Müller Ice Cap sits on Umingmat Nunaat (Axel Heiberg Island), Nunavut, Canada, ~ 80°N. Its high latitude and elevation suggest it experiences relatively little melt and preserves an undisturbed paleoclimate record. Here, we present a suite of field measurements, complemented by remote sensing, that constrain the ice thickness, accumulation rate, temperature, ice-flow velocity, and surface-elevation change of Müller Ice Cap. These measurements show that some areas near the top of the ice cap are more than 600 m thick, have nearly stable surface elevation, and flow slowly, making them good candidates for an ice core. The current mean annual surface temperature is −19.6 °C, which combined with modeling of the temperature profile indicates that the ice is frozen to the bed. Modeling of the depth-age scale indicates that Pleistocene ice is likely to exist with measurable resolution (300–1000 yr m−1) 20–90 m from the bed, assuming that Müller Ice Cap survived the Holocene Climatic Optimum with substantial ice thickness (~400 m or more). These conditions suggest that an undisturbed Holocene climate record could likely be recovered from Müller Ice Cap. We suggest 91.795°W, 79.874°N as the most promising drill site.

Upernavik Isstrøm, the largest contributor to sea-level rise in northwest Greenland, has experienced complex and contrasting ice-flow-speed changes across its five outlets over the last two decades. In this study, we present a detailed remote-sensing analysis of the ice dynamics at Upernavik's outlets from 2000 to 2021 to evaluate the details of these changes. Previous research suggested that the presence or absence of floating ice tongues strongly influences Upernavik's ice dynamics. We use several lines of evidence to document the presence of floating ice tongues, and find that, while several outlets experienced ice-tongue formation and/or loss during the study period, these changes do not explain observed fluctuations in ice-flow velocity. Further exploration of ice-dynamic forcings using a flowline model suggests that changes in basal slipperiness near the terminus have a strong impact on upstream ice dynamics and can explain the velocity variations. Our results suggest that speed fluctuations at Upernavik's outlets may be seasonally and interannually controlled by bed conditions near the terminus, and highlight the need for further research on the influence of basal conditions on complex tidewater glacier dynamics.

Ice-crystal fabric can induce mechanical anisotropy that significantly affects flow, but ice-flow models generally do not include fabric development or its effect upon flow. Here, we incorporate a new spectral expansion of fabric, and more complete description of its evolution, into the ice-flow model Elmer/Ice. This approach allows us to model the effect of both lattice rotation and migration recrystallization on large-scale ice flow. The fabric evolution is coupled to flow using an unapproximated non-linear orthotropic rheology that better describes deformation when the stress and fabric states are misaligned. These improvements are most relevant for simulating dynamically interesting areas, where recrystallization can be important, tuning data are scarce and rapid flow can lead to misalignment between stress and fabric. We validate the model by comparing simulated fabric to ice-core and phase-sensitive radar measurements on a transect across Dome C, East Antarctica. With appropriately tuned rates for recrystallization, the model is able to reproduce observations of fabric. However, these tuned rates differ from those previously derived from laboratory experiments, suggesting a need to better understand how recrystallization acts differently in the laboratory compared to natural settings.

Following the landmark essay of T. H. Marshall, Citizenship and the Social Class (1949), it has conventionally been assumed that the introduction and expansion of social rights in Europe happened as the final stage of a long process of democratization that included the granting of first civil and then political rights. We present a radically different perspective on the relationship between the extension of suffrage (under meaningful competition for government power) and social rights, that is state-financed entitlements that make citizens’ livelihood independent from the labor market in the instance of events such as unemployment or sickness. First, some countries institutionalized a state-financed poor relief system much before mass democratization. In these countries, the primary effect of suffrage extension was to reduce public social spending, not expand it. Second, the way this retrenchment occurred was partly by creating a negative link between social rights, on the one hand, and civil and political rights, on the other. We test our argument with case studies of nineteenth- to early-twentieth-century England, Denmark, Norway, and Prussia, all of which are paradigmatic cases that represent the variation in welfare state types.

Bulk directional enhancement factors are determined for axisymmetric (girdle and single-maximum) orientation fabrics using a transversely isotropic grain rheology with an orientation-dependent non-linear grain fluidity. Compared to grain fluidities that are simplified as orientation independent, we find that bulk strain-rate enhancements for intermediate-to-strong axisymmetric fabrics can be up to a factor of ten larger, assuming stress homogenization over the polycrystal scale. Our work thus extends previous results based on simple basal slip (Schmid) grain rheologies to the transversely isotropic rheology, which has implications for large-scale anisotropic ice-flow modelling that relies on a transversely isotropic grain rheology. In order to derive bulk enhancement factors for arbitrary evolving fabrics, we expand the c-axis distribution in terms of a spherical harmonic series, which allows the rheology-required structure tensors through order eight to easily be calculated and provides an alternative to current structure-tensor-based modelling.

We prove a generalisation of the Brill-Noether theorem for the variety of special divisors $W^r_d(C)$ on a general curve C of prescribed gonality. Our main theorem gives a closed formula for the dimension of $W^r_d(C)$ . We build on previous work of Pflueger, who used an analysis of the tropical divisor theory of special chains of cycles to give upper bounds on the dimensions of Brill-Noether varieties on such curves. We prove his conjecture, that this upper bound is achieved for a general curve. Our methods introduce logarithmic stable maps as a systematic tool in Brill-Noether theory. A precise relation between the divisor theory on chains of cycles and the corresponding tropical maps theory is exploited to prove new regeneration theorems for linear series with negative Brill-Noether number. The strategy involves blending an analysis of obstruction theories for logarithmic stable maps with the geometry of Berkovich curves. To show the utility of these methods, we provide a short new derivation of lifting for special divisors on a chain of cycles with generic edge lengths, proved using different techniques by Cartwright, Jensen, and Payne. A crucial technical result is a new realisability theorem for tropical stable maps in obstructed geometries, generalising a well-known theorem of Speyer on genus $1$ curves to arbitrary genus.

An insect trap constructed using three-dimensional (3D) printing technology was tested in potato (Solanum tuberosum Linnaeus; Solanaceae) fields to determine whether it could substitute for the standard yellow sticky card used to monitor Bactericera cockerelli (Šulc) (Hemiptera: Psylloidea: Triozidae). Sticky cards have shortcomings that prompted search for a replacement: cards are messy, require weekly replacement, are expensive to purchase, and accumulate large numbers of nontarget insects. Bactericera cockerelli on sticky cards also deteriorate enough that specimens cannot be tested reliably for the presence of vectored plant pathogens. A prototype trap constructed using 3D printing technology for monitoring Diaphorina citri Kuwayama (Hemiptera: Psylloidea: Liviidae) was tested for monitoring B. cockerelli. The trap was designed to attract B. cockerelli visually to the trap and then funnel specimens into preservative-filled vials at the trap bottom. Prototype traps were paired against yellow sticky cards at multiple fields to compare the captures of B. cockerelli between cards and traps. The prototype trap was competitive with sticky cards early in the growing season when B. cockerelli numbers were low. We estimated that two or three prototype traps would collect as many B. cockerelli as one sticky card under these conditions. Efficacy of the prototype declined as B. cockerelli numbers increased seasonally. The prototype trap accumulated nontarget taxa that are common on sticky cards (especially Thysanoptera and Diptera), and was also found to capture taxa of possible interest in integrated pest management research, including predatory insects, parasitic Hymenoptera, and winged Aphididae (Hemiptera), suggesting that the traps could be useful outside of the purpose targeted here. We believe that 3D printing technology has substantial promise for developing monitoring tools that exploit behavioural traits of the targeted insect. Ongoing work includes the use of this technology to modify the prototype, with a focus on making it more effective at capturing psyllids and less susceptible to capture of nontarget species.

OBJECTIVES/SPECIFIC AIMS: Clostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea and an increasingly common infection in children in both hospital and community settings. Between 20% and 30% of pediatric patients will have a recurrence of symptoms in the days to weeks following an initial infection. Multiple recurrences have been successfully treated with fecal microbiota transplantation (FMT), though the body of evidence in pediatric patients is limited primarily to case reports and case series. The goal of our study was to better understand practices, success, and safety of FMT in children as well as identify risk factors associated with a failed FMT in our pediatric patients. METHODS/STUDY POPULATION: This multicenter retrospective analysis included 373 patients who underwent FMT for CDI between January 1, 2006 and January 1, 2017 from 18 pediatric centers. Demographics, baseline characteristics, FMT practices, C. difficile outcomes, and post-FMT complications were collected through chart abstraction. Successful FMT was defined as no recurrence of CDI within 60 days after FMT. Of the 373 patients in the cohort, 342 had known outcome data at two months post-FMT and were included in the primary analysis evaluating risk factors for recurrence post-FMT. An additional six patients who underwent FMT for refractory CDI were excluded from the primary analysis. Unadjusted analysis was performed using Wilcoxon rank-sum test, Pearson χ2 test, or Fisher exact test where appropriate. Stepwise logistic regression was utilized to determine independent predictors of success. RESULTS/ANTICIPATED RESULTS: The median age of included patients was 10 years (IQR; 3.0, 15.0) and 50% of patients were female. The majority of the cohort was White (89.0%). Comorbidities included 120 patients with inflammatory bowel disease (IBD) and 14 patients who had undergone a solid organ or stem cell transplantation. Of the 336 patients with known outcomes at two months, 272 (81%) had a successful outcome. In the 64 (19%) patients that did have a recurrence, 35 underwent repeat FMT which was successful in 20 of the 35 (57%). The overall success rate of FMT in preventing further episodes of CDI in the cohort with known outcome data was 87%. Unadjusted predictors of a primary FMT response are summarized. Based on stepwise logistic regression modeling, the use of fresh stool, FMT delivery via colonoscopy, the lack of a feeding tube, and a lower number of CDI episodes before undergoing FMT were independently associated with a successful outcome. There were 20 adverse events in the cohort assessed to be related to FMT, 6 of which were felt to be severe. There were no deaths assessed to be related to FMT in the cohort. DISCUSSION/SIGNIFICANCE OF IMPACT: The overall success of FMT in pediatric patients with recurrent or severe CDI is 81% after a single FMT. Children without a feeding tube, who receive an early FMT, FMT with fresh stool, or FMT via colonoscopy are less likely to have a recurrence of CDI in the 2 months following FMT. This is the first large study of FMT for CDI in a pediatric cohort. These findings, if confirmed by additional prospective studies, will support alterations in the practice of FMT in children.