Quantum field theory predicts a nonlinear response of the vacuum to strong electromagnetic fields of macroscopic extent. This fundamental tenet has remained experimentally challenging and is yet to be tested in the laboratory. A particularly distinct signature of the resulting optical activity of the quantum vacuum is vacuum birefringence. This offers an excellent opportunity for a precision test of nonlinear quantum electrodynamics in an uncharted parameter regime. Recently, the operation of the high-intensity Relativistic Laser at the X-ray Free Electron Laser provided by the Helmholtz International Beamline for Extreme Fields has been inaugurated at the High Energy Density scientific instrument of the European X-ray Free Electron Laser. We make the case that this worldwide unique combination of an X-ray free-electron laser and an ultra-intense near-infrared laser together with recent advances in high-precision X-ray polarimetry, refinements of prospective discovery scenarios and progress in their accurate theoretical modelling have set the stage for performing an actual discovery experiment of quantum vacuum nonlinearity.

Current understanding of word-finding (WF) difficulties in children and their underlying language processing deficit is poor. Authors have proposed that different underlying deficits may result in different profiles. The current study aimed to better understand WF difficulties by identifying difficult tasks for children with WF difficulties and by focusing on semantic vs. phonological profiles. Twenty-four French-speaking children with WF difficulties and 22 children without WF difficulties, all aged 7- to 12-years-old, participated. They were compared on a range of measures to cover the overall mechanism of WF and the quality of semantic and phonological representations. The largest differences were found on a parent questionnaire and a word definition task. Cluster analyses revealed “high performance” and “low performance” clusters, with intermediary groups. These clusters did not match the expected semantic vs. phonological profiles derived from models of lexical access, suggesting that WF difficulties may be linked to both semantic and phonological deficits.

Since 2015, more than 58,000 Syrian refugees have settled in Canada and, at the time of the 2016 national census, more than a fifth had settled in the province of Quebec. The rising numbers of refugees and the risks associated with families’ forced displacement have underscored the need to better understand and support the language of refugee children. The article reports on the oral language of three Syrian children ages five and six years, drawing on data from parent interviews, teacher reports, measures of the children’s language, and observations of their language use in a dual-language stimulation group, StimuLER. By triangulating this data, we were able to develop a rich and realistic portrait of each child’s language abilities. For these three boys, we observed that the home language was vulnerable to delays and weaknesses, and that learning the language of school was a drawn-out process. We also documented that parents and teachers had difficulties communicating with one another, and thus had difficulty meeting the educational needs of these children. We conclude that to foster resiliency in these children who are refugees, schools must find a way to build bridges with the parents to support the children’s language learning in both the language of school and at home.

We describe the performance of the Boolardy Engineering Test Array, the prototype for the Australian Square Kilometre Array Pathfinder telescope. Boolardy Engineering Test Array is the first aperture synthesis radio telescope to use phased array feed technology, giving it the ability to electronically form up to nine dual-polarisation beams. We report the methods developed for forming and measuring the beams, and the adaptations that have been made to the traditional calibration and imaging procedures in order to allow BETA to function as a multi-beam aperture synthesis telescope. We describe the commissioning of the instrument and present details of Boolardy Engineering Test Array’s performance: sensitivity, beam characteristics, polarimetric properties, and image quality. We summarise the astronomical science that it has produced and draw lessons from operating Boolardy Engineering Test Array that will be relevant to the commissioning and operation of the final Australian Square Kilometre Array Path telescope.

After having been very abundant in the Early Maastrichtian Globotruncana gansseri zone, Inoceramus remains disappear from five stratigraphic sections in the Basque region of France and Spain in the lower Abathomphalus mayaroensis zone, ~2.5 m.y. before the Cretaceous–Tertiary boundary. Several lines of evidence demonstrate that these shell fragments are preserved in place and accurately record the pattern of the decline and disappearance of the group. The dominant taphonomic process seems to have been passive disaggregation of the shell as shell proteins decayed. The resulting shell fragments were dispersed only locally by burrowing organisms. Shell fragments decline in abundance over tens of meters of section and there are subtle differences between sections which suggests Inoceramus was eliminated by gradual changes in ecological conditions that affected the basin roughly simultaneously but with some geographic variability.

The efficacy of intravenous phenytoin for the treatment of status epilepticus is related to the rapid entry of phenytoin into brain parenchyma. There is no information concerning the correlation between phenytoin serum and CSF concentrations in children, and the application of CSF data to clinical use. We report 7 children (2–11 yrs) who were treated or exposed to phenytoin in doses between 10.5–230 mg/kg. Lumbar puncture was performed 9 times in 6 of the patients. In one patient, an intraventricular catheter permitted successive assessment of CSF phenytoin concentrations. The ratio of CSF/serum phenytoin concentrations was 0.16 ± 0.08, with gradual increase over the first 8 hours as the serum phenytoin concentration decreased. There was good correlation between therapeutic outcome and CSF phenytoin levels higher than 2 mcg/ml. In one patient the coma state secondary to phenytoin intoxication was associated with high CSF concentration (6 mcg/ml).

This paper describes the system architecture of a newly constructed radio telescope – the Boolardy engineering test array, which is a prototype of the Australian square kilometre array pathfinder telescope. Phased array feed technology is used to form multiple simultaneous beams per antenna, providing astronomers with unprecedented survey speed. The test array described here is a six-antenna interferometer, fitted with prototype signal processing hardware capable of forming at least nine dual-polarisation beams simultaneously, allowing several square degrees to be imaged in a single pointed observation. The main purpose of the test array is to develop beamforming and wide-field calibration methods for use with the full telescope, but it will also be capable of limited early science demonstrations.

Information on the incidence of Chlamydia trachomatis (CT) is essential for models of the effectiveness and cost-effectiveness of screening programmes. We developed two independent estimates of CT incidence in women in England: one based on an incidence study, with estimates ‘recalibrated’ to the general population using data on setting-specific relative risks, and allowing for clearance and re-infection during follow-up; the second based on UK prevalence data, and information on the duration of CT infection. The consistency of independent sources of data on incidence, prevalence and duration, validates estimates of these parameters. Pooled estimates of the annual incidence rate in women aged 16–24 and 16–44 years for 2001–2005 using all these data were 0·05 [95% credible interval (CrI) 0·035–0·071] and 0·021 (95% CrI 0·015–0·028), respectively. Although, the estimates apply to England, similar methods could be used in other countries. The methods could be extended to dynamic models to synthesize, and assess the consistency of data on contact and transmission rates.

Since its initial introduction into North America (Saunders 1916) the European skipper Thymelicus lineola (Ochs.) has been found attacking timothy grass throughout much of eastern Canada and the United States reaching pest status in Ontario (Arthur 1966), Prince Edward Island (Thompson 1977), and Quebec (Doyle and Richard 1971; McNeil et al. 1975). Bucher and Arthur (1961) examined skipper larvae, collected near Princeville, Ontario, for naturally occurring pathogens and reported the presence of a nuclear polyhedrosis virus, a cytoplasmic polyhedrosis gut virus, and a spore forming bacterium. They stated that such pathogens represented a possible means of biological control if the skipper became economically important. An epizootic caused by an NPV in dense skipper populations near Normandin, Quebec (Smirnoff 1974), led to a series of experiments evaluating its efficacy as a microbial insecticide (Smirnoff et al. 1976; Duchesne 1980), its long term impact on the population dynamics of T. lineola (Duchesne 1980), and its possible effects on non-target organisms (Smirnoff et al. 1979).

The montane cloud-forests of the north-central Andes and the montane grassland and transitional elfin forest of the central Andean páramo contain a high diversity of bird species including several restricted range and uncommon species. Little is known of how densities of Andean cloud-forest species are affected by habitat degradation. Bird densities within pristine and degraded habitats at the Guandera Biological Reserve, Carchi province, Ecuador were recorded over a 10-week period. Densities were calculated for 48 species; where densities could be compared, 69% of species occurred at a higher density in pristine habitats. Pristine forest had the highest species richness with 72 species and páramo contained 44 species. In total, 26% of pristine forest species were only found in pristine forest, 39% of páramo species only in páramo, 13% of farmland species only in farmland and there were no exclusively secondary scrub species; 47% of species found in pristine forest, and 50% found in páramo were found in both secondary scrub and farmland. Restricted range species recorded at Guandera included the Carunculated Caracara Phalcobenus carunculatus, Black-thighed Puffleg Eriocnemis derbyi, Chestnut-bellied Cotinga Doliornis remseni, Crescent-faced Antpitta Grallaricula lineifrons, Masked Mountain-tanager Buthraupis wetmorei and Black-backed Bush-tanager Urothraupis stolzmanni. Three further species that occurred at Guandera of relatively local occurrence were the Grey-breasted Mountain Toucan Andigena hypoglauca, Golden-breasted Puffleg Eriocnemis mosquera and Mountain Avocetbill Opisthoprora euryptera. Of these nine species at least five used degraded habitats, while three occurred only in pristine treeline habitats.

A small collection of cephalopod beaks from the stomach of a sperm whale caught off Vigo is described, identified and the weight of cephalopods represented is estimated. Comparisons are made with a similar collection previously described from a whale caught off Madeira.

INTRODUCTION

This analysis of cephalopod remains, particularly the mandibles or beaks, from sperm whales caught off Iceland is one of a series made by the authors on remains from various geographical regions including Madeira (Clarke, 1962a), Spain (Clarke & MacLeod, 1974), Western South America (Clarke, MacLeod & Paliza, 1976, South Africa, Western Australia, the Antarctic and the South Atlantic (Clarke, 1976, 1977). Other workers have described similar collections from New Zealand (Gaskell & Cawthorne, 1967; see also Clarke, 1976, 1977) and the North Pacific (Akimushkin, 1954; Betesheva & Akimushkin, 1955; Tarasevich, 1963). The present analysis has depended upon a development in the technique of identification of cephalopod lower beaks from an early search for criteria (Clarke, 19626) to a point where many species can be identified from lower beaks (Mangold & Fioroni, 1966; Iversen & Pinkas, 1971; Clarke, 1977).

The incidence of various infectious and non-infectious diseases as causes of death in lambs up to 8 months of age was studied in relation to breed, inbreeding and other factors. The data from an upland grazing flock covered 6 years and involved the Scottish Blackface, Cheviot and Welsh Mountain breeds and the crosses among them.

Infectious and non-infectious diseases were directly responsible for almost a quarter of the mortality and their presence contributed to many more deaths. The organisms mainly responsible were Escherichia coli, Pasteurella spp. and Fusobacterium necrophorum.

The incidence of infectious diseases in general and enteritis in particular varied significantly between the breeds and was lower in the cross-breds than in the purebreds. Variation between the breeds in the incidence of non-infectious diseases was statistically significant only in respect of digestive upsets for which there was a similar ranking of breeds to that for infectious disease.

Inbreeding of the lamb (25–59%) significantly increased the incidence of infectious diseases, especially respiratory diseases, but not of non-infectious diseases. There was little difference between singles and twins in susceptibility to disease. The lower the birth weight of the lamb the greater the risk, particularly of non-infectious disease.

Rumen pH was varied and controlled over the range 5·2–7·1 by manipulating the infusions of buffer solution to the rumen and by using an automated system of recording pH. The total concentrations of volatile fatty acids (VFA) in the rumen were not altered by changes in pH but there were changes in the relative proportions of VFA. As the pH of rumen liquor fell, the proportion of acetic acid increased, and the proportions of propionic and butyric acids decreased relative to their respective proportions in the infusate. At rumen pH of about 7·2 the molar proportions found were similar to the molar proportions infused while at pH 5·3 the molar proportion for acetic acid in the rumen was 100 mmol/mol higher than in the infusate. There was no apparent relationship between osmotic pressure and differences between VFA proportions in the infusates and in the rumen liquor.

A total of 146 nulliparous gilts at two centres were assigned to lactation lengths of 10, 25 or 40 days and maintained on the same weaning regime for up to five parities.

The interval between weaning and conception tended to be shorter for the 40-day treatment with little difference between the 10- and 25-day treatments. The data from all parities were pooled on the basis of an assumed herd structure giving the number of litters produced per sow per year aa 2·63, 2·37 and 2·18 for the 10-, 25- and 40-day treatments respectively.

The number of pigs born alive per litter remained more or less static with successive parities on the 10-day treatment but increased on the 40-day treatment with differences between treatment s reaching or approaching significance in parities 4 and 5. Although this trend was reflected in the number of pigs weane d per litter, the differences between lactation treatments were non-significant as a result of higher post-natal mortality in the larger litters of the longer lactating sows.

Consequently sows on the 10-day treatment reared the highest number of pigs per year, 22·4 compared with 20·2 and 19·8 for 25- and 40-day lactations respectively.

Data are also presented on changes in sow live weight.

A high culling rate and an extended interval betwee n weaning and conception were experienced at one centre in parity 1. The possible reasons and effect on subsequent litter size are discussed.