8 results
Recreating the OSIRIS-REx slingshot manoeuvre from a network of ground-based sensors
- Trent Jansen-Sturgeon, Benjamin A. D. Hartig, Gregory J. Madsen, Philip A. Bland, Eleanor K. Sansom, Hadrien A. R. Devillepoix, Robert M. Howie, Martin Cupák, Martin C. Towner, Morgan A. Cox, Nicole D. Nevill, Zacchary N. P. Hoskins, Geoffrey P. Bonning, Josh Calcino, Jake T. Clark, Bryce M. Henson, Andrew Langendam, Samuel J. Matthews, Terence P. McClafferty, Jennifer T. Mitchell, Craig J. O’Neill, Luke T. Smith, Alastair W. Tait
-
- Journal:
- Publications of the Astronomical Society of Australia / Volume 37 / 2020
- Published online by Cambridge University Press:
- 27 November 2020, e049
-
- Article
-
- You have access Access
- HTML
- Export citation
-
Optical tracking systems typically trade off between astrometric precision and field of view. In this work, we showcase a networked approach to optical tracking using very wide field-of-view imagers that have relatively low astrometric precision on the scheduled OSIRIS-REx slingshot manoeuvre around Earth on 22 Sep 2017. As part of a trajectory designed to get OSIRIS-REx to NEO 101955 Bennu, this flyby event was viewed from 13 remote sensors spread across Australia and New Zealand to promote triangulatable observations. Each observatory in this portable network was constructed to be as lightweight and portable as possible, with hardware based off the successful design of the Desert Fireball Network. Over a 4-h collection window, we gathered 15 439 images of the night sky in the predicted direction of the OSIRIS-REx spacecraft. Using a specially developed streak detection and orbit determination data pipeline, we detected 2 090 line-of-sight observations. Our fitted orbit was determined to be within about 10 km of orbital telemetry along the observed 109 262 km length of OSIRIS-REx trajectory, and thus demonstrating the impressive capability of a networked approach to Space Surveillance and Tracking.
Intellectual abilities in tuberous sclerosis complex: risk factors and correlates from the Tuberous Sclerosis 2000 Study
- P. F. Bolton, M. Clifford, C. Tye, C. Maclean, A. Humphrey, K. le Maréchal, J. N. P. Higgins, B. G. R. Neville, F. Rijsdjik, The Tuberous Sclerosis 2000 Study Group, J. R. W. Yates
-
- Journal:
- Psychological Medicine / Volume 45 / Issue 11 / August 2015
- Published online by Cambridge University Press:
- 01 April 2015, pp. 2321-2331
-
- Article
- Export citation
-
Background
Tuberous sclerosis complex (TSC) is associated with intellectual disability, but the risk pathways are poorly understood.
MethodThe Tuberous Sclerosis 2000 Study is a prospective longitudinal study of the natural history of TSC. One hundred and twenty-five UK children age 0–16 years with TSC and born between January 2001 and December 2006 were studied. Intelligence was assessed using standardized measures at ≥2 years of age. The age of onset of epilepsy, the type of seizure disorder, the frequency and duration of seizures, as well as the response to treatment was assessed at interview and by review of medical records. The severity of epilepsy in the early years was estimated using the E-Chess score. Genetic studies identified the mutations and the number of cortical tubers was determined from brain scans.
ResultsTSC2 mutations were associated with significantly higher cortical tuber count than TSC1 mutations. The extent of brain involvement, as indexed by cortical tuber count, was associated with an earlier age of onset and severity of epilepsy. In turn, the severity of epilepsy was strongly associated with the degree of intellectual impairment. Structural equation modelling supported a causal pathway from genetic abnormality to cortical tuber count to epilepsy severity to intellectual outcome. Infantile spasms and status epilepticus were important contributors to seizure severity.
ConclusionsThe findings support the proposition that severe, early onset epilepsy may impair intellectual development in TSC and highlight the potential importance of early, prompt and effective treatment or prevention of epilepsy in tuberous sclerosis.
Behavioural Marital Therapy for Alcoholics: Effects on Communication Skills and Marital Satisfaction
- Michael P. Baker, Neville M. Blampied, Lynne Haye
-
- Journal:
- Behaviour Change / Volume 6 / Issue 3-4 / September 1989
- Published online by Cambridge University Press:
- 06 October 2014, pp. 178-186
-
- Article
- Export citation
-
Four married couples were recruited from an outpatient alcohol counselling centre. Four husbands and one wife had recently received therapy for alcoholism and all but one was abstinent during the study. All scored as distressed on the Marital Adjustment Test. They participated in ten sessions of behavioural marital therapy emphasising positive reinforcement, communication, expression of feelings and problem solving. Problem solving discussions were audio-recorded at each session and analysed using a behaviour code. Measures of marital satisfaction, conflict and depression showed modest gains which were generally maintained at follow-up. Communication skills improved most with training, problem solving less so and feelings expression declined below baseline levels. These changes did not appear to be very durable. The non-abstinent client reduced his drinking to a level satisfactory to his wife during therapy. These findings support other recent work, draw attention to the need to find ways of promoting the maintenance and transfer of therapeutic changes and suggest that behavioural marital therapy may usefully be employed in outpatient alcohol counselling settings.
Use of vitamin D supplements during infancy in an international feeding trial
- Eveliina Lehtonen, Anne Ormisson, Anita Nucci, David Cuthbertson, Susa Sorkio, Mila Hyytinen, Kirsi Alahuhta, Carol Berseth, Marja Salonen, Shayne Taback, Margaret Franciscus, Teba González-Frutos, Tuuli E Korhonen, Margaret L Lawson, Dorothy J Becker, Jeffrey P Krischer, Mikael Knip, Suvi M Virtanen, , Thomas Mandrup-Poulsen, Elias Arjas, Åke Lernmark, Barbara Schmidt, Jeffrey P. Krischer, Hans K. Åkerblom, Mila Hyytinen, Mikael Knip, Katriina Koski, Matti Koski, Eeva Pajakkala, Marja Salonen, David Cuthbertson, Jeffrey P. Krischer, Linda Shanker, Brenda Bradley, Hans-Michael Dosch, John Dupré, William Fraser, Margaret Lawson, Jeffrey L. Mahon, Mathew Sermer, Shayne P. Taback, Dorothy Becker, Margaret Franciscus, Anita Nucci, Jerry Palmer, Minna Pekkala, Suvi M. Virtanen, Jacki Catteau, Neville Howard, Patricia Crock, Maria Craig, Cheril L. Clarson, Lynda Bere, David Thompson, Daniel Metzger, Colleen Marshall, Jennifer Kwan, David K. Stephure, Daniele Pacaud, Wendy Schwarz, Rose Girgis, Marilyn Thompson, Shayne P. Taback, Daniel Catte, Margaret L. Lawson, Brenda Bradley, Denis Daneman, Mathew Sermer, Mary-Jean Martin, Valérie Morin, Lyne Frenette, Suzanne Ferland, Susan Sanderson, Kathy Heath, Céline Huot, Monique Gonthier, Maryse Thibeault, Laurent Legault, Diane Laforte, Elizabeth A. Cummings, Karen Scott, Tracey Bridger, Cheryl Crummell, Robyn Houlden, Adriana Breen, George Carson, Sheila Kelly, Koravangattu Sankaran, Marie Penner, Richard A. White, Nancy King, James Popkin, Laurie Robson, Eva Al Taji, Irena Aldhoon, Pavla Mendlova, Jan Vavrinec, Jan Vosahlo, Ludmila Brazdova, Jitrenka Venhacova, Petra Venhacova, Adam Cipra, Zdenka Tomsikova, Petra Krckova, Pavla Gogelova, Ülle Einberg, Mall-Anne Riikjärv, Anne Ormisson, Vallo Tillmann, Päivi Kleemola, Anna Parkkola, Heli Suomalainen, Anna-Liisa Järvenpää, Anu-Maaria Hämälainen, Hannu Haavisto, Sirpa Tenhola, Pentti Lautala, Pia Salonen, Susanna Aspholm, Heli Siljander, Carita Holm, Samuli Ylitalo, Raisa Lounamaa, Anja Nuuja, Timo Talvitie, Kaija Lindström, Hanna Huopio, Jouni Pesola, Riitta Veijola, Päivi Tapanainen, Abram Alar, Paavo Korpela, Marja-Liisa Käär, Taina Mustila, Ritva Virransalo, Päivi Nykänen, Bärbel Aschemeier, Thomas Danne, Olga Kordonouri, Dóra Krikovszky, László Madácsy, Yeganeh Manon Khazrai, Ernesto Maddaloni, Paolo Pozzilli, Carla Mannu, Marco Songini, Carine de Beaufort, Ulrike Schierloh, Jan Bruining, Margriet Bisschoff, Aleksander Basiak, Renata Wasikowa, Marta Ciechanowska, Grazyna Deja, Przemyslawa Jarosz-Chobot, Agnieszka Szadkowska, Katarzyna Cypryk, Malgorzata Zawodniak-Szalapska, Luis Castano, Teba Gonzalez Frutos, Mirentxu Oyarzabal, Manuel Serrano-Ríos, María Teresa Martínez-Larrad, Federico Gustavo Hawkins, Dolores Rodriguez Arnau, Johnny Ludvigsson, Malgorzata Smolinska Konefal, Ragnar Hanas, Bengt Lindblad, Nils-Osten Nilsson, Hans Fors, Maria Nordwall, Agne Lindh, Hans Edenwall, Jan Aman, Calle Johansson, Margrit Gadient, Eugen Schoenle, Dorothy Becker, Ashi Daftary, Margaret Franciscus, Carol Gilmour, Jerry Palmer, Rachel Taculad, Marilyn Tanner-Blasiar, Neil White, Uday Devaskar, Heather Horowitz, Lisa Rogers, Roxana Colon, Teresa Frazer, Jose Torres, Robin Goland, Ellen Greenberg, Maudene Nelson, Holly Schachner, Barney Softness, Jorma Ilonen, Massimo Trucco, Lynn Nichol, Erkki Savilahti, Taina Härkönen, Mikael Knip, Outi Vaarala, Kristiina Luopajärvi, Hans-Michael Dosch
-
- Journal:
- Public Health Nutrition / Volume 17 / Issue 4 / April 2014
- Published online by Cambridge University Press:
- 24 June 2013, pp. 810-822
-
- Article
-
- You have access Access
- HTML
- Export citation
-
Objective
To examine the use of vitamin D supplements during infancy among the participants in an international infant feeding trial.
DesignLongitudinal study.
SettingInformation about vitamin D supplementation was collected through a validated FFQ at the age of 2 weeks and monthly between the ages of 1 month and 6 months.
SubjectsInfants (n 2159) with a biological family member affected by type 1 diabetes and with increased human leucocyte antigen-conferred susceptibility to type 1 diabetes from twelve European countries, the USA, Canada and Australia.
ResultsDaily use of vitamin D supplements was common during the first 6 months of life in Northern and Central Europe (>80 % of the infants), with somewhat lower rates observed in Southern Europe (>60 %). In Canada, vitamin D supplementation was more common among exclusively breast-fed than other infants (e.g. 71 % v. 44 % at 6 months of age). Less than 2 % of infants in the USA and Australia received any vitamin D supplementation. Higher gestational age, older maternal age and longer maternal education were study-wide associated with greater use of vitamin D supplements.
ConclusionsMost of the infants received vitamin D supplements during the first 6 months of life in the European countries, whereas in Canada only half and in the USA and Australia very few were given supplementation.
Encouraging behaviour change in mild cognitive impairment patients: development of educational material
- C. E. Neville, H. J. McCourt, M. C. McKinley, C. Lowis, S. L. Barrett, B. McGuinness, S. Todd, B. Lawlor, M. Gibb, R. F. Coen, A. P. Passmore, J. V. Woodside
-
- Journal:
- Proceedings of the Nutrition Society / Volume 71 / Issue OCE2 / 2012
- Published online by Cambridge University Press:
- 19 October 2012, E154
-
- Article
-
- You have access Access
- HTML
- Export citation
Contributors
-
- By Graeme J.M. Alexander, Heung Bae Kim, Michael Burch, Andrew J. Butler, Tanveer Butt, Roy Calne, Edward Cantu, Robert B. Colvin, Paul Corris, Charles Crawley, Hiroshi Date, Francis L. Delmonico, Bimalangshu R. Dey, Kate Drummond, John Dunning, John D. Firth, John Forsythe, Simon M. Gabe, Robert S. Gaston, William Gelson, Paul Gibbs, Alex Gimson, Leo C. Ginns, Samuel Goldfarb, Ryoichi Goto, Walter K. Graham, Simon J.F. Harper, Koji Hashimoto, David G. Healy, Hassan N. Ibrahim, David Ip, Fadi G. Issa, Neville V. Jamieson, David P. Jenkins, Dixon B. Kaufman, Kiran K. Khush, Heung Bae Kim, Andrew A. Klein, John Klinck, Camille Nelson Kotton, Vineeta Kumar, Yael B. Kushner, D. Frank. P. Larkin, Clive J. Lewis, Yvonne H. Luo, Richard S. Luskin, Ernest I. Mandel, James F. Markmann, Lorna Marson, Arthur J. Matas, Mandeep R. Mehra, Stephen J. Middleton, Giorgina Mieli-Vergani, Charles Miller, Sharon Mulroy, Faruk Özalp, Can Ozturk, Jayan Parameshwar, J.S. Parmar, Hari K. Parthasarathy, Nick Pritchard, Cristiano Quintini, Axel O. Rahmel, Chris J. Rudge, Stephan V.B. Schueler, Maria Siemionow, Jacob Simmonds, Peter Slinger, Thomas R. Spitzer, Stuart C. Sweet, Nina E. Tolkoff-Rubin, Steven S.L. Tsui, Khashayar Vakili, R.V. Venkateswaran, Hector Vilca-Melendez, Vladimir Vinarsky, Kathryn J. Wood, Heidi Yeh, David W. Zaas, Jonathan G. Zaroff
- Edited by Andrew A. Klein, Clive J. Lewis, Joren C. Madsen
-
- Book:
- Organ Transplantation
- Published online:
- 07 September 2011
- Print publication:
- 11 August 2011, pp vii-x
-
- Chapter
- Export citation
Dietary antioxidants and DNA damage in patients on long-term acid-suppression therapy: a randomized controlled study
- K. L. M. White, D. M. Chalmers, I. G. Martin, S. M. Everett, P. M. Neville, G. Naylor, A. E. Sutcliffe, M. F. Dixon, P. C. Turner, C. J. Schorah
-
- Journal:
- British Journal of Nutrition / Volume 88 / Issue 3 / September 2002
- Published online by Cambridge University Press:
- 09 March 2007, pp. 265-271
- Print publication:
- September 2002
-
- Article
-
- You have access Access
- Export citation
-
Free radicals and reactive species produced in vivo can trigger cell damage and DNA modifications resulting in carcinogenesis. Dietary antioxidants trap these species limiting their damage. The present study evaluated the role of vitamins C and E in the prevention of potentially premalignant modifications to DNA in the human stomach by supplementing patients who, because of hypochlorhydria and possible depletion of gastric antioxidants, could be at increased risk of gastric cancer. Patients undergoing surveillance for Barrett's oesophagus (n 100), on long-term proton pump inhibitors were randomized into two groups: vitamin C (500 mg twice/d) and vitamin E (100 mg twice/d) for 12 weeks (the supplemented group) or placebo. Those attending for subsequent endoscopy had gastric juice, plasma and mucosal measurements of vitamin levels and markers of DNA damage. Seventy-two patients completed the study. Plasma ascorbic acid, total vitamin C and vitamin E were elevated in the supplemented group consistent with compliance. Gastric juice ascorbic acid and total vitamin C levels were raised significantly in the supplemented group (P=0·01) but supplementation had no effect on the mucosal level of this vitamin. However, gastric juice ascorbic acid and total vitamin C were within normal ranges in the unsupplemented group. Mucosal malondialdehyde, chemiluminescence and DNA damage levels in the comet assay were unaffected by vitamin supplementation. In conclusion, supplementation does not affect DNA damage in this group of patients. This is probably because long-term inhibition of the gastric proton pump alone does not affect gastric juice ascorbate and therefore does not increase the theoretical risk of gastric cancer because of antioxidant depletion.
Wayland's Smithy, Oxfordshire: Excavations at the Neolithic Tomb in 1962–63 by R. J. C. Atkinson and S. Piggott
- Alasdair Whittle, Don Brothwell, Rachel Cullen, Neville Gardner, M. P. Kerney
-
- Journal:
- Proceedings of the Prehistoric Society / Volume 57 / Issue 2 / 1991
- Published online by Cambridge University Press:
- 18 February 2014, pp. 61-101
- Print publication:
- 1991
-
- Article
- Export citation
-
Wayland's Smithy, on the north scarp of the downs above the Vale of the White Horse, is a two-phase Neolithic tomb. It has been a recognized feature of the historic landscape since at least the 10th century AD. It was recorded by Aubrey and later antiquaries, and continued to be of interest in the 19th century. It was amongst the first monuments to be protected by scheduling from 1882. The first excavations in 1919–20 were haphazardly organized and poorly recorded, but served to confirm, as suggested by Akerman and Thurnam, that the stone terminal chamber was transepted, to show that it had held burials, and to indicate the likely existence of an earlier structural phase.
Further excavations took place in 1962–63 to explore the monument more and restore it for better presentation. The excavations revealed a two-phase monument. Wayland's Smithy I is a small oval barrow, defined by flanking ditches, an oval kerb, and a low chalk and sarsen barrow. It contains a mortuary structure defined by large pits which held posts of split trunks, a pavement, and opposed linear cairns of sarsen. This has been seen as the remains of a pitched and ridged mortuary tent, in the manner proposed also for the structure under the Fussell's Lodge long barrow, but in the light of ensuing debate and of subsequent discoveries elsewhere, it can also be seen as an embanked, box-like structure, perhaps with a flat wooden roof. This structure contained the remains of at least fourteen human skeletons, in varying states of completeness. The burial rite may have included primary burial or exposure elsewhere, but some at least of the bodies could have been deposited directly into the mortuary structure, and subsequent circulation or removal of bones cannot be discounted. Little silt accumulated in the ditches of phase I before the construction of phase II, and a charcoal sample from this interval gave a date of 3700–3390 BC.
Wayland's Smithy II consists of a low sarsen-kerbed trapezoidal barrow, with flanking ditches, which follows the north–south alignment of phase I. At the south end there was a façade of larger sarsen stones, from which ran back a short passage leading to a transepted chamber, roofed with substantial capstones. This could have risen above the surrounding barrow. The excavations of 1919–20 revealed the presence of incomplete human burials in the west transept; the chamber had probably already been disturbed. The excavations of 1962–63 revealed further structural detail of the surrounds of the chamber, including a sarsen cairn piled in front and around it; deposits of calcium carbonate well up the walls of the chamber could be taken to suggest the former existence of chalk rubble blocking, in the manner of the West Kennet long barrow.
The monuments were built over a thin chalk soil which had been a little disturbed. The molluscan evidence shows open surroundings. Molluscan samples from the ditch of Wayland's Smithy II show subsequent regeneration of woodland.
Later activity on the site took the form of field ditches and lynchets, part of locally extensive field systems in the Iron Age and Romano-British period. Molluscan samples show again open country. There is evidence for disturbance of the tomb in late prehistoric and Roman times, and the denudation of the barrow had probably largely been effected by the end of the Roman era.
Wayland's Smithy provides important evidence for the sequence and development of Neolithic mortuary structures and burials. It is possible to suggest a gradual development for the structures ofWayland's Smithy I, in which opposed pits and substantial posts were incorporated into a box-like, linear mortuary structure, which in turn was incorporated into a small barrow. The subsequent construction of Wayland's Smithy II has become a classic example of the succession from small to large, and fits the late date of tombs with transepted chambers suggested by recent study of other sites. The nature of the circumstances surrounding this transformation remains unclear. The burials of phase I suggest the necessity of revising current notions about the ubiquity of secondary disposal in mortuary structures and tombs. In situ transformations suggest a very active concern with the dead, and offset the non-monumental character of the primary mortuary structure. In the relative absence of other detailed local evidence it is hard to relate the site to its local context, though comparisons can be drawn with the sequences of the neighbouring upper Thames valley and the upper Kennet valley and surrounding downland.