This article presents the preliminary results of investigations at the site of Qach Rresh on the Erbil Plain of the Kurdistan Region of Iraq, conducted by the Rural Landscapes of Iron Age Imperial Mesopotamia project (RLIIM). The site of Qach Rresh is estimated to have been founded in the mid–eighth century B.C.E., at the height of the Assyrian Empire, and continued to be utilised in varying capacity until the onset of the Hellenistic period (c. 320 B.C.E.). Magnetic gradiometry survey and excavations currently suggest that Qach Rresh served as a rural administrative/storage center during the Assyrian Empire, which fell into disrepair following the empire’s collapse. The following post-Assyrian/Iron Age III period then saw several of its large buildings repurposed as refuse areas containing debris from largely domestic contexts. Qach Rresh is the first rural settlement investigated within the Assyrian imperial heartland. The results from this project seem to indicate a high degree of Assyrian state or elite involvement in the countryside, serving as a critical first foray into assessing the relationship between urban governing centers and their “hinterlands”.

Glyphosate-resistant (GR) Palmer amaranth is one of the most difficult to control weeds in soybean production fields in Nebraska and the United States. An integrated approach is required for effective management of GR Palmer amaranth. Cultural practices such as narrow row spacing might augment herbicide efficacy for management of GR Palmer amaranth. The objectives of this study were to evaluate the effect of row spacing and herbicide programs for management of GR Palmer amaranth in dicamba/glyphosate-resistant (DGR) soybean. Field experiments were conducted in a grower’s field with a uniform population of GR Palmer amaranth near Carleton, Nebraska, in 2018 and 2019. Year-by-herbicide program-by-row spacing interactions were significant for all variables; therefore, data were analyzed by year. Herbicides applied PRE controlled GR Palmer amaranth ≥95% in both years 14 d after PRE (DAPRE). Across soybean row-spacing, most PRE followed by (fb) early-POST (EPOST) herbicide programs provided 84% to 97% control of Palmer amaranth compared with most EPOST fb late-post (LPOST) programs, excluding dicamba in single and sequential applications (82% to 95% control). Mixing microencapsulated acetochlor with a POST herbicide in PRE fb EPOST herbicide programs controlled Palmer amaranth ≥93% 14 d after EPOST and ≥96% 21 d after LPOST with no effect on Palmer amaranth density. Interaction of herbicide program-by-row spacing on Palmer amaranth control was not significant; however, biomass reduction was significant at soybean harvest in 2019. The herbicide programs evaluated in this study caused no soybean injury. Due to drought conditions during a majority of the 2018 growing season, soybean yield in 2018 was reduced compared with 2019.

The Cal-DSH Diversion Guidelines provide 10 general guidelines that jurisdictions should consider when developing diversion programs for individuals with a serious mental illness (SMI) who become involved in the criminal justice system. Screening for SMI in a jail setting is reviewed. In addition, important treatment interventions for SMI and substance use disorders are highlighted with the need to address criminogenic risk factors highlighted.

Accelerating innovation translation is a priority for improving healthcare and health. Although dissemination and implementation (D&I) research has made significant advances over the past decade, it has attended primarily to the implementation of long-standing, well-established practices and policies. We present a conceptual architecture for speeding translation of promising innovations as candidates for iterative testing in practice. Our framework to Design for Accelerated Translation (DART) aims to clarify whether, when, and how to act on evolving evidence to improve healthcare. We view translation of evidence to practice as a dynamic process and argue that much evidence can be acted upon even when uncertainty is moderately high, recognizing that this evidence is evolving and subject to frequent reevaluation. The DART framework proposes that additional factors – demand, risk, and cost, in addition to the evolving evidence base – should influence the pace of translation over time. Attention to these underemphasized factors may lead to more dynamic decision-making about whether or not to adopt an emerging innovation or de-implement a suboptimal intervention. Finally, the DART framework outlines key actions that will speed movement from evidence to practice, including forming meaningful stakeholder partnerships, designing innovations for D&I, and engaging in a learning health system.

Agents that block the renin–angiotensin system (RAS) improve glucoregulation in the metabolic syndrome disorder. We evaluated the effects of egg white hydrolysate (EWH), previously shown to modulate the protein abundance of RAS component in vivo, on glucose homeostasis in diet-induced insulin-resistant rats. Sprague–Dawley rats were fed a high-fat diet (HFD) for 6 weeks to induce insulin resistance. They were then randomly divided into four groups receiving HFD or HFD supplemented with different concentrations of EWH (1, 2 and 4 %) for another 6 weeks in the first trial. In the second trial, insulin-resistant rats were divided into two groups receiving only HFD or HFD+4 % EWH for 6 weeks. Glucose homeostasis was assessed by oral glucose tolerance and insulin tolerance tests. Insulin signalling and protein abundance of RAS components, gluconeogenesis enzymes and PPARγ were evaluated in muscle, fat and liver. Adipocyte morphology and inflammatory markers were evaluated. In vivo administration of EWH increased insulin sensitivity, improved oral glucose tolerance (P < 0·0001) and reduced systemic inflammation (P < 0·05). EWH potentiated insulin-induced Akt phosphorylation in muscle (P = 0·0341) and adipose tissue (P = 0·0276), but minimal differences in the protein abundance of tissue RAS components between the EWH and control groups were observed. EWH treatment also reduced adipocyte size (P = 0·0383) and increased PPARγ2 protein abundance (P = 0·0237). EWH treatment yielded positive effects on the inflammatory profile, glucose tolerance, insulin sensitivity and adipocyte differentiation in HFD-induced insulin resistance rats. The involvement of local RAS activity requires further investigation.

Modelling of Solar Energetic Particles (SEPs) is usually carried out by means of the 1D focused transport equation and the same approach is adopted within several SEP Space Weather forecasting frameworks. We present an alternative approach, based on test particle simulations, which naturally describes 3D particle propagation. The SPARX forecasting system is an example of how test particle simulations can be used in real time in a Space Weather context. SPARX is currently operational within the COMESEP Alert System. The performance of the system, which is triggered by detection of a solar flare of class >M1.0 is evaluated by comparing forecasts for flare events between 1997 and 2017 with actual SEP data from the GOES spacecraft.

Irreversible monoamine oxidase inhibitor (MAOI) antidepressants have significant efficacy in treatment-resistant unipolar depression, but in some instances patients may not achieve remission. Among the adjunctive and augmentation strategies, certain second-generation antipsychotics (SGAs) have approval for inadequate responders to antidepressant therapy, including aripiprazole, brexpiprazole, and quetiapine, with lurasidone and the olanzapine/fluoxetine combination indicated for bipolar depression. Clinicians may eschew SGA options in part due to the limited literature on SGA–MAOI combinations, with only one published case involving aripiprazole, and none for olanzapine, lurasidone, or brexpiprazole. In addition to the limited publication history on SGA–MAOI treatment, clinicians may also be deterred by uncertainty regarding SGA mechanisms and the risk of serotonin syndrome or other adverse outcomes. This paper describes the case of a 54-year-old male with a history of psychotic unipolar depression treated with a combination of phenelzine, aripiprazole, and quetiapine, and reviews the 12 published cases of SGA–MAOI combination therapy with a focus on the pharmacological basis for serotonin syndrome, and the SGA mechanisms that should not be associated with a risk for this syndrome.

Mental health research funding priorities in high-income countries must balance longer-term investment in identifying neurobiological mechanisms of disease with shorter-term funding of novel prevention and treatment strategies to alleviate the current burden of mental illness. Prioritising one area of science over others risks reduced returns on the entire scientific portfolio.

Endothelial dysfunction and arterial stiffness are early predictors of CVD. Intervention studies have suggested that diet is related to vascular health, but most prior studies have tested individual foods or nutrients and relied on small samples of younger adults. The purpose of the present study was to examine the relationships between adherence to the 2010 Dietary Guidelines for Americans and vascular health in a large cross-sectional analysis. In 5887 adults in the Framingham Heart Study Offspring and Third Generation cohorts, diet quality was quantified with the 2010 Dietary Guidelines Adherence Index (DGAI-2010). Endothelial function was assessed via brachial artery ultrasound and arterial stiffness via arterial tonometry. In age-, sex- and cohort-adjusted analyses, a higher DGAI-2010 score (greater adherence) was modestly associated with a lower resting flow velocity, hyperaemic response, mean arterial pressure, carotid–femoral pulse wave velocity (PWV), and augmentation index, but not associated with resting arterial diameter or flow-mediated dilation (FMD). In multivariable models adjusting for cardiovascular risk factors, only the association of a higher DGAI-2010 score with a lower baseline flow velocity and augmentation index persisted (β = − 0·002, P= 0·003 and β = − 0·05 ± 0·02, P< 0·001, respectively). Age-stratified multivariate-adjusted analyses suggested that the relationship of higher DGAI-2010 scores with lower mean arterial pressure, PWV and augmentation index was more pronounced among adults younger than 50 years. Better adherence to the 2010 Dietary Guidelines for Americans, particularly in younger adults, is associated with a lower peripheral blood flow velocity and arterial wave reflection, but not FMD. The present results suggest a link between adherence to the Dietary Guidelines and favourable vascular health.