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VIII.114 - Q Fever

from Part VIII - Major Human Diseases Past and Present

Published online by Cambridge University Press:  28 March 2008

Kenneth F. Kiple
Affiliation:
Bowling Green State University, Ohio
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Summary

The “Q” in Q fever stands for “query,” the designation applied by E. H. Derrick to an acute illness with fever and severe headache of unknown cause occurring in abattoir workers and dairy farmers in Queensland, Australia, in 1935. Despite the discovery of the causative agent, a rickettsia-like organism, this unenlightening name has remained current, although an alternative is abattoir fever. Q fever, occurring in epidemics in military personnel stationed in the Balkans and Italy during World War II, was known as Balkan influenza or Balkan grippe.

Q fever is caused by infection with Coxiella burnetii, previously known as Rickettsia burnetii, and is the sole member of the genus Coxiella, family Rickettsiaceae. It was initially confused with viruses, but though C. burnetii is an obligate intracellular parasite, it has a true bacterial cell wall.

Q fever is a zoonosis of worldwide distribution, and many species of animals, birds, ticks, and other biting insects are natural hosts. In animals, naturally acquired infection appears to be asymptomatic so that Q fever is not of any economic significance to farmers. Transmission to humans occurs via inhalation of contaminated dust while infected animals, carcasses, or animal products are being handled; via laboratory accidents; and sometimes via tick bite and the consumption of unpasteurized milk. Asymptomatic infection is common. Illness may take two forms. Acute Q fever is usually a self-limiting febrile flulike illness or atypical pneumonia lasting up to 4 weeks. Untreated, the fatality rate is less than 1 percent. Chronic Q fever may develop months to years later, presenting as endocarditis and/or hepatitis. Endocarditis usually occurs in those with preexisting heart valve disease; untreated, it is usually fatal.

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Publisher: Cambridge University Press
Print publication year: 1993

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References

,American Journal of Hygiene. 1946. Reports. Paper on Q fever. 44.
Baca, O. G., and Paretsky, D.. 1983. Q fever and Coxiella burnetii: A model for host-parasite interactions. Microbiological Reviews 47.Google ScholarPubMed
Burnet, F. M., and Freeman, M.. 1937. Experimental studies on the virus of “Q” fever. Medical Journal of Australia 2.Google Scholar
Burnet, M. 1967. Derrick and the story of Q fever. Medical Journal of Australia 54.Google Scholar
Davis, G. E., and Cox, H. R.. 1938. A filter–passing infectious agent isolated from ticks. 1. Isolation from Dermacentor andersoni, reactions in animals, and filtration experiments. Public Health Reports 53.Google Scholar
Dennig, H. 1947. Q fever (Balkan influenza). Deutsche medizinische Wochenschrift 72.CrossRefGoogle Scholar
Derrick, E. H. 1937. Q fever, a new fever entity: Clinical features, diagnosis and laboratory investigation. Medical Journal of Australia 2.Google Scholar
Kaplan, M. M., and Bertagna, P.. 1955. The geographical distribution of Q fever. Bulletin of the World Health Organization 13.Google ScholarPubMed
Leedom, J. M. 1980. Q fever: An update. In Current clinical topics in infectious disease. Vol. I, ed. Remington, J. S. and Swartz, M. N.. New York.Google Scholar
Marmion, B. P. 1967. Development of Q fever vaccines 1937 to 1967. Medical Journal of Australia 54.Google Scholar
Palmer, S. R., and Young, Susan. 1982. Q fever endocarditis in England and Wales, 1975–81. Lancet 2.Google ScholarPubMed
Saah, A. J., and Hornick, R. B.. 1985. Coxiella burnetii (Q fever). In Principles and practice of infectious diseases, 2d edition, ed. Mandell, G. L. et al.. New York.Google Scholar
Spicer, A. J. 1978. Military significance of Q fever: A review. Journal of the Royal Society of Medicine 71.CrossRefGoogle ScholarPubMed
Stoker, M. G. P., and Fiset, P.. 1956. Phase variation of the Nine Mile and other strains of Rickettsia burnetü. Canadian Journal of Microbiology 2.CrossRefGoogle Scholar
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  • Q Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.176
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  • Q Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.176
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Q Fever
  • Edited by Kenneth F. Kiple, Bowling Green State University, Ohio
  • Book: The Cambridge World History of Human Disease
  • Online publication: 28 March 2008
  • Chapter DOI: https://doi.org/10.1017/CHOL9780521332866.176
Available formats
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