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Manned lunar landers must ensure astronaut safety while enhancing payload capacity. Due to traditional landers being weak in high-impact energy absorb and heavy payload capacity, a Starship-type manned lunar lander is proposed in this paper. Firstly, a comprehensive analysis was conducted on the traditional cantilever beam cushioning mechanism for manned lander. Subsequently, a 26-ton manned lander and its landing mechanism were designed, and a rigid-flexible coupling dynamic analysis was performed on the compression process of the primary and auxiliary legs. Secondly, the landing performance of the proposed Starship-type manned lunar lander was compared with the traditional 14-ton manned lander in multiple landing conditions. The results indicate that under normal conditions, the largest acceleration of the proposed 26-ton Starship-type manned lander decreases more than 13.1%. It enables a significant increase in payload capacity while mitigating impact loads under various landing conditions.
Rogue waves (RWs) can form on the ocean surface due to the well-known quasi-four-wave resonant interaction or superposition principle. The first is known as the nonlinear focusing mechanism and leads to an increased probability of RWs when unidirectionality and narrowband energy of the wave field are satisfied. This work delves into the dynamics of extreme wave focusing in crossing seas, revealing a distinct type of nonlinear RWs, characterised by a decisive longevity compared with those generated by the dispersive focusing (superposition) mechanism. In fact, through fully nonlinear hydrodynamic numerical simulations, we show that the interactions between two crossing unidirectional wave beams can trigger fully localised and robust development of RWs. These coherent structures, characterised by a typical spectral broadening then spreading in the form of dual bimodality and recurrent wave group focusing, not only defy the weakening expectation of quasi-four-wave resonant interaction in directionally spreading wave fields, but also differ from classical focusing mechanisms already mentioned. This has been determined following a rigorous lifespan-based statistical analysis of extreme wave events in our fully nonlinear simulations. Utilising the coupled nonlinear Schrödinger framework, we also show that such intrinsic focusing dynamics can be captured by weakly nonlinear wave evolution equations. This opens new research avenues for further explorations of these complex and intriguing wave phenomena in hydrodynamics as well as other nonlinear and dispersive multi-wave systems.
Liquid metal flows are important for many industrial processes, including liquid metal batteries (LMBs), whose efficiency and lifetime can be affected by fluid mixing. We experimentally investigate flows driven by electrical currents in an LMB model. In our cylindrical apparatus, we observe a poloidal flow that descends near the centreline for strong currents, and a poloidal flow that rises near the centreline for weak currents. The first case is consistent with electrovortex flow, which is an interaction between current and its own magnetic field, whereas the second case is consistent with an interaction between current and the external field, which drives Ekman pumping. Notably, we also observe an intermediate case where the two behaviours appear to compete. Comparing results with Frick et al. (2022 J. Fluid Mech.949, A20), we test prior estimates of the scaling of flow speed with current to predict the observed reversal. Based on these data, we propose two different ways to apply the Davidson et al. (1999 J. Fluid Mech.245, 669–699) poloidal suppression theory that explain both experimental results simultaneously: either taking the wire radius into account to scale the Lorentz force, or taking viscous dissipation into account to scale the swirl velocity, following Herreman et al. (2021 J. Fluid Mech.915, A17).
We introduce, test, and compare two auction-based methods for eliciting discount rates. In these “patience auctions”, participants bid the smallest future sum they would prefer -or- the longest time they would wait for a reward, rather than receive a smaller, immediate payoff. The most patient bidder receives the delayed reward; all others receive the immediate payoff. These auctions allow us to compare discounting when participants’ attention is focused on the temporal versus monetary dimension of delayed rewards. We find that the estimated parameters in the three most commonly used discount functions (exponential, hyperbolic, and quasi-hyperbolic) differ across these two bidding methods (time-bids vs. money-bids). Specifically, our participants tend to show more impatience under time-bids. Furthermore, we find that people are more likely to exhibit exponential (as opposed to hyperbolic) discounting and exhibit less present bias under time-bids, compared to money-bids. To our knowledge, this paper is the first to directly compare time versus money preference elicitations, within the same subjects, using an incentive-compatible mechanism.
The viruses associated with bats have generated significant concern; however, there is limited knowledge regarding the endoparasites that affect these mammals. This study involved the collection of seven nematode specimens (three males and four females) from the intestines of Hipposideros armiger in Shaoguan City, Guangdong, China. Next-generation sequencing was employed to obtain the mitochondrial DNA (mtDNA) genome, which was determined to be 14,130 base pairs in length. The mitochondrial genome comprised 12 protein-coding genes, 21 tRNA genes, 2 rRNA genes, and an AT-rich non-coding region. Phylogenetic analyses based on mtDNA sequences indicated that the nematode forms a sister clade to Nematodirus, exhibiting only 74% nucleotide identity. In contrast, the nuclear ITS1 gene demonstrated a high degree of nucleotide identity (98.6%–98.8%) with Durettenema guangdongense. Consequently, the parasitic nematode identified from H. armiger is likely to belong to the genus Durettenema and has been designated as Durettenema sp. 888. Furthermore, an epidemiological investigation revealed the presence of the parasitic nematode infections in H. armiger collected from Guangdong, Guangxi, and Guizhou Provinces. Given the widespread distribution of H. armiger and their tendency to inhabit areas in close proximity to human dwellings, the influence of parasite prevalence on bat population numbers and potential for human and domestic animal transmission of this pathogen warrants further investigation.
Patients discharged from emergency departments (ED) with antibiotics for common infections often receive unnecessarily prolonged durations, representing a target for transition of care (TOC) antimicrobial stewardship intervention.
Methods:
This study aimed to evaluate the effectiveness of TOC pharmacists’ review on decreasing the duration of discharge oral antibiotics in patients discharged from the ED at an academic medical center. Pharmacist interventions were guided by an antibiotic duration of therapy guidance focused on respiratory, urinary, and skin infections developed and implemented by the antimicrobial stewardship program. Pharmacist interventions from January 27, 2023, to December 29, 2023, were analyzed to quantify the total number of antibiotic days saved and the percentage of provider acceptance.
Results:
The ED TOC pharmacists reviewed a total of 157 oral antibiotic prescriptions. 86.6% percent of the reviews required pharmacist interventions. The most common indications for the discharge antibiotics were urinary tract infections (50.0%) and skin infections (23.4%). The total number of antibiotic days saved was 155 days with the provider acceptance rate of 76.5%. In 21% of cases, providers did not count the antibiotic doses administered in the ED, contributing to unnecessarily prolonged duration. 10.2% of patients re-presented to the ED while 6.4% of patients were hospitalized within 30 days of index ED discharge.
Conclusion:
The transitions of care pharmacist-led intervention was successful in optimizing the duration of discharge oral antibiotics in the ED utilizing prospective audit and feedback based on institutional guidance. The ED represents a high-yield setting for TOC-directed antimicrobial stewardship.
Liouville-type theorems for the steady incompressible Navier–Stokes system are investigated for solutions in a three-dimensional (3-D) slab with either no-slip boundary conditions or periodic boundary conditions. When the no-slip boundary conditions are prescribed, we prove that any bounded solution is trivial if it is axisymmetric or $ru^r$ is bounded, and that general 3-D solutions must be Poiseuille flows when the velocity is not big in $L^\infty$ space. When the periodic boundary conditions are imposed on the slab boundaries, we prove that the bounded solutions must be constant vectors if either the swirl or radial velocity is independent of the angular variable, or $ru^r$ decays to zero as $r$ tends to infinity. The proofs are based on the fundamental structure of the equations and energy estimates. The key technique is to establish a Saint-Venant type estimate that characterizes the growth of the Dirichlet integral of non-trivial solutions.
We present the first results from a new backend on the Australian Square Kilometre Array Pathfinder, the Commensal Realtime ASKAP Fast Transient COherent (CRACO) upgrade. CRACO records millisecond time resolution visibility data, and searches for dispersed fast transient signals including fast radio bursts (FRB), pulsars, and ultra-long period objects (ULPO). With the visibility data, CRACO can localise the transient events to arcsecond-level precision after the detection. Here, we describe the CRACO system and report the result from a sky survey carried out by CRACO at 110-ms resolution during its commissioning phase. During the survey, CRACO detected two FRBs (including one discovered solely with CRACO, FRB 20231027A), reported more precise localisations for four pulsars, discovered two new RRATs, and detected one known ULPO, GPM J1839 $-$10, through its sub-pulse structure. We present a sensitivity calibration of CRACO, finding that it achieves the expected sensitivity of 11.6 Jy ms to bursts of 110 ms duration or less. CRACO is currently running at a 13.8 ms time resolution and aims at a 1.7 ms time resolution before the end of 2024. The planned CRACO has an expected sensitivity of 1.5 Jy ms to bursts of 1.7 ms duration or less and can detect $10\times$ more FRBs than the current CRAFT incoherent sum system (i.e. 0.5 $-$2 localised FRBs per day), enabling us to better constrain the models for FRBs and use them as cosmological probes.
The dynamic behaviour of helicopter during water impact, considering variations in initial downward velocity and pitching angle, have been investigated numerically and theoretically in the present study. The air-water two-phase flows are simulated by solving unsteady Reynolds-averaged Navier-Stokes equations enclosed by standard $k - \omega $ turbulence model. A treatment for computational domain in combination with a global dynamic mesh technique is applied to deal with the relative motion between the helicopter and water. Results indicate that the initial downward velocity of helicopter exhibits behaviour similar to that of a V-shaped body impacting on water, as does the initial pitching angle. To extend the theoretical approach for predicting the kinematic parameters during helicopter ditching, a shape factor capturing the combined effect of various attributes and an average deadrise angle for asymmetric wedges are also introduced.
Vaccines have revolutionised the field of medicine, eradicating and controlling many diseases. Recent pandemic vaccine successes have highlighted the accelerated pace of vaccine development and deployment. Leveraging this momentum, attention has shifted to cancer vaccines and personalised cancer vaccines, aimed at targeting individual tumour-specific abnormalities. The UK, now regarded for its vaccine capabilities, is an ideal nation for pioneering cancer vaccine trials. This article convened experts to share insights and approaches to navigate the challenges of cancer vaccine development with personalised or precision cancer vaccines, as well as fixed vaccines. Emphasising partnership and proactive strategies, this article outlines the ambition to harness national and local system capabilities in the UK; to work in collaboration with potential pharmaceutic partners; and to seize the opportunity to deliver the pace for rapid advances in cancer vaccine technology.
To meet the development needs of aeroengines for high thrust-to-weight ratios and fuel-air ratios, a high temperature rise triple-swirler main combustor was designed with a total fuel-air ratio of 0.037, utilising advanced technologies including staged combustion, multi-point injection and multi-inclined hole cooling. Fluent software was used to conduct numerical simulations under both takeoff and idle conditions, thereby obtaining the distribution characteristics of the velocity and temperature fields within the combustor, as well as the generation of pollutants. The simulation results indicate that under takeoff conditions, the high temperature rise triple-swirler combustor achieves a total pressure loss coefficient of less than 6% and a combustion efficiency exceeding 99%. Under takeoff conditions, the OTDF and RTDF values are 0.144 and 0.0738, respectively. The mole fraction of NOx emissions is 3,700ppm, while the mole fraction of soot emissions is 2.55×10−5ppm. Under idle conditions, the triple-swirler combustor maintains a total pressure loss coefficient of less than 6% and a combustion efficiency greater than 99.9%. The OTDF and RTDF values are 0.131 and 0.0624, respectively. The mole fractions of CO and UHC emissions are both 0×10−32ppm at the calculation limit of Fluent software.
This paper develops a novel full-state-constrained intelligent adaptive control (FIAC) scheme for a class of uncertain nonlinear systems under full state constraints, unmodeled dynamics and external disturbances. The key point of the proposed scheme is to appropriately suppress and compensate for unmodeled dynamics that are coupled with other states of the system under the conditions of various disturbances and full state constraints. Firstly, to guarantee that the time-varying asymmetric full state constraints are obeyed, a simple and valid nonlinear error transformation method has been proposed, which can simplify the constrained control problem of the system states into a bounded control problem of the transformed states. Secondly, considering the coupling relationship between the unmodeled dynamics and other states of the controlled system such as system states and control inputs, a decoupling approach for coupling uncertainties is introduced. Thereafter, owing to the employed dynamic signal and bias radial basis function neural network (BIAS-RBFNN) improved on traditional RBFNN, the adverse effects of unmodeled dynamics on the controlled system can be suppressed appropriately. Furthermore, the matched and mismatched disturbances are reasonably estimated and circumvented by a mathematical inequality and a disturbance observer, respectively. Finally, numerical simulations are provided to demonstrate the effectiveness of the proposed FIAC strategy.
During the automatic docking assembly of aircraft wing-fuselage, using monocular camera or dual-camera to monitor the docking stage of the fork-ear will result in an incomplete identification of the fork-ear pose-position and an inaccurate description of the deviation in the intersection holes’ position coordinates. To address this, a quality inspection and error correction method is proposed for the fork-ear docking assembly based on multi-camera stereo vision. Initially, a multi-camera stereo vision detection system is established to inspect the quality of fork-ear docking assembly. Subsequently, a spatial position solution mathematical model of the fork-ear feature points is developed, and a spatial pose determination mathematical model of fork-ear is established by utilised the elliptical cone. Finally, an enhanced artificial fish swarm particle filter algorithm is proposed to track and estimate the coordinate of the fork-ear feature points. An adaptive weighted fusion algorithm is employed to fuse the detection data from the multi-camera and the laser tracker, and a wing pose-position fine-tuning error correction model is constructed. Experimental results demonstrate that the method enhances the effect of the assembly quality inspection and effectively improves the wing-fuselage docking assembly accuracy of the fork-ear type aircraft.
A careful theoretical analysis of the excitation of Alfvén eigenmodes (AEs), such as TAE (toroidicity-induced AE) and RSAE (reversed shear AE), by superalfvenic energetic particles is required for reliable predictions of energetic ion relaxation in present day fusion experiments. This includes the evaluation of different AE damping mechanisms including radiative and continuum dampings which are the focus of this study. A recent comprehensive benchmark of different eigenmode solvers including gyrokinetic, gyrofluid and hybrid magenetohydrodynamics (MHD) has shown that employed models may have deficiencies when addressing some of them (Taimourzadeh et al., Nucl. Fusion, vol. 59, 2019, 066006). In this paper, we are studying the radiative and continuum dampings of RSAEs in details which were missing in hybrid NOVA/NOVA-C calculations to prepare a NOVA-C package with a substantial upgrade. Both dampings require the finite Larmor radius (FLR) corrections to AE mode structures to be accounted for. Accurately calculating different damping rates and understanding their parametric dependencies, we resolve the limitation coming out of the perturbative approach. In particular, here, the radiative damping is included perturbatively, whereas the continuum damping is computed non-perturbatively. Our comparison leads to the conclusion that the non-perturbative treatment of the unstable RSAE modes is needed to find the agreement with the gyrokinetic calculations. We expect that the RSAE mode structure modification plays a dominant role in determining the RSAE stability.
To investigate the flame acceleration to detonation in 2.0 and 0.5 mm planar glass combustion chambers, the experiments have been conducted utilising ethylene/oxygen mixtures at atmospheric pressure and temperature. The high-speed camera has been used to record the revolution of flame front and pressure inside the combustion chamber. Different equivalence ratios and ignition locations have been considered in the experiments. The results show that the detonation pressure in the 2 mm thick chamber is nearly three times of Chapman-Jouguet pressure, while detonation pressure in the 0.5 mm thick chamber is only 45.7% of the Chapman-Jouguet value at the stoichiometric mixture. This phenomenon is attributed to the larger pressure loss in the thinner chamber during the detonation propagation. As the value of equivalence ratio is 2.2, the detonation cannot be produced in the 2 mm thick chamber, while the detonation can be generated successfully in the 0.5 mm thick chamber. This phenomenon indicates that the deflagration is easily to be accelerated and transformed into the detonation, due to a larger wall friction and reflection. Besides, the micro-obstacle has been added into the combustor can shorten the detonation transition time and reduces the distance of the detonation transition.
In this paper, a brand-new adaptive fault-tolerant non-affine integrated guidance and control method based on reinforcement learning is proposed for a class of skid-to-turn (STT) missile. Firstly, considering the non-affine characteristics of the missile, a new non-affine integrated guidance and control (NAIGC) design model is constructed. For the NAIGC system, an adaptive expansion integral system is introduced to address the issue of challenging control brought on by the non-affine form of the control signal. Subsequently, the hyperbolic tangent function and adaptive boundary estimation are utilised to lessen the jitter due to disturbances in the control system and the deviation caused by actuator failures while taking into account the uncertainty in the NAIGC system. Importantly, actor-critic is introduced into the control framework, where the actor network aims to deal with the multiple uncertainties of the subsystem and generate the control input based on the critic results. Eventually, not only is the stability of the NAIGC closed-loop system demonstrated using Lyapunov theory, but also the validity and superiority of the method are verified by numerical simulations.
This study presents observations of coherent modes (CMs) in a spherical tokamak using a microwave interferometer near the midplane. The CMs within the 30–60 kHz frequency range were observed during electron cyclotron resonance heating only, and the frequency of the CMs increased proportionally with the square root of the electron temperature near $R = 0.7m$. Generally, these modes displayed bursting and chirping signatures with strong density rise and fall. Their appearance indicated an increase in the intensity of hard x rays, suggesting a deterioration in energetic electron confinement. Furthermore, the effect of CMs on the intensity of energetic electron-driven whistler waves was observed. They decreased when CMs were present and gradually increased with the decrease in CM intensity. The CMs may influence the intensity of whistler waves by affecting the energetic electron confinement.
This study presents a direct numerical simulation that investigates the transport mechanisms of sand particles in the neutrally stable atmospheric Ekman boundary layer (AEBL). The simulation models the AEBL in a half-channel flow, taking into account the Earth's rotation and adding a Coriolis term to the Navier–Stokes equations. The Lagrangian point-particle method with one-way coupling is used to track the sand particles. The main objective is to examine the impact of gravity and particle Stokes number on the sand particle dynamics. The results indicate that gravity has a significant effect on large-size sand particles, as seen in the mean and root-mean-square sand velocity profiles. The slip velocity profiles of sand particles relative to the surrounding air show that larger particles experience higher drag forces in the viscous sublayer, which hinders their forward movement. This effect is also amplified by gravity. Furthermore, the mean profiles of the streamwise and spanwise slip velocities exhibit distinct demarcations of the viscous sublayer, buffer layer and log-law region. The spatial and temporal Voronoï analysis reveals that gravity increases the clustering level of sand particles in the entire turbulent Ekman layer and reduces the time for the change of the Voronoï volume, particularly for large-size particles.
This study aimed to examine the efficacy of the automated mechanical repositioning chairs compared to canalith repositioning manoeuvres for elderly patients with benign paroxysmal positional vertigo (BPPV).
Methods:
A retrospective study included 969 patients with BPPV who were first diagnosed at Beijing Chaoyang Hospital, Capital Medical University between 1 January 2020 and 31 December 2020. Patients were followed up for one year. Demographics, disease status, treatment and various outcomes were collected through medical record reviews and follow-up interviews.
Results:
Based on the criteria for evaluating treatment efficacy using objective and subjective indicators, BPPV patients treated with automated mechanical repositioning chair therapy showed a significantly better prognosis and lower recurrence rates.
Conclusion:
Automated mechanical repositioning chair therapy is an effective approach for BPPV treatment, with advantages over conventional manual canalith repositioning procedures.