This study employs direct numerical simulations to investigate the influence of a vibrating wall panel on the oblique shock wave/turbulent boundary layer interaction flows at incoming free-stream Mach number 2.9. We examine two distinct low-frequency vibration modes, defined by their streamwise deformation patterns: a full-panel (symmetric) mode and a half-panel (antisymmetric) mode. By analysing phase-average flow quantities, we demonstrate that the antisymmetric mode primarily forces a streamwise oscillation of the separation bubble, whereas the symmetric mode amplifies its inherent expansion–contraction (‘breathing’) motion. Both panel vibrating modes enhance quasi-periodic shock oscillation and modulate the plateau in the mean wall pressure distributions. Spectral analysis confirms that low-frequency pressure fluctuations are amplified not only at the mean separation point but also in the mid-region of the panel. Through correlation analysis and dynamic mode decomposition, we establish that these vibrations lead to strong spatiotemporal coherence, associating upstream fluctuations near the separation to downstream propagation. Critically, a comparative analysis reveals that the symmetric mode facilitates significantly longer downstream propagation of pressure disturbances than the antisymmetric mode. This highlights how the spatial pattern of panel deformation, not just the vibration frequency, modulates the unsteady flow characteristics.

In hypersonic boundary-layer flows over blunt bodies, laminar–turbulent transition exhibits two distinct regimes: for small nose radii, increased bluntness delays transition; beyond a critical radius, further increasing bluntness reverses this trend. The latter regime corresponds to a bypass transition route, whose onset remains challenging to predict. The primary difficulty lies in capturing the excitation of non-modal streaks in the nose region, which is strongly affected by the bow shock and entropy layer effects. Recently, Zhao & Dong (J. Fluid Mech., 2025, vol. 1013, A44) developed a high-efficiency, high-accuracy shock-fitting harmonic linearised Navier–Stokes (SF-HLNS) approach to quantify the excitation of linear non-modal perturbations. In this paper, we present a predictive framework for bypass transition by integrating the SF-HLNS approach with the nonlinear parabolised stability equations (NPSE) and the bi-global stability analysis (BSA). The NPSE are employed to track the nonlinear evolution of the streaky perturbations up to nonlinear saturation, while the BSA approach is used to capture the high-growth secondary instabilities. By integrating the growth rates of these secondary instabilities from their neutral positions, an amplitude amplification factor is obtained, enabling the prediction of transition onset. Under slow acoustic forcing conditions drawn from wind-tunnel experiments, the present hybrid framework successfully reproduces the transition reversal phenomenon at large nose radii, and yields quantitative agreement with measured transition locations, thereby validating its predictive capability.

Interoception refers to the ability to perceive and integrate physiological signals originating from within the body, such as heartbeat and respiration. This process involves both bottom-up and top-down. As a key neurophysiological marker of interoception, the heartbeat-evoked potential (HEP) reflects the cortical processing of cardiac signals in the brain. In this review, we first outline the neural mechanisms underlying interoception and HEP, followed by a comprehensive overview of the methodologies commonly employed in HEP research. Based on the directionality of interoceptive information flow, we categorize HEP-related experimental designs into three types: bottom-up bodily sensory input, top-down predictive perception, and top-down regulation. Additionally, we explore the clinical relevance of HEP in areas such as psychiatric disorders and cardiac-related conditions. Finally, we recommend expanding research on top-down predictive perception and top-down regulation in clinical contexts.

Isoproturon is widely used to control Italian ryegrass [Lolium perenne L. ssp. multiflorum (Lam.) Husnot] in wheat (Triticum aestivum L.) fields across China. Here, we identified a highly resistant population (HR) from 87 populations collected from wheat fields; it showed 4.6-fold resistance to isoproturon compared with a susceptible control (HS). DNA sequencing of the full-length psbA gene revealed no sequence differences between HR and HS plants. However, psbA expression in the HR population was significantly higher than in the HS population, both before and after isoproturon application. Transgenic assays confirmed that psbA gene overexpression in rice (Oryza sativa L.) plants confers resistance to photosystem II (PSII) inhibitors, including isoproturon. Under isoproturon application, the HR population also demonstrated elevated antioxidant enzyme activities and maintained higher chlorophyll and carotenoid levels. Furthermore, the HR population remained susceptible to pyroxsulam and pinoxaden, suggesting that these herbicides are practical alternatives for control. These findings indicate that psbA gene overexpression contributes to isoproturon resistance in L. perenne ssp. multiflorum, likely through the overproduction of the D1 protein to mitigate herbicide-induced PSII dysfunction. Our study provides the first confirmation and mechanistic explanation of isoproturon resistance in L. perenne ssp. multiflorum, revealing psbA gene overexpression as the key driver.

The recent discovery of polymer diffusive instability (PDI) by Beneitez et al. (2023 Phys. Rev. Fluids 8, L101901), poses challenges in implementing artificial conformation diffusion (ACD) in transition simulations of viscoelastic wall-shear flows. In this paper, we demonstrate that the unstable PDI is primarily induced by the conformation boundary conditions additionally introduced in the ACD equation system, which could be eliminated if a new set of conformation conditions is adopted. To address this issue, we begin with an asymptotic analysis of the PDI within the near-wall thin diffusive layer, which simplifies the complexity of the instability system by reducing the number of the controlling parameters from five to zero. Then, based on this simplified model, we construct a stable asymptotic solution that minimises the perturbations in the wall sublayer. From the near-wall behaviour of this solution, we derive a new set of conformation boundary conditions, prescribing a Neumann-type condition for its streamwise stretching component, $c_{11}$, and Dirichlet-type conditions for all the other conformation components. These boundary conditions are subsequently validated within the original ACD instability system, incorporating both the Oldroyd-B and the finitely extensible nonlinear elastic Peterlin constitutive models. Finally, we perform direct numerical simulations based on the traditional and the new conformation conditions, demonstrating the effectiveness of the latter in eliminating the unstable PDI. Importantly, this improvement does not affect the calculations of other types of instabilities. Therefore, this work offers a promising approach for achieving reliable polymer-flow simulations with ACD, ensuring both numerical stability and accuracy.

This paper focuses on the concept of delaying laminar–turbulent transition in hypersonic boundary layers by stabilising fundamental resonance (FR), a key nonlinear mechanism in which finite-amplitude Mack modes support the rapid growth of oblique perturbations. As a pioneering demonstration of this control strategy, we introduce surface heating applied exclusively during the nonlinear phase. Unlike traditional control methods that target the linear phase, the suppressive effect of surface heating on secondary instability modes during FR is evident across various Reynolds numbers, wall temperatures and fundamental frequencies, as confirmed by direct numerical simulations (DNS) and secondary instability analyses (SIA). To gain deeper insights into this control concept, an asymptotic analysis is conducted, revealing an almost linear relationship between the suppression effect and the heating intensity. The asymptotic predictions align overall with the DNS and SIA calculations. The asymptotic theory reveals that the suppression effect of FR is primarily influenced by modifications to the fundamental-mode profile, while mean-flow distortion has a comparatively modest yet opposing impact on this process. This research presents a promising approach to controlling transition considering the nonlinear evolution of boundary-layer perturbations, demonstrating advantages over conventional methods that are sensitive to frequency variations.

Milk fat is a crucial component for evaluating the production performance and nutritional value of goat milk. Previous research indicated that the composition of ruminal microbiota plays a significant role in regulating milk fat percentage in ruminants. Thus, this study aimed to identify key ruminal microorganisms and blood metabolites relevant to milk fat synthesis in dairy goats as a mean to explore their role in regulating milk fat synthesis. Sixty clinically healthy Xinong Saanen dairy goats at mid-lactation and of similar body weight, and similar milk yield were used in a feeding study for 15 days. Based on daily milk yield of dairy goats and the results of milk component determination on the 1st and 8th days, five goats with the highest milk fat content (H group) and five goats with the lowest milk fat content (L group) were selected for further analysis. Before the morning feeding on the 15th day of the experiment, samples of milk, blood and ruminal fluid were collected for analyses of components, volatile fatty acids, microbiota and metabolites. Results revealed that acetate content in the rumen of H group was greater compared with L group. H group had abundant beneficial bacteria including Ruminococcaceae_UCG-005, Saccharofermentans, Ruminococcaceae-UCG-002 and Prevotellaceae_UCG-3, which were important for plant cellulose and hemicellulose degradation and immune regulation. Metabolomics analysis revealed H group had greater relative concentrations of 4-acetamidobutanoic acid and azelaic acid in serum, and had lower relative concentrations of Arginyl-Alanine, SM(d18:1/12:0) and DL-Tryptophan. These altered metabolites are involved in the sphingolipid signaling pathway, arginine and proline metabolism. Overall, this study identified key ruminal microorganisms and serum metabolites associated with milk fat synthesis in dairy goats. These findings offer insights for enhancing the quality of goat milk and contribute to a better understanding of the regulatory mechanisms involved in milk fat synthesis in dairy goats.

In this paper, we study the receptivity of non-modal perturbations in hypersonic boundary layers over a blunt wedge subject to free stream vortical, entropy and acoustic perturbations. Due to the absence of the Mack-mode instability and the rather weak growth of the entropy-layer instability within the domain under consideration, the non-modal perturbation is considered as the dominant factor triggering laminar–turbulent transition. This is a highly intricate problem, given the complexities arising from the presence of the bow shock, the entropy layer and their interactions with oncoming disturbances. To tackle this challenge, we develop a highly efficient numerical tool, the shock-fitting harmonic linearised Navier–Stokes (SF-HLNS) approach, which offers a comprehensive investigation on the dependence of the receptivity efficiency on the nose bluntness and properties of the free stream forcing. The numerical findings suggest that the non-modal perturbations are more susceptible to free stream acoustic and entropy perturbations compared with the vortical perturbations, with the optimal spanwise length scale being comparable with the downstream boundary-layer thickness. Notably, as the nose bluntness increases, the receptivity to the acoustic and entropy perturbations intensifies, reflecting the transition reversal phenomenon observed experimentally in configurations with relatively large bluntness. In contrast, the receptivity to free stream vortical perturbations weakens with increasing bluntness. Additionally, through the SF-HLNS calculations, we examine the credibility of the optimal growth theory (OGT) on describing the evolution of non-modal perturbations. While the OGT is able to predict the overall streaky structure in the downstream region, its accuracy in predicting the early-stage evolution and the energy amplification proves to be unreliable. Given its high-efficiency and high-accuracy nature, the SF-HLNS approach shows great potential as a valuable tool for conducting future research on hypersonic blunt-body boundary-layer transition.

We investigate the linear instability of flows that are stable according to Rayleigh’s criterion for rotating fluids. Using Taylor–Couette flow as a primary test case, we develop large-Reynolds-number-matched asymptotic expansion theories. Our theoretical results not only aid in detecting instabilities previously reported by Deguchi (Phys. Rev. E, vol 95, 2017, p. 021102(R)) across a wide parameter range, but also clarify the physical mechanisms behind this counterintuitive phenomenon. Instability arises from the interaction between large-scale inviscid vortices and the viscous flow structure near the wall, which is analogous to Tollmien–Schlichting waves. Furthermore, our asymptotic theories and numerical computations reveal that similar instability mechanisms occur in boundary layer flows over convex walls.

Investigations are conducted on the effect of wall proximity on the flow around a cylinder under an axial magnetic field, using the electrical potential probe technology to measure the velocity of liquid metal flow. The study focused on the impact of the inlet velocity of the fluid, the magnetic field and wall proximity on the characteristics of velocity fields, particularly on the vortex-shedding mode. Based on different magnitudes of the magnetic field and the distance from the cylinder to the duct wall, three types of vortex-shedding modes are identified, (I) shear layer oscillation state, (II) quasi-two-dimensional vortex-shedding states and (III) transition of the magnetohydrodynamic to hydrodynamic Kármán street. The transitions between these modes are analysed in detail. The experimental results show that the weak wall-proximity effect leads to the formation of the Kármán vortex street, while a reverse Kármán vortex street and secondary vortices emerge under a strong wall-proximity effect. It is noticed that the Kelvin–Helmholtz instability drives vortex shedding under regime I, leading to an increase in the Strouhal number (St) with stronger magnetic fields. Additionally, under a strong axial magnetic field, the wall-proximity effect (‘Shercliff layer effect’) promotes the instability of shear layers on both sides of the cylinder. These unique coupling effects are validated by variations in modal coefficients and energy proportions under different vortex-shedding regimes using the proper orthogonal decomposition method.

In this paper, we study the effect of lateral wall vibrations on the excitation and evolution of non-modal perturbations in hypersonic boundary layers subject to low-frequency freestream vortical disturbances (FSVDs). A novel, high-efficiency numerical approach, combining the harmonic weakly nonlinear Navier–Stokes and nonlinear parabolised stability equation approaches, is developed, which is sufficient to accommodate both the rapid distortion of the perturbation in the leading-edge vicinity and the nonlinear development of finite-amplitude high-order harmonics in the downstream region. The boundary-layer response to low-frequency FSVDs shows a longitudinal streaky structure, for which the temperature perturbation shows much greater magnitude than the streamwise velocity perturbation. The lateral vibration induces a Stokes layer solution for the spanwise velocity perturbation, which interacts with the FSVD-induced perturbations and leads to a suppression of the non-modal perturbation and an enhancement of the downstream modal perturbation. The new perturbations excited by the FSVD–vibration interaction strengthen as the vibration intensifies, and they could become comparable with the FSVD-induced perturbations in downstream locations at a high vibration intensity, indicating a remarkable modification of the streaky structure and its instability property. Secondary instability (SI) analyses based on the streaky base flow indicate that the vibration could enhance or suppress the SI modes, depending on their initial phases over the vibration period. Overall, the average effect is that the low-frequency and high-frequency SI modes are stabilised and destabilised by the vibration, respectively. Since the high-frequency SI modes undergo higher amplifications, the subsequent bypass transition is likely to be promoted by relatively strong vibrations.

Artificial sweeteners are generally used and recommended to alternate added sugar for health promotion. However, the health effects of artificial sweeteners remain unclear. In this study, we included 6371 participants from the National Health and Nutrition Examination Survey with artificial sweetener intake records. Logistic regression and Cox regression were applied to explore the associations between artificial sweeteners and risks of cardiometabolic disorders and mortality. Mendelian randomisation was performed to verify the causal associations. We observed that participants with higher consumption of artificial sweeteners were more likely to be female and older and have above medium socio-economic status. After multivariable adjustment, frequent consumers presented the OR (95 % CI) for hypertension (1·52 (1·29, 1·80)), hypercholesterolaemia (1·28 (1·10, 1·50)), diabetes (3·74 (3·06, 4·57)), obesity (1·52 (1·29, 1·80)), congestive heart failure (1·89 (1·35, 2·62)) and heart attack (1·51 (1·10, 2·04)). Mendelian randomisation confirmed the increased risks of hypertension and type 2 diabetes. Moreover, an increased risk of diabetic mortality was identified in participants who had artificial sweeteners ≥ 1 daily (HR = 2·62 (1·46, 4·69), P = 0·001). Higher consumption of artificial sweeteners is associated with increased risks of cardiometabolic disorders and diabetic mortality. These results suggest that using artificial sweeteners as sugar substitutes may not be beneficial.

In the present study, we performed direct numerical simulations for a hypersonic turbulent boundary layer over the windward side of a lifting body, the HyTRV model, at Mach number $6$ and attack angle 2$^{\circ }$ to investigate the global and local turbulent features, and evaluate its difference from canonical turbulent boundary layers. By scrutinizing the instantaneous and averaged flow fields, we found that the transverse curvature on the windward side of the HyTRV model induces the transverse opposing pressure gradients that push the flow on both sides towards the windward symmetry plane, yielding significant effects of the azimuthal inhomogeneity and large-scale cross-stream circulations, moderate and azimuthal independent influences of adverse pressure gradient, and negligible impact of the mean flow three-dimensionality. Further inspecting the local turbulent statistics, we identified that the mean and fluctuating velocity become increasingly similar to the highly decelerated turbulent boundary layers over flat plates in that the mean velocity deficit is enhanced, and the outer layer Reynolds stresses are amplified as it approaches the windward symmetry plane, and prove to be self-similar under the scaling of Wei & Knopp (J. Fluid Mech., vol. 958, 2023, A9) for adverse-pressure-gradient turbulent boundary layers. Conditionally averaged Reynolds stresses based on strong sweeping and ejection events demonstrated that the Kelvin–Helmholtz instability of the strong embedded shear layer induced by the large-scale cross-stream circulations is responsible for the turbulence amplification in the outer layer. The strong Reynolds analogy that relates the mean velocity and temperature was refined to incorporate the non-canonical effects, showing considerable improvements in the accuracy of such a formula. On the other hand, the temperature fluctuations are still transported passively, as indicated by their resemblance to the velocity. The conclusions obtained in the present study provide potentially profitable information for turbulent modelling modification for the accurate predictions of skin friction and wall heat transfer.

Dilatational motions in the shape of travelling wave packets have been identified recently to be dynamically significant in hypersonic turbulent boundary layers. The present study investigates the mechanisms of their generation and their association with the solenoidal motions, especially the well-recognized near-wall self-sustaining process of the regeneration cycle between the velocity streaks and quasi-streamwise vortices. By exploiting the direct numerical simulation databases and orchestrating numerical experiments, we explore systematically the near-wall flow dynamics in the processes of the formation and transient growth of low-speed streaks. We conclude via theoretical ansatz that the nonlinearity related to the parallel density and pressure gradients close to the wall due to the restriction of the isothermal boundary condition is the primary cause of the generation of the dilatational structures at small scales. In fully developed turbulence, the formation and the existence of healthy dilatational travelling wave packets require the participation of the turbulence at scales larger than those of the near-wall regeneration cycles, especially the occurrence of the bursting events that generate vortex clusters. This is proven by the less intensified dilatational motions in the numerical experiments in which the Orr mechanism is alleviated and the vortical structures and turbulent bursts are weakened.

Aiming at the problems of small good workspace, many singular configurations, and limited carrying capacity of non-redundant parallel mechanisms, a full-redundant drive parallel mechanism is designed and developed, and its performance evaluation, good workspace identification, and scale optimization design are studied. First, the kinematics analysis of the planar 6R parallel mechanism is completed. Then, the motion/force transmission performance evaluation index of the mechanism is established, and the singularity analysis of the mechanism is completed. Based on this, the fully redundant driving mode of the mechanism is determined, and the good transmission workspace of the mechanism in this mode is identified. Then, the mapping relationship between the performance and scale of the mechanism is established by using the space model theory, and the scale optimization of the mechanism is completed. Finally, the robot prototype is made according to the optimal scale, and the performance verification is carried out based on the research of dynamics and control strategy. The results show that the fully redundant actuation parallel mechanism obtained by design optimization has high precision and large bearing capacity. The position repeatability and position accuracy are 0.053 mm and 0.635 mm, respectively, and the load weight ratio can reach 15.83%. The research results of this paper complement and improve the performance evaluation and scale optimization system of redundantly actuated parallel mechanisms.

Very-large-scale motions are commonly observed in moderate- and high-Reynolds-number wall turbulence, constituting a considerable portion of the Reynolds stress and skin friction. This study aims to investigate the behaviour of these motions in high-speed and high-Reynolds-number turbulent boundary layers at varying Mach numbers. With the aid of high-precision numerical simulations, numerical experiments and theoretical analysis, it is demonstrated that the very-large-scale motions are weakened in high-Mach-number turbulence at the same friction Reynolds numbers, leading to the reduction in turbulent kinetic energy in the outer region. Conversely, the lower wall temperature enhances the very-large-scale motions but shortens the scale separation between the structures in the near-wall and outer regions.

The fundamental resonance (FR) in the nonlinear phase of the boundary-layer transition to turbulence appears when a dominant planar instability mode reaches a finite amplitude and the low-amplitude oblique travelling modes with the same frequency as the dominant mode, together with the stationary streak modes, undergo the strongest amplification among all the Fourier components. This regime may be the most efficient means to trigger the natural transition in hypersonic boundary layers. In this paper, we aim to reveal the intrinsic mechanism of the FR in the weakly nonlinear framework based on the large-Reynolds-number asymptotic technique. It is found that the FR is, in principle, a triad resonance among a dominant planar fundamental mode, a streak mode and an oblique mode. In the major part of the boundary layer, the nonlinear interaction of the fundamental mode and the streak mode seeds the growth of the oblique mode, whereas the interaction of the oblique mode and the fundamental mode drives the roll components (transverse and lateral velocity) of the streak mode, which leads to a stronger amplification of the streamwise component of the streak mode due to the lift-up mechanism. This asymptotic analysis clearly shows that the dimensionless growth rates of the streak and oblique modes are the same order of magnitude as the dimensionless amplitude of the fundamental mode $(\bar {\epsilon }_{10})$, and the amplitude of the streak mode is $O(\bar {\epsilon }_{10}^{-1})$ greater than that of the oblique mode. The main-layer solution of the streamwise velocity, spanwise velocity and temperature of both the streak and the oblique modes become singular as the wall is approached, and so a viscous wall layer appears underneath. The wall layer produces an outflux velocity to the main-layer solution, inclusion of which leads to an improved asymptotic theory whose accuracy is confirmed by comparing with the calculations of the nonlinear parabolised stability equations (NPSEs) at moderate Reynolds numbers and the secondary instability analysis (SIA) at sufficiently high Reynolds numbers.

Childhood maltreatment is an established risk factor for psychopathology. However, it remains unclear how childhood traumatic events relate to mental health problems and how the brain is involved. This study examined the serial mediation effect of brain morphological alterations and emotion-/reward-related functions on linking the relationship from maltreatment to depression. We recruited 156 healthy adolescents and young adults and an additional sample of 31 adolescents with major depressive disorder for assessment of childhood maltreatment, depressive symptoms, cognitive reappraisal and anticipatory/consummatory pleasure. Structural MRI data were acquired to identify maltreatment-related cortical and subcortical morphological differences. The mediation models suggested that emotional maltreatment of abuse and neglect, was respectively associated with increased gray matter volume in the ventral striatum and greater thickness in the middle cingulate cortex. These structural alterations were further related to reduced anticipatory pleasure and disrupted cognitive reappraisal, which contributed to more severe depressive symptoms among healthy individuals. The above mediating effects were not replicated in our clinical group partly due to the small sample size. Preventative interventions can target emotional and reward systems to foster resilience and reduce the likelihood of future psychiatric disorders among individuals with a history of maltreatment.