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Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Medicinal cannabis has been trialled for Tourette syndrome in adults, but it has not been studied in adolescents. This open-label, single-arm trial study evaluated the feasibility, acceptability and signal of efficacy of medicinal cannabis in adolescents (12–18 years), using a Δ9-tetrahydrocannabinol:cannabidiol ratio of 10:15, with dose varying from 5 to 20 mg/day based on body weight and response. The study demonstrated feasibility of recruitment, acceptability of study procedures, potential benefits and a favourable safety profile, with no serious adverse events. Commonly reported adverse events were tiredness and drowsiness, followed by dry mouth. Statistically significant improvement was observed in parent and clinician reports on tics (paired t-test P = 0.003), and behavioural and emotional issues (paired t-test P = 0.048) and quality of life as reported by the parent and young person (paired t-test P = 0.027 and 0.032, respectively). A larger-scale, randomised controlled trial is needed to validate these findings.
The chapter explores the social relations of renewable energy and everyday life in the Indian state of Karnataka, focusing on the 2 GW Pavagada solar energy park, said to be the largest in Asia, and on the experience of wind energy at the local level. It analyses these installations in the historical context of national and state-level energy policy, framed by wider developmental dynamics and stratification in the Karnataka locality. We contrast the renewable ‘resource’ with fossil fuel sources and highlight differences between solar and wind power. We discuss the drive to attract renewable investment to the region, along with development finance, in the context of Karnataka’s development trajectory. We interpret the transition to renewable energy in terms of social structures and the extent to which it exacerbates or alleviates pre-existing social divides. There is a strong focus on implications for land, water, livelihood, caste, gender, and environment, including for instance the role, or displacement, of rural landless and lower-caste groups.
The Introduction sets the rationale and parameters for the study. The rationale begins with the growing climate crisis and the urgent necessity to decarbonise energy. It outlines the limits of the current assumption that private sector investment can deliver the required decarbonisation. Public legitimacy for renewables, we argue, has moved to the centre of the energy transition, requiring stronger forms of social ownership over the emerging energy systems. New roles for the state in decarbonising society are highlighted, along with a ‘re-commoning’ agenda and issues of sufficiency. Finally, the book’s focus on investigating and comparing region-level ‘success’ stories is outlined.
We outline the socio-ecological appropriation of ‘nature’s free gifts’ of wind and sun for renewable energy, understood as a process of capture, which opens a new ‘frontier’ in capital-nature relations. We elaborate on the term ‘nature’s free gifts’, originally derived from Marx, and its use in Marxist approaches to ecology and social theory as documented by Saito (2022). Second, we highlight the process of securing a spatial, temporal, and social ‘fix’ for large-scale renewables, to enable accumulation, and as an emerging aspect of rivalry between region-level authorities and developers to reap the rewards of the renewable energy transition. Third, we focus on the social relations of renewable accumulation, encompassing state authorities, corporates, workers, landowners, and communities, engaged in a contest to define models for renewable transition and lay claim to ‘nature’s free gifts’. These three strands are used to develop a conceptual model to interpret the social legitimacy of renewable transition and to guide the comparative analysis.
The chapter centres on the expansion of wind power and the subsequent ‘solar rush’ in the German ‘energy state’ of Brandenburg, where the energy transition (or Energiewende) has been underway for more than two decades. We follow the unfolding process of renewable energy development and socio-ecological capture, paying particular attention to the changing scale of operations exemplified by a move to larger wind turbines and the current shift to large-scale solar farms. The chapter provides a rich account of the nexus between a well-established renewables sector and other forms of land use, such as leisure, aesthetics, agriculture, or forestry. The conflict between narratives of regional and local development, prompted, defined, and mobilised in the energy transition, is seen as opening new fields of engagement and disputation in the emerging ‘green’ economy.
The chapter tracks the field of renewable energy transition in the three sub-national states where the ethnographic studies are located: Karnataka, Brandenburg, and South Australia. It applies the conceptual model outlined in Chapter 1 to address the full scope of the transition in these regions. The model is used to analytically ‘unbundle’ the dimensions of transition in the three contrasting regions of study, allowing deeper understanding of the relations in play. The chapter focuses on each state in turn, providing historical and contemporary data about renewable energy policy-making and development at the region level in the context of national authorities and global institutions and agencies. We demonstrate the process of renewable ‘capture’ by capital, but also how it is contested and the extent to which it prefigures more democratic social relations and new ‘forms of collective life’.
The Conclusions widen the lens to develop a series of substantive recommendations for policymakers, regional, national, and global, who are seeking to strengthen public legitimacy for electricity decarbonisation. It also seeks to draw out implications, in the long haul, for recasting socio-ecological relations under climate change in more democratic directions, to realise its fullest potential for societal transformation, and democratic engagement. As with energy transitions in the past, the current juncture offers manifold (still undreamt-of) possibilities: we argue for a transition regime that allows for such possibilities to be fostered and realised. There is capacity and agency for distributed renewables, for energy transformations and new forms of energy social ownership and democratisation, in other words, for a ‘re-commoning’ of socio-ecological relations.
The chapter focuses on South Australia’s Upper Spencer Gulf region in South Australia, which now aspires to 500% renewable energy by 2050. The state has access to world-best onshore wind and solar, with downstream industrial linkages that are now fuelling new spatio-temporal planning horizons. While the state promotes the new energy industry as a ‘green’ industrial economy, ethnographic research reveals mixed outcomes. Local socio-ecological relations are changing favourably for some groups, such as for host landowners and Aboriginal native title holders. Others find themselves left out or further marginalised. Post-construction, renewable energy installations offer few jobs, in localities where unemployment rates are high. Dissatisfaction erupts during the project application processes, where the limits of local demands for meaningful involvement, equitable sharing of benefits, and accountable planning regulation become clear. These, we argue, pose significant threats to the social legitimacy of renewable energy.
This chapter centres on comparative analysis, drawing together evidence-based insights into how renewable energy has been developed in the three regions. The three-part framework outlined in the opening chapter is used to analyse problems of legitimacy in renewable energy development in the three contexts. The three dimensions of appropriation, accumulation, and regulation shape the comparative analysis and underpin a suggested schema for interpreting legitimacy issues in renewable energy transitions. We discuss how renewables have been progressed, both locally and in terms of the intersecting dynamics of global policy, finance, and advocacy in constituting region-level transitions.
Multicenter clinical trials are essential for evaluating interventions but often face significant challenges in study design, site coordination, participant recruitment, and regulatory compliance. To address these issues, the National Institutes of Health’s National Center for Advancing Translational Sciences established the Trial Innovation Network (TIN). The TIN offers a scientific consultation process, providing access to clinical trial and disease experts who provide input and recommendations throughout the trial’s duration, at no cost to investigators. This approach aims to improve trial design, accelerate implementation, foster interdisciplinary teamwork, and spur innovations that enhance multicenter trial quality and efficiency. The TIN leverages resources of the Clinical and Translational Science Awards (CTSA) program, complementing local capabilities at the investigator’s institution. The Initial Consultation process focuses on the study’s scientific premise, design, site development, recruitment and retention strategies, funding feasibility, and other support areas. As of 6/1/2024, the TIN has provided 431 Initial Consultations to increase efficiency and accelerate trial implementation by delivering customized support and tailored recommendations. Across a range of clinical trials, the TIN has developed standardized, streamlined, and adaptable processes. We describe these processes, provide operational metrics, and include a set of lessons learned for consideration by other trial support and innovation networks.
The current shift to renewable energy is dominated by globalised energy companies building large-scale wind and solar plants. This book discusses the consequences and possibilities of this shift in India, Germany, and Australia, focusing on regions which have now largely decarbonised electricity generation. The authors show how centralised models of energy provision are maintained, and chart their impacts in terms of energy geography, social stratification, and socio-ecological appropriation. The chapters emphasise the prominent role played by state regulation, financial incentives, and public infrastructure for corporate renewables, arguing that public provision should be re-purposed for distributed renewables, social equity in affected regions, and for wider social benefit. This interdisciplinary book provides fertile building ground for research in - and application of - future energy transitions. It will appeal to students, researchers, and policy makers from anthropology, sociology, politics and political economy, geography, and environmental and sustainability studies.
Disasters and emergencies cause devastating impacts on communities, infrastructure, economies, and health. Protecting health from emergencies and disasters are the goals in the WHO’s thirteenth and fourteenth General Program of Work (GPW 13 and GPW 14).
Objectives:
Build robust scientific evidence and support, facilitate, and celebrate reliable research to for informed decision-making and effective policy and practice.
Method/Description:
WHO established a global expert network in 2018, “WHO Thematic Platform for Health EDRM Research Network (Health EDRM RN)”. The WHO Centre for Health Development (WHO Kobe Centre (WKC)), the secretariat of the Health EDRM RN, facilitates international collaboration for better knowledge generation, synthesis, and dissemination.
In 2021, in collaboration with 164 experts from WHO HQ, all Regional Offices, and 30 countries, WHO Guidance on Research Methods for Health EDRM (the Guidance) was developed, which provides concrete guidance on how to plan, conduct and report Health EDRM research.
Results/Outcomes:
The Health EDRM has promoted numerous training and policy meetings including (i) In 2023, a joint webinar by WHO Regional Office for Europe (EURO), WHO Regional Office for Eastern Mediterranean, and WKC;(ii) In 2024, a joint workshop for European countries and partners by WHO EURO and WKC with support of UK Health Security Agency; (iii) Symposiums and workshops in collaboration with academic societies including World Association of Disaster and Emergency Medicine, ASEAN Academic Conference, and Japanese Association for Disaster Medicine since 2021.
Conclusion:
WHO will continue to collate and improve scientific evidence that informs more effective and sustainable disaster and emergency policies and practices.
Marine sedimentary rocks of the late Eocene Pagat Member of the Tanjung Formation in the Asem Asem Basin near Satui, Kalimantan, provide an important geological archive for understanding the paleontological evolution of southern Kalimantan (Indonesian Borneo) in the interval leading up the development of the Central Indo-Pacific marine biodiversity hotspot. In this paper, we describe a moderately diverse assemblage of marine invertebrates within a sedimentological and stratigraphical context. In the studied section, the Pagat Member of the Tanjung Formation records an interval of overall marine transgression and chronicles a transition from the marginal marine and continental siliciclastic succession in the underlying Tambak Member to the carbonate platform succession in the overlying Berai Formation.
The lower part of the Pagat Member contains heterolithic interbedded siliciclastic sandstone and glauconitic shale, with thin bioclastic floatstone and bioclastic rudstone beds. This segues into a calcareous shale succession with common foraminiferal packstone/rudstone lenses interpreted as low-relief biostromes. A diverse trace fossil assemblage occurs primarily in a muddy/glauconitic sandstone, sandy mudstone, and bioclastic packstone/rudstone succession, constraining the depositional setting to a mid-ramp/mid to distal continental shelf setting below fair-weather wave base but above storm wave base.
Each biostrome rests upon a storm-generated ravinement surface characterized by a low-diversity Glossifungites or Trypanites trace fossil assemblage. The erosional surfaces were colonized by organisms that preferred stable substrates, including larger benthic foraminifera, solitary corals, oysters, and serpulid annelid worms.
The biostromes comprised islands of high marine biodiversity on the mud-dominated Pagat coastline. Together, the biostromes analyzed in this study contained 13 genera of symbiont-bearing larger benthic foraminifera, ~40 mollusk taxa, at least 5 brachyuran decapod genera, and 6 coral genera (Anthemiphyllia, Balanophyllia, Caryophyllia, Cycloseris, Trachyphyllia, and Trochocyathus), as well as a variety of bryozoans, serpulids, echinoids, and asterozoans. High foraminiferal and molluscan diversity, coupled with modest coral diversity, supports the hypothesis that the origin of the diverse tropical invertebrate faunas that characterize the modern Indo-Australian region may have occurred in the latest Eocene/earliest Oligocene.