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The relationship between emotional symptoms and cognitive impairments in major depressive disorder (MDD) is key to understanding cognitive dysfunction and optimizing recovery strategies. This study investigates the relationship between subjective and objective cognitive functions and emotional symptoms in MDD and evaluates their contributions to social functioning recovery.
Methods
The Prospective Cohort Study of Depression in China (PROUD) involved 1,376 MDD patients, who underwent 8 weeks of antidepressant monotherapy with assessments at baseline, week 8, and week 52. Measures included the Hamilton Depression Rating Scale (HAMD-17), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Chinese Brief Cognitive Test (C-BCT), Perceived Deficits Questionnaire for Depression-5 (PDQ-D5), and Sheehan Disability Scale (SDS). Cross-lagged panel modeling (CLPM) was used to analyze temporal relationships.
Results
Depressive symptoms and cognitive measures demonstrated significant improvement over 8 weeks (p < 0.001). Baseline subjective cognitive dysfunction predicted depressive symptoms at week 8 (HAMD-17: β = 0.190, 95% CI: 0.108–0.271; QIDS-SR16: β = 0.217, 95% CI: 0.126–0.308). Meanwhile, baseline depressive symptoms (QIDS-SR16) also predicted subsequent subjective cognitive dysfunction (β = 0.090, 95% CI: 0.003-0.177). Recovery of social functioning was driven by improvements in depressive symptoms (β = 0.384, p < 0.0001) and subjective cognition (β = 0.551, p < 0.0001), with subjective cognition contributing more substantially (R2 = 0.196 vs. 0.075).
Conclusions
Subjective cognitive dysfunction is more strongly associated with depressive symptoms and plays a significant role in social functioning recovery, highlighting the need for targeted interventions addressing subjective cognitive deficits in MDD.
Two-dimensional gaseous detonations near critical propagation state were studied numerically in a channel with stoichiometric H$_2$/air and H$_2$/O$_2$ mixtures. Detonation waves exhibit a mode-locking effect (MLE) in a single-headed mode regime. Increasing the channel width alters the strength and propagation period of the single transverse wave. This leads to MLE failure and the occurrence of the single-dual-headed critical mode, featuring the emergence of a new transverse wave. For a stoichiometric H$_2$/air mixture, generation of the new transverse wave is due to interactions between the detonation front and the local explosion wave originating from interactions between the transverse wave and unreacted gas pocket downstream. Whereas, for a stoichiometric H$_2$/O$_2$ mixture, a transverse wave interacting with the wall produces Mach reflection bifurcation, causing MLE failure and generation of the new transverse wave. Our results show that all transverse waves manifest as strong transverse wave (STW) structures, with most belonging to the second kind, and an acoustic coupling exists between the typical second kind of STW structure and the acoustic wave in the induction zone behind the Chapman–Jouguet detonation front. A high-pressure region close to the STW structure plays a crucial role in exploring the transverse dynamics of this structure. Shock polars with rational assumptions are adopted to predict flow states in this region. The roles of pivotal factors in influencing the flow states and wave structure are clarified, and characteristic pressure values derived adequately represent the STW structure’s transverse dynamic behaviours. Lastly, the relationship between the kinematics and kinds of STW structures is unveiled.
A method is proposed for identifying robot gravity and friction torques based on joint currents. The minimum gravity term parameters are obtained using the Modified Denavit–Hartenberg (MDH) parameters, and the dynamic equations are linearized. The robot’s friction torque is identified using the Stribeck friction model. Additionally, a zero-force drag algorithm is designed to address the issue of excessive start-up torque during dragging. A sinusoidal compensation algorithm is proposed to perform periodic friction compensation for each stationary joint, utilizing the identified maximum static friction torque. Experimental results show that when the robot operates at a uniform low speed, the theoretical current calculated based on the identified gravity and friction fits the actual current well, with a maximum root mean square error within 50 mA, confirming the accuracy of the identification results. The start-up torque compensation algorithm reduces the robot’s start-up torque by an average of $ 60.58\mathrm{\%}$, improving the compliance of the dragging process and demonstrating the effectiveness of the compensation algorithm.
Pediatric bipolar disorder (PBD) is characterized by abnormal functional connectivity among distributed brain regions. Increasing evidence suggests a role for the limbic network (LN) and the triple network model in the pathophysiology of bipolar disorder (BD). However, the specific relationship between the LN and the triple network in PBD remains unclear. This study aimed to investigate the aberrant causal connections among these four core networks in PBD.
Method
Resting-state functional MRI scans from 92 PBD patients and 40 healthy controls (HCs) were analyzed. Dynamic Causal Modeling (DCM) was employed to assess effective connectivity (EC) among the four core networks. Parametric empirical Bayes (PEB) analysis was conducted to identify ECs associated with group differences, as well as depression and mania severity. Leave-one-out cross-validation (LOOCV) was used to test predictive accuracy.
Result
Compared to HCs, PBD patients exhibited primarily excitatory bottom-up connections from the LN to the salience network (SN) and bidirectional excitatory connections between the default mode network (DMN) and SN. In PBD, top-down connectivity from the triple network to the LN was excitatory in individuals with higher depression severity but inhibitory in those with higher mania severity. LOOCV identified dysconnectivity circuits involving the caudate and hippocampus as being associated with mania and depression severity, respectively.
Conclusions
Disrupted bottom-up connections from the LN to the triple network distinguish PBD patients from healthy controls, while top-down disruptions from the triple network to LN relate to mood state differences. These findings offer insight into the neural mechanisms of PBD.
Natural infection by Trichinella sp. has been reported in humans and more than 150 species of animals, especially carnivorous and omnivorous mammals. Although the presence of Trichinella sp. infection in wild boars (Sus scrofa) has been documented worldwide, limited information is known about Trichinella circulation in farmed wild boars in China. This study intends to investigate the prevalence of Trichinella sp. in farmed wild boars in China. Seven hundred and sixty-one (761) muscle samples from farmed wild boars were collected in Jilin Province of China from 2017 to 2020. The diaphragm muscles were examined by artificial digestion method. The overall prevalence of Trichinella in farmed wild boars was 0.53% [95% confidence interval (CI): 0.51–0.55]. The average parasite loading was 0.076 ± 0.025 larvae per gram (lpg), and the highest burden was 0.21 lpg in a wild boar from Fusong city. Trichinella spiralis was the only species identified by multiplex polymerase chain reaction. The 5S rDNA inter-genic spacer region of Trichinella was amplified and sequenced. The results showed that the obtained sequence (GenBank accession number: OQ725583) shared 100% identity with the T. spiralis HLJ isolate (GenBank accession number: MH289505). Since the consumption of farmed wild boars is expected to increase in the future, these findings highlight the significance of developing exclusive guidelines for the processing of slaughtered farmed wild boar meat in China.
Coronary artery lesions are the most severe complications of Kawasaki disease. Despite recent advances, evidence of the association between risk factors and coronary artery lesion is lacking. In this study, we demonstrated the potential clinical indicators that could assist to evaluate the prevalence of coronary artery lesion among paediatric patients with Kawasaki disease.
Methods:
We retrospectively enrolled 260 paediatric patients with Kawasaki disease. Patients with coronary dilation, coronary aneurysm, and intimal thickening of coronary arteries were included in this study. Medical records of each patient were collected. Logistic regression analysis was performed to explore risk factors and the occurrence of coronary artery lesion in patients with Kawasaki disease.
Results:
Respectively, 64 (24.6%), 39 (15%), and 56 patients (21.5%) of the participants had coronary dilation, coronary aneurysm, and intimal thickening of coronary arteries. Univariate analysis revealed that age, gender, duration of fever, time of initial use of intravenous immunoglobulin, erythrocyte sedimentation rate, white blood cell counts, time of platelet increase, the maximum value of platelet, albumin, and immunoglobulin G level was associated with coronary artery lesion. In multivariable logistic analysis, those younger and mainly males were associated with all three outcomes of coronary artery lesion, lower serum albumin levels, and later initial use of intravenous immunoglobulin were linked to a higher risk of coronary dilation and coronary aneurysm.
Conclusions:
The potential risk factors that could be used to estimate the occurrence of coronary artery lesion in Kawasaki disease patients are young age, male, lower serum albumin lever, and later initial use of intravenous immunoglobulin. However, long-term follow-up and multi-centre studies are required to verify our findings in the future.
The Chinese Loess Plateau (CLP), recognized as the world's largest loess plateau, has been a subject of ongoing debate regarding the continuity of its sedimentary loess sequence due to its intricate depositional environment. In this study, we conducted dating on a 9.8-m-long Malan loess core obtained from the Sanmen Gorge in the southern CLP using optically stimulated luminescence (OSL). The OSL dates indicate loess deposition between 52.4 and 11.3 ka, with no apparent hiatus on a millennial scale, and a sedimentation rate (SR) exhibiting six distinct episodes. Additionally, a comprehensive review of 613 OSL ages from 18 sections at 14 sites across the CLP was conducted. The results reveal loess deposition at most sites shows no apparent hiatus on a millennial scale over the past 60 ka, except for two specific locations. High SR episodes during Marine Isotope Stage (MIS) 3 across the CLP were attributed to heightened dust emissions from the source region and an enhanced dust deposition efficiency, while MIS 2 deposits were influenced by an intensified East Asian winter monsoon. Low SR episodes during MIS 1 at most sites were likely associated with reduced atmospheric transportation and pedogenesis. Spatially heterogeneous SR variations across the CLP might be influenced by local depositional environments.
Integrons are important genetic elements that allow easy acquisition and dissemination of antimicrobial resistance genes. Studies reporting occurrence of integrons in Staphylococcus aureus (S. aureus) isolated from bovine mastitis in large dairy farms across China are scarce. The aim of this study was to investigate the occurrence of class 1 integrons (intI1), antimicrobial resistance (AMR) and associated genes in S. aureus isolated from bovine mastitis and their associations. Minimum inhibitory concentrations (MICs) were determined to evaluate the AMR phenotypes, whereas PCR was carried out to assess the occurrence of AMR genes and intI1. In addition, index cluster analysis was used to estimate associations between AMR phenotype, genotype and intI1 in 103 isolates. Overall, 83% of S. aureus were intI1-positive and 5 types of gene cassettes were detected. Susceptibility against single antimicrobial agents ranged from 0% (erythromycin), 12% (ampicillin) and 16% (penicillin G) to 96% (gentamicin). Most isolates (64%) were intermediate-resistant against erythromycin, whereas resistance against ceftriaxone (22%), clindamycin (4%), cefotaxime (2%), tetracycline (1%) and ciprofloxacin (1%) were relatively uncommon. The predominant resistant gene was blaZ gene (n = 88, 85%) followed by tetD gene (n = 85, 83%). With an estimated prevalence of 12% of the mecA gene, methicillin-resistant S. aureus isolates had higher MIC50 and MIC90 for majority of antimicrobials than methicillin-susceptible S. aureus isolates. Presence of the ermC gene was associated with erythromycin resistance. Ampicillin, erythromycin and penicillin G resistance were associated with intI1. The data presented in our study indicated that class 1 integron-mediated resistance possibly plays an important role in dissemination of AMR in S. aureus isolated from bovine mastitis.
The widespread use of finite-element analysis (FEA) in industry has led to a large accumulation of cases. Leveraging past FEA cases can improve accuracy and efficiency in analyzing new complex tasks. However, current engineering case retrieval methods struggle to measure semantic similarity between FEA cases. Therefore, this article proposed a method for measuring the similarity of FEA cases based on ontology semantic trees. FEA tasks are used as indexes for FEA cases, and an FEA case ontology is constructed. By using named entity recognition technology, pivotal entities are extracted from FEA tasks, enabling the instantiation of the FEA case ontology and the creation of a structured representation for FEA cases. Then, a multitree algorithm is used to calculate the semantic similarity of FEA cases. Finally, the correctness of this method was confirmed through an FEA case retrieval experiment on a pressure vessel. The experimental results clearly showed that the approach outlined in this article aligns more closely with expert ratings, providing strong validation for its effectiveness.
Double-cone ignition [Zhang et al., Phil. Trans. R. Soc. A 378, 20200015 (2020)] was proposed recently as a novel path for direct-drive inertial confinement fusion using high-power lasers. In this scheme, plasma jets with both high density and high velocity are required for collisions. Here we report preliminary experimental results obtained at the Shenguang-II upgrade laser facility, employing a CHCl shell in a gold cone irradiated with a two-ramp laser pulse. The CHCl shell was pre-compressed by the first laser ramp to a density of 3.75 g/cm3 along the isentropic path. Subsequently, the target was further compressed and accelerated by the second laser ramp in the cone. According to the simulations, the plasma jet reached a density of up to 15 g/cm3, while measurements indicated a velocity of 126.8 ± 17.1 km/s. The good agreements between experimental data and simulations are documented.
Collaborative robots are becoming intelligent assistants of human in industrial settings and daily lives. Dynamic model identification is an active topic for collaborative robots because it can provide effective ways to achieve precise control, fast collision detection and smooth lead-through programming. In this research, an improved iterative approach with a comprehensive friction model for dynamic model identification is proposed for collaborative robots when the joint velocity, temperature and load torque effects are considered. Experiments are conducted on the AUBO I5 collaborative robots. Two other existing identification algorithms are adopted to make comparison with the proposed approach. It is verified that the average error of the proposed I-IRLS algorithm is reduced by over 14% than that of the classical IRLS algorithm. The proposed I-IRLS method can be widely used in various application scenarios of collaborative robots.
Various magmatisms during the subduction-collision process are crucial to reveal the long-term tectonic evolution of the eastern Central Asian Orogenic Belt. In this paper, we present major and trace elements of whole-rock, zircon U-Pb dating and Hf isotope of the Shanmen pluton. Results imply that the Shanmen pluton consists of quartz diorite and mylonitic granite, with zircon U-Pb ages of 263.7–259.6 Ma. The studied quartz diorite contains high Sr/Y (51.19–90.87) and (La/Yb)N (7.82–13.62) ratios, and belongs to adakitic rocks. Coupled with the positive εHf(t) values of +5.71 to +12.8 with no obvious Eu anomaly, we propose that quartz diorite is the product of the interaction between different degrees of slab melt and the overlying mantle wedge. In contrast, the mylonitic granite has lower MgO (0.28 wt% – 0.47 wt%) contents and positive εHf(t) values of +7.79 to +10.15, indicating an affinity with I-type granite originated by partial melting of the intermediate-basic lower crust. The geochemical characteristics and lithological assemblages, along with the Permian magmatic rocks in the Changchun-Kaiyuan area displaying arc rocks affinity, propose their formation is related to the southward subduction of the Paleo-Asian Ocean (PAO). Based on this study and previous evidence, we lean towards adopting a middle-late Permian slab break-off model, wherein the PAO did not close until the late Permian.
Halloysite nanotubes (HNTs) have attracted much attention as delivery carriers for various drugs, but the loading of one such drug, quercetin, on HNTs has been investigated only rarely and usually involved cyclic vacuum pumping. The main objective of the present study was to develop a novel carrier system based on HNTs for quercetin delivery without a vacuum process and to investigate the effect of chemical modification of HNTs on the loading and release of quercetin. For this purpose, comparative studies of five chemical modification reagents (sodium lauroamphoacetate, cocoamidopropyl betaine, 1-hydroxyethyl 2-nonyl imidazoline betaine, triethanolamine, and dipicolinic acid) functionalized on HNTs were investigated for quercetin loading and in vitro release. Characterization of raw halloysite, modified halloysite, and quercetin-loaded halloysite were done by X-ray diffraction (XRD), Fourier-transform infrared spectrometry (FTIR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The results indicated that chemical modification could improve the interactions between HNTs and quercetin. After chemical modification, quercetin was anchored to both the inner and outer surfaces of HNTs by electrostatic attraction, hydrogen bonding, and van der Waals forces. Sodium lauroamphoacetate-modified HNTs were given the highest loading of 1.96 wt.% among the five reagents. Cocamidopropyl betaine-modified HNTs exhibited the best sustained-release profile with only 29.07% for initial burst release and 480 h of consecutive release. Carboxyl groups of the modification reagent improved the loading capacity of quercetin. Amide groups prolonged drug release due to the strong affinity between amine and phenolic hydroxyl groups of quercetin. The release of quercetin from the cocamidopropyl betaine-modified HNTs fitted a first-order kinetics model well. The present study suggested that cocamidopropyl betaine-modified HNTs offer promise as vehicles for delivery of quercetin and for extending the application of quercetin.
In order to establish a compact all-optical Thomson scattering source, experimental studies were conducted on the 45 TW Ti: sapphire laser facility. By including a steel wafer, mixed gas, and plasma mirror into a double-exit jet, several mechanisms, such as shock-assisted ionization injection, ionization injection, and driving laser reflection, were integrated into one source. So, the source of complexity was remarkably reduced. Electron bunches with central energy fluctuating from 90 to 160 MeV can be produced. Plasma mirrors were used to reflect the driving laser. The scattering of the reflected laser on the electron bunches led to the generation of X-ray photons. Through comparing the X-ray spots under different experimental conditions, it is confirmed that the X-ray photons are generated by Thomson scattering. For further application, the energy spectra and source size of the Thomson scattering source were measured. The unfolded spectrum contains a large amount of low-energy photons besides a peak near 67 keV. Through importing the electron energy spectrum into the Monte Carlo simulation code, the different contributions of the photons with small and large emitting angles can be used to explain the origin of the unfolded spectrum. The maximum photon energy extended to about 500 keV. The total photon production was 107/pulse. The FWHM source size was about 12 μm.
The velocity interferometer system for any reflector (VISAR) coupled with a streaked optical pyrometer (SOP) system is used as a diagnostic tool in inertial confinement fusion (ICF) experiments involving equations of state and shock timing. To validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition (DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.
Social anxiety disorder is a psychological disorder that refers to excessive nervousness, fear, and fear of being judged or shamed by others in social situations. Although traditional psychotherapy methods are effective, their effectiveness is not good. Intangible cultural heritage elements cultural design uses traditional cultural elements to create unique products and experiences, which can provide a bridge for patients to communicate with others.
Subjects and Methods
100 patients with social anxiety disorder were randomly assigned to the experimental and control groups. The experimental group received the intangible cultural design intervention, while the control group received conventional psychotherapy. The mental health status of the subjects was assessed by Stanford Acute Stress Response Questionnaire (SASRQ) and 3-Minute Delirium Diagnosis Scale (3D-CAM) scale scores before and after the intervention.
Results
The results showed that the social anxiety of the experimental group was significantly reduced and the mental health status was significantly improved after the intervention, while the intervention effect of the control group was relatively limited. It shows that intangible cultural and creative design has a positive impact on the mental health of patients with social anxiety disorder.
Conclusions
Through the cultural and creative design of intangible cultural heritage elements, patients can reduce anxiety by creating and appreciating works. At the same time, patients can understand and experience traditional culture to enhance their cultural identity and self-esteem. In addition, patients can share work and exchange creative experiences with others to improve social skills. This method provides a new approach to the psychological treatment of patients with social anxiety disorder.
We present a theoretical asymptotic solution for high-speed transient flow through microporous media in this work by addressing the inertia effect in the high-pressure-difference pulse-decay process. The capillaric model is adopted, in which a bundle of straight circular tubes with a high length–radius ratio is used to represent the internal flow paths of microporous media so that the flow is described by a simplified incompressible Navier–Stokes equation based on the mean density, capturing the major characteristics of mass flow rate. By order-of-magnitude analysis and asymptotic perturbation, the inertial solution with its dimensionless criterion for the high-pressure-difference pulse-decay process is derived. To be compared with experimental data, the theoretical solution involves all three related effects, including the inertia effect, the slippage effect and the compressibility effect. A self-built experimental platform is therefore established to measure the permeability of microporous media by both pulse-decay and steady-state methods to validate the theoretical solution. The results indicate that the relative difference between two methods is less than 30 % even for permeability at as low as $48.2$ nD $(10^{-21}\,{\rm m}^2)$, and the present theoretical solution can accurately capture the inertia effect in the high-pressure-difference pulse-decay process, which significantly accelerates the measurements for ultra-low-permeability samples.
As the southernmost part of the central segment of the Central Asian Orogenic Belt, the northern Alxa area is characterized by abundant Permian magmatism and records key information on the geological evolution of the Palaeo-Asian Ocean. This study reports new zircon U–Pb and Lu–Hf isotopic and whole-rock geochemical data of the early Permian (285–286 Ma) Huisentala gabbro and Huodonghaer diorites from the Zhusileng–Hangwula Belt in the northern Alxa area. The gabbro is characterized by high Al, Ca, Mg# and light rare-earth elements, and low K, P and high field strength elements (e.g., Ti, Nb and Ta). Furthermore, the gabbro shows heterogeneous zircon ϵHf(t) value (−2.5 to +2.6). The Huodonghaer diorites show high MgO (3.46–6.32 wt%), Mg# (49–58), Sr (408–617 ppm) and Ba (223–419 ppm), and low FeOT/MgO (1.27–1.83) and TiO2 (0.48–0.90 wt%), with geochemical features similar to the high-Mg andesite/diorite. They show radiogenic zircon ϵHf(t) values of +1.2 to +4.9 and high Th/Nb ratios. These features suggest that the Huisentala gabbro and the Huodonghaer diorites were derived from the partial melting of mantle peridotite that was metasomatized by subduction-related fluids and by subducted sediment-derived melts, respectively.
The selection of an analogical source is a critical step in the design-by-analogy process. Previous researchers have explored the reasons and preferences of individual designers or design teams in selecting analogical sources. Non-designers, who instead have more knowledge of other fields, may offer new possibilities for retrieving novel analogical sources. This study focuses on differences in the selection of analogical sources between collaborative design teams composed of designers and nondesigners. There are indeed significant differences in the selection of the source type, the reasons for selecting the source, the level of abstraction in inspiration stimuli, and the novelty of design ideas between designers and non-designers. This work may provide theoretical guidance for the development of collaborative design tools and methods for teams composed of designers and non-designers with different knowledge bases.