42 results
361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
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- Christopher Hubert, Kelly Mitchell, Samuel Sprowls, Sajina Shakya, Sonali Arora, Daniel J. Silver, Christopher M. Goins, Lisa Wallace, Gustavo Roversi, Rachel Schafer, Kristen Kay, Tyler E. Miller, Adam Lauko, John Bassett, Anjali Kashyap, J. D’Amato Kass, Erin E. Mulkearns-Hubert, Sadie Johnson, Joseph Alvarado, Jeremy N. Rich, Patrick J. Paddison, Anoop P. Patel, Shaun R. Stauffer, Christopher G. Hubert, Justin D. Lathia
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue s1 / April 2023
- Published online by Cambridge University Press:
- 24 April 2023, p. 107
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OBJECTIVES/GOALS: Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that are driven by populations of cancer stem cells (CSCs). In this study, we perform an epigenetic-focused functional genomics screen in GBM organoids and identify WDR5 as an essential epigenetic regulator in the SOX2-enriched, therapy resistant cancer stem cell niche. METHODS/STUDY POPULATION: Despite their importance for tumor growth, few molecular mechanisms critical for CSC population maintenance have been exploited for therapeutic development. We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators in the SOX2-enriched, therapy resistant niche. Our niche-specific screens identified WDR5, an H3K4 histone methyltransferase responsible for activating specific gene expression, as indispensable for GBM CSC growth and survival. RESULTS/ANTICIPATED RESULTS: In GBM CSC models, WDR5 inhibitors blocked WRAD complex assembly and reduced H3K4 trimethylation and expression of genes involved in CSC-relevant oncogenic pathways. H3K4me3 peaks lost with WDR5 inhibitor treatment occurred disproportionally on POU transcription factor motifs, required for stem cell maintenance and including the POU5F1(OCT4)::SOX2 motif. We incorporated a SOX2/OCT4 motif driven GFP reporter system into our CSC cell models and found that WDR5 inhibitor treatment resulted in dose-dependent silencing of stem cell reporter activity. Further, WDR5 inhibitor treatment altered the stem cell state, disrupting CSC in vitro growth and self-renewal as well as in vivo tumor growth. DISCUSSION/SIGNIFICANCE: Our results unveiled the role of WDR5 in maintaining the CSC state in GBM and provide a rationale for therapeutic development of WDR5 inhibitors for GBM and other advanced cancers. This conceptual and experimental framework can be applied to many cancers, and can unmask unique microenvironmental biology and rationally designed combination therapies.
449 Progression of silica-induced pulmonary fibrosis is arrested after selective ablation of Col1a1+ fibroblasts
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- Daniel G Foster, Nomin Javkhlan, Jasmine Wilson, Benjamin L. Edelman, David W. H. Riches, Elizabeth F. Redente
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- Journal:
- Journal of Clinical and Translational Science / Volume 7 / Issue s1 / April 2023
- Published online by Cambridge University Press:
- 24 April 2023, pp. 133-134
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OBJECTIVES/GOALS: Silicosis is a highly fatal progressive fibrotic disease of the lungs characterized by accumulation and persistence of fibroblasts that excessively deposit Collagen1a1. We sought to eliminate Collagen1a1-expressing fibroblasts through a targeted genetic ablation strategy and hypothesized that this would arrest the progression of Silicosis. METHODS/STUDY POPULATION: Silicosis was induced with a single intratracheal (i.t.) instillation of silica particles ( RESULTS/ANTICIPATED RESULTS: Targeted ablation of Col1a1+ fibroblast in established Silicosis resulted in a decrease in: 1) Col1a1+ fibroblasts by flow cytometry and within fibrotic nodules by immunofluorescent staining, 2) total lung collagen content by histology and hydroxyproline assay, 3) tissue-associated disease by microCT and an increase in arterial oxygen saturation by pulse oximetry. Cessation of targeted Col1a1+ fibroblast ablation resulted in a rebound effect in Silicosis disease progression. Following ablation, Col1a1+ fibroblasts expanded by proliferation (Ki67+) and total lung collagen levels returned to pre-ablation levels. DISCUSSION/SIGNIFICANCE: Silicosis is a often fatal disease with no FDA approved therapies. These results suggest that targeted loss of Col1a1+ fibroblasts in Silicosis is sufficient to arrest disease progression. Thus, it is essential to understand how targeted loss of pro-fibrotic fibroblasts can alter disease progression as a tool to develop novel therapeutic strategies.
Associations between antibiotic prescriptions and recurrent urinary tract infections in female college students
- S. N. Rich, E. M. Klann, C. R. Almond, E. M. Larkin, G. Nicolette, J. D. Ball
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- Journal:
- Epidemiology & Infection / Volume 147 / 2019
- Published online by Cambridge University Press:
- 08 March 2019, e119
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Urinary tract infections (UTIs) are common among college-aged women and often recur. Some antibiotics recommended to treat UTIs trigger dysbiosis of intestinal and vaginal microbiomes – where uropathogens originate, though few studies have investigated associations between these therapies with recurrent infections. We retrospectively analysed the electronic medical records of 6651 college-aged women diagnosed with a UTI at a US university student health centre between 2006 and 2014. Women were followed for 6 months for incidence of a recurrent infection. In a secondary analysis, associations in women whose experienced UTI recurrence within 2 weeks were also considered for potential infection relapse. Logistic regression was used to assess associations between infection recurrence or relapse and antibiotics prescribed, in addition to baseline patient characteristics including age, race/ethnicity, region of origin, year of encounter, presence of symptomology, pyelonephritis, vaginal coinfection and birth control consultation. There were 1051 instances of infection recurrence among the 6620 patients, indicating a prevalence of 16%. In the analysis of patient characteristics, Asian women were statistically more likely to experience infection recurrence whereas African American were less likely. No significant associations were identified between the antibiotic administered at the initial infection and the risk of infection recurrence after multivariable adjustment. Treatment with trimethoprim-sulphamethoxazole and being born outside of the USA were significantly associated with increased odds of infection relapse in the multivariate analysis. The results of the analyses suggest that treatment with trimethoprim-sulphamethoxazole may lead to an increased risk of UTI relapse, warranting further study.
NEW TAXA AND NEW COMBINATIONS IN THE BRITISH FLORA
- T. C. G. Rich, A. McVeigh, C. A. Stace
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- Journal:
- Edinburgh Journal of Botany / Volume 76 / Issue 2 / July 2019
- Published online by Cambridge University Press:
- 03 December 2018, pp. 173-180
- Print publication:
- July 2019
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Four new taxa and nine new combinations are required for forthcoming floristic works by the authors. The new taxa are Centaurium tenuiflorum (Hoffmanns. & Link) Fritsch subsp. anglicum T.C.G.Rich & McVeigh, subsp. nov.; Centaurium × klattii P.Fourn. ex T.C.G.Rich, hyb. nov.; Centaurium × ubsdellii T.C.G.Rich, hyb. nov.; and Gentianella amarella (L.) Börner subsp. occidentalis T.C.G.Rich & McVeigh, subsp. nov. The new combinations are Centaurium erythraea Rafn var. latifolium (Sm.) T.C.G.Rich, comb. et stat. nov.; Gentianella amarella (L.) Börner subsp. anglica (Pugsley) T.C.G.Rich & McVeigh, comb. et stat. nov.; Aria parviloba (T.C.G.Rich) Sennikov & Kurtto, comb. nov.; Cotula sessilis (Ruiz & Pav.) Stace, comb. nov.; Elymus × drucei (Stace) Stace, comb. nov.; Elymus repens (L.) Gould f. aristatus (Schumach.) Stace, comb. nov.; Elymus athericus (Link) Kerguélen f. setigerus (Dumort.) Stace, comb. nov.; Ulmus minor Mill. subsp. cornubiensis (Weston) Stace, comb. et stat. nov.; and Dysphania ambrosioides (L.) Mosyakin & Clemants var. anthelmintica (L.) Stace, comb. nov.
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
- Jiayi Xu, Traci M. Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W. Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L. Booth, Guy G. Brusselle, Ian H. de Boer, Myriam Fornage, Alexis C. Frazier-Wood, Mariaelisa Graff, Vilmundur Gudnason, Tamara B. Harris, Albert Hofman, Ruixue Hou, Denise K. Houston, David R. Jacobs, Jr, Stephen B. Kritchevsky, Jeanne Latourelle, Rozenn N. Lemaitre, Pamela L. Lutsey, George O’Connor, Elizabeth C. Oelsner, James S. Pankow, Bruce M. Psaty, Rebecca R. Rohde, Stephen S. Rich, Jerome I. Rotter, Lewis J. Smith, Bruno H. Stricker, V. Saroja Voruganti, Thomas J. Wang, M. Carola Zillikens, R. Graham Barr, Josée Dupuis, Sina A. Gharib, Lies Lahousse, Stephanie J. London, Kari E. North, Albert V. Smith, Lyn M. Steffen, Dana B. Hancock, Patricia A. Cassano
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- Journal:
- British Journal of Nutrition / Volume 120 / Issue 10 / 28 November 2018
- Published online by Cambridge University Press:
- 12 September 2018, pp. 1159-1170
- Print publication:
- 28 November 2018
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The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (Prace difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (Prace difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.
Barriers to Providing Prehospital Care to Ischemic Stroke Patients: Predictors and Impact on Care
- Timmy Li, Jeremy T. Cushman, Manish N. Shah, Adam G. Kelly, David Q. Rich, Courtney M. C. Jones
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- Journal:
- Prehospital and Disaster Medicine / Volume 33 / Issue 5 / October 2018
- Published online by Cambridge University Press:
- 29 August 2018, pp. 501-507
- Print publication:
- October 2018
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Introduction
Ischemic stroke treatment is time-sensitive, and barriers to providing prehospital care encountered by Emergency Medical Services (EMS) providers have been under-studied.
Hypothesis/ProblemThis study described barriers to providing prehospital care, identified predictors of these barriers, and assessed the impact of these barriers on EMS on-scene time and administration of tissue plasminogen activator (tPA) in the emergency department (ED).
MethodsA retrospective cohort study was performed using the Get With The Guidelines-Stroke (GWTG-S; American Heart Association [AHA]; Dallas, Texas USA) registry at two hospitals to identify ischemic stroke patients arriving by EMS. Variables were abstracted from prehospital and hospital medical records and merged with registry data. Barriers to care were grouped into themes. Logistic regression was used to identify predictors of barriers to care, and bi-variate tests were used to assess differences in EMS on-scene time and the proportion of patients receiving tPA between patients with and without barriers.
ResultsBarriers to providing prehospital care were documented for 15.5% of patients: 29.6% related to access, 26.7% communication, 23.0% extrication and transportation, 20.0% refusal, and 14.1% assessment/management. Non-white and non-black race (OR: 3.69; 95% CI, 1.63-8.36) and living alone (OR: 1.53; 95% CI, 1.05-2.23) were associated with greater odds of barriers to providing care. The EMS on-scene time was ≥15 minutes for 70.4% of patients who had a barrier to care, compared with 49.0% of patients who did not (P<.001). There was no significant difference in the proportion of patients who were administered tPA between those with and without barriers to care (14.1% vs 19.2%; P=.159).
ConclusionsBarriers to providing prehospital care were documented for a sizable proportion of ischemic stroke patients, with the majority related to patient access and communication, and occurred more frequently among non-white and non-black patients and those living alone. Although EMS on-scene time was longer for patients with barriers to care, the proportion of patients receiving tPA in the ED did not differ.
,Li T ,Cushman JT ,Shah MN ,Kelly AG ,Rich DQ .Jones CMC Barriers to Providing Prehospital Care to Ischemic Stroke Patients: Predictors and Impact on Care . Prehosp Disaster Med.2018 ;33 (5 ):501 –507 .
P061: Implementing CBME in emergency medicine: lessons learned from the first 6 months of transition at Queens University
- A. K. Hall, J. Rich, J. Dagnone, K. Weersink, J. Caudle, J. Sherbino, J. R. Frank, G. Bandiera, E. Van Melle
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- Journal:
- Canadian Journal of Emergency Medicine / Volume 20 / Issue S1 / May 2018
- Published online by Cambridge University Press:
- 11 May 2018, p. S78
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- May 2018
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Introduction: The specialist Emergency Medicine (EM) postgraduate training program at Queens University implemented a new Competency-Based Medical Education (CBME) model on July 1 2017. This occurred one year ahead of the national EM cohort, in the model of Competence By Design (CBD) as outlined by the Royal College of Physicians and Surgeons of Canada (RCPSC). This presents an opportunity to identify critical steps, successes, and challenges in the implementation process to inform ongoing national CBME implementation efforts. Methods: A case-study methodology with Rapid Cycle Evaluation was used to explore the lived experience of implementing CBME in EM at Queens, and capture evidence of behavioural change. Data was collected at 3- and 6- months post-implementation via multiple sources and methods, including: field observations, document analysis, and interviews with key stakeholders: residents, faculty, program director, CBME lead, academic advisors, and competence committee members. Qualitative findings have been triangulated with available quantitative electronic assessment data. Results: The critical processes of implementation have been outlined in 3 domain categories: administrative transition, resident transition, and faculty transition. Multiple themes emerged from stakeholder interviews including: need for holistic assessment beyond Entrustable Professional Activity (EPA) assessments, concerns about the utility of milestones in workplace based assessment by front-line faculty, trepidation that CBME is adding to, rather than replacing, old processes, and a need for effective data visualisation and filtering for assessment decisions by competency committees. We identified a need for administrative direction and faculty development related to: new roles and responsibilities, shared mental models of EPAs and entrustment scoring. Quantitative data indicates that the targeted number of assessments per EPA and stage of training may be too high. Conclusion: Exploring the lived experience of implementing CBME from the perspectives of all stakeholders has provided early insights regarding the successes and challenges of operationalizing CBME on the ground. Our findings will inform ongoing local implementation and higher-level national planning by the Canadian EM Specialty Committee and other programs who will be implementing CBME in the near future.
P033: Reducing pantoprazole infusions in ED GI bleed patients by optimizing electronic order sets
- S. K. Dowling, E. S. Lang, G. Kaplan, K. Novak, C. Hall, J. King, J. Larsson, T. Rich
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- Journal:
- Canadian Journal of Emergency Medicine / Volume 20 / Issue S1 / May 2018
- Published online by Cambridge University Press:
- 11 May 2018, p. S68
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- May 2018
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Introduction: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common presentation to the emergency department (ED) accounting for significant morbidity, mortality and health care resource usage. In Alberta, a provincial care pathway was recently developed to provide an evidence informed approach to managing patients with an UGIBs in the ED. Pantoprazole infusions are a commonly used treatment despite evidence that suggests they are generally not indicated prior to endoscopy in the ED. The goal of this project was to optimize management of patients with a NVUGIB, in particular reduce pre-endoscopy pantoprazole infusions. Methods: In July 2016, we implemented a multi-faceted intervention to optimize management of ED patients with NVUGIB including 1. de-emphasizing IV pantoprazole infusions in the ED, 2. clinical decision support (CDS) embedded (for endoscopy, disposition and transfusions) within the order set and 3. educating clinicians about the care pathway. We used a pre/post-order set design, analyzing 391 days pre and 189 days post-order set changes. Data was extracted from our fully integrated electronic health records system. The primary outcome was the % of patients receiving IV pantoprazole infusion ordered by an emergency physician (EP) among all patients with NVUGIB. Secondary outcomes included % transfused with hgb >70g/L and whether using the GIB order set impacted management of NVUGIB patients. Results: In the 391 days pre-order set changes, there were 2165 patients included and in the 189 days post-order set changes, there were 901 patients. For baseline characteristics, patients in the post-order set change group were significantly older (64.4 yrs vs 60.9 yrs p-value=0.0016) and had a lower hgb (115 vs 118, p-value=0.049) but otherwise for gender, measures of severity of illness (systolic blood pressure, heart rate, CTAS, % admitted) there were no significantly differences. For the primary outcome, in the pre-order set phase, 47.1% received a pantoprazole infusion ordered by an EP, compared to 31.5% in the post-order phase, for an absolute reduction of 15.6% (p-value= <0.001). For the secondary outcomes, transfusion rates were similar pre/post (22.08% vs 22.75%). Significant inter-site variability exists with respect to the reduction in pantoprazole infusion rates across the four sites (-23.3% to +6.12%). Conclusion: Our interventions resulted in a significant overall reduction in pantoprazole infusions in ED patients with NVUGIB. Reductions in pantoprazole infusions varied significantly across the different sites, future work in our department will explore and address this variability. Keys to the success of this project included engaging clinicians as well as leveraging the SCM order sets as well as the provincial care pathway. Although there were no changes in transfusion rates, it in unclear if this a function of the CDS not being effective or whether these transfusions were clinically indicated.
Towards meeting VLTA challenges for evacuation slides and slide-rafts
- P. D. Gosling, C. G. Riches
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- Journal:
- The Aeronautical Journal / Volume 107 / Issue 1070 / April 2003
- Published online by Cambridge University Press:
- 04 July 2016, pp. 185-200
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The intrinsic dependence on the necessary minimum structural performance of inflatable aircraft evacuation slides and slide-rafts in the event of and emergency or precautionary aircraft evacuation is described in the context of the certification of both new (or modified) aircraft and slide designs. The concepts of the pneumatic structure with analytical and numerical methodologies are briefly reviewed. Fundamental principles of inflatable evacuation slide performance and assessment are presented, while the characteristics of typical structural responses are identified for single deck aircraft. The implications of evacuation from an upper deck of a VLTA are identified in the interpretation of two new commercial inflatable evacuation slide designs. Alternative meso and macro pneumatic structural forms are proposed as evolutions of the conventional inflated tube. Outline details of a simple mixed finite element and vector-based simulation algorithm for the analysis of pneumatic structures precede examples verifying the numerical formulation and demonstrating the potential of multi-cell beam (meso) and “semi-pneumatic shell membrane” (macro) pneumatic concepts. Recommendations for future research conclude the paper.
Phylogenetic systematics of Tertiary monophorasterid sand dollars (Clypeasteroida: Echinoidea) from South America
- Rich Mooi, Sergio Martínez, Sara G. Parma
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- Journal:
- Journal of Paleontology / Volume 74 / Issue 2 / March 2000
- Published online by Cambridge University Press:
- 20 May 2016, pp. 263-281
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Sand dollars in the Monophorasteridae Lahille, 1896, form an important part of the South American Cenozoic echinoid fauna. Re-examination of type and other material adds significantly to our knowledge of the morphology and taxonomy of the family, and shows that besides Monophoraster darwini (Desor, 1847), M. duboisi (Cotteau, 1884), Amplaster coloniensis Martínez, 1984, and A. alatus Rossi de Garcia and Levy, 1989, there is a new species, A. ellipticus. We also show that Karlaster Marchesini Santos, 1958, is not a monophorasterid as once thought. A phylogenetic analysis of 24 characters assessed from all species of Monophoraster Lambert and Thiéry, 1921, and Amplaster Martínez, 1984, along with genera of the Mellitidae Stefanini, 1912, produced a single most parsimonious tree. The analysis demonstrates monophyly of mellitids and monophorasterids, and that Iheringiella Berg, 1898, should be excluded from the latter. Although both Monophoraster Lambert and Thiéry, 1921, and Amplaster Martínez, 1984, retain many features of an ancestor in common with the Mellitidae Stefanini, 1912, they also exhibit bizarre morphologies quite different from those of mellitids. The study has also resulted in a clearer picture of the biogeography and biostratigraphy of the Monophorasteridae, and their great significance in the evolution of lunulate sand dollars in the Americas.
Urchins in the meadow: paleobiological and evolutionary implications of cidaroid predation on crinoids
- Tomasz K. Baumiller, Rich Mooi, Charles G. Messing
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- Journal:
- Paleobiology / Volume 34 / Issue 1 / Winter 2008
- Published online by Cambridge University Press:
- 08 April 2016, pp. 22-34
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Deep-sea submersible observations made in the Bahamas revealed interactions between the stalked crinoid Endoxocrinus parrae and the cidaroid sea urchin Calocidaris micans. The in situ observations include occurrence of cidaroids within “meadows” of sea lilies, close proximity of cidaroids to several upended isocrinids, a cidaroid perched over the distal end of the stalk of an upended isocrinid, and disarticulated crinoid cirri and columnals directly underneath a specimen of C. micans. Guts of two C. micans collected from the crinoid meadow contain up to 70% crinoid material. Two of three large museum specimens of another cidaroid species, Histocidaris nuttingi, contain 14–99% crinoid material.
A comparison of cidaroid gut contents with local sediment revealed significant differences: sediment-derived material consists of single crinoid ossicles often abraded and lacking soft tissue, whereas crinoid columnals, cirrals, brachials, and pinnulars found in the cidaroids are often articulated, linked by soft tissue, and unabraded. Furthermore, articulated, multi-element fragments often show a mode of fracture characteristic of fresh crinoid material. Taken together, these data suggest that cidaroids prey on live isocrinids.
We argue that isocrinid stalk-shedding, whose purpose has remained a puzzle, and the recently documented rapid crawling of isocrinids are used in escaping benthic predators: isocrinids sacrifice and shed the distal stalk portion when attacked by cidaroids and crawl away, reducing the chance of a subsequent encounter. If such predation occurred throughout the Mesozoic and Cenozoic (possibly since the mid-Paleozoic), several evolutionary trends among crinoids might represent strategies to escape predation by slow-moving benthic predators.
Complex sentence profiles in children with Specific Language Impairment: Are they really atypical?*
- NICK G. RICHES
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- Journal:
- Journal of Child Language / Volume 44 / Issue 2 / March 2017
- Published online by Cambridge University Press:
- 15 February 2016, pp. 269-296
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Children with Specific Language Impairment (SLI) have language difficulties of unknown origin. Syntactic profiles are atypical, with poor performance on non-canonical structures, e.g. object relatives, suggesting a localized deficit. However, existing analyses using ANOVAs are problematic because they do not systematically address unequal variance, or fully model random effects. Consequently, a Generalised Linear Model (GLM) was used to analyze data from a Sentence Repetition (SR) task involving relative clauses. seventeen children with SLI (mean age 6;7), twenty-one Language Matched (LM) children (mean age 4;8), and seventeen Age Matched (AM) children (mean age 6;5) repeated 100 canonical and non-canonical sentences. ANOVAs found a significant Group by Canonicity interaction for the SLI versus AM contrast only. However, the GLM found no significant interaction. Consequently, arguments for a localized deficit may depend on statistical methods which are prone to exaggerate profile differences. Nonetheless, a subgroup of SLI exhibited particularly severe structural language difficulties.
Contributors
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- By Janice Capel Anderson, S. Wesley Ariarajah, Constantine Belezos, Ian Boxall, Marc Zvi Brettler, Edward Breuer, Daniel Bruno, Mark Chapman, W. T. Dickens, Mark W. Elliott, Eldon Epp, Tassilo Erhardt, Timothy Gorringe, Harriet Harris, Peter C. Hodgson, Leslie Howsam, Werner G. Jeanrond, Scott McLaren, Wayne A. Meeks, Néstor Míguez, Stephen D. Moore, Robert Morgan, Halvor Moxnes, Peter Neuner, Mark Noll, Jorunn Økland, Gaye Ortiz, John Riches, Christopher Rowland, Nicolaas A. Rupke, Edmund J. Rybarczyk, Lamin Sanneh, Constantine Scouteris, R. S. Sugirtharajah, Willard M. Swartley, William R. Telford, David Thompson, Elena Volkova, J. R. Watson, Gerald West, Michael Wheeler, Keith Whitelam
- Edited by John Riches, University of Glasgow
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- The New Cambridge History of the Bible
- Published online:
- 09 June 2015
- Print publication:
- 13 April 2015, pp xi-xii
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PSEUDOMACROMIA NATALENSIS AND MERUENSIS (ODONATA)
- S. G. Rich
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- The Canadian Entomologist / Volume 53 / Issue 2 / February 1921
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- 31 May 2012, pp. 46-47
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Control of Cattle Grub and Lice with Systemic Insecticides
- G. B. Rich, M. A. Khan
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- Journal:
- The Canadian Entomologist / Volume 96 / Issue 1-2 / February 1964
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- 31 May 2012, p. 142
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A. The effect of 6 annual systemic insecticide treatments on cattle grub infestation was ohserved in a range herd of beef cattle that are isolated during the fly oviposition period by at least 10 miles from areas where adjacent herds could have dropped pupae. The herd is ranged throughout the year on a large and rugged semi-mountainous area, and was increased during the study from 1200 to 1600 animals. Bulls were the only imports made into the herd. Beef and cull females were marketed in late autumn. Treatments were applied in early December during the annual weaning-culling gather of the herd. Treatments in 1957, 1958 and 1959 were with Trolene boluses and each animal was weighed before treatment. Treatments in 1960, 1961 and 1962 were with Ruelene pour-on and weights were estimated. Annually a randomly selected group of calves was left untreated, and grubs were removed from chis and a similar group of treated calves at intervals throughout the grub season. By comparison of the untreated and treated samples, the insecticides produced the following grub reductions: 1957 − 76.8%, 1958 − 89.0%, 1959 − 87.5%, 1960 − 91.7%, 1961 − 91.0% and 1962 − 100.0%. The average numbers of grubs per untreated calf were: 1957 − 30.2, 1958 − 14.5, 1959 − 1.6, 1960 − 2.5, 1961 − 2.7, and 1962 − 0.2. Prior to these treatments gadding had seriously disrupted summer management of the herd but it has not occurred since 1957. The quality of the herd has improved, but because of changes in management and bull quality, the precise effect of the treatments cannot be assessed. (G.B.R.)
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. 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Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. 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Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Ticks (Ixodoidea) of domestic animals in Cyprus
- P. D. Le Riche, Y. Altan, J. B. Campbell, G. C. Efstathiou
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- Bulletin of Entomological Research / Volume 64 / Issue 1 / August 1974
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- 10 July 2009, pp. 53-63
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A total of 15 835 ticks was identified, mainly from sheep and goats, in a livestock survey in Cyprus in 1970–72. Hyalomma anatolicum anatolicum Koch, H. a. excavatum Koch, H. marginatum marginatum Koch, H. m. turanicum Pom., H. m. rufipes Koch, Haemaphysalis sulcata C. & F., Ixodes crenulatus Koch and Rhipicephalus turanicus Pom. & Matikashvili are recorded for the first time in Cyprus. H. sulcata was found in all parts of the island; Hyalomma spp. and Rhipicephalus spp. were mostly seen in the low drier areas, and Ixodes gibbosus Nutt. in the wetter areas; Boophilus annulatus (Say) was confined to one small area. Ticks were most common in autumn and early winter. Haemaphysalis sulcata and I. gibbosus were only found in the winter months, whereas Hyalomma spp. were found all the year round but especially in the warmer months. The Hyalomma subspecies showed some differences in seasonal distribution. Immature Rhipicephalus ticks were found in the colder months whereas the adults were seen mainly in the spring and early summer. Immature Haemaphysalis sulcata and Hyalomma spp. were extremely rare on ruminants. Only adults of I. gibbosus were seen in the first year of the survey, whereas only immatures, mainly larvae, were seen in the second year. The period of attachment of R. bursa C. & F. adults was shorter than that of R. turanicus and corresponded closely to the incidence of babesiosis in sheep and goats. The predilection sites of ticks for cattle, sheep and goats are given.
A Helminth Survey of Sheep and Goats in Cyprus.Part I. The Seasonal Distribution and Prevalence of Gastro-Intestinal Parasites
- P. D. Le Riche, G. C. Efstathiou, J. B. Campbell, Y. Altan
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- Journal of Helminthology / Volume 47 / Issue 3 / September 1973
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- 05 June 2009, pp. 237-250
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889 complete alimentary tracts were examined for helminths during a two-year survey of sheep and goats in Cyprus. Faecal samples were also examined for worm eggs.
The most common parasites found were Ostertagia and Trichostrongylus spp. and a list of all the parasites and their prevalence is given.
Bunostomum trigonoceplialum, Parabronema skrjabini and Skrjabinema ovis were found for the first time in Cyprus.
The infection rate of each of the worms was studied and the results showed that most of the worms followed the same general pattern, having a peak in the spring and another in the autumn, separated by a trough during the hot dry summer period, when the infection rate yvas low. There were variations within this pattern, Trichostrongylus spp. having a spring peak that was more pronounced than the autumn peak. The reverse occurred with Ostertagia, Chabertia and Oesophagostomum spp., which had a more pronounced autumn peak than spring peak and a lower rate of infection in the summer.
Variations in the infection rate were also noted between the two years of study.
The reasons for these variations are discussed and it appears that weather has some influence on the timing and duration of the peaks but that other factors must also be involved. It is suggested that with some species inhibition of development of the immature stages may occur over the hot dry period, and that these immature worms resume their development towards the end of summer.
A similarity was noticed between the seasonal distribution of the different worm species in Cyprus and in the winter rainfall areas of Australia.
A Helminth Survey of Sheep and Goats in Cyprus. Part II. Age Distribution and the Severity of Infection with Gastro-Intestinal Parasites
- P. D. Le Riche, G. C. Efstathiou, Y. Altan, J. B. Campbell
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- Journal of Helminthology / Volume 47 / Issue 3 / September 1973
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- 05 June 2009, pp. 251-262
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889 alimentary tracts from sheep and goats were examined for worms during 1970 and 1971.
The severity of infection with each of the worm species is discussed and it is concluded that infections with Ostertagia spp. and Trichostrongylus spp. are the most important and that Haemonchus contortus, Bunostomum trigonocephalum and Chabertia ovina are of secondary importance.
The animals were divided into different age groups and a study was made of the severity of mixed infections in each group. The point system adopted by Parnell et al. (1954) was used for the study.
The most unexpected finding was that lambs and kids under 8 months old rarely suffered from infections of any significance. Infections built up slowly after that age. It was therefore presumed that animals remained vulnerable to infections at a much later age than in other countries.
Infections that might cause sub-clinical disease were seen in 31% of all animals and heavier infections were seen in 20% of the animals. This was considered a conservative estimate and shows the importance of gastro-intestinal parasites in sheep and goats in Cyprus.
Adult sheep appeared to be more heavily infected than goats, although some differences in animal husbandry between the two may have contributed to this.
From this study of age distribution, it was found that the autumn peak in the infection rate was not caused by the infection of young animals, which remained low at this time of the year.
J. Colombo, P. McCardle & P. Freund (eds), Infant pathways to language: Methods, models, and research directions. Hove: Psychology Press. Pp. 336. ISBN: 978-0-8058-6063-4.
- Nick G. Riches
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- Journal of Child Language / Volume 37 / Issue 2 / March 2010
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- 03 June 2009, pp. 460-465
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