Book contents
- Fetal and Neonatal Lung Development
- Lung Growth, Development, and Disease
- Fetal and Neonatal Lung Development
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 The Genetic Programs Regulating Embryonic Lung Development and Induced Pluripotent Stem Cell Differentiation
- Chapter 2 Early Development of the Mammalian Lung-Branching Morphogenesis
- Chapter 3 Pulmonary Vascular Development
- Chapter 4 Transcriptional Mechanisms Regulating Pulmonary Epithelial Maturation:
- Chapter 5 Environmental Effects on Lung Morphogenesis and Function:
- Chapter 6 Congenital Malformations of the Lung
- Chapter 7 Lung Structure at Preterm and Term Birth
- Chapter 8 Surfactant During Lung Development
- Chapter 9 Initiation of Breathing at Birth
- Chapter 10 Perinatal Modifiers of Lung Structure and Function
- Chapter 11 Chronic Neonatal Lung Injury and Care Strategies to Decrease Injury
- Chapter 12 Apnea and Control of Breathing
- Chapter 13 Alveolarization into Adulthood
- Chapter 14 Physiologic Assessment of Lung Growth and Development Throughout Infancy and Childhood
- Chapter 15 Perinatal Disruptions of Lung Development:
- Chapter 16 Lung Growth Through the “Life Course” and Predictors and Determinants of Chronic Respiratory Disorders
- Chapter 17 The Lung Structure Maintenance Program: Sustaining Lung Structure during Adulthood and Implications for COPD Risk
- Index
- References
Chapter 2 - Early Development of the Mammalian Lung-Branching Morphogenesis
Published online by Cambridge University Press: 05 April 2016
- Fetal and Neonatal Lung Development
- Lung Growth, Development, and Disease
- Fetal and Neonatal Lung Development
- Copyright page
- Contents
- Contributors
- Preface
- Chapter 1 The Genetic Programs Regulating Embryonic Lung Development and Induced Pluripotent Stem Cell Differentiation
- Chapter 2 Early Development of the Mammalian Lung-Branching Morphogenesis
- Chapter 3 Pulmonary Vascular Development
- Chapter 4 Transcriptional Mechanisms Regulating Pulmonary Epithelial Maturation:
- Chapter 5 Environmental Effects on Lung Morphogenesis and Function:
- Chapter 6 Congenital Malformations of the Lung
- Chapter 7 Lung Structure at Preterm and Term Birth
- Chapter 8 Surfactant During Lung Development
- Chapter 9 Initiation of Breathing at Birth
- Chapter 10 Perinatal Modifiers of Lung Structure and Function
- Chapter 11 Chronic Neonatal Lung Injury and Care Strategies to Decrease Injury
- Chapter 12 Apnea and Control of Breathing
- Chapter 13 Alveolarization into Adulthood
- Chapter 14 Physiologic Assessment of Lung Growth and Development Throughout Infancy and Childhood
- Chapter 15 Perinatal Disruptions of Lung Development:
- Chapter 16 Lung Growth Through the “Life Course” and Predictors and Determinants of Chronic Respiratory Disorders
- Chapter 17 The Lung Structure Maintenance Program: Sustaining Lung Structure during Adulthood and Implications for COPD Risk
- Index
- References
Summary
The lung is an essential organ for mammalian health throughout life and represents a critical interface with the external environment in the regulation of gas exchange. To achieve these goals the mammalian lung has evolved into a highly complex system of branching epithelial and vascular structures that connects to a vast network of alveolar gas-exchanging units. The generation of this complex organ involves multiple steps and encompasses events that span prenatal and postnatal life. This chapter focuses on the mechanisms that regulate early lung development and branching morphogenesis and the various signaling molecules, extracellular matrix proteins, and genetic changes that influence this process. These research areas are critical for understanding the various causes of respiratory disease, which are a major contributor to morbidity and mortality at all stages of life.
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- Chapter
- Information
- Fetal and Neonatal Lung DevelopmentClinical Correlates and Technologies for the Future, pp. 22 - 33Publisher: Cambridge University PressPrint publication year: 2016
References
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