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The effect of older age on outcomes of rTMS treatment for treatment-resistant depression
- Michael K. Leuchter, Cole Citrenbaum, Andrew C. Wilson, Tristan D. Tibbe, Nicholas J. Jackson, David E. Krantz, Scott A. Wilke, Juliana Corlier, Thomas B. Strouse, Gil D. Hoftman, Reza Tadayonnejad, Ralph J. Koek, Aaron R. Slan, Nathaniel D. Ginder, Margaret G. Distler, Hewa Artin, John H. Lee, Adesewa E. Adelekun, Evan H. Einstein, Hanadi A. Oughli, Andrew F. Leuchter
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- Journal:
- International Psychogeriatrics , First View
- Published online by Cambridge University Press:
- 25 March 2024, pp. 1-6
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Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16–100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%–57%/25%–33%; <60: 32%–49%/18%–25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.
Characteristics of healthcare personnel who reported concerns related to PPE use during care of COVID-19 patients
- Nora Chea, Stephanie Tavitian, Cedric Brown, Taniece Eure, Rebecca Alkis, Gregory Blazek, Austin Penna, Joelle Nadle, Linda Frank, Christopher Czaja, Helen Johnston, Devra Barter, Kathleen Angell, Kristen Marshall, James Meek, Monica Brackney, Stacy Carswell, Stepy Thomas, Scott Fridkin, Lucy Wilson, Ashley Fell, Sara Lovett, Sarah Lim, Ruth Lynfield, Ruth SarahShrum, Erin C. Phipps, Marla Sievers, Ghinwa Dumyati, Cate Concannon, Kathryn McCullough, Woods, Sandhya Seshadri, Christopher Myers, Rebecca Pierce, Valerie Ocampo, Judith Guzman-Cottrill, Gabriela Escutia, Monika Samper, Sandra Pena, Cullen Adre, Tiffanie Markus, Kathryn Billings, Matthew Groenewold, Ronda Sinkowitz-Cochran, Shelley Magill, Cheri Grigg, Betsy Miller
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- Journal:
- Antimicrobial Stewardship & Healthcare Epidemiology / Volume 2 / Issue S1 / July 2022
- Published online by Cambridge University Press:
- 16 May 2022, pp. s8-s9
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Background: Healthcare facilities have experienced many challenges during the COVID-19 pandemic, including limited personal protective equipment (PPE) supplies. Healthcare personnel (HCP) rely on PPE, vaccines, and other infection control measures to prevent SARS-CoV-2 infections. We describe PPE concerns reported by HCP who had close contact with COVID-19 patients in the workplace and tested positive for SARS-CoV-2. Method: The CDC collaborated with Emerging Infections Program (EIP) sites in 10 states to conduct surveillance for SARS-CoV-2 infections in HCP. EIP staff interviewed HCP with positive SARS-CoV-2 viral tests (ie, cases) to collect data on demographics, healthcare roles, exposures, PPE use, and concerns about their PPE use during COVID-19 patient care in the 14 days before the HCP’s SARS-CoV-2 positive test. PPE concerns were qualitatively coded as being related to supply (eg, low quality, shortages); use (eg, extended use, reuse, lack of fit test); or facility policy (eg, lack of guidance). We calculated and compared the percentages of cases reporting each concern type during the initial phase of the pandemic (April–May 2020), during the first US peak of daily COVID-19 cases (June–August 2020), and during the second US peak (September 2020–January 2021). We compared percentages using mid-P or Fisher exact tests (α = 0.05). Results: Among 1,998 HCP cases occurring during April 2020–January 2021 who had close contact with COVID-19 patients, 613 (30.7%) reported ≥1 PPE concern (Table 1). The percentage of cases reporting supply or use concerns was higher during the first peak period than the second peak period (supply concerns: 12.5% vs 7.5%; use concerns: 25.5% vs 18.2%; p Conclusions: Although lower percentages of HCP cases overall reported PPE concerns after the first US peak, our results highlight the importance of developing capacity to produce and distribute PPE during times of increased demand. The difference we observed among selected groups of cases may indicate that PPE access and use were more challenging for some, such as nonphysicians and nursing home HCP. These findings underscore the need to ensure that PPE is accessible and used correctly by HCP for whom use is recommended.
Funding: None
Disclosures: None
Repetitive transcranial magnetic stimulation treatment of major depressive disorder and comorbid chronic pain: response rates and neurophysiologic biomarkers
- Juliana Corlier, Reza Tadayonnejad, Andrew C Wilson, Jonathan C Lee, Katharine G Marder, Nathaniel D Ginder, Scott A Wilke, Jennifer Levitt, David Krantz, Andrew F Leuchter
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- Journal:
- Psychological Medicine / Volume 53 / Issue 3 / February 2023
- Published online by Cambridge University Press:
- 22 June 2021, pp. 823-832
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Background
Major depressive disorder (MDD) and chronic pain are highly comorbid, and pain symptoms are associated with a poorer response to antidepressant medication treatment. It is unclear whether comorbid pain also is associated with a poorer response to treatment with repetitive transcranial magnetic stimulation (rTMS).
Methods162 MDD subjects received 30 sessions of 10 Hz rTMS treatment administered to the left dorsolateral prefrontal cortex (DLPFC) with depression and pain symptoms measured before and after treatment. For a subset of 96 patients, a resting-state electroencephalogram (EEG) was recorded at baseline. Clinical outcome was compared between subjects with and without comorbid pain, and the relationships among outcome, pain severity, individual peak alpha frequency (PAF), and PAF phase-coherence in the EEG were examined.
Results64.8% of all subjects reported pain, and both depressive and pain symptoms were significantly reduced after rTMS treatment, irrespective of age or gender. Patients with severe pain were 27% less likely to respond to MDD treatment than pain-free individuals. PAF was positively associated with pain severity. PAF phase-coherence in the somatosensory and default mode networks was significantly lower for MDD subjects with pain who failed to respond to MDD treatment.
ConclusionsPain symptoms improved after rTMS to left DLPFC in MDD irrespective of age or gender, although the presence of chronic pain symptoms reduced the likelihood of treatment response. Individual PAF and baseline phase-coherence in the sensorimotor and midline regions may represent predictors of rTMS treatment outcome in comorbid pain and MDD.
A simulation study to evaluate contamination during reuse of N95 respirators and effectiveness of interventions to reduce contamination
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- Daniel F. Li, Heba Alhmidi, Jacob G. Scott, Ian C. Charnas, Basya Pearlmutter, Sandra Y. Silva, Brigid M. Wilson, Curtis J. Donskey
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 43 / Issue 6 / June 2022
- Published online by Cambridge University Press:
- 10 May 2021, pp. 764-769
- Print publication:
- June 2022
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Objective:
To assess the potential for contamination of personnel, patients, and the environment during use of contaminated N95 respirators and to compare the effectiveness of interventions to reduce contamination.
Design:Simulation study of patient care interactions using N95 respirators contaminated with a higher and lower inocula of the benign virus bacteriophage MS2.
Methods:In total, 12 healthcare personnel performed 3 standardized examinations of mannequins including (1) control with suboptimal respirator handling technique, (2) improved technique with glove change after each N95 contact, and (3) control with 1-minute ultraviolet-C light (UV-C) treatment prior to donning. The order of the examinations was randomized within each subject. The frequencies of contamination were compared among groups. Observations and simulations with fluorescent lotion were used to assess routes of transfer leading to contamination.
Results:With suboptimal respirator handling technique, bacteriophage MS2 was frequently transferred to the participants, mannequin, and environmental surfaces and fomites. Improved technique resulted in significantly reduced transfer of MS2 in the higher inoculum simulations (P < .01), whereas UV-C treatment reduced transfer in both the higher- and lower-inoculum simulations (P < .01). Observations and simulations with fluorescent lotion demonstrated multiple potential routes of transfer to participants, mannequin, and surfaces, including both direct contact with the contaminated respirator and indirect contact via contaminated gloves.
Conclusion:Reuse of contaminated N95 respirators can result in contamination of personnel and the environment even when correct technique is used. Decontamination technologies, such as UV-C, could reduce the risk for transmission.
Impact of a Central-Line Insertion Site Assessment (CLISA) score on localized insertion site infection to prevent central-line–associated bloodstream infection (CLABSI)
- Shruti K. Gohil, Jennifer Yim, Kathleen Quan, Maurice Espinoza, Deborah J. Thompson, Allen P. Kong, Bardia Bahadori, Tom Tjoa, Chris Paiji, Scott Rudkin, Syma Rashid, Suzie S. Hong, Linda Dickey, Mohamad N. Alsharif, William C. Wilson, Alpesh N. Amin, Justin Chang, Usme Khusbu, Susan S. Huang
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 41 / Issue 1 / January 2020
- Published online by Cambridge University Press:
- 08 November 2019, pp. 59-66
- Print publication:
- January 2020
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Objective:
To assess the impact of a newly developed Central-Line Insertion Site Assessment (CLISA) score on the incidence of local inflammation or infection for CLABSI prevention.
Design:A pre- and postintervention, quasi-experimental quality improvement study.
Setting and participants:Adult inpatients with central venous catheters (CVCs) hospitalized in an intensive care unit or oncology ward at a large academic medical center.
Methods:We evaluated CLISA score impact on insertion site inflammation and infection (CLISA score of 2 or 3) incidence in the baseline period (June 2014–January 2015) and the intervention period (April 2015–October 2017) using interrupted times series and generalized linear mixed-effects multivariable analyses. These were run separately for days-to-line removal from identification of a CLISA score of 2 or 3. CLISA score interrater reliability and photo quiz results were evaluated.
Results:Among 6,957 CVCs assessed 40,846 times, percentage of lines with CLISA score of 2 or 3 in the baseline and intervention periods decreased by 78.2% (from 22.0% to 4.7%), with a significant immediate decrease in the time-series analysis (P < .001). According to the multivariable regression, the intervention was associated with lower percentage of lines with a CLISA score of 2 or 3, after adjusting for age, gender, CVC body location, and hospital unit (odds ratio, 0.15; 95% confidence interval, 0.06–0.34; P < .001). According to the multivariate regression, days to removal of lines with CLISA score of 2 or 3 was 3.19 days faster after the intervention (P < .001). Also, line dwell time decreased 37.1% from a mean of 14 days (standard deviation [SD], 10.6) to 8.8 days (SD, 9.0) (P < .001). Device utilization ratios decreased 9% from 0.64 (SD, 0.08) to 0.58 (SD, 0.06) (P = .039).
Conclusions:The CLISA score creates a common language for assessing line infection risk and successfully promotes high compliance with best practices in timely line removal.
Glycaemic regulation, appetite and ex vivo oxidative stress in young adults following consumption of high-carbohydrate cereal bars fortified with polyphenol-rich berries
- Tracey J. Smith, James Philip Karl, Marques A. Wilson, Claire C. Whitney, Ann Barrett, Nicole Favreau Farhadi, Chung-Yen Oliver Chen, Scott J. Montain
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- Journal:
- British Journal of Nutrition / Volume 121 / Issue 9 / 14 May 2019
- Published online by Cambridge University Press:
- 07 May 2019, pp. 1026-1038
- Print publication:
- 14 May 2019
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Consumption of certain berries appears to slow postprandial glucose absorption, attributable to polyphenols, which may benefit exercise and cognition, reduce appetite and/or oxidative stress. This randomised, crossover, placebo-controlled study determined whether polyphenol-rich fruits added to carbohydrate-based foods produce a dose-dependent moderation of postprandial glycaemic, glucoregulatory hormone, appetite and ex vivo oxidative stress responses. Twenty participants (eighteen males/two females; 24 (sd 5) years; BMI: 27 (sd 3) kg/m2) consumed one of five cereal bars (approximately 88 % carbohydrate) containing no fruit ingredients (reference), freeze-dried black raspberries (10 or 20 % total weight; LOW-Rasp and HIGH-Rasp, respectively) and cranberry extract (0·5 or 1 % total weight; LOW-Cran and HIGH-Cran), on trials separated by ≥5 d. Postprandial peak/nadir from baseline (Δmax) and incremental postprandial AUC over 60 and 180 min for glucose and other biochemistries were measured to examine the dose-dependent effects. Glucose AUC0–180 min trended towards being higher (43 %) after HIGH-Rasp v. LOW-Rasp (P=0·06), with no glucose differences between the raspberry and reference bars. Relative to reference, HIGH-Rasp resulted in a 17 % lower Δmax insulin, 3 % lower C-peptide (AUC0–60 min and 3 % lower glucose-dependent insulinotropic polypeptide (AUC0–180 min) P<0·05. No treatment effects were observed for the cranberry bars regarding glucose and glucoregulatory hormones, nor were there any treatment effects for either berry type regarding ex vivo oxidation, appetite-mediating hormones or appetite. Fortification with freeze-dried black raspberries (approximately 25 g, containing 1·2 g of polyphenols) seems to slightly improve the glucoregulatory hormone and glycaemic responses to a high-carbohydrate food item in young adults but did not affect appetite or oxidative stress responses at doses or with methods studied herein.
Reductions in Clostridium difficile Infection (CDI) Rates Using Real-Time Automated Clinical Criteria Verification to Enforce Appropriate Testing
- Kathleen A. Quan, Jennifer Yim, Doug Merrill, Usme Khusbu, Keith Madey, Linda Dickey, Amish A. Dangodara, Scott E. Rudkin, Margaret O’Brien, Daniel Thompson, Nimisha Parekh, C. Gregory Albers, William C. Wilson, Lauri Thrupp, Cassiana E. Bittencourt, Susan S. Huang, Shruti K. Gohil
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 39 / Issue 5 / May 2018
- Published online by Cambridge University Press:
- 19 March 2018, pp. 625-627
- Print publication:
- May 2018
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The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis
- James G. Scott, David Gillis, Alex E. Ryan, Hethal Hargovan, Nagaraj Gundarpi, Gemma McKeon, Sean Hatherill, Martin P. Newman, Peter Parry, Kerri Prain, Sue Patterson, Richard C. W. Wong, Robert J. Wilson, Stefan Blum
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- BJPsych Open / Volume 4 / Issue 2 / March 2018
- Published online by Cambridge University Press:
- 16 March 2018, pp. 69-74
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Background
Antineuronal antibodies are associated with psychosis, although their clinical significance in first episode of psychosis (FEP) is undetermined.
AimsTo examine all patients admitted for treatment of FEP for antineuronal antibodies and describe clinical presentations and treatment outcomes in those who were antibody positive.
MethodIndividuals admitted for FEP to six mental health units in Queensland, Australia, were prospectively tested for serum antineuronal antibodies. Antibody-positive patients were referred for neurological and immunological assessment and therapy.
ResultsOf 113 consenting participants, six had antineuronal antibodies (anti-N-methyl-D-aspartate receptor antibodies [n = 4], voltage-gated potassium channel antibodies [n = 1] and antibodies against uncharacterised antigen [n = 1]). Five received immunotherapy, which prompted resolution of psychosis in four.
ConclusionsA small subgroup of patients admitted to hospital with FEP have antineuronal antibodies detectable in serum and are responsive to immunotherapy. Early diagnosis and treatment is critical to optimise recovery.
Declaration of interestNone.
Late Quaternary Ice-Surface Fluctuations of Beardmore Glacier, Transantarctic Mountains
- George H. Denton, James G. Bockheim, Scott C. Wilson, James E. Leide, Björn G. Andersen
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- Quaternary Research / Volume 31 / Issue 2 / March 1989
- Published online by Cambridge University Press:
- 20 January 2017, pp. 183-209
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Former longitudinal profiles of Beardmore Glacier, an outlet through the Transantarctic Mountains, constrain polar plateau elevations near the center of Antarctica and ice-shelf grouding in the southern Ross Embayment. Three gravel drift sheets of late Quaternary age occur alongside Beardmore Glacier. Plunket drift, the youngest, is parallel to and 7–30 m above the present ice surface. The upper limit of Beardmore drift, intermediate in age, is within 35–40 m of the present ice surface near the polar plateau but about 1100 m above the present ice surface near the glacier mouth. The upper limit of Meyer drift, the oldest, is parallel to and 30–50 m above Beardmore drift. From correlation with numerically dated drifts farther north, we assign an early Holocene age to Plunket drift, a late Wisconsin age to Beardmore drift, and an age of marine isotope Stage 6 to Meyer drift. By our age model, Beardmore Glacier was close to current elevations in its upper reaches and thickened considerably in its middle and lower reaches during the last two global glaciations represented by Beardmore and Meyer drifts. Most likely, grounded ice in the southern Ross Embayment caused such thickening of Beardmore Glacier almost to the polar plateau. A concomitant decline in precipitation is implied by ice-cap retreat on the nearby Dominion Range and is consistent with little change of upper Beardmore Glacier. Ice-shelf grounding most likely resulted from lowered sea level and/or basal melting. Lower than present precipitation was probably caused by colder air temperatures and more-distant open water. The Plunket profile records Holocene ice-surface lowering from increased surface ablation, decreased ice flow, or grounding-line recession.
Program Approaches to Control Herbicide-Resistant Barnyardgrass (Echinochloa crus-galli) in Midsouthern United States Rice
- Michael J. Wilson, Jason K. Norsworthy, Robert C. Scott, Edward E. Gbur
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- Weed Technology / Volume 28 / Issue 1 / March 2014
- Published online by Cambridge University Press:
- 20 January 2017, pp. 39-46
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The goal of this research was to develop herbicide programs for controlling acetolactate synthase (ALS)–, propanil-, quinclorac-, and clomazone-resistant barnyardgrass. Two applications of imazethapyr alone at 70 g ai ha−1 failed to control the ALS-resistant biotype more than 36%; however, when imazethapyr at 70 g ha−1 was applied early POST (EPOST) followed by imazethapyr at 70 g ha−1 plus fenoxaprop at 120 g ai ha−1 immediately prior to flooding (PREFLD), barnyardgrass control improved to 78% at 10 wk after planting. When imazethapyr was applied twice following PRE or delayed PRE applications of clomazone at 336 g ai ha−1, quinclorac at 560 g ai ha−1, pendimethalin at 1,120 g ai ha−1, or thiobencarb at 4,480 g ai ha−1 control was 92 to 100%. A single-pass program consisting of a delayed PRE application of clomazone at 336 g ha−1 plus quinclorac at 560 g ha−1 plus pendimethalin at 1,120 g ha−1 plus thiobencarb at 4,480 g ha−1 controlled all herbicide-resistant barnyardgrass biotypes at the same level as a standard multiple application program.
Late Wisconsin and Early Holocene Glacial History, Inner Ross Embayment, Antarctica
- George H. Denton, James G. Bockheim, Scott C. Wilson, Minze Stuiver
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- Quaternary Research / Volume 31 / Issue 2 / March 1989
- Published online by Cambridge University Press:
- 20 January 2017, pp. 151-182
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Lateral drift sheets of outlet glaciers that pass through the Transantarctic Mountains constrain past changes of the huge Ross ice drainage system of the Antarctic Ice Sheet. Drift stratigraphy suggests correlation of Reedy III (Reedy Glacier), Beardmore (Beardmore Glacier), Britannia (Hatherton/Darwin Glaciers), Ross Sea (McMurdo Sound), and “younger” (Terra Nova Bay) drifts; radiocarbon dates place the outer limits of Ross Sea drift in late Wisconsin time at 24,000–13,000 yr B.P. Outlet-glacier profiles from these drifts constrain late Wisconsin ice-sheet surface elevations. Within these constraints, we give two extreme late Wisconsin reconstructions of the Ross ice drainage system. Both show little elevation change of the polar plateau coincident with extensive ice-shelf grounding along the inner Ross Embayment. However, in the central Ross Embayment one reconstruction shows floating shelf ice, whereas the other shows a grounded ice sheet. Massive late Wisconsin/Holocene recession of grounded ice from the western Ross Embayment, which was underway at 13,040 yr B.P. and completed by 6600-6020 yr B.P., was accompanied by little change in plateau ice levels inland of the Transantarctic Mountains. Sea level and basal melting probably controlled the extent of grounded ice in the Ross Embayment. The interplay between the precipitation (low late Wisconsin and high Holocene values) and the influence of grounding on outlet glaciers (late Wisconsin thickening and late Wisconsin/Holocene thinning, with effects dying out inland) probably controlled minor elevation changes of the polar plateau.
Weed Management in a Furrow-Irrigated Imidazolinone-Resistant Hybrid Rice Production System
- Jason K. Norsworthy, Robert C. Scott, Sanjeev K. Bangarwa, Griff M. Griffith, Michael J. Wilson, Marilyn McCelland
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- Weed Technology / Volume 25 / Issue 1 / March 2011
- Published online by Cambridge University Press:
- 20 January 2017, pp. 25-29
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Research was conducted in 2007 and 2008 to evaluate weed-control options in an imazethapyr-resistant rice production system. Raised beds were formed, and imidazolinone-resistant hybrid rice ‘CL 730’ was drill-seeded on beds. Five herbicide programs applied up to the four- to six-leaf stage of rice were evaluated with and without additional “as-needed” herbicide at later stages. All the herbicide combinations and as-needed herbicides tested in this research were labeled for rice, and only minor transient injury (< 5%) was initially observed. Weeds emerged throughout the growing season, and as-needed herbicides were applied after the four- to six-leaf stage of rice to control these late-emerging weeds and weeds not effectively controlled with earlier applications, primarily Palmer amaranth. Most of the Palmer amaranth at this site was insensitive to imazethapyr (possibly acetolactate synthase resistant). Therefore, application of as-needed herbicides with different modes of action, such as 2,4-D, were used to improve Palmer amaranth control. Rice yields were often numerically higher in plots that received additional herbicide after the six-leaf stage of rice, but yields were not significantly improved.
Late Quaternary Ice-Surface Fluctuations of Hatherton Glacier, Transantarctic Mountains
- James G. Bockheim, Scott C. Wilson, George H. Denton, Björn G. Andersen, Minze Stuiver
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- Quaternary Research / Volume 31 / Issue 2 / March 1989
- Published online by Cambridge University Press:
- 20 January 2017, pp. 229-254
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Former longitudinal profiles of Hatherton Glacier, an outlet through the Transantarctic Mountains, constrain nearby polar plateau elevations and ice-shelf grounding in the southwestern Ross Embayment. Four gravel drift sheets of late Quaternary age beside Hatherton Glacier are, from youngest to oldest, Hatherton, Britannia I, Britannia II, and Danum. The Hatherton drift limit is uniformly 20 to 70 m above the present ice surface. The Britannia II drift limit is within 100 m of the present surface of uppermost Hatherton Glacier but is 450 m above middle Hatherton Glacier. Extrapolation of this profile downglacier indicates a surface elevation 1100 m above the present Ross Ice Shelf. The Britannia I drift limit is parallel to, but 50–100 m below, Britannia II drift. The Danum drift limit is parallel to, but 50–100 m above, the Britannia II profile. From correlation with drifts near McMurdo Sound and from local 14C dates, we assign an early Holocene age to Hatherton drift, a late Wisconsin age to Britannia drifts, and an age of marine isotope Stage 6 to Danum drift. By our age model, the upper reaches of Hatherton Glacier (and presumably the adjacent polar plateau) have not exceeded their current elevations by more than 100–150 m during the last two complete global glacial-interglacial cycles, whereas the middle and lower reaches of Hatherton Glacier have thickened considerably during the last two global glaciations (late Wisconsin and marine isotope Stage 6). The effect of ice-shelf grounding probably was the major control of these changes of Hatherton Glacier. Holocene ice-surface lowering probably represents the last pulse of grounding-line recession in the southwestern Ross Embayment.
Summary of the Snowmastodon Project Special Volume A high-elevation, multi-proxy biotic and environmental record of MIS 6–4 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA
- Ian M. Miller, Jeffrey S. Pigati, R. Scott Anderson, Kirk R. Johnson, Shannon A. Mahan, Thomas A. Ager, Richard G. Baker, Maarten Blaauw, Jordon Bright, Peter M. Brown, Bruce Bryant, Zachary T. Calamari, Paul E. Carrara, Michael D. Cherney, John R. Demboski, Scott A. Elias, Daniel C. Fisher, Harrison J. Gray, Danielle R. Haskett, Jeffrey S. Honke, Stephen T. Jackson, Gonzalo Jiménez-Moreno, Douglas Kline, Eric M. Leonard, Nathaniel A. Lifton, Carol Lucking, H. Gregory McDonald, Dane M. Miller, Daniel R. Muhs, Stephen E. Nash, Cody Newton, James B. Paces, Lesley Petrie, Mitchell A. Plummer, David F. Porinchu, Adam N. Rountrey, Eric Scott, Joseph J.W. Sertich, Saxon E. Sharpe, Gary L. Skipp, Laura E. Strickland, Richard K. Stucky, Robert S. Thompson, Jim Wilson
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- Quaternary Research / Volume 82 / Issue 3 / November 2014
- Published online by Cambridge University Press:
- 20 January 2017, pp. 618-634
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In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the ocean–atmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 2010–2011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5.
Influence of laser polarization on collective electron dynamics in ultraintense laser–foil interactions
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- Bruno Gonzalez-Izquierdo, Ross J. Gray, Martin King, Robbie Wilson, Rachel J. Dance, Haydn Powell, David A. MacLellan, John McCreadie, Nicholas M. H. Butler, Steve Hawkes, James S. Green, Chris D. Murphy, Luca C. Stockhausen, David C. Carroll, Nicola Booth, Graeme G. Scott, Marco Borghesi, David Neely, Paul McKenna
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- High Power Laser Science and Engineering / Volume 4 / 2016
- Published online by Cambridge University Press:
- 27 September 2016, e33
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The collective response of electrons in an ultrathin foil target irradiated by an ultraintense (${\sim}6\times 10^{20}~\text{W}~\text{cm}^{-2}$) laser pulse is investigated experimentally and via 3D particle-in-cell simulations. It is shown that if the target is sufficiently thin that the laser induces significant radiation pressure, but not thin enough to become relativistically transparent to the laser light, the resulting relativistic electron beam is elliptical, with the major axis of the ellipse directed along the laser polarization axis. When the target thickness is decreased such that it becomes relativistically transparent early in the interaction with the laser pulse, diffraction of the transmitted laser light occurs through a so called ‘relativistic plasma aperture’, inducing structure in the spatial-intensity profile of the beam of energetic electrons. It is shown that the electron beam profile can be modified by variation of the target thickness and degree of ellipticity in the laser polarization.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. 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Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. 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Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- 05 August 2015
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- By Tod C. Aeby, Melanie D. Altizer, Ronan A. Bakker, Meghann E. Batten, Anita K. Blanchard, Brian Bond, Megan A. Brady, Saweda A. Bright, Ellen L. Brock, Amy Brown, Ashley Carroll, Jori S. Carter, Frances Casey, Weldon Chafe, David Chelmow, Jessica M. Ciaburri, Stephen A. Cohen, Adrianne M. Colton, PonJola Coney, Jennifer A. Cross, Julie Zemaitis DeCesare, Layson L. Denney, Megan L. Evans, Nicole S. Fanning, Tanaz R. Ferzandi, Katie P. Friday, Nancy D. Gaba, Rajiv B. Gala, Andrew Galffy, Adrienne L. Gentry, Edward J. Gill, Philippe Girerd, Meredith Gray, Amy Hempel, Audra Jolyn Hill, Chris J. Hong, Kathryn A. Houston, Patricia S. Huguelet, Warner K. Huh, Jordan Hylton, Christine R. Isaacs, Alison F. Jacoby, Isaiah M. Johnson, Nicole W. Karjane, Emily E. Landers, Susan M. Lanni, Eduardo Lara-Torre, Lee A. Learman, Nikola Alexander Letham, Rachel K. Love, Richard Scott Lucidi, Elisabeth McGaw, Kimberly Woods McMorrow, Christopher A. Manipula, Kirk J. Matthews, Michelle Meglin, Megan Metcalf, Sarah H. Milton, Gaby Moawad, Christopher Morosky, Lindsay H. Morrell, Elizabeth L. Munter, Erin L. Murata, Amanda B. Murchison, Nguyet A. Nguyen, Nan G. O’Connell, Tony Ogburn, K. Nathan Parthasarathy, Thomas C. Peng, Ashley Peterson, Sarah Peterson, John G. Pierce, Amber Price, Heidi J. Purcell, Ronald M. Ramus, Nicole Calloway Rankins, Fidelma B. Rigby, Amanda H. Ritter, Barbara L. Robinson, Danielle Roncari, Lisa Rubinsak, Jennifer Salcedo, Mary T. Sale, Peter F. Schnatz, John W. Seeds, Kathryn Shaia, Karen Shelton, Megan M. Shine, Haller J. Smith, Roger P. Smith, Nancy A. Sokkary, Reni A. Soon, Aparna Sridhar, Lilja Stefansson, Laurie S. Swaim, Chemen M. Tate, Hong-Thao Thieu, Meredith S. Thomas, L. Chesney Thompson, Tiffany Tonismae, Angela M. Tran, Breanna Walker, Alan G. Waxman, C. Nathan Webb, Valerie L. Williams, Sarah B. Wilson, Elizabeth M. Yoselevsky, Amy E. Young
- Edited by David Chelmow, Virginia Commonwealth University, Christine R. Isaacs, Virginia Commonwealth University, Ashley Carroll, Virginia Commonwealth University
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- By J. Todd Arnedt, Sharon Aronovich, Alon Y. Avidan, Alp Sinan Baran, Johnathan Barkham, Lizabeth Binns, Tiffany J. Braley, Devin Brown, Paul R. Carney, Philip Cheng, Ronald D. Chervin, Naricha Chirakalwasan, Wattanachai Chotinaiwattarakul, Deirdre A. Conroy, Charles R. Davies, Dawn Dore-Stites, Alan S. Eiser, Todd Favorite, Barbara T. Felt, James D. Geyer, Jennifer R. Goldschmied, Cathy A. Goldstein, John J. Harrington, Fauziya Hassan, Judith L. Heidebrink, Joseph I. Helman, Shelley Hershner, Timothy F. Hoban, Edward D. Huntley, Rahul K. Kakkar, Douglas Kirsch, Raman K. Malhotra, Beth A. Malow, Lauren O’Connell, Shalini Paruthi, Meredith D. Peters, Scott M. Pickett, Satya Krishna Ramachandran, Fouad Reda, Daniel I. Rifkin, Emerson Robinson, Helena M. Schotland, Q. Afifa Shamim-Uzzaman, Anita Valanju Shelgikar, Renée A. Shellhaas, Jeffrey J. Stanley, Leslie M. Swanson, Mihai C. Teodorescu, Mihai C. Teodorescu, Sheila C. Tsai, Katherine Wilson, Michael E. Yurcheshen, Sarah Nath Zallek
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- By Krista Adamek, Ana Luisa K. Albernaz, J. Marcio Ayres†, Andrew J. Baker, Karen L. Bales, Adrian A. Barnett, Christopher Barton, John M. Bates, Jennie Becker, Bruna M. Bezerra, Júlio César Bicca-Marques, Richard Bodmer, Jean P. Boubli, Mark Bowler, Sarah A. Boyle, Christini Barbosa Caselli, Janice Chism, Elena P. Cunningham, José Maria C. da Silva, Lesa C. Davies, Nayara de Alcântara Cardoso, Manuella A. de Souza, Stella de la Torre, Ana Gabriela de Luna, Thomas R. Defler, Anthony Di Fiore, Eduardo Fernandez-Duque, Stephen F. Ferrari, Wilsea M.B. Figueiredo-Ready, Tracy Frampton, Paul A. Garber, Brian W. Grafton, L. Tremaine Gregory, Maria L. Harada, Amy Harrison-Levine, Walter C. Hartwig, Stefanie Heiduck, Eckhard W. Heymann, André Hirsch, Leandro Jerusalinsky, Gareth Jones, Richard F. Kay, Martin M. Kowalewski, Shawn M. Lehman, Laura Marsh, Jesús Martinez, William A. Mason, Hope Matthews, Wynlyn McBride, Shona McCann-Wood, W. Scott McGraw, D. Jeffrey Meldrum, Sally P. Mendoza, Nohelia Mercado, Russell A. Mittermeier, Mirjam N. Nadjafzadeh, Marilyn A. Norconk, Robert Gary Norman, Marcela Oliveira, Marcelo M. Oliveira, Maria Juliana Ospina Rodríguez, Erwin Palacios, Suzanne Palminteri, Liliam P. Pinto, Marcio Port-Carvalho, Leila Porter, Carlos Portillo-Quintero, George Powell, Ghillean T. Prance, Rodrigo C. Printes, Pablo Puertas, P. Kirsten Pullen, Helder L. Queiroz, Luis Reginaldo R. Rodrigues, Adriana Rodríguez, Alfred L. Rosenberger, Anthony B. Rylands, Ricardo R. Santos, Horacio Schneider, Eleonore Z.F. Setz, Suleima S.B. Silva, José S. Silva Júnior, Andrew T. Smith, Marcelo C. Sousa, Antonio S. Souto, Wilson R. Spironello, Masanaru Takai, Marcelo F. Tejedor, Cynthia L. Thompson, Diego G. Tirira, Raul Tupayachi, Bernardo Urbani, Liza M. Veiga, Marianela Velilla, João Valsecchi, Jean-Christophe Vié, Tatiana M. Vieira, Suzanne E. Walker-Pacheco, Rob Wallace, Patricia C. Wright, Charles E. Zartman
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- By James Ahn, Eric L. Anderson, Annette L. Beautrais, Dennis Beedle, Jon S. Berlin, Benjamin L. Bregman, Peter Brown, Suzie Bruch, Jonathan Busko, Stuart Buttlaire, Laurie Byrne, Gerald Carroll, Valerie A. Carroll, Margaret Cashman, Joseph R. Check, Lara G. Chepenik, Robert N. Cuyler, Preeti Dalawari, Suzanne Dooley-Hash, William R. Dubin, Mila L. Felder, Avrim B. Fishkind, Reginald I. Gaylord, Rachel Lipson Glick, Travis Grace, Clare Gray, Anita Hart, Ross A. Heller, Amanda E. Horn, David S. Howes, David C. Hsu, Andy Jagoda, Margaret Judd, John Kahler, Daryl Knox, Gregory Luke Larkin, Patricia Lee, Jerrold B. Leikin, Eddie Markul, Marc L. Martel, J. D. McCourt, MaryLynn McGuire Clarke, Mark Newman, Anthony T. Ng, Barbara Nightengale, Kimberly Nordstrom, Jagoda Pasic, Jennifer Peltzer-Jones, Marcia A. Perry, Larry Phillips, Paul Porter, Seth Powsner, Michael S. Pulia, Erin Rapp, Divy Ravindranath, Janet S. Richmond, Silvana Riggio, Harvey L. Ruben, Derek J. Robinson, Douglas A. Rund, Omeed Saghafi, Alicia N. Sanders, Jeffrey Sankoff, Lorin M. Scher, Louis Scrattish, Richard D. Shih, Maureen Slade, Susan Stefan, Victor G. Stiebel, Deborah Taber, Vaishal Tolia, Gary M. Vilke, Alvin Wang, Michael A. Ward, Joseph Weber, Michael P. Wilson, James L. Young, Scott L. Zeller
- Edited by Leslie S. Zun
- Edited in association with Lara G. Chepenik, Mary Nan S. Mallory
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