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VIII.155 - Varicella Zoster

from Part VIII - Major Human Diseases Past and Present

Published online by Cambridge University Press:  28 March 2008

Kenneth F. Kiple
Affiliation:
Bowling Green State University, Ohio
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Summary

Varicella (chickenpox) is an acute infection of short duration caused by Varicella-Zoster virus (VZV), which is spread in the early stages of disease by droplets of secretions from the nasopharynx. It is followed by lifetime latency that may be broken in occasional patients by reactivation of virus in sensory ganglia manifested as herpes zoster (shingles).

Epidemiology and Incidence

Chickenpox is endemic worldwide, is highly communicable, and commonly appears as epidemics among children who are usually attacked between 2 and 8 years of age. (Infants are protected by transplacental maternal antibodies.) Few escape infection until adult life, and these usually live in isolated rural communities. Probably most of those who have seemed to escape the disease had subclinical infections. (The annual Report of Morbidity and Mortality in the United States shows, for 1984, 221,983 cases of varicella reported from 33 states, an incidence of 138 cases per 100,000 population. The age was known in 28 percent; 56 percent of these cases appeared in the 5- to 9-year age group, less than 6 percent were 15 years of age or older.)

The sporadic reactivation of the virus as shingles is unrelated to exposure to exogenous infection and, in general, is uncommon even in populations in which practically all have had chickenpox. Its peak incidence is after age 50. Of those who develop shingles, only 1 percent have two attacks. Patients with impaired cellular immunity are at risk, and herpes zoster is not uncommon in those suffering from malignant disease.

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Publisher: Cambridge University Press
Print publication year: 1993

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References

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  • Varicella Zoster
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.217
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  • Varicella Zoster
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.217
Available formats
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Save book to Google Drive

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  • Varicella Zoster
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.217
Available formats
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