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This article addresses the historical and ongoing exclusion of descendant and local communities, particularly in the Middle East and North Africa (MENA), from digital archaeological archives. We contend that current digitization practices often perpetuate colonial-era biases through limited, monolingual metadata that fail to reflect or engage with local histories and knowledge systems. Noting the insufficiency of current FAIR (Findable, Accessible, Interoperable, Reusable) and CARE (Collective Benefit, Authority to Control, Responsibility, Ethics) data frameworks for this specific context, we propose a shift toward reparative, co-stewardship models. Drawing on practice-led pilot projects within digital archaeological archives using Linked Open Data (LOD) and community-facilitated annotation, this article demonstrates practical pathways for integrating diverse, multilingual perspectives to enrich archive metadata. In so doing, it demonstrates how digital interventions have the potential to destabilize power dynamics and work toward reparative practice. Ultimately, we advocate for conscious professional collaboration and institutional reform to transform archives from static repositories into dynamic spaces of equitable engagement, actively combating digital colonialism.
Punctuated equilibria argue for intervals of long-term net stasis and comparatively abrupt change in the morphology of individual species lineages resulting from the process of allopatric speciation as recorded in the stratigraphic and fossil record. The concept of coordinated stasis extends punctuated equilibria to posit that not only individual species, but groups of coexisting lineages within a basin, display concurrent morphological and ecological stability over the same extended intervals of geologic time (105 to 106 yr). These blocks of stability termed ecological–evolutionary subunits (EESUs) are separated by shorter-lived (on the order of 103 to 104 yr) episodes of change characterized by varying combinations of speciation, extinction, immigration, and emigration. The result is a pattern of evolutionary and ecological stasis and change that is coincident and highly punctuational.
Here, we assess the connections among environment, evolution, and ecology by documenting patterns of stability, geographic extent, and synchronous turnover during medium-scale bioevents in the Middle Devonian of the eastern United States, and we briefly compare these with patterns of EESUs across the Late Ordovician mass extinction (LOME) based on ongoing work. We quantify the geographic extent and stability of faunas originally documented in the Appalachian Basin and identify their likely places of origin and refugia during turnovers. Faunas are geographically widespread during times of stability and border comparably stable faunas in adjacent provinces. During geologically brief intervals, assemblages display near-synchronous shifts involving local extirpation/extinction and coordinated migration of biogeographic boundaries over very long distances. Allopatric speciation in small, locally isolated populations along the edges of basins during brief windows of dramatically altered environmental conditions is more consistent with the geological record, emphasizes the role of environment and biogeography in driving evolutionary change, and confirms the prevalence of punctuated equilibria.
Patients with posttraumatic stress disorder (PTSD) exhibit smaller regional brain volumes in commonly reported regions including the amygdala and hippocampus, regions associated with fear and memory processing. In the current study, we have conducted a voxel-based morphometry (VBM) meta-analysis using whole-brain statistical maps with neuroimaging data from the ENIGMA-PGC PTSD working group.
Methods
T1-weighted structural neuroimaging scans from 36 cohorts (PTSD n = 1309; controls n = 2198) were processed using a standardized VBM pipeline (ENIGMA-VBM tool). We meta-analyzed the resulting statistical maps for voxel-wise differences in gray matter (GM) and white matter (WM) volumes between PTSD patients and controls, performed subgroup analyses considering the trauma exposure of the controls, and examined associations between regional brain volumes and clinical variables including PTSD (CAPS-4/5, PCL-5) and depression severity (BDI-II, PHQ-9).
Results
PTSD patients exhibited smaller GM volumes across the frontal and temporal lobes, and cerebellum, with the most significant effect in the left cerebellum (Hedges’ g = 0.22, pcorrected = .001), and smaller cerebellar WM volume (peak Hedges’ g = 0.14, pcorrected = .008). We observed similar regional differences when comparing patients to trauma-exposed controls, suggesting these structural abnormalities may be specific to PTSD. Regression analyses revealed PTSD severity was negatively associated with GM volumes within the cerebellum (pcorrected = .003), while depression severity was negatively associated with GM volumes within the cerebellum and superior frontal gyrus in patients (pcorrected = .001).
Conclusions
PTSD patients exhibited widespread, regional differences in brain volumes where greater regional deficits appeared to reflect more severe symptoms. Our findings add to the growing literature implicating the cerebellum in PTSD psychopathology.
Multicenter clinical trials are essential for evaluating interventions but often face significant challenges in study design, site coordination, participant recruitment, and regulatory compliance. To address these issues, the National Institutes of Health’s National Center for Advancing Translational Sciences established the Trial Innovation Network (TIN). The TIN offers a scientific consultation process, providing access to clinical trial and disease experts who provide input and recommendations throughout the trial’s duration, at no cost to investigators. This approach aims to improve trial design, accelerate implementation, foster interdisciplinary teamwork, and spur innovations that enhance multicenter trial quality and efficiency. The TIN leverages resources of the Clinical and Translational Science Awards (CTSA) program, complementing local capabilities at the investigator’s institution. The Initial Consultation process focuses on the study’s scientific premise, design, site development, recruitment and retention strategies, funding feasibility, and other support areas. As of 6/1/2024, the TIN has provided 431 Initial Consultations to increase efficiency and accelerate trial implementation by delivering customized support and tailored recommendations. Across a range of clinical trials, the TIN has developed standardized, streamlined, and adaptable processes. We describe these processes, provide operational metrics, and include a set of lessons learned for consideration by other trial support and innovation networks.
Despite its relative invisibility to most people living in the urban Asia-Pacific, endemic malaria occurs across the region. The unique character of Asian-Pacific malaria includes a serious problem of drug resistance, dominance of a particularly difficult species to control and treat, and another that normally dwells in monkeys but often infects humans. Most nations in the region with endemic malaria have called for its elimination by the year 2030. Meeting that ambitious goal will require mobilizing technical and financial resources, and social and political will. Malaria is a formidable foe fully capable of defeating halfhearted efforts to eliminate it.
On July 3, 1945 the Japanese occupation government of the East Indies executed by sword the prominent Professor Achmad Mochtar. Until his arrest by the Kenpeitai in October 1944 he directed the Eijkman Institute in Jakarta, a prestigious Nobel Prize-winning medical research laboratory. Mochtar was not only an internationally known scientist physician, but he was also closely connected to powerful Indonesian nationalist elites. The complex swirl of violent military and political currents, together with the complex technical elements of the events impelling Mochtar's execution, composes what the scholar of Indonesian history Theodore Friend referred to as “the Mochtar affair”. The defining event of this affair was the murder of 900 conscripted Javanese laborers (called romusha, a Japanese word meaning unskilled laborer but adopted in Indonesian language to mean slave laborer) at a transit camp on the outskirts of Jakarta in August 1944. They all died of acute tetanus within three days of receiving vaccinations against typhus, cholera and dysentery.
Children with left aortic arch and aberrant right subclavian artery may present with either respiratory or swallowing symptoms beyond the classically described solid-food dysphagia. We describe the clinical features and outcomes of children undergoing surgical repair of an aberrant right subclavian artery.
Materials and methods:
This was a retrospective review of children undergoing repair of an aberrant right subclavian artery between 2017 and 2022. Primary outcome was symptom improvement. Pre- and post-operative questionnaires were used to assess dysphagia (PEDI-EAT-10) and respiratory symptoms (PEDI-TBM-7). Paired t-test and Fisher’s exact test were used to analyse symptom resolution. Secondary outcomes included perioperative outcomes, complications, and length of stay.
Results:
Twenty children, median age 2 years (IQR 1–11), were included. All presented with swallowing symptoms, and 14 (70%) also experienced respiratory symptoms. Statistically significant improvements in symptoms were reported for both respiratory and swallowing symptoms. Paired (pre- and post-op) PEDI-EAT-10 and PEDI-TBM-7 scores were obtained for nine patients, resulting in mean (± SD) scores decreasing (improvement in symptoms) from 19.9 (± 9.3) to 2.4 (± 2.5) p = 0.001, and 8.7 (± 4.7) to 2.8 (± 4.0) p = 0.006, respectively. Reoperation was required in one patient due to persistent dysphagia from an oesophageal stricture. Other complications included lymphatic drainage (n = 4) and transient left vocal cord hypomobility (n = 1).
Conclusion:
Children with a left aortic arch with aberrant right subclavian artery can present with oesophageal and respiratory symptoms beyond solid food dysphagia. A thorough multidisciplinary evaluation is imperative to identify patients who can benefit from surgical repair, which appears to be safe and effective.
Methiozolin is labeled for goosegrass and smooth crabgrass control in golf course putting greens, but no peer-reviewed literature exists regarding this use. Greenhouse experiments were conducted evaluating goosegrass and smooth crabgrass response to increasing rates of methiozolin as affected by weed growth stage. In general, as weed growth stage increased, the methiozolin rate required to reduce weed biomass 90% (WR90) increased. Goosegrass was more sensitive to preemergence-applied methiozolin than smooth crabgrass, and the WR90 was 30.4 and 118 g ai ha–1 for goosegrass and smooth crabgrass, respectively. However, smooth crabgrass was generally more sensitive to postemergence-applied methiozolin than goosegrass. Subsequent field studies were conducted to evaluate goosegrass and smooth crabgrass control with methiozolin applied singularly or sequentially at standard preemergence timings. Results indicated methiozolin applied singularly or sequentially at the label-recommended rate (500 g ha–1) is not persistent enough to provide season-long control of goosegrass and smooth crabgrass. Ten field studies were conducted in Alabama, California, Florida, and Virginia to evaluate frequent methiozolin application programs with the objective of providing selective, season-long goosegrass and smooth crabgrass control. Results from these studies indicate methiozolin can be safely applied to hybrid bermudagrass and creeping bentgrass putting greens despite exceeding the yearly maximum use rate for putting greens (2,500 g ha–1) with some treatments. Methiozolin effectively controlled smooth crabgrass throughout the growing season in California and Virginia when 10 biweekly applications were applied at 250 g ha–1 or higher. In Florida, methiozolin did not acceptably (80%) control goosegrass regardless of application rate. In Virginia, methiozolin acceptably controlled goosegrass only when applied at rates and frequencies that exceeded the maximum yearly methiozolin usage rate. These data indicate that methiozolin has the potential to control smooth crabgrass preemergence when applied frequently, but does not provide acceptable goosegrass control at labeled rates.
We have employed the VULCAN laser facility to generate a laser plasma X-ray source for use in photoionization experiments. A nanosecond laser pulse with an intensity of order 1015 Wcm−2 was used to irradiate thin Ag or Sn foil targets coated onto a parylene substrate, and the L-shell emission in the 3.3–4.4 keV range was recorded for both the laser-irradiated and nonirradiated sides. Both the experimental and simulation results show higher laser to X-ray conversion yields for Ag compared with Sn, with our simulations indicating yields approximately a factor of two higher than those found in the experiments. Although detailed angular data were not available experimentally, the simulations indicate that the emission is quite isotropic on the laser-irradiated side but shows close to a cosine variation on the nonirradiated side of the target as seen experimentally in the previous work.
It is widely thought that lobbyists exert influence over legislators’ policy positions and, as a result, over policy outcomes. One mechanism of influence is the provision of policy expertise. Yet, there is little credible empirical evidence that lobbyists’ expertise influences legislative outcomes. Across four experiments fielded with three lobbyists in two state legislatures that examine two public measures of legislators’ positions, we find no evidence that lobbyists’ expertise influences legislators’ policy positions. We do find, in contrast, that the same policy expertise treatment is influential when provided by a legislative staffer. We conclude that policy information can influence legislators’ positions, but that legislators are cautious when that information is provided by lobbyists.
This introduction probes the relationship between textual and material approaches to houses of the ancient Mediterranean. Drawing on the contributions to the volume, it traces some of the ways in which documentary and archaeological sources, and the relationships between these, have shaped our knowledge of the housing and households of the Graeco-Roman world.
One of the places where the disjuncture between the different qualities of written and material sources is perhaps most clear is in their temporal aspects. For example, ancient documents such as papyri were produced in a particular moment, within formal constraints of documentary practices. By contrast, the life cycles of houses tend to pivot around human – and less formal – scales of generational time: the biological life cycles of individual people and the life cycles of families. Archaeological houses hold the material memory of such cycles. This chapter examines the way the material form of the house can hold these different forms of time, and explores the way archaeological time can disrupt other ways of conceptualizing the past, for instance, in historical periodization. With specific reference to the houses of Dura-Europos in Arsacid and Roman Syria, the chapter questions the differing temporalities of the different forms of evidence and asks how these might be used together, avoiding the urge to force them to align, in order to paint a richer picture of ancient houses.
One of the greatest benefits of studying the ancient Greek and Roman past is the ability to utilise different forms of evidence, in particular both written and archaeological sources. The contributors to this volume employ this evidence to examine ancient housing, and what might be learned of identities, families, and societies, but they also use it as a methodological locus from which to interrogate the complex relationship between different types of sources. Chapters range from the recreation of the house as it was conceived in Homeric poetry, to the decipherment of a painted Greek lekythos to build up a picture of household activities, to the conjuring of the sensorial experience of a house in Pompeii. Together, they present a rich tapestry which demonstrates what can be gained for our understanding of ancient housing from examining the interplay between the words of ancient texts and the walls of archaeological evidence.