg, Annette Y. Schure, B. Scott Segal, Navil F. Sethna, Swapneel K. Shah, Shaheen F. Shaikh, Fred E. Shapiro, Torin D. Shear, Prem S. Shekar, Stanton K. Shernan, Naomi Shimizu, Douglas C. Shook, Kamal K. Sikka, Pankaj K. Sikka, David A. Silver, Jeffrey H. Silverstein, Emily A. Singer, Ken Solt, Spiro G. Spanakis, Wolfgang Steudel, Matthias Stopfkuchen-Evans, Michael P. Storey, Gary R. Strichartz, Balachundhar Subramaniam, Wariya Sukhupragarn, John Summers, Shine Sun, Eswar Sundar, Sugantha Sundar, Neelakantan Sunder, Faraz Syed, Usha B. Tedrow, Nelson L. Thaemert, George P. Topulos, Lawrence C. Tsen, Richard D. Urman, Charles A. Vacanti, Francis X. Vacanti, Joshua C. Vacanti, Assia Valovska, Ivan T. Valovski, Mary Ann Vann, Susan Vassallo, Anasuya Vasudevan, Kamen V. Vlassakov, Gian Paolo Volpato, Essi M. Vulli, J. Matthias Walz, Jingping Wang, James F. Watkins, Maxwell Weinmann, Sharon L. Wetherall, Mallory Williams, Sarah H. Wiser, Zhiling Xiong, Warren M. Zapol, Jie Zhou
- Edited by Charles Vacanti, Scott Segal, Pankaj Sikka, Richard Urman
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- Book:
- Essential Clinical Anesthesia
- Published online:
- 05 January 2012
- Print publication:
- 11 July 2011, pp xv-xxviii
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