Adrenocortical activity and time budgets in a robotic milking system in two variants of cow traffic (partially forced, free) were compared with a conventional milking system, focusing on the relationships between adrenocortical activity, time budgets, and social rank of the cows. Both groups were housed in identical conditions and consisted of 30 cows each. Within each experiment, direct observations of social behaviour and 24-hour video recordings were conducted during six two-day blocks. We calculated the dominance value and the time budget (‘lying’, ‘feeding’, ‘other activity’) of each cow. Faeces from each cow were collected to determine the concentration of cortisol metabolites (CCM) as an indicator of baseline adrenocortical activity and possible chronic stress. Analysis of CCM and time budgets did not indicate any adverse effects of the robotic milking system, with one exception: under partially-forced cow traffic, cows of low social rank had longer waiting times in front of the robot. Considering the fact that the number of cows milked by the robot was less than half of that recommended by the manufacturers, our results do not exclude the possibility that a higher stocking rate may lead to further adverse effects.

Excessive salt intake is a common feature of Western dietary patterns, and has been associated with important metabolic changes including cerebral redox state imbalance. Considering that little is known about the effect on progeny of excessive salt intake during pregnancy, the present study investigated the effect of a high-salt diet during pregnancy and lactation on mitochondrial parameters and the redox state of the brains of resulting offspring. Adult female Wistar rats were divided into two dietary groups (n 20 rats/group): control standard chow (0·675 % NaCl) or high-salt chow (7·2 % NaCl), received throughout pregnancy and for 7 d after delivery. On postnatal day 7, the pups were euthanised and their cerebellum, hypothalamus, hippocampus, prefrontal and parietal cortices were dissected. Maternal high-salt diet reduced cerebellar mitochondrial mass and membrane potential, promoted an increase in reactive oxygen species allied to superoxide dismutase activation and decreased offspring cerebellar nitric oxide levels. A significant increase in hypothalamic nitric oxide levels and mitochondrial superoxide in the hippocampus and prefrontal cortex was observed in the maternal high-salt group. Antioxidant enzymes were differentially modulated by oxidant increases in each brain area studied. Taken together, our results suggest that a maternal high-salt diet during pregnancy and lactation programmes the brain metabolism of offspring, favouring impaired mitochondrial function and promoting an oxidative environment; this highlights the adverse effect of high-salt intake in the health state of the offspring.

Snow accumulation and its variability on the East Antarctic plateau are poorly understood due to sparse and regionally confined measurements. We present a 5.3 GHz (C-band) ground-penetrating radar (GPR) profile with a total length of 860 km recovered during the joint Norwegian–US International Polar Year traverse 2007/08. Mean surface mass balance (SMB) over the last 200 years was derived from the GPR data by identifying the volcanic deposition of the Tambora eruption in 1815. It varies between 9.1 and 37.7 kg m−2 a−1 over the profile, with a mean of 23.7 kg m−2 a−1 and a standard deviation of 4.7 kg m−2 a−1. The 200 year SMB estimated is significantly lower than most of the SMB estimates over shorter time periods in this region. This can be partly explained by a SMB minimum in the vicinity of the ice divide. However, it is more likely that a recent increase in SMB observed by several studies is largely responsible for the observed discrepancy.

Meltwater intrusions of glacial origin complicate the operation of a coalmine situated approximately 200 m below the bed of Gruvefonna ice cap, Svalbard. The magnitude of this water input is expected to increase with the intended enlargement of the mine. The current praxis, evacuation of the water by pumping, is an expensive undertaking and prompts the investigation of alternative solutions. The evaluation of different options requires reliable values of the total volume and the input rate of the water to be drained. To quantify the melt rate at the glacier surface, we applied a distributed temperature-index model. The model parameters were calibrated using mass-balance measurements performed at Gruvefonna during the 2003 ablation season. The water discharge in the mine during the same period was derived from records of the pump rate. Comparing the records of modelled melt and measured discharge reveals an efficient hydraulic connection between the glacier surface and the mine. The total discharge volume in the mine over the 2003 melt season was about 2.8 × 106m3, exceeding significantly the total melt- and rainwater production on the glacier surface directly above the mine (1.2 × 106m3). This implies that the mine discharge receives contributions from a larger surface area. Based on the distribution of hydraulic potential at the glacier bed, we estimate this contributing area. In a number of scenarios, we calculate the amount of meltwater intrusions for several steps of the planned mine enlargement.

We have measured the glacier area changes in the central Southern Alps, New Zealand, between 1978 and 2002 and have compiled the 2002 glacier outlines using an image scene from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER). Three automated classification methods were tested: (1) band ratio, (2) normalized-difference snow index and (3) supervised classification. The results were compared with the glacier outlines photo-interpreted from the ASTER data, and were further validated using GPS-aided field mapping of selected test glaciers. The ASTER 3/4 band ratio provided the best results. However, all the classification methods failed to extract extensive debris-covered parts of the glaciers. Therefore, the photo-interpreted 2002 outlines were used when comparing with the existing 1978 glacier inventory derived from aerial photographs. Our results show a ∼17% reduction of glacier area, mainly driven by the retreat of the large valley glaciers. Despite the large climatic gradient from west to east, glaciers on both sides of the Main Divide lost similar percentages of area, except Franz Josef and Fox Glaciers which advanced. Smaller glaciers were found to have changed very little in the study period.

Observations show that glaciers around the world are in retreat and losing mass. Internationally coordinated for over a century, glacier monitoring activities provide an unprecedented dataset of glacier observations from ground, air and space. Glacier studies generally select specific parts of these datasets to obtain optimal assessments of the mass-balance data relating to the impact that glaciers exercise on global sea-level fluctuations or on regional runoff. In this study we provide an overview and analysis of the main observational datasets compiled by the World Glacier Monitoring Service (WGMS). The dataset on glacier front variations (∼42 000 since 1600) delivers clear evidence that centennial glacier retreat is a global phenomenon. Intermittent readvance periods at regional and decadal scale are normally restricted to a subsample of glaciers and have not come close to achieving the maximum positions of the Little Ice Age (or Holocene). Glaciological and geodetic observations (∼5200 since 1850) show that the rates of early 21st-century mass loss are without precedent on a global scale, at least for the time period observed and probably also for recorded history, as indicated also in reconstructions from written and illustrated documents. This strong imbalance implies that glaciers in many regions will very likely suffer further ice loss, even if climate remains stable.

Radio-echo soundings in four different frequency bands ranging from 30 to 1000 MHz were compared with temperature measurements in boreholes in the accumulation area and ablation area of Finsterwalderbreen (77°26′ N, 15°15′ E), southern Spitsbergen. Finsterwalderbreen is a polythermal surge-type glacier in the quiescent phase after its last surge around AD 1900. The objective of the study was to investigate the relation between internal echos and the glacier ice temperature to map the overall thermal structure of the glacier. The thermal structure is important for ice flow velocities and hydrology of glaciers, and it also affects their ability to surge. At the borehole site in the accumulation area (three boreholes within a range of 60 m), a change in the relative amplitude of the reflected signal is detected in the 320–370 and 600–650 MHz bands at 52–55 m depth. The high-resolution temperature measurements with 2 m intervals show that the transition zone between cold and temperate ice corresponds to the change in the relative amplitude on the 320–370 and 600–650 MHz bandwidth data. The overall thermal structure of the glacier was mapped based on the radar sounding. The radar results show (a) that the glacier is at the pressure-melting point over most of its bed except within 500–700 m of the terminus, and (b) that there is an upper cold ice layer of variable thickness (25–170 m) underlain by temperate ice. This thermal structure is confirmed by the thermistor-instrumented access holes to the bed in both the accumulation and ablation zones of the glacier. The variations in the thermal structure in lower parts of the accumulation area are explained by superimposed ice and ice layers that cause variations in the downward heat transfer by refreezing of meltwater.

The formation of ice-cored moraines and push moraines is discussed in the light of glacier thermal regime and glacier dynamics. Data from two Svalbard valley glaciers, Erikbreen and Usherbreen are presented. On Erikbreen, fossil forms were investigated, while on Usherbreen a surge ending in 1985 caused the formation of new push-moraine ridges. The push moraines are considered as a soil-mechanical problem. In a theoretical discussion the stress transmitted by the glaciers to the proglacial sediments is estimated. On Usherbreen, the compressive flow results in deformation both in old front ridges and in undisturbed frozen sediment layers in the front sandur. Thus, folding, thrust faulting and overriding all occur. Deformation of proglacial sediments seems to be highly dependent on the mechanical properties of the sediments. The sediments are strongly influenced by permafrost conditions. The unfrozen water content in the sediments governs the deformability, which in turn is partly determined by pore-water salinity. The distribution of push moraines in Svalbard is therefore restricted to areas below the Holocene marine limit, and they occur most frequently in areas of sedimentary bedrock. This study concludes that push moraines and ice-cored moraines require permafrost conditions. Push-moraine ridges are not formed in direct contact with the glacier, so they are geomorphologically not moraines, but deformed permafrost sediments. A model for glacier debris sedimentation and deformation is outlined for Svalbard glaciers ending on land.

Proton beam therapy (PBT) offers compelling advantages in physical dose distribution compared to photon therapy. There are increasing numbers of gantry-based proton facilities worldwide but no such facilities exist in Canada. To access PBT, Canadian patients must travel abroad for treatment at high cost. In the face of limited access, this report seeks to provide recommendations for the selection of patients most likely to benefit from PBT and suggests an out-of-country referral process. METHODS: A systematic literature search for studies between January 1990 and May 2014 evaluating clinical outcomes after PBT. A draft report was developed through review of evidence, externally reviewed, and approved by the Alberta Health Services Cancer Care Proton Therapy Guidelines steering committee. RESULTS: Proton therapy is often used to treat tumours close to radiosensitive tissues, and children at risk of developing significant late effects of radiation therapy (RT). Local control rates with PBT appear similar to or, in some cases, higher than photon RT in uncontrolled and retrospective studies. Randomized trials comparing equivalent doses of PBT and photon RT are not available. SUMMARY: Referral for PBT is recommended for patients being treated with curative intent, with an expectation for long-term survival, and who are able and willing to travel abroad to a proton facility. Commonly accepted indications for referral include chordoma and chondrosarcoma, intraocular melanoma, and solid tumours in children and adolescents occurring in patients with greatest risk of long-term sequelae. Current data do not provide sufficient evidence to recommend routine referral of patients with most head and neck, breast, lung, gastrointestinal tract, and pelvic cancers including prostate cancer. It is recommended that all referrals be considered by a multidisciplinary team to select appropriate cases.

Heated or cooled fluids at supercritical pressure show large variations in thermophysical properties, such as the density, dynamic viscosity and molecular Prandtl number, which strongly influence turbulence characteristics. To investigate this, direct numerical simulations were performed of a turbulent flow at supercritical pressure (CO $_{2}$ at 8 MPa) in an annulus with a hot inner wall and a cold outer wall. The pseudo-critical temperature lies close to the inner wall, which results in strong thermophysical property variations in that region. The turbulent shear stress and the turbulent intensities significantly decrease near the hot inner wall, but increase near the cold outer wall, which can be partially attributed to the mean dynamic viscosity and density stratification. This leads to decreased production of turbulent kinetic energy near the inner wall and vice versa near the outer wall. However, by analysing a transport equation for the coherent streak flank strength, it was found that thermophysical property fluctuations significantly affect streak evolution. Near the hot wall, thermal expansion and buoyancy tend to decrease streak coherence, while the viscosity gradient that exists across the streaks interacts with mean shear to act as either a source or a sink in the evolution equation for the coherent streak flank strength. The formation of streamwise vortices on the other hand is hindered by the torque that is the result of the kinetic energy and density gradients. Near the cold wall, the results are reversed, i.e. the coherent streak flank strength and the streamwise vortices are enhanced due to the variable density and dynamic viscosity. The results show that not only the mean stratification but also the large instantaneous thermophysical property variations that occur in heated or cooled fluids at supercritical pressure have a significant effect on turbulent structures that are responsible for the self-regeneration process in near-wall turbulence. Thus, instantaneous density and dynamic viscosity fluctuations are responsible for decreased (or increased) turbulent motions in heated (or cooled) fluids at supercritical pressure.