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Allergies to food

from Medical topics

Published online by Cambridge University Press:  18 December 2014

Mary Gregerson
Affiliation:
Family Therapy Institute of Alexandria
Susan Ayers
Affiliation:
University of Sussex
Andrew Baum
Affiliation:
University of Pittsburgh
Chris McManus
Affiliation:
St Mary's Hospital Medical School
Stanton Newman
Affiliation:
University College and Middlesex School of Medicine
Kenneth Wallston
Affiliation:
Vanderbilt University School of Nursing
John Weinman
Affiliation:
United Medical and Dental Schools of Guy's and St Thomas's
Robert West
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Features

Food allergies are immunologic hyper-reactions to ingested substances considered non-pharmacologic, for the most part. Either the failure to develop or a breakdown in oral tolerance may be at fault in Immunoglobulin E (IgE) mediated allergy while inflammatory mediators are implicated in non-IgE cell mediated food allergies. Some food allergies have a mix of IgE and non-IgE mediation (Sampson, 2003). Generally, food allergies engage multiple classic immune mechanisms found in allergies (see ‘Allergies: general’).

Irrespective of aetiology, food allergies are the number one cause of generalized anaphylaxis treated in hospital accident and emergency (A&E) departments, and cover one-third of the total emergency room/A&E visits in the USA and the UK (respectively, Yocum & Kahn, 1994; Pumphrey & Stanworth, 1996). Anaphylaxis is when the smooth muscles vasodilate and constrict causing vasculature collapse because there is no blood pressure. Unknown, though, is why different individuals respond with different symptoms to different foods.

Food allergies can produce a range of discomfort and disease. Allergic immune dysfunction may create gastrointestinal, respiratory, or dermatologic symptoms like migraine, gluten enteropathy, Crohn's disease, eczema, wheeze, urticaria, irritable bowel syndrome or abdominal pain, and, in extreme cases, systemic anaphylactic shock (Del Rio Navarro & Sienra-Monge, 1993) (see ‘Inflammatory bowel disease’ and ‘Irritable bowel syndrome’). Besides producing discomfort and disease, these allergies can be fatal, and need serious consideration.

Food allergies are different from food intolerance and food aversions (Ferguson, 1992). Allergy requires an immune over-reaction, typically with elevated immunoglobulin E (IgE).

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Publisher: Cambridge University Press
Print publication year: 2007

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References

Bock, S. A. (1987). Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life. Pediatrics, 79, 633–8.Google Scholar
Bock, S. A. (1982). The natural history of food sensitivity. Journal of Allergy and Clinical Immunology, 69, 173–7.Google Scholar
Burks, A. H. & Sampson, H. A. (1992). Diagnostic approaches to the patient with suspected food allergies. The Journal of Pediatrics, 121(5, Pt. 1, Suppl.), S64–S71.Google Scholar
Businco, L., Benincori, N., Cantani, A.et al. (1989). Chronic diarrhea due to cow's milk allergy: A 4- to 10-year follow-up study. Annals of Allergy, 55, 844–7.Google Scholar
Del Rio Navarro, B. E. & Sienra, , Monge, J. J. (1993). Food allergy. Boliva Medical Hospital Infant Mexico, 50(6), 422–9.Google Scholar
Department of Health (1998). Peanut allergy. London: HMSO
Esteban, M. M. (1992). Adverse food reactions in infancy and childhood. The Journal of Pediatrics, 121(5, Pt. 2, Suppl.).Google Scholar
Evans, R. III (1992). Environmental control and immunotherapy for allergic disease. Journal of Allergy and Clinical Immunology, 90(3, Pt. 2), 462–8.Google Scholar
Fergusson, D. M., Horwood, L. J. & Shannon, F. T. (1990). Early solid feeding and recurrent eczea: a 10-year longitudinal study. Pediatrics, 86, 541–6.Google Scholar
Ferguson, A. (1992). Definitions and diagnosis of food intolerance and food allergy: consensus and controversy. Journal of Pediatrics, 121(5, Pt. 2), S7–11.Google Scholar
Finn, R. (1992). Food allergy – fact or fiction: a review. Journal of the Royal Society of Medicine, 85(9), 560–4.Google Scholar
Gluck, U. (1992). Neglected allergens. Therapeutische Umschau, 49(10), 669–73.Google Scholar
Grulee, C. G. & Sanford, H. N. (1936). The influence of breast feeding and artificial feeding in infantile eczema. Journal of Pediatrics, 9, 223–5.Google Scholar
Grundy, J., Matthews, S., Bateman, B. J.et al. (1994). Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. Journal of Allergy and Clinical Immunology, 110, 784–9.Google Scholar
Hanson, D. G. (1981). Ontogeny of orally induced tolerance to soluble proteins in mice: priming and tolerance in newborn. Journal of Immunology, 127, 1518–24.Google Scholar
Hill, D. J., Firer, M. A., Shelton, M. J. & Hosking, C. S. (1986). Manifestations of milk allergy in infancy: clinical and immunological findings. Journal of Pediatrics, 109, 270–6.Google Scholar
Hill, D. J., Firer, M. A., Ball, G. & Hosking, C. S. (1989). Recovery from milk allergy in early childhood: antibody study. Journal of Pediatrics, 114(5), 761–6.Google Scholar
Host, A. (1994). Cow's milk protein allergy and intolerance in infancy. Pediatric Allergy Immunology, 5(Suppl. 5), 5–36.Google Scholar
Host, A. & Halken, S. (1990). A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Allergy, 45, 587–96.Google Scholar
Host, A., Halken, S., Jacobsen, H. P.et al. (1997). The natural course of cow's milk protein allergy/intolerance. Journal of Allergy and Clinical Immunology, 99, S490 (abstract).Google Scholar
Kajosaari, M. & Saarinen, U. M. (1983). Prophylaxis of atopic disease by six months; total solid food elimination. Archives of Paediatrics Scandinavia, 72, 411–14.Google Scholar
Kay, A. B. & Lessof, M. H. (1992). Allergy. Conventional and alternative concepts. A report of the Royal College of Physicians Committee on Clinical Immunology and Allergy. Clinical and Experimental Allergy, 22(Suppl. 3), 1–44.Google Scholar
Laird, D. (1986). Using biofeedback to uncover food sensitive persons. Journal of Orthomolecular Medicine, 1(2), 78–83.Google Scholar
May, C. D. (1976). Objective clinical and laboratory studies of immediate hypersensitivity reactions to food in asthmatic children. Journal of Allergy and Clinical Immunology, 58(4), 500–15.Google Scholar
Niestijl Jansen, J. J., Kardinaal, A. F., Huijbers, G. H.et al. (1994). Prevalence of food allergy and intolerance in the adult Dutch population. Journal of Allergy and Clinical Immunology, 93, 446–56.Google Scholar
Novembre, E., Martino, M. & Vierucci, A. (1988). Foods and respiratory allergy. Journal of Allergy and Clinical Immunology, 81, 1059–65.Google Scholar
Parker, S. L., Garner, D. M., Leznoff, A.et al. (1991). Psychological characteristics of patients with reported adverse reactions to foods. International Journal of Eating Disorders, 10(4), 433–9.Google Scholar
Pastorello, E., Stocchi, L., Pravetonni, V.et al. (1989). Role of the food elimination diet in adults with food allergy. Journal of Allergy and Clinical Immunology, 84, 475–83.Google Scholar
Pumphrey, R. S. & Stanworth, S. J. (1996). The clinical spectrum of anaphylaxis in north-west England. Clinical Experimental Allergy, 26, 1364–70.Google Scholar
Sampson, H. A. (1996). Managing peanut allergy. British Medical Journal, 312, 1050–1.Google Scholar
Sampson, H. A. (2003). Adverse reactions to foods. In Yunginger, J. W., Busse, W. W., Bochner, B. S.et al. (Eds.). (2003). Middleton's Allergy Principles and Practice. Vol. 2. (6th edn.). (pp. 1619–1643), St. Louis, IL: CV Mosby Publishers.
Sampson, H. A. & Scanlon, S. M. (1989). Natural history of food hypersensitivity in children with atopic dermatitis. Journal of Pediatrics, 115, 23–7.Google Scholar
Sicherer, S. H., Munoz-Furlong, A., Burks, A. W. & Sampson, H. A. (1999). Prevalence of peanut and tree nut allergy in the United States of America. Journal of Allergy and Clinical Immunology, 103, 559–62.Google Scholar
Tariq, S. M., Steens, M., Matthews, S.et al. (1996). Cohort study of peanut and tree nut sensitization by age of 4 years. British Medical Journal, 313, 514–17.Google Scholar
Wisocki, P. A. & King, D. S. (1992). The construction of a food-behavior inventory to measure beliefs about the behavioral effects of food. Paper presented at the annual conference of the American Psychological Association, San Francisco, CA.
Yocum, M. W. & Khan, D. A. (1994). Assessment of patients who have experienced anaphylaxis: a 3-year study. Mayo Clinic Proceedings, 69, 16–23.Google Scholar
Young, E., Patel, S., Stoneham, M. D.et al. (1987). The prevalence of reactions to food additives in a survey population. Journal of Research for College Physicians in London, 21, 241–71.Google Scholar
Young, E., Stoneham, M. D., Petruckevitch, A.et al. (1994). A population study of food intolerance. Lancet, 343, 1127–30.Google Scholar
Zeiger, R. & Heller, S. (1995). The development and prediction of atopy in high-risk children: follow-up at seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. Journal of Immunology, 127, 1518–24.Google Scholar

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