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Chapter 13 - Alveolarization into Adulthood

Published online by Cambridge University Press:  05 April 2016

By
Manjith Narayanan
Edited by
Alan H. Jobe ,
Jeffrey A. Whitsett  and
Steven H. Abman
Alan H. Jobe
Affiliation:
University of Cincinnati
Jeffrey A. Whitsett
Affiliation:
Cincinnati Children’s Hospital
Steven H. Abman
Affiliation:
University of Colorado School of Medicine
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Summary

Abstract

Alveolarization has been traditionally thought to be complete in the human lung by three to seven years of age. These estimates were based on traditional morphologic measurements from autopsy specimens. Recently new techniques have been used to estimate airway dimensions and alveolar size and numbers with aerosol deposition and hyperpolarized helium in living subjects. hyperpolarized helium measurements by magnetic resonance demonstrated increases in alveolar numbers until adulthood, a result that changes concepts about lung growth. Further, this technology applied to school-age children who had been premature infants with bronchopulmonary dysplasia demonstrated catch-up alveolarization. Application of new imaging technologies to different patient groups will likely change concepts about how the lung grows, repairs, and remodels with age.

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Chapter
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Fetal and Neonatal Lung Development
Clinical Correlates and Technologies for the Future
 , pp. 238 - 252
Publisher: Cambridge University Press
Print publication year: 2016

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