On February 6, 2023, a strong earthquake (7.8 Richter scale) shook southwestern Türkiye, and also affected areas in northwest Syria, resulting in over 50 000 fatalities and more than 100 000 injured in Türkiye, in addition to the displacement of approximately 3 million people. In response to an international request for assistance from the Turkish government, the United Kingdom (UK) government deployed an Emergency Medical Team (EMT) Type 1 to provide outpatient care. This report describes the type of medical conditions treated at the facility from 1 week to 3 months post-earthquake. Consultations and diagnoses were recorded using standardized UK EMT patient records and reported through the WHO Minimum Data Set (MDS) format. A total of 7048 patient consultations were documented during the deployment.

The majority of cases involved infectious conditions, primarily respiratory illnesses, rather than trauma. Noncommunicable diseases (NCDs), such as cardiovascular diseases and diabetes, were also prevalent, particularly among adults and older patients. The report outlines some recommendations to better adapt data collection in order to improve EMT preparedness for future earthquake responses.

The coherent vortical structures in turbulent flow through a strong 16 : 1 three-dimensional contraction are studied using time-resolved volumetric measurements. Visualization using the vorticity magnitude criterion shows the emergence of long, stretched cylindrical vortices aligned with the mean flow. This alignment is quantified by probability density functions (p.d.f.s) of the direction cosines. We propose two measures to quantify the alignment, the peak height in the probability and a coefficient from the moment of the p.d.f., both of which reaffirm the strong streamwise alignment. The root mean square streamwise vorticity grows within the contraction to become 4.5 times larger than the transverse component, at the downstream location where the contraction ratio is $C=11$. The characteristic vortices become as long as the measurement volume, or more than 4 times the integral scale at the entrance to the contraction. We also characterize the vorticity enhancement along individual vortices, measuring 65 % strengthening over the distance where $C$ goes from 4 to 11. The prevalence of these coherent structures is estimated from 700 000 measured volumes, showing that near the outlet, it is more likely to have one or two of these structures present than none.

Poisonous birds are rare but on New Guinea, including Indonesia’s easternmost provinces, no less than nine poisonous species, eight pitohuis and one species of ifrita, are found. Pitohuis when handled can cause sneezing with numbness and burning of nasal tissue and nausea in humans. In the bird markets of western Indonesia novelty birds are traded at a premium and overexploitation of popular songbirds leads traders to find replacement species to meet demand. We conducted over 800 surveys in the bird markets of Sumatra, Java, Bali, Lombok, and Sulawesi between 1994 and 2023 and from 2015 onwards we assessed the online trade in pitohuis and Blue-capped Ifrit Ifrita kowaldi. We identified the species, recorded their prices and location, and the date when the birds were offered for sale. We analysed temporal trends, volumes, prices, and geographical origin of the sellers. Between 1994 and 2014 we did not encounter a single pitohui in the Indonesian bird markets. In the following years we recorded 113 pitohuis in 12 bird markets and we recorded 199 pitohuis for sale online; 248 were variable pitohuis and 54 were Hooded Pitohui Pitohui dichrous. No ifritas were recorded. Most pitohuis were recorded in eastern Java and Bali. Prices differed between eastern Java (mean of US$93) and western Java and Bali (US$185), possibly suggesting pitohuis arrive from West Papua in eastern Java and from there make their way to the outer markets. Pitohuis are marketed as “Papuan Straw-headed Bulbuls”; the Straw-headed Bulbul Pycnonotus zeylanicus is a very popular and expensive songbird from Southeast Asia, including western Indonesia, that has become rare both in the wild and in the markets due to overexploitation. Discussions about pitohuis on online forums rarely mention “poisonous” but when it is mentioned traders dismiss this as something not to worry about and they claim it to be dietary-dependent. Poisonous pitohuis are novelty, as well as master, birds in Indonesia, where they are marketed for their song ignoring any negative side-effects of them being poisonous. The trade in novelty species, when detected early, does allow for the authorities to intervene in a timely manner to ensure that this trade does not impede their conservation.

Flows over a disc are studied in a wind tunnel over incidence angles between $0^\circ \text { and }36^\circ$, a Reynolds number of $2.7 \times 10^4$ and rotational speed ratios of $0\unicode{x2013}10$. Smoke-wire visualization, particle image velocimetry and hot-film anemometry are employed. Two vortex shedding modes originating from the upstream surface of the disc are observed. The first is dominant at incidence angles up to ${\sim }21^\circ$. Beyond $21^\circ$, the second mode dominates. It appears as a soliton on the vortices and has a shedding frequency nearly twice that of the first at the highest incidence angle. The Strouhal number monotonically increases with incidence angle from approximately 0.2 to 0.4. Spectral analysis of the hot-film measurements confirms the findings from flow visualization experiments. Flows over the spinning disc generally mimic the stationary disc flows; however, centrifugal forces lead to cross-stream instability features that may be attributed to spiral wave instabilities intrinsic to the boundary layers in rotating flows. Velocity measurements are used to construct streamline patterns to compare with the smoke streaklines. The unsteadiness of the flows results in large variances. Mean strain rates are extracted from velocity data, where the fixed disc case at normal incidence compares well with theoretical predictions. The unsteady boundary layer thickness over the fixed disc, however, is approximately twice that predicted by theory for steady flow, stemming from the dominance of large unsteady vortices. Limited comparisons are made of the Strouhal numbers from experiments and numerical calculations in the literature.

A fourth-order bandpass filter with dual-wide passbands is proposed in this article. The novelty of the proposed work is the realization of a dual-band bandpass filter with closely spaced passbands, wide passband bandwidth, high rejection between the passbands, using a novel combination of open stub tapped series coupled lines (CLs) and shunt transmission line loaded with end connected CLs. The characteristics of the proposed dual-wideband bandpass filter are investigated by adopting even–odd mode analysis. The transmission zeros generated by the transmission line loaded with an end-connected CL and open stub are utilized to achieve a high skirt rate. A rejection better than 55 dB is achieved with a single transmission zero between the two passbands indicating high isolation and close passbands. The dual-wideband filter is designed and manufactured to operate at 1.33 and 2.32 GHz. The experimented 3-dB fractional bandwidths of the two pass frequency bands are 40.6% and 24.13%. The proposed filter’s tested frequency responses agree well with simulated results. The proposed device can be used in various applications such as telecommunications, satellite communications, radar systems, imaging, and spectroscopy.

We perform a detailed numerical study of modal and non-modal stability in oblique Couette–Poiseuille profiles, which are among the simplest examples of three-dimensional boundary layers. Through a comparison with the Orr–Sommerfeld operator for the aligned case, we show how an effective wall speed succinctly characterizes modal stability. Large-scale parameter sweeps reveal that the misalignment between the pressure gradient and wall motion is, in general, destabilizing. For flows that are sufficiently oblique, the instability is found to depend exclusively on the direction of wall motion and not on its speed, a conclusion supported, in part, by the perturbation energy budget and the evolution of the critical layers. Closed forms for the critical parameters in this regime are derived using a simple analysis. From a non-modal perspective, pseudoresonance is examined through the resolvent and the $\epsilon$-pseudospectra. An analysis of the unforced initial value problem shows that the maximum energy gain is highly dependent on both the magnitude and direction of the wall velocity. However, the strongest amplification is always achieved for configurations that are only weakly skewed. Finally, the optimal perturbations appear to develop via a lift-up effect enhanced by an Orr-like mechanism, the latter driven by cross-flow shear.

Deficiency of vitamin B12 (B12 or cobalamin), an essential water-soluble vitamin, leads to neurological damage, which can be irreversible and anaemia, and is sometimes associated with chronic disorders such as osteoporosis and cardiovascular diseases. Clinical tests to detect B12 deficiency lack specificity and sensitivity. Delays in detecting B12 deficiency pose a major threat because the progressive decline in organ functions may go unnoticed until the damage is advanced or irreversible. Here, using targeted unbiased metabolomic profiling in the sera of subjects with low B12 levels v control individuals, we set out to identify biomarker(s) of B12 insufficiency. Metabolomic profiling identified seventy-seven metabolites, and partial least squares discriminant analysis and hierarchical clustering analysis showed a differential abundance of taurine, xanthine, hypoxanthine, chenodeoxycholic acid, neopterin and glycocholic acid in subjects with low B12 levels. Random forest multivariate analysis identified a taurine/chenodeoxycholic acid ratio, with an AUC score of 1, to be the best biomarker to predict low B12 levels. Mechanistic studies using a mouse model of B12 deficiency showed that B12 deficiency reshaped the transcriptomic and metabolomic landscape of the cell, identifying a downregulation of methionine, taurine, urea cycle and nucleotide metabolism and an upregulation of Krebs cycle. Thus, we propose taurine/chenodeoxycholic acid ratio in serum as a potential biomarker of low B12 levels in humans and elucidate using a mouse model of cellular metabolic pathways regulated by B12 deficiency.

Background: The Uganda Ministry of Health (MoH) and implementing partners instituted an infection prevention and control (IPC) response strategy during the Uganda SVD outbreak in 2022 that involved rapid enhancement of screening capacity at HCFs. Rapid scale-up of screening for infectious diseases, such as SVD, is critical for early identification and triage of suspected or confirmed cases in HCFs. We describe the rapid deployment of a multimodal IPC strategy implemented in response to the SVD outbreak and the resulting impact on screening measures at HCFs. Methods: We implemented a multimodal IPC strategy in HCFs from five high risk districts to improve screening practices from November 2022–January 2023. The strategy included training health workers (HCWs) identified as IPC mentors; establishing screening areas; and providing screening supplies and communication materials. The three-day training utilized an MoH standardized training package with didactic and practice sessions. The mentors then cascaded screening information and skills to other HCWs through onsite trainings and mentorships and established screening areas. Baseline and endline (3 months after baseline) cross-sectional assessments were conducted using the MoH IPC Assessment Tool adapted from the WHO Ebola IPC Scorecard. The five main screening parameters assessed included presence of ≥ 1 meter distance between screener and the person screened, availability of a functional handwashing facility and infrared thermometer, correct record of each person’s temperature, and appropriate referral process for those suspected of having SVD to holding areas. IPC capacity was measured through the summation of each of these parameter results and calculated as an overall percentage. IBM SPSS Statistics 20 software was used for data analysis and a paired t-test done to determine any significant findings between mean scores (percentage) at baseline and endpoint. Results: A total of 296 IPC mentors were trained, screening information was cascaded to 3,899 HCWs, and screening areas were established in 1,135 HCFs. Based on the screening results from the MoH IPC assessment tool, capacity improved from 44% (SD=37) at baseline to 67% (SD=34) at endpoint. Screening capacity improved from baseline to endpoint among level II and public HCFs from 33% (SD=35) to 60% (SD=35) (p < 0 .05) and from 54% (SD=38) to 76% (SD=31) (p < 0 .05), respectively. Conclusion: Rapid implementation of a multimodal IPC strategy was successful in enhancing screening capacity across Uganda’s HCFs during a SVD response, which is critical for early identification of infected patients to interrupt transmission. This multimodal approach should be recommended for future response actions.

This retrospective study compared central line-associated bloodstream infection (CLABSI) rates per 1 000 central line days, and overall mortality before and during the COVID-19 pandemic in adult, paediatric, and neonatal ICU patients at King Abdul-Aziz Medical City-Riyadh who had a central line and were diagnosed with CLABSI according to the National Healthcare Safety Network standard definition. The study spanned between January 2018 and December 2019 (pre-pandemic), and January 2020 and December 2021 (pandemic). SARS-CoV-2 was confirmed by positive RT-PCR testing. The study included 156 CLABSI events and 46 406 central line days; 52 and 22 447 (respectively) in pre-pandemic, and 104 and 23 959 (respectively) during the pandemic. CLABSI rates increased by 2.02 per 1 000 central line days during the pandemic period (from 2.32 to 4.34, p < 0.001). Likewise, overall mortality rates increased by 0.86 per 1 000 patient days (from 0.93 to 1.79, p = 0.003). Both CLABSI rates (6.18 vs. 3.7, p = 0.006) and overall mortality (2.72 vs. 1.47, p = 0.014) were higher among COVID-19 patients compared to non-COVID-19 patients. The pandemic was associated with a substantial increase in CLABSI-associated morbidity and mortality.

Second language (L2) anxiety has been proposed to play a causal role in L2 achievement. However, most studies have failed to acknowledge confounding variables that may be relevant to the study of anxiety and L2 achievement or to investigate the causal effect of L2 anxiety using longitudinal data. For these reasons, we investigated the effect of L1 reading achievement, L2 aptitude, and L2 anxiety as covariates on the growth of L2 reading achievement across three time points. We used the latent growth curve model (LGCM) to estimate the growth trajectory of US secondary school students’ L2 reading growth in Spanish (N = 307) over three school years. The findings showed that students’ L1 reading achievement and L2 aptitude strongly and significantly predicted L2 reading achievement growth. However, L2 anxiety did not predict L2 reading achievement growth. Findings suggest that growth in L2 reading achievement depends on the language-related skills used for L1 reading and the language skills that comprise L2 aptitude, but not on anxiety. Similar to past cross-sectional studies, L2 anxiety related only to initial levels of L2 reading achievement, suggesting that anxiety reflects students’ initial experience of L2 reading but not their L2 achievement.