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This study delves into the intricate relationship between chief executive officers' (CEOs') experiences of poverty and the digital transformation of their firms. Employing comprehensive data collection on CEOs' birthplaces and leveraging advanced text analytics to quantify digitalization, our analysis encompasses a wide array of listed companies in China. The findings reveal that CEOs' impoverished experiences exert a detrimental influence on their firms' digital transformation efforts, primarily due to a lack of motivation and social resources necessary for such initiatives. However, this adverse effect can be ameliorated when CEOs gain access to substantial social resources in later life. Our conclusions are robust, supported by rigorous testing, and underscore not only the impact of CEOs' early-life poverty on corporate digitalization but also the potential for overcoming these challenges through the acquisition of external social resources and connections in adulthood. This study contributes significantly to existing literature and offers practical implications for enhancing corporate digital transformation strategies.
Evidence suggests the crucial role of dysfunctional default mode (DMN), salience and frontoparietal (FPN) networks, collectively termed the triple network model, in the pathophysiology of treatment-resistant depression (TRD).
Aims
Using the graph theory- and seed-based functional connectivity analyses, we attempted to elucidate the role of low-dose ketamine in the triple networks, namely the DMN, salience and FPN.
Method
Resting-state functional connectivity magnetic resonance imaging (rs–fcMRI) data derived from two previous clinical trials of a single, low-dose ketamine infusion were analysed. In clinical trial 1 (Trial 1), patients with TRD were randomised to either a ketamine or normal saline group, while in clinical trial 2 (Trial 2) those patients with TRD and pronounced suicidal symptoms received a single infusion of either 0.05 mg/kg ketamine or 0.045 mg/kg midazolam. All participants underwent rs–fcMRI pre and post infusion at Day 3. Both graph theory- and seed-based functional connectivity analyses were performed independently.
Results
Trial 1 demonstrated significant group-by-time effects on the degree centrality and cluster coefficient in the right posterior cingulate cortex (PCC) cortex ventral 23a and b (DMN) and the cluster coefficient in the right supramarginal gyrus perisylvian language (salience). Trial 2 found a significant group-by-time effect on the characteristic path length in the left PCC 7Am (DMN). In addition, both ketamine and normal saline infusions exerted a time effect on the cluster coefficient in the right dorsolateral prefrontal cortex a9-46v (FPN) in Trial 1.
Conclusions
These findings may support the utility of the triple-network model in elucidating ketamine’s antidepressant effect. Alterations in DMN, salience and FPN function may underlie this effect.
The study aims were to present in vitro susceptibilities of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) collected in China. GNBSI isolates were collected from 18 tertiary hospitals in 7 regions of China from 2018 to 2020. Minimum inhibitory concentrations were assessed using a Trek Diagnostic System. Susceptibility was determined using CLSI broth microdilution, and breakpoints were interpreted using CLSI M100 (2021). A total of 1,815 GNBSI strains were collected, with E. coli (42.4%) and Klebsiella pneumoniae (28.6%) being the most prevalent species, followed by P. aeruginosa (6.7%). Susceptibility analyses revealed low susceptibilities (<40%) of ESBL-producing E. coli and K. pneumonia to third-/fourth-generation cephalosporins, monobactamases, and fluoroquinolones. High susceptibilities to colistin (95.0%) and amikacin (81.3%) were found for K. pneumoniae, while Acinetobacter baumannii exhibited a high susceptibility (99.2%) to colistin but a low susceptibility to other antimicrobials (<27.5%). Isolates from ICUs displayed lower drug susceptibility rates of K. pneumoniae and A. baumannii than isolates from non-ICUs (all P < 0.05). Carbapenem-resistant and ESBL-producing K. pneumoniae detection was different across regions (both P < 0.05). E. coli and K. pneumoniae were major contributors to GNBSI, while A. baumannii exhibited severe drug resistance in isolates obtained from ICU departments.
This study proposes two novel time-varying model-averaging methods for time-varying parameter regression models. When the number of predictors is small, we propose a novel time-varying complete subset-averaging (TVCSA) procedure, where the optimal time-varying subset size is obtained by minimizing the local leave-h-out cross-validation criterion. The TVCSA method is asymptotically optimal for achieving the lowest possible local mean squared error. When the number of predictors is relatively large, we propose a factor TVCSA method to reduce the computational burden by first reducing the dimension of predictors by extracting a few factors using principal component analysis and then obtaining the TVCSA forecasts from time-varying models with the generated factors. We show that the TVCSA estimator remains asymptotically optimal in the presence of generated factors. Monte Carlo simulation studies have provided favorable evidence for the TVCSA methods relative to the popular model-averaging methods in the literature. Empirical applications to equity premiums and inflation forecasting highlight the practical merits of the proposed methods.
Xiangranggounan is an intensively occupied settlement associated with the Kayue culture on the north-eastern Qinghai-Tibet Plateau. Excavations in 2022 and 2023 revealed five house types with clear stratigraphic relationships that help to expand current understanding of the evolution of prehistoric settlement patterns in harsh plateau environments.
Knowledge is growing on the essential role of neural circuits involved in aberrant cognitive control and reward sensitivity for the onset and maintenance of binge eating.
Aims
To investigate how the brain's reward (bottom-up) and inhibition control (top-down) systems potentially and dynamically interact to contribute to subclinical binge eating.
Method
Functional magnetic resonance imaging data were acquired from 30 binge eaters and 29 controls while participants performed a food reward Go/NoGo task. Dynamic causal modelling with the parametric empirical Bayes framework, a novel brain connectivity technique, was used to examine between-group differences in the directional influence between reward and executive control regions. We explored the proximal risk factors for binge eating and its neural basis, and assessed the predictive ability of neural indices on future disordered eating and body weight.
Results
The binge eating group relative to controls displayed fewer reward-inhibition undirectional and directional synchronisations (i.e. medial orbitofrontal cortex [mOFC]–superior parietal gyrus [SPG] connectivity, mOFC → SPG excitatory connectivity) during food reward_nogo condition. Trait impulsivity is a key proximal factor that could weaken the mOFC–SPG connectivity and exacerbate binge eating. Crucially, this core mOFC–SPG connectivity successfully predicted binge eating frequency 6 months later.
Conclusions
These findings point to a particularly important role of the bottom-up interactions between cortical reward and frontoparietal control circuits in subclinical binge eating, which offers novel insights into the neural hierarchical mechanisms underlying problematic eating, and may have implications for the early identification of individuals suffering from strong binge eating-associated symptomatology in the general population.
We present 35 AMS 14C dates from 26 horizons on a 30-cm gravity core from Shira Lake in the republic of Khakassia, Central Russia. The chronology of the core is determined by 210Pb/137Cs dating results and interpretation of elemental geochemistry with historic documents, covering deposition since ca. 1870 CE. This study assesses the old carbon influence (OCI) on organic carbon 14C by comparison with the 210Pb/137Cs dates, sources of carbon, and lake conditions interpreted from elemental proxies. These include elemental concentrations in 0.5N HCl leaches and Aqua Regia dissolution fractions, as well as organic C, N and C/N measurements. From these data we establish a succession of the following six zones: I) (1870∼1900 CE) relatively fresh lake with high lake level, low productivity and high surface runoff (wet conditions); II) (1900∼1940 CE) a “white zone” reflected by high carbonate and low magnetic signal formed in a saline, oxidizing and holomictic lake stage; III) (1940∼1963 CE) reduced carbonate with elevated organic C, N, C/N, Mo and magnetic signal, indicating a stratified and anaerobic lake; IV) (1963∼1994 CE) increased salinity and productivity with the highest observed magnetic signal and elevated heavy metal and Mo contents, implying enhanced anoxic conditions and human impact; V) (1994∼2003 CE) high C/N, organic and carbonate contents suggesting meromictic and anaerobic lake conditions; VI) (2003∼2020 CE) decreased carbonate content with increased organic C and N, and heavy metals showing a deteriorating lake environment under human impact.
Research on female leadership has documented that female-led firms tend to engage in lower risk-taking activities than male-led firms and attributed it to females' higher propensity for risk aversion. Nevertheless, this claim and its associated findings have been increasingly challenged. In this article, we address the unclear pattern of females' risk preference in leadership by contextualizing the effect of chair gender on corporate acquisitions in the context of state-owned enterprises (SOEs) in China. Drawing on expectancy violation theory, we propose that female chairs are more inclined to take risks when they operate in contexts that encourage female agency. We further explore self-affirmation mechanisms through two moderators: gender stereotype threats and self-efficacy. An analysis of chairs of 1,265 publicly listed SOEs in China from 2008 to 2020 supports predictions that female chairs are more likely than male chairs to engage in firm acquisitions. The effects are amplified under low levels of female executive representation and high levels of political appointments held by female chairs. The study shows that context determines how extensively gender affects risk-taking. It offers new insights into when and why female leaders exhibit higher levels of risk-taking in Chinese SOEs.
The Northwest Tibet region is defined by several terranes, magmatic belts, basins and sutures, which were primarily shaped by the tectonic activities associated with Proto-, Palaeo- and Neo-Tethys Oceans. However, the basement nature and Precambrian tectonic evolution of the Northwest Tibet region, particularly within the Tashikuergan-Tianshuihai terrane, remain largely unknown. The Hongliutan area, located in the northeastern part of the Tashikuergan-Tianshuihai terrane, contains a critical sequence of Precambrian metamorphic rock strata. Detailed petrological, geochronological, and geochemical analyses of these metamorphic rocks – including plagioclase schist, quartz schist, amphibolite and nearby leucogranite – reveal the intricate processes of tectonic evolution within the Tianshuihai unit. Combining these findings with previous geochronological results is crucial for re-evaluating the nature of the Tashikuergan-Tianshuihai basement and its Precambrian tectonic evolution of the Tashikuergan-Tianshuihai basement. Our results reveal the following: (1) the leucogranite and amphibolite, identified as Cambrian igneous rocks, display distinct geochemical signatures indicative of a continental arc origin. These include calc-alkaline characteristics, enrichment in Th, U, Pb, Zr and Hf and depletion in Ba, Nb, Sr and Ti. Their εNd(t) values, close to zero, further support this tectonic setting, with the leucogranite and amphibolite formed at 506 and 522 Ma, respectively. (2) The plagioclase schist and quartz schist are interpreted to be Neoproterozoic volcaniclastic rocks that formed in a rifted (passive) continental margin setting. The quartz schist is particularly rich in detrital zircons, displaying a broad spectrum of 207Pb/206Pb ages, ranging from 901 to 3364 Ma. (3) A significant subset of detrital zircons within the quartz schist exhibits oscillatory zoning, high Th/U ratios and sharp-edged, anhedral-to-subhedral crystal forms, suggesting a derivation from proximal or deep-seated terranes. The concordant U–Pb zircon ages of 2468 and 974 Ma from the quartz schist, along with the 978 Ma age from the inherited zircons in the amphibolite, and the 1.2–2.1 Ga T2DM(Nd) from leucogranite and metamorphic rocks, collectively suggest that the Tianshuihai unit is likely underpinned by a Palaeoproterozoic basement that indicates Neoproterozoic reworking.
Therefore, our findings suggest the presence of a continuous, northwest-southeast trending Palaeoproterozoic basement underlying the entire Tashikuergan-Tianshuihai terrane. An alternative scenario posits that the ancient basement, currently beneath the Tashikuergan terrane, could extend into the Tianshuihai region, potentially indicating a Cambrian continental margin arc interspersed with remnants of older terranes.
The rapid and efficient removal of weeds is currently a research hotspot. With the integration of robotics and automation technology into agricultural production, intelligent field-weeding robots have emerged. An overview of the development status of weeding robots based on bibliometric and scientific mapping methods is presented. Two key technologies of weeding robots are summarized, and the research progress of precision-spraying weeding robots, mechanical weeding robots, and thermal weeding robots with laser devices, categorized by weeding method, is reviewed. Finally, a summary and an outlook on the future development trends of intelligent field-weeding robots are provided, aiming to offer a reference for further promoting the development of weeding robots.
This paper presents a compact broad dual-band rectifier based on a transmission line matching network. This method improves the overall impedance matching performance over two bands, and improves bandwidth of the rectifier’s efficiency. A π-type direct current filter with excellent harmonic suppression performance is proposed. The multi-section transmission line used as the dual-band input impedance matching network is analyzed to achieve an arbitrary frequency ratio. A rectifier is designed and implemented using a three-stage transmission-line matching network. Simulation and experimental results show that a dual-band rectifier is successfully performed with the measured power conversion efficiency (PCE) of 75.7% and 76.3% at 0.915 and 2.45 GHz, respectively. Additionally, the rectifier exhibits bandwidths of 0.48 and 0.25 GHz when the PCE exceeds 70%. Significant enhancement of bandwidth over conventional rectifiers is demonstrated.
Although dietary factors have been examined as potential risk factors for liver cancer, the evidence is still inconclusive. Using a diet-wide association analysis, our research evaluated the associations of 126 foods and nutrients on the risk of liver cancer in a Chinese population. We obtained the diet consumption of 72,680 women in the Shanghai Women’s Health Study using baseline dietary questionnaires. The association between each food and nutrient and liver cancer risk was quantified by Cox regression model. A false discovery rate of 0.05 was used to determine the foods and nutrients which need to be verified. Totally 256 incident liver cancer cases were identified in 1,267,391 person-years during the follow-up duration. At the statistical significance level (P ≤ 0.05), higher intakes of cooked wheaten foods, pear, grape and copper were inversely associated with liver cancer risk, while spinach, leafy vegetables, eggplant and carrots showed the positive associations. After considering multiple comparisons, no dietary variable was associated with liver cancer risk. Similar findings were seen in the stratification, secondary and sensitivity analyses. Our findings observed no significant association between dietary factors and liver cancer risk after considering multiple comparisons in Chinese women. More evidence is needed to explore the associations between diet and female liver cancer occurrence.
A high-energy pulsed vacuum ultraviolet (VUV) solid-state laser at 177 nm with high peak power by the sixth harmonic of a neodymium-doped yttrium aluminum garnet (Nd:YAG) amplifier in a KBe2BO3F2 prism-coupled device was demonstrated. The ultraviolet (UV) pump laser is a 352 ps pulsed, spatial top-hat super-Gaussian beam at 355 nm. A high energy of a 7.12 mJ VUV laser at 177 nm is obtained with a pulse width of 255 ps, indicating a peak power of 28 MW, and the conversion efficiency is 9.42% from 355 to 177 nm. The measured results fitted well with the theoretical prediction. It is the highest pulse energy and highest peak power ever reported in the VUV range for any solid-state lasers. The high-energy, high-peak-power, and high-spatial-uniformity VUV laser is of great interest for ultra-fine machining and particle-size measurements using UV in-line Fraunhofer holography diagnostics.
Natural infection by Trichinella sp. has been reported in humans and more than 150 species of animals, especially carnivorous and omnivorous mammals. Although the presence of Trichinella sp. infection in wild boars (Sus scrofa) has been documented worldwide, limited information is known about Trichinella circulation in farmed wild boars in China. This study intends to investigate the prevalence of Trichinella sp. in farmed wild boars in China. Seven hundred and sixty-one (761) muscle samples from farmed wild boars were collected in Jilin Province of China from 2017 to 2020. The diaphragm muscles were examined by artificial digestion method. The overall prevalence of Trichinella in farmed wild boars was 0.53% [95% confidence interval (CI): 0.51–0.55]. The average parasite loading was 0.076 ± 0.025 larvae per gram (lpg), and the highest burden was 0.21 lpg in a wild boar from Fusong city. Trichinella spiralis was the only species identified by multiplex polymerase chain reaction. The 5S rDNA inter-genic spacer region of Trichinella was amplified and sequenced. The results showed that the obtained sequence (GenBank accession number: OQ725583) shared 100% identity with the T. spiralis HLJ isolate (GenBank accession number: MH289505). Since the consumption of farmed wild boars is expected to increase in the future, these findings highlight the significance of developing exclusive guidelines for the processing of slaughtered farmed wild boar meat in China.
Background: Mild behavioral impairment (MBI) in older people refers to a group of syndromes that are characterized primarily by clusters of neuropsychiatric symptoms without severe cognitive impairment, which is a high-risk population for dementia. Patients often experience a variety of symptoms and exhibit high heterogeneity in symptomatology across different individuals. Classifying the psychotic symptom characteristics of MBI patients aids in the implementation of precise interventions for the next steps.
Objectives: To explore the symptom characteristics of older people with MBI and to classify them based on their symptoms.
Methods: Using a multi-stage sampling Methods, the MBI-Checklist was employed to investigate symptom characteristics in 255 older people with MBI from 32 nursing homes in Fujian Province. Latent Class Analysis (LCA) was then employed to categorize these individuals based on their symptom profiles.
Results: The neuropsychiatric symptoms clusters in older people with MBI often present as a combination of lack of motivation and emotional dysregulation, lack of motivation and impulse control disorders, or emotional dysregulation and impulse control disorders; presentation of a single symptom cluster is relatively less common, accounting for 45.49%. Older people with MBI can be divided into 2 latent classes (P < 0.05) based on symptom characteristics. According to the conditional probability of each class, they were named the “high- level group’’ [211 (82.69%)] and the “low-level group’’[44 (17.31%)].
Discussion: As individuals with MBI are at high risk for developing dementia, early intervention can effectively delay or reduce the occurrence of dementia. Future interventions should be personalized based on the specific symptom characteristics of this population.
Objectives: The aim of this study was to identify core and bridge symptoms between emergent neuropsychiatric symptoms and sleep disturbance in dementia-risk older adults with depressive symptoms in nursing homes using network analysis, and to further compare the structural differences in symptom networks between subthreshold depressive and depressive groups.
Methods: A total of 853 older adults in nursing homes participated in this study. We used the Mild Behavioral Impairment (MBI) and the Pittsburgh Sleep Quality Index (PSQI) to assess the severity of emergent neuropsychiatric symptoms and sleep disturbances, respectively, and the analyses also generated a network model of the MBI-PSQI in the sample and examined subthreshold depressive and depressive groups’ potential differences between network structure and connectivity.
Results: The core symptom in the global MBI-PSQI network of older adults with depressive symptoms in nursing homes was MBI8’’ (Lack of pleasure experience: 8.340), and the bridge symptom was PSQI7’’ (Daytime Dysfunction: 3.894). The edges connecting the nodes MBI2’’ (Lost curiosity in usual interests) and MBI3’’ (Decreased social initiative) in the global MBI-PSQI network has the strongest weight (0.798). Compared to the global network, for participants in the depression group, MBI8’’ (7.647) remains the most core symptom, and PSQI7’’ (4.028) serves as a critical bridge symptom between emergent neuropsychiatric symptoms and sleep disturbances. However, in the subthreshold depression group, the MBI-PSQI network structure exhibits distinct characteristics, with MBI2’’ (5.563) being revealed as the most significant symptom, closely followed by MBI8’’ (5.453). Furthermore, the bridge symptom connecting emergent neuropsychiatric symptoms to sleep disturbances shifts to PSQI4’’ (Sleep Efficiency: 1.386). Intriguingly, the strongest edge in both the global network and the subgroup network is MBI2-MBI3.
Conclusions: There is an association between emergent neuropsychiatric symptoms and sleep disturbance in dementia-risk older adults with depressive symptoms in nursing homes. In addition, heterogeneity in the network structure of subthreshold depression and depression, with shifts in core and bridge symptoms, providing directions for designing novel and targeted interventions.
This paper presents a compact and ultra-wideband high-efficiency microwave rectifier for wireless power transmission (WPT) applications. The input-matching-network utilizes a compact asymmetric coupled transmission line structure, contributing to wideband performance. The rectifier adopts a voltage-doubler topology, resulting in a smooth input impedance across a wide bandwidth. The working principle of the asymmetric coupled transmission line matching network is analyzed. Simulation and measurement are conducted on the proposed rectifier. The fabricated prototype demonstrates a wide bandwidth of 162.5% (0.3–2.9 GHz with the power conversion efficiency (PCE) exceeding 60% at an input power of 18 dBm. Even at an input power of 10 dBm, the measured PCE remains above 50% over the working band. The proposed ultra-wideband rectifier shows promising potential for WPT applications including wireless powering of low-power electronic devices and sensors.