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Lessons learned from an enterprise-wide clinical datathon
- Andrew J. Zimolzak, Jessica A. Davila, Vamshi Punugoti, Ashok Balasubramanyam, Paul E. Klotman, Laura A. Petersen, Ryan H. Rochat, Gloria Liao, Rory R. Laubscher, Lee Leiber, Christopher I. Amos
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- Journal:
- Journal of Clinical and Translational Science / Volume 6 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 24 August 2022, e125
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In 2020, Baylor College of Medicine held a datathon to inform potential users of a new data warehouse, allow users to address clinical questions, identify warehouse capabilities and limitations, foster collaborations, and engage trainees. Senior faculty selected proposals based on feasibility and impact. Selectees worked with Information Technology for 2 months and presented findings. A survey of participants showed diverse levels of experience, high perceived value of the datathon, high rates of collaboration, and significant increases in knowledge. A datathon can promote familiarity with a new data warehouse, guide data warehouse improvement, and promote collaboration.
The Texas Community-Engagement Research Alliance Against COVID-19 in Disproportionately Affected Communities (TX CEAL) Consortium
- Rebecca A. Seguin-Fowler, Chris Amos, Bettina M. Beech, Robert L. Ferrer, Lorna McNeill, Jasmine J. Opusunju, Emily Spence, Erika L. Thompson, Luis R. Torres-Hostos, Jamboor K. Vishwanatha
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- Journal:
- Journal of Clinical and Translational Science / Volume 6 / Issue 1 / 2022
- Published online by Cambridge University Press:
- 25 April 2022, e64
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The coronavirus disease 2019 (COVID-19) pandemic requires urgent implementation of effective community-engaged strategies to enhance education, awareness, and inclusion of underserved communities in prevention, mitigation, and treatment efforts. The Texas Community-Engagement Alliance Consortium was established with support from the United States’ National Institutes of Health (NIH) to conduct community-engaged projects in selected geographic locations with a high proportion of medically underserved minority groups with a disproportionate burden of COVID-19 disease and hospitalizations. The purpose of this paper is to describe the development of the Consortium. The Consortium organized seven projects with focused activities to address COVID-19 clinical and vaccine trials in highly affected counties, as well as critical statewide efforts. Five Texas counties (Bexar, Dallas, Harris, Hidalgo, and Tarrant) were chosen by NIH because of high concentrations of underserved minority communities, existing community infrastructure, ongoing efforts against COVID-19, and disproportionate burden of COVID-19. Policies and practices can contribute to disparities in COVID-19 risk, morbidity, and mortality. Community engagement is an essential element for effective public health strategies in medically underserved minority areas. Working with partners, the Consortium will use community engagement strategies to address COVID-19 disparities.
Reconsidering the variable context: A phonological argument for (t) and (d) deletion
- Jenny Amos, Jonathan R. Kasstan, Wyn Johnson
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- Journal:
- English Today / Volume 36 / Issue 3 / September 2020
- Published online by Cambridge University Press:
- 02 September 2020, pp. 6-13
- Print publication:
- September 2020
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Final consonant cluster simplification, or what variationists have traditionally labelled (t, d)-deletion, remains one of the most well studied variables in the analysis of English (e.g. Labov, 2001: 13). In this body of work, (t, d)-deletion refers to the process whereby /t/ or /d/ can be omitted in word final Ct or Cd coda clusters (e.g. last, mind). However, despite the attention paid to this feature of connected speech, very little (if any) focus has been dedicated to the complementary distribution of the coronal stops /t/ and /d/ in monomorphemic final clusters, as well as other phonological influences, such as the effect of intonational boundaries (IBs) on deletion patterns. This has led to a consistent practice of analysing (t, d) as a single linguistic variable, instead of considering the value of their separation, based on both sound linguistic reasoning and empirical evidence. After a brief review of current literature on multivariate analyses of (t, d)-deletion, this paper presents a socio-phonologically oriented research design that has been used to gather data from a peripheral southeastern variety of English. We martial these data to illustrate how (t) and (d) can be modelled as distinct dependent variables that are sensitive to particular factor groups: we focus in particular on the role of IBs in the deletion process.
Preparing for a Foreign Animal Disease Outbreak Using a Novel Tabletop Exercise
- Eric J. Linskens, Abby E. Neu, Emily J. Walz, Kaitlyn M. St. Charles, Marie R. Culhane, Amos Ssematimba, Timothy J. Goldsmith, David A. Halvorson, Carol J. Cardona
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- Journal:
- Prehospital and Disaster Medicine / Volume 33 / Issue 6 / December 2018
- Published online by Cambridge University Press:
- 13 September 2018, pp. 640-646
- Print publication:
- December 2018
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Introduction
Foreign animal disease (FAD) outbreaks can have devastating impacts, but they occur infrequently in any specific sector anywhere in the United States (US). Training to proactively discuss implementation of control and prevention strategies are beneficial in that they provide stakeholders with the practical information and educational experience they will need to respond effectively to an FAD. Such proactive approaches are the mission of the Secure Food System (SFS; University of Minnesota; St. Paul, Minnesota USA).
MethodsThe SFS exercises were designed as educational activities based on avian influenza (AI) outbreaks in commercial poultry scenarios. These scenarios were created by subject matter experts and were based on epidemiology reports, risk pathway analyses, local industry practices, and site-specific circumstances. Target audiences of an exercise were the groups involved in FAD control: animal agriculture industry members; animal health regulators; and diagnosticians. Groups of industry participants seated together at tables represented fictional poultry premises and were guided by a moderator to respond to an on-farm situation within a simulated outbreak. The impact of SFS exercises was evaluated through interviews with randomized industry participants and selected table moderators. Descriptive statistics and qualitative analyses were performed on interview feedback.
ResultsEleven SFS exercises occurred from December 2016 through October 2017 in multiple regions of the US. Exercises were conducted as company-wide, state-wide, or regional trainings. Nine were based on highly pathogenic avian influenza (HPAI) outbreaks and two focused on outbreaks of co-circulating HPAI and low pathogenicity avian influenza (LPAI). Poultry industry participants interviewed generally found attending an SFS exercise to be useful. The most commonly identified benefits of participation were its value to people without prior outbreak experience and knowledge gained about Continuity of Business (COB)-permitted movement. After completing an exercise, most participants evaluated their preparedness to respond to an outbreak as somewhat to very ready, and more than one-half reported their respective company or farms had discussions or changed actions due to participation.
Conclusion:Evaluation feedback suggests the SFS exercises were an effective training method to supplement preparedness efforts for an AI outbreak. The concept of using multi-faceted scenarios and multiple education strategies during a tabletop exercise may be translatable to other emergency preparedness needs.
,Linskens EJ ,Neu AE ,Walz EJ ,St. Charles KM ,Culhane MR ,Ssematimba A ,Goldsmith TJ ,Halvorson DA .Cardona CJ Preparing for a Foreign Animal Disease Outbreak Using a Novel Tabletop Exercise . Prehosp Disaster Med.2018 ;33 (6 ):640 –646 .
Emeralds from the Delbegetey deposit (Kazakhstan): mineralogical characteristics and fluid-inclusion study
- E.V. Gavrilenko, B. Calvo Pérez, R. Castroviejo Bolibar, D. García del Amo
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- Journal:
- Mineralogical Magazine / Volume 70 / Issue 2 / April 2006
- Published online by Cambridge University Press:
- 05 July 2018, pp. 159-173
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The aim of this study is to provide the first detailed mineralogical and fluid-inclusion description of emeralds from the Delbegetey deposit (Kazakhstan). The characteristic features of Delbegetey emeralds are established: they have dissolution figures on crystal faces, bluish colour and distinct colour zoning; the refractive indices are ω = 1.566–1.570, ε = 1.558–1.562, and the specific gravity is 2.65±0.005, relatively low for natural emeralds; they have very small concentrations of the impurities (Fe, Mg, Na and others) typical of other emeralds, and contain Cr and V; there is a significant preponderance of vapour in fluid inclusions of all types and there is liquid-to-vapour homogenization of primary fluid inclusions (at 395–420°C). The lattice oxygen isotope composition data obtained (δ18O SMOW value of 11.3%o) situate the deposit within the range characteristic of other granite-related emerald deposits. Emerald crystallization took place in low-density (0.40–0.55 g/cm3) aqueous fluid, with the following chemical composition (mol.%): 75.6-97.4 H2O, 0.0-18.4 CO2, 0.0-0.9 CH4, and 4.06-9.65 wt.% NaCl equiv. salinity. According to the calculated isochores, the pressure of formation of the Delbegetey emeralds can be estimated at 570–1240 bar.
Experimental evidence for the species character of Calcidiscus leptoporus morphotypes
- Patrick Quinn, Hans R. Thierstein, Larry Brand, Amos Winter
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- Journal:
- Journal of Paleontology / Volume 77 / Issue 5 / September 2003
- Published online by Cambridge University Press:
- 20 May 2016, pp. 825-830
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Culturing experiments of the intermediate morphotype of the cosmopolitan coccolithophore Calcidiscus leptoporus, indicate that the size of its coccosphere and of its coccoliths are affected only in a minor way by temperature. The changes observed in clones growing under different temperature and light conditions are within the range defined for this morphotype in the plankton and Holocene sediments. This outcome suggests that the three morphotypes of living C. leptoporus may be reproductively isolated species rather than stages in a life cycle of a single species or ecophenotypic adaptations of a single species with considerable morphological plasticity. Numerous extinct morphotypes of C. leptoporus have been recorded from marine sediments deposited during the last approximately 25 Ma. In the light of our experiments, these may in fact represent genetically distinct species, which experienced rapid evolution.
Revision and reassignment of Strophomena cornuta Hall, 1843 (Brachiopoda, Silurian) to Strophochonetes Muir-Wood, 1962
- Patrick R. Racheboeuf, Fred C. Amos
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- Journal of Paleontology / Volume 71 / Issue 5 / September 1997
- Published online by Cambridge University Press:
- 20 May 2016, pp. 816-819
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Restudy of Strophomena cornuta Hall, 1843, confirms that it belongs to the superfamily Chonetoidea and establishes its assignment to Strophochonetes within the family Strophochonetidae. This is the first recorded occurrence of the genus in the Silurian of New York, and its late Llandovery age makes S. cornutus (Hall) one of the earliest representatives of the genus.
Conservation agriculture in Southern Africa: Advances in knowledge
- Christian Thierfelder, Leonard Rusinamhodzi, Amos R. Ngwira, Walter Mupangwa, Isaiah Nyagumbo, Girma T. Kassie, Jill E. Cairns
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- Journal:
- Renewable Agriculture and Food Systems / Volume 30 / Issue 4 / August 2015
- Published online by Cambridge University Press:
- 19 February 2014, pp. 328-348
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The increasing demand for food from limited available land, in light of declining soil fertility and future threats of climate variability and change have increased the need for more sustainable crop management systems. Conservation agriculture (CA) is based on the three principles of minimum soil disturbance, surface crop residue retention and crop rotations, and is one of the available options. In Southern Africa, CA has been intensively promoted for more than a decade to combat declining soil fertility and to stabilize crop yields. The objective of this review is to summarize recent advances in knowledge about the benefits of CA and highlight constraints to its widespread adoption within Southern Africa. Research results from Southern Africa showed that CA generally increased water infiltration, reduced soil erosion and run-off, thereby increasing available soil moisture and deeper drainage. Physical, chemical and biological soil parameters were also improved under CA in the medium to long term. CA increased crop productivity and also reduced on-farm labor, especially when direct seeding techniques and herbicides were used. As with other cropping systems, CA has constraints at both the field and farm level. Challenges to adoption in Southern Africa include the retention of sufficient crop residues, crop rotations, weed control, pest and diseases, farmer perception and economic limitations, including poorly developed markets. It was concluded that CA is not a ‘one-size-fits-all’ solution and often needs significant adaptation and flexibility when implementing it across farming systems. However, CA may potentially reduce future soil fertility decline, the effects of seasonal dry-spells and may have a large impact on food security and farmers’ livelihoods if the challenges can be overcome.
Twins, Tissue, and Time: An Assessment of SNPs and CNVs
- Paul Scheet, Erik A. Ehli, Xiangjun Xiao, Catharina E. M. van Beijsterveldt, Abdel Abdellaoui, Robert R. Althoff, Jouke Jan Hottenga, Gonneke Willemsen, Kelly A. Nelson, Patricia E. Huizenga, Yueshan Hu, Christopher I. Amos, Meike Bartels, Maria M Groen-Blokhuis, Eco JC de Geus, James J. Hudziak, Gareth E. Davies, Dorret I. Boomsma
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- Journal:
- Twin Research and Human Genetics / Volume 15 / Issue 6 / December 2012
- Published online by Cambridge University Press:
- 28 September 2012, pp. 737-745
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With the desire to assess genetic variation across the lifespan in large-scale collaborative projects, one question is whether inference of copy number (CN) is sensitive to the source of material for deoxyribonucleic acid (DNA) analysis (e.g., blood and buccal) and another question is whether CN is stable as individuals age. Here, we address these questions by applying Affymetrix 6.0 single nucleotide polymorphism (SNP) micro-arrays to 1,472 DNA samples from 710 individuals from the Netherlands Twin Register, including twin and non-twin individuals (372 with buccal and blood derived DNA and 388 with longitudinal data). Similar concordance for CN and genotype inference between samples from the same individual [or from the monozygotic (MZ) co-twins] was found for blood and buccal tissues. There was a small but statistically significant decrease in across-tissue concordance compared with concordance of samples from the same tissue type. No temporal effect was seen on CN variation from the 388 individuals sampled at two time points ranging from 1 to 12 years apart. The majority of our individuals were sampled at age younger than 20 years. Genotype concordance was very high (R2 > 99%) between co-twins from 43 MZ pairs. For 75 dizygotic (DZ) pairs, R2 was ≈65%. CN estimates were highly consistent between co-twins from MZ pairs for both deletions (R2 ≈ 90%) and duplications (R2 ≈ 86%). For DZ, these were similar for within-individual comparisons, but naturally lower between co-twins (R2 ≈ 50–60%). These results suggest that DNA from buccal samples perform as well as DNA from blood samples on the current generation of micro-array technologies.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
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Contributors
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- By Susan E. Abbey, James J. Amos, Philip A. Bialer, James A. Bourgeois, Joanne A. Byars, Jaspreet Chahal, Kathy Coffman, Mary Ann Cohen, Catherine Crone, Carlos Fernandez-Robles, Jess G. Fiedorowicz, Mary J. Fitz-Gerald, Gregory Fricchione, Donna Greenberg, Thomas W. Heinrich, Debra R. Kahn, Raheel A. Khan, Robin C. Kopelman, Jeanne M. Lackamp, Joseph A. Locala, Michael Marcangelo, Laura Marsh, Anthony C. Miller, Romina Mizrahi, Megan Moore Brennan, Maryland Pao, John Querques, Davin Quinn, Vani Rao, Robert G. Robinson, Oludamilola Salami, Sanjeev Sockalingam, Sergio E. Starkstein, Scott Stuart, Adrienne Tan, Janeta Tansey, Scott Temple, Alex Thompson, Susan Turkel, Michelle Weckmann, Marcus Wellen, Thomas Wise
- Edited by James J. Amos, University of Iowa, Robert G. Robinson, University of Iowa
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- Book:
- Psychosomatic Medicine
- Published online:
- 04 August 2010
- Print publication:
- 27 May 2010, pp xi-xiv
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Protein-Based Disk Recording at Areal Densities beyond 10 Terabits/in.2
- S. Khizroev, R. Ikkawi, N. Amos, R. Chomko, V. Renugopalakrishnan, R. Haddon, D. Litvinov
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- Journal:
- MRS Bulletin / Volume 33 / Issue 9 / September 2008
- Published online by Cambridge University Press:
- 31 January 2011, pp. 864-871
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- September 2008
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The concept of optical protein-based memory has been of interest since the early 1970s. Yet, no commercially available protein-based memory devices exist. This review presents an analysis of the main challenges associated with the practical implementation of such devices. In addition, the discussion includes details on the potential of using the unparalleled properties of photochromic proteins by creating an optical data storage disk drive with unmatched features and, particularly, record-high data densities and rates.
12 - Life on earth: the role of proteins
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- By Jayanth R. Banavar, Pennsylvania State University, Amos Maritan, Instituto Nazionale per la Fisica della Materia, Dipartimento da Fisica G. Galilei, Universita di Padova
- Edited by John D. Barrow, University of Cambridge, Simon Conway Morris, University of Cambridge, Stephen J. Freeland, University of Maryland, Baltimore, Charles L. Harper, Jr
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- Fitness of the Cosmos for Life
- Published online:
- 18 December 2009
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- 06 December 2007, pp 225-255
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Summary
Introduction
It is now believed that our universe was created around 13.8 billion years ago. Our planet earth came into existence around 4.5 billion years ago. For nearly a billion years or so after it was formed, the earth was stark and bereft of life. The matter contained on earth was inorganic with relatively small molecules. There were endless rock formations, oceans, and an atmosphere.
And then there was life.
The problem of how life was created is a fascinating one. Our focus is on looking at life on earth and asking how it works. The lessons we learn provide hints to the answer to the deep and fundamental question pondered by our ancients: Was life on earth inevitable? Then there are the questions posed by Henderson [1]: Is the nature of our physical world biocentric? Is there a need for fine-tuning in biochemistry to provide for the fitness of life in the cosmos – or, even less ambitiously, for life here on earth? Surprisingly, as we will show, a physics approach turns out to be valuable for thinking about these questions.
All living organisms have a genetic map consisting of a one-dimensional string of information encoded in the DNA molecule. An essential question that one seeks to answer is how an organism converts that information into a three-dimensional living being.
Life has many common patterns. All living cells follow certain simple “universal” themes.
Focused Ion Beam as a Nanofabrication Tool for Rapid Prototyping of Nanomagnetic Devices
- S Khizroev, A Lavrenov, N Amos, R Chomko, D Litvinov
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- Journal:
- Microscopy and Microanalysis / Volume 12 / Issue S02 / August 2006
- Published online by Cambridge University Press:
- 31 July 2006, pp. 128-129
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- August 2006
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Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2005
6 - A Belief-Based Account of Decision under Uncertainty
- from PART TWO - THE UNCERTAINTY EFFECT AND THE WEIGHTING FUNCTION
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- By Craig R. Fox, Duke University, Amos Tversky, Stanford University
- Edited by Daniel Kahneman, Princeton University, New Jersey, Amos Tversky, Stanford University, California
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- Book:
- Choices, Values, and Frames
- Published online:
- 01 February 2019
- Print publication:
- 25 September 2000, pp 118-142
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Summary
ABSTRACT. We develop a belief-based account of decision under uncertainty. This model predicts decisions under uncertainty from (i) judgments of probability, which are assumed to satisfy support theory; and (ii) decisions under risk, which are assumed to satisfy prospect theory. In two experiments, subjects evaluated uncertain prospects and assessed the probability of the respective events. Study 1 involved the 1995 professional basketball playoffs; Study 2 involved the movement of economic indicators in a simulated economy. The results of both studies are consistent with the belief-based account, but violate the partition inequality implied by the classical theory of decision under uncertainty.
KEY WORDS decision making; risk; uncertainty; expected utility; prospect theory; support theory; decision weights; judgment; probability
INTRODUCTION
It seems obvious that the decisions to invest in the stock market, undergo a medical treatment, or settle out of court depend on the strength of people's beliefs that the market will go up, that the treatment will be successful, or that the court will decide in their favor. It is less obvious how to elicit and measure such beliefs. The classical theory of decision under uncertainty derives beliefs about the likelihood of uncertain events from people's choices between prospects whose consequences are contingent on these events. This approach, first advanced by Ramsey (1931), gives rise to an elegant axiomatic theory that yields simultaneous measurement of utility and subjective probability, thereby bypassing the thorny problem of how to interpret direct expressions of belief.
30 - Ambiguity Aversion and Comparative Ignorance
- from PART SIX - THE MULTIPLICITY OF VALUE: REVERSALS OF PREFERENCE
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- By Craig R. Fox, Duke University, Amos Tversky, Stanford University
- Edited by Daniel Kahneman, Princeton University, New Jersey, Amos Tversky, Stanford University, California
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- Book:
- Choices, Values, and Frames
- Published online:
- 01 February 2019
- Print publication:
- 25 September 2000, pp 528-542
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Summary
ABSTRACT. Decisions under uncertainty depend not only on the degree of uncertainty but also on its source, as illustrated by Ellsberg's observation of ambiguity aversion. In this article we propose the comparative ignorance hypothesis, according to which ambiguity aversion is produced by a comparison with less ambiguous events or with more knowledgeable individuals. This hypothesis is supported in a series of studies showing that ambiguity aversion, present in a comparative context in which a person evaluates both clear and vague prospects, seems to disappear in a noncomparative context in which a person evaluates only one of these prospects in isolation.
INTRODUCTION
One of the fundamental problems of modern decision theory is the analysis of decisions under ignorance or ambiguity, where the probabilities of potential outcomes are neither specified in advance nor readily assessed on the basis of the available evidence. This issue was addressed by Knight [1921], who distinguished between measurable uncertainty or risk, which can be represented by precise probabilities, and unmeasurable uncertainty, which cannot. Furthermore, he suggested that entrepreneurs are compensated for bearing unmeasurable uncertainty as opposed to risk. Contemporaneously, Keynes [1921] distinguished between probability, representing the balance of evidence in favor of a particular proposition and the weight of evidence, representing the quantity of evidence supporting that balance. He then asked, “If two probabilities are equal in degree, ought we, in choosing our course of action, to prefer that one which is based on a greater body of knowledge?” [p. 313].
5 - Weighing Risk and Uncertainty
- from PART TWO - THE UNCERTAINTY EFFECT AND THE WEIGHTING FUNCTION
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- By Amos Tversky, Stanford University, Craig R. Fox, Duke University
- Edited by Daniel Kahneman, Princeton University, New Jersey, Amos Tversky, Stanford University, California
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- Book:
- Choices, Values, and Frames
- Published online:
- 01 February 2019
- Print publication:
- 25 September 2000, pp 93-117
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Summary
ABSTRACT. Decision theory distinguishes between risky prospects, where the probabilities associated with the possible outcomes are assumed to be known, and uncertain prospects, where these probabilities are not assumed to be known. Studies of choice between risky prospects have suggested a nonlinear transformation of the probability scale that overweights low probabilities and underweights moderate and high probabilities. The present article extends this notion from risk to uncertainty by invoking the principle of bounded subadditivity: An event has greater impact when it turns impossibility into possibility, or possibility into certainty, than when it merely makes a possibility more or less likely. A series of studies provides support for this principle in decision under both risk and uncertainty and shows that people are less sensitive to uncertainty than to risk. Finally, the article discusses the relationship between probability judgments and decision weights and distinguishes relative sensitivity from ambiguity aversion.
Decisions are generally made without definite knowledge of their consequences. The decisions to invest in the stock market, to undergo a medical operation, or to go to court are generally made without knowing in advance whether the market will go up, the operation will be successful, or the court will decide in one's favor. Decision under uncertainty, therefore, calls for an evaluation of two attributes: the desirability of possible outcomes and their likelihood of occurrence. Indeed, much of the study of decision making is concerned with the assessment of these values and the manner in which they are - or should be - combined.
An educational intervention for front-line health professionals in the assessment and management of suicidal patients (The STORM Project)
- L. APPLEBY, R. MORRISS, L. GASK, M. ROLAND, B. LEWIS, A. PERRY, L. BATTERSBY, N. COLBERT, G. GREEN, T. AMOS, L. DAVIES, B. FARAGHER
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- Journal:
- Psychological Medicine / Volume 30 / Issue 4 / July 2000
- Published online by Cambridge University Press:
- 01 July 2000, pp. 805-812
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Background. Suicide prevention is a health priority in many countries. Improved management of suicide risk may improve suicide prevention. This study aimed to assess the feasibility of health district-wide training in the assessment and management of people at risk of suicide; and to assess the impact of training on assessment and management skills.
Methods. Staff in three health care settings, namely primary care, accident and emergency departments and mental health services (N = 359), were offered suicide risk management training in a district-wide programme, using a flexible ‘facilitator’ approach. The main outcomes were the rate of attendance at training, and changes in suicide risk assessment and management skills following training.
Results. It was possible to deliver training to 167 health professionals (47% of those eligible) during a 6 month training period. This included 95 primary care staff (39%), 21 accident and emergency staff (42%) and 51 mental health staff (78%). Of these, 103 (69%) attended all training. A volunteer sample of 28 staff who underwent training showed improvements in skills in the assessment and management of suicide risk. Satisfaction with training was high. The expected costs of district-wide training, if it were able to produce a 2·5% reduction in the suicide rate, would be £99747 per suicide prevented and £3391 per life year gained.
Conclusions. Training in the assessment and management of suicide risk can be delivered to approximately half the targeted staff in primary care, accident and emergency departments and mental health services. The current training package can improve skills and is well accepted. If it were to produce a modest fall in the suicide rate, such training would be cost-effective. However, a future training programme should develop a broader training package to reach those who will not attend.
Conditional ETDT analysis of the Human Leukocyte Antigen region in type 1 diabetes
- B. P. C. KOELEMAN, M. H. HERR, P. ZAVATTARI, F. DUDBRIDGE, R. MARCH, D. CAMPBELL, A. H. BARNETT, S. C. BAIN, A. P. MULARGIA, M. LODDO, W. AMOS, F. CUCCA, J. A. TODD
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- Journal:
- Annals of Human Genetics / Volume 64 / Issue 3 / May 2000
- Published online by Cambridge University Press:
- 23 October 2000, pp. 215-221
- Print publication:
- May 2000
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Several studies have indicated that additional genes in the major histocompatibility complex (MHC) region, other than the class II genes HLA-DQB1 and -DRB1 (the IDDM1 locus), may contribute to susceptibility and resistance to type 1 diabetes. The relative magnitude of these non- DR/DQ effects is uncertain and their map location is unknown owing to the extraordinary linkage disequilibrium that extends over the 3.5 Mb of the MHC. The homozygous parent test has been proposed as a method for detection of additional risk factors conditional on HLA-DQB1 and -DRB1. However, this method is inefficient since it uses only parents homozygous for the primary disease locus, the DQB1-DRB1 haplotype. To overcome this limitation, Conditional ETDT was used in the present report to test for association conditional on the DQB1-DRB1 haplotype, thereby allowing all parents to be included in the analysis. First, we confirm in UK and Sardinian type 1 diabetic families that allelic variation at HLA-DRB1 has a very significant effect on the association of DQB1 and vice versa. The Conditional ETDT was then applied to the HLA TNF (tumour necrosis factor) region and microsatellite marker D6S273 region, both of which have been reported to contribute to IDDM1 independent of the HLA-DQB1-DRB1 genes. We found no evidence for a major role for either of these two regions in IDDM1.
Scoring functions in protein folding and design
- RUXANDRA I. DIMA, JAYANTH R. BANAVAR, AMOS MARITAN
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- Journal:
- Protein Science / Volume 9 / Issue 4 / April 2000
- Published online by Cambridge University Press:
- 01 April 2000, pp. 812-819
- Print publication:
- April 2000
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We present an analysis of the assumptions behind some of the most commonly used methods for evaluating the goodness of the fit between a sequence and a structure. Our studies on a lattice model show that methods based on statistical considerations are easy to use and can capture some of the features of protein-like sequences and their corresponding native states, but unfortunately are incapable of recognizing, with certainty, the native-like conformation of a sequence among a set of decoys. Meanwhile, an optimization method, entailing the determination of the parameters of an effective free energy of interaction, is much more reliable in recognizing the native state of a sequence. However, the statistical method is shown to perform quite well in tests of protein design.