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We report the unified constitutive law of vibroconvective turbulence in microgravity, i.e. $Nu \sim a^{-1} Re_{os}^\beta$ where the Nusselt number $Nu$ measures the global heat transport, $a$ is the dimensionless vibration amplitude, $Re_{os}$ is the oscillational Reynolds number and $\beta$ is the universal exponent. We find that the dynamics of boundary layers plays an essential role in vibroconvective heat transport and the $Nu$-scaling exponent $\beta$ is determined by the competition between the thermal boundary layer (TBL) and vibration-induced oscillating boundary layer (OBL). Then a physical model is proposed to explain the change of scaling exponent from $\beta =2$ in the TBL-dominant regime to $\beta = 4/3$ in the OBL-dominant regime. Our finding elucidates the emergence of universal constitutive laws in vibroconvective turbulence, and opens up a new avenue for generating a controllable effective heat transport under microgravity or even microfluidic environment in which the gravity effect is nearly absent.
The impact of a liquid droplet with another droplet or onto a solid surface are important basic processes that occur in many applications such as agricultural sprays and inkjet printing, and in nature such as pathogens transport by raindrops. We investigated the head-on collision of unequal-size droplets of the same liquid on wetting surfaces using the direct numerical simulations technique at different size ratios. The unsteady Navier–Stokes equations are solved and the liquid–gas interface is tracked using the geometric volume-of-fluid method. The numerical model is validated by comparing simulation results of two extreme cases of droplets bouncing with the experimental data from previous studies and the agreement is quite accurate. The validated model is employed to simulate droplets bouncing at several size ratios at different Weber numbers and Ohnesorge number. Two distinct regimes are identified, namely, the inertial regime, where the restitution coefficient is a constant value close to 0.3, the viscous regime, where the restitution coefficient declines. To understand the bouncing behaviour, the velocity field is analysed and an energy budget calculation is performed. The distribution of the sessile droplet energy is found to be important and the sessile droplet surface energy is calculated by its deformation characteristics such as crater depth. Finally, a scaling analysis is performed to rationalize the insensitivity of the coefficient of restitution in the inertial regime, and its decline in the viscous regime, at large size ratios.
An enhanced wideband tracking method for characteristic modes (CMs) is investigated in this paper. The method consists of three stages, and its core tracking stage (CTS) is based on a classical eigenvector correlation-based algorithm. To decrease the tracking time and eliminate the crossing avoidance (CRA), we append a commonly used eigenvalue filter (EF) as the preprocessing stage and a novel postprocessing stage to the CTS. The proposed postprocessing stage can identify all CRA mode pairs by analyzing their trajectory and correlation characteristics. Subsequently, it can predict corresponding CRA frequencies and correct problematic qualities rapidly. Considering potential variations in eigenvector numbers at consecutive frequency samples caused by the EF, a new execution condition for the adaptive frequency adjustment in the CTS is introduced. Finally, CMs of a conductor plate and a fractal structure are investigated to demonstrate the performance of the proposed method, and the obtained results are discussed.
Expertise in social perception, defined as the ability to decode another person's mental states based on basic behavioral signals (Allison et al., 2000; Beauchamp et al., 2008). The Reading the Mind in the Eyes Test (RMET) is a social-perception task of theory of mind (ToM, Meinhardt-Injac et al., 2020) and used to test different clinical disorders, like autism spectrum disorders (ASD, Peñuelas-Calvo et al., 2019). RMET has been used to demonstrate gender, cultural, genetic, and personality trait influences on ToM and elucidate its neurobiological mechanisms (Adams et al., 2010). In Taiwan, there has few sensitive tools to evaluate children's social perception, thus the purpose of this study is to examine psychometric properties of child's version of RMET in Taiwan (RMET-C-TW) and cross-cultural comparisons.
Participants and Methods:
RMET-C (Baron-Cohen et al., 2001) was used to assess mental state/emotion recognition (Vellante et al., 2013). It consists of photographs of the eye regions of 28 faces. Participants were asked to make a choice between four words presented, choose the one that best described for feel or think. One point was given to each correctly response. RMET-C-TW was double-translation of words to ensure cultural applicability in Taiwan. This study included both a normative sample and criteria sample. The normative sample consisted of 769 (385 male, 384 female) 3 to 9 grades students from northern Taiwan. The normative sample completed both the RMET-C-TW and Chinese Vocabulary Test (CVT) in groups at their own schools, the CVT was to ensure that participants had sufficient vocabulary skills to understand the options provided in REMT-C-TW. The criteria sample were collected from 46 matched, school-aged children with ASD (age mean = 10.52, SD = 1.62; IQ = 108.39, SD = 11.75), and normally developing controls (age mean = 10.66, SD=1.68; IQ = 109.70, SD = 12.12). These two groups were administered the (1) WISC-III (2) CVT (3) RMET-C-TW and (4) ToM Test.
Results:
The results showed that RMET-C-TW had acceptable test-retest reliability and internal consistency (test-retest reliability = .71, Cronbach α= .40). There were significant gender and age difference in the performance of RMET-C-TW, example female, older participants performed better. Item analysis showed 93% of items in the RMET-C-TW had cross- cultural consistency in the distribution of respondents' choices. In criteria sample, the control group's RMET-C-TW scores significantly better than ASD group. Physician diagnosis (r = .49, p < .01) and high-order ToM's scores (r = .33, p < .01) were significantly associated with RMET-C-TW scores.
Conclusions:
RMET-C-TW has acceptable reliability and good developmental validity (age-related growth) in three to nine grades, and future can be extended to different age and clinicians to understand the development of social perception. Therefore, RMET-C-TW can be used as an initial screening and cross-cultural tool for ASD. In addition, EF is divided into cold and hot, and hot EF makes a unique contribution to ToM in ASD (Kouklari et al., 2017), thus this tool may also be used in the future to understand the association of hot EF with social perception.
The preschool children born very low birth weight(VLBW) still have executive functions(EFs) deficits even with normal early development(Ni, Huang, & Guo, 2011). Consequently, early intervention might be more important than expected. This study aims to investigate the follow-up outcome of the therapeutic effects of integrative neuropsychological training model(INTM) focused on EFs for school-age VLBW children with EFs deficits.
Participants and Methods:
The VLBW children, recruited from the Regional Cohort Network for premature infants who were admitted to neonatal intensive care units, had normal scores in Bayley and Wechsler Intelligence systems before 6 years old. They also received follow-up neuropsychological assessment for EFs at 6 or 8-year-old. The deficits of EFs were defined from the result of Digit Span Subtest of WISC-IV, Knox's Cube Test(KCT), Tower of London(ToL), Wisconsin Card Sorting Test(WCST), and Comprehensive Nonverbal Attention Test Battery(CNAT). A total of 8 VLBW children with EFs deficits were recruited and received EFs training at 6 or 8-year-old. The INTM combined with Comprehensive Memory Training System(CMTS), Executive FUNction Training(EFT), and multi-ecological materials focused on enhancing the four aspects of EFs, including working memory, planning, cognitive flexibility, and inhibition ability. Then, they received follow-up neuropsychological assessment for EFs at 8 or 10-year-old.
Results:
The results showed that all children got benefits from 20 hours of INTM and most of the EF aspects remained improved at follow-up. A total of 8 VLBW children with an average of 3.4 aspects EFs deficits had an average of 1.4 aspects of EFs deficits left at the follow-up. More precisely, 5 of them had 1 aspects of EFs deficits and 3 of them had 2 aspects of EFs deficits.
Conclusions:
This study revealed that such a short-term INTM had long-term effects in enhancing the EFs of those VLBW children who had normal early development but later grew into EFs deficits at school-age. Besides, their EFs are still improving even after two years of intervention. Further study on more subjects with longer follow-up might help VLBW children to achieve better neuropsychological function.
Previous studies had shown that even with normal early development, preterm children at age six still have executive function deficits, including planning, cognitive flexibility, and nonverbal working memory. The present study aims to discuss further the correlation between IQ and EF of preterm children with different birthweight in order to clarify the potential influence of birthweight.
Participants and Methods:
The preterm children were recruited from the Regional Cohort Network for premature infants who were admitted to neonatal intensive care units. Inclusion criteria were their scores of Bayley Scales of Infant and Toddler Development, second or third edition at 12 and 24 months, and Wechsler Preschool and Primary Scale of Intelligence, Revised Edition at 5 years old were higher than 70. Meanwhile, their FSIQ of Wechsler Intelligence Scale for Children, Fourth Edition were higher than 85 at age 6. Exclusion criteria were visual impairment, hearing impairment, and cerebral palsy. There was a total of 251 preterm children recruited in the present study. Preterm children were then divided into very low birthweight (VLBW) and extremely low birth weight (ELBW) groups. The VLBW group included 183 preterm children, whose birthweight is between 1000-1500g, and gestational age is less than 37 weeks. The ELBW group included 68 preterm children, whose birthweight is less than 1000g and gestational age is less than 37 weeks. Four types of executive function were assessed. Inhibition was assessed through Comprehensive Nonverbal Attention Test Battery (CNAT), cognitive flexibility was assessed through Wisconsin Card Sorting Test (WCST), verbal working memory was assessed through the Longest Digit Span Forward (LDSB) index of Digit Span Subtest of Wechsler Intelligence Scale for Children-IV (WISC-IV), and nonverbal working memory was assessed through Knox's Cube Test (KCT), and planning ability was assessed through Tower of London (ToL). Data were analyzed with independent T-test and Pearson Correlation.
Results:
In VLBW preterm group, results showed that there were significant correlations (p<.05) between FSIQ and EF indexes in five out of six indexes of WCST, LDSB of Digit Span of WISC-IV, Backward score of Knox's Cube Test, and three out of six indexes of ToL. As to the CNAT, there was no index of CNAT that was significantly correlated with FSIQ in the VLBW preterm group. In ELBW preterm group, results showed that there were significant correlations (p<.05) between FSIQ and EF indexes in one out of five indexes of CNAT, one out of six indexes of WCST, Backward score of Knox's Cube Test, and two out of six indexes of ToL. And the LDSB of Digit Span of WISC-IV was not significantly correlated with FSIQ in ELBW preterm group.
Conclusions:
There were fewer EF indexes significantly correlated with FSIQ in ELBW preterm children with normal early development than VLBW preterm children with normal early development, suggesting that even with an IQ higher than 85, lower the birthweight, especially lower than 1000g, higher the EF performance should be concerned. Therefore, in the clinical setting, it is very important to assess the EF independently. And birthweight may be a crucial factor in preterm children's prefrontal cortex maturity.
Fast neutron absorption spectroscopy is widely used in the study of nuclear structure and element analysis. However, due to the traditional neutron source pulse duration being of the order of nanoseconds, it is difficult to obtain a high-resolution absorption spectrum. Thus, we present a method of ultrahigh energy-resolution absorption spectroscopy via a high repetition rate, picosecond duration pulsed neutron source driven by a terawatt laser. The technology of single neutron count is used, which results in easily distinguishing the width of approximately 20 keV at 2 MeV and an asymmetric shape of the neutron absorption peak. The absorption spectroscopy based on a laser neutron source has one order of magnitude higher energy-resolution power than the state-of-the-art traditional neutron sources, which could be of benefit for precisely measuring nuclear structure data.
All-fiber coherent beam combiners based on the self-imaging effect can achieve a near-perfect single laser beam, which can provide a promising way to overcome the power limitation of a single-fiber laser. One of the key points is combining efficiency, which is determined by various mismatches during fabrication. A theoretical model has been built, and the mismatch error is analyzed numerically for the first time. The mismatch errors have been numerically studied with the beam quality and combining efficiency being chosen as the evaluation criteria. The tolerance of each mismatch error for causing 1% loss is calculated to guide the design of the beam combiners. The simulation results are consistent with the experimental results, which show that the mismatch error of the square-core fiber is the main cause of the efficiency loss. The results can provide useful guidance for the fabrication of all-fiber coherent beam combiners.
Taste preference is a pivotal predictor of nutrient intake, yet its impact on mild cognitive impairment (MCI) remains poorly understood. We aimed to investigate the association between taste preferences and MCI and the role of cardiometabolic diseases (CMD) in this association. The study included older adults, aged 65–90 years, with normal cognitive function at baseline who were enrolled in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2008 to 2018. MCI was measured by the Mini-Mental State Examination, and multivariable Cox regression models were applied. Among 6423 participants, 2534 (39·45 %) developed MCI with an incidence rate of 63·12 - per 1000 person-years. Compared with individuals with insipid taste, those preferring sweetness or spiciness had a higher MCI risk, while saltiness was associated with a lower risk. This association was independent of objective dietary patterns and was more pronounced among urban residents preferring sweetness and illiterate participants preferring spiciness. Notably, among sweet-liking individuals, those with one CMD experienced a significant detrimental effect, and those with co-occurring CMD had a higher incidence rate of MCI. Additionally, regional variations were observed: sweetness played a significant role in regions known for sweet cuisine, while the significance of spiciness as a risk factor diminishes in regions where it is commonly preferred. Our findings emphasize the role of subjective taste preferences in protecting cognitive function and highlight regional variations. Target strategies should focus on assisting individuals with CMD to reduce excessive sweetness intake and simultaneously receiving treatment for CMD to safeguard cognitive function.
Purple nutsedge (Cyperus rotundus L.) is a globally distributed noxious weed that poses a significant challenge for control due to its fast and efficient propagation through the tuber, which is the primary reproductive organ. Gibberellic acid (GA3) has proven to be crucial for tuberization in tuberous plants. Therefore, understanding the relationship between GA3 and tuber development and propagation of C. rotundus will provide valuable information for controlling this weed. This study shows that the GA3 content decreases with tuber development, which corresponds to lower expression of bioactive GA3 synthesis genes (CrGA20ox, two CrGA3ox genes) and two upregulated GA3 catabolism genes (CrGA2ox genes), indicating that GA3 is involved in tuber development. Simultaneously, the expression of two CrDELLA genes and CrGID1 declines with tuber growth and decreased GA3, and yeast two-hybrid assays confirm that the GA3 signaling is DELLA-dependent. Furthermore, exogenous application of GA3 markedly reduces the number and the width of tubers and represses the growth of the tuber chain, further confirming the negative impact that GA3 has on tuber development and propagation. Taken together, these results demonstrate that GA3 is involved in tuber development and regulated by the DELLA-dependent pathway in C. rotundus and plays a negative role in tuber development and propagation.
Ankle rehabilitation robots are widely used due to nerve injuries and sports injuries leading to decreased mobility of the ankle joint. However, the motion of most ankle rehabilitation robots has distinctions with human ankle physiological structure. In order to achieve more accurate rehabilitation training of the ankle joint, this paper proposes a novel 3-UPU parallel rehabilitation mechanism. In a certain range, the mechanism can perform rotation around any axis within the midplane, which means that the mechanism can achieve non-fixed-point rotation around the instantaneous axis of the ankle joint. The mechanism has three degrees of freedom and can perform ankle pronation/supination and inversion/eversion movements. Taking into account the structural differences of different human bodies, the rotating axis of the mechanism can be adjusted in both height and angle. Then, the workspace of the mechanism was solved, and the size parameters of the mechanism are analyzed based on the characteristics of the size parameters of the mechanism and the motion range of the ankle. A genetic algorithm was employed to optimize the mechanism’s parameters. Next, the motion trajectory of the mechanism was planned, and the length change of the mechanism driving pair during the motion planning of the angle was obtained through kinematics simulation. Finally, experimental verification of the above rehabilitation training methods indicates that the mechanism meets the requirements of ankle rehabilitation.
How do corporate political ties impact firm performance in a transition economy? This topic has attracted wide attention in the strategy field. Accordingly, our study replicates a highly influential study, ‘Managerial ties and firm performance in a transition economy: The nature of a micro-macro link’ (Peng & Luo, 2000). The original study found that managerial political ties greatly improve organizational performance, and that this ‘micro-macro’ link varies across ownership types, business sectors, firm sizes, and industry growth rates. This replication study offers a hierarchical view of political ties by extending it from the individual to the organizational level and explores the complex link between the two levels of corporate political ties and firm performance. The results of a staged quasi-replication exercise show some similarities with the original study in the mechanism of corporate political ties on firm performance but, more importantly, reveal some key differences in the effect size and contingent effects. Furthermore, an extended test shows that corporate political ties are multilevel, and different levels of political ties vary in their mechanisms and effects on firm performance. The findings reveal temporal and contextual sensitivities of political ties studies in transition economies.
Patients with cirrhosis experience worse health-related quality of life (HRQoL), and attempts are warranted further exploration of modifiable factors to improve HRQoL. Data on the impact of malnutrition risk on HRQoL among cirrhosis are limited; thus, we aimed to strengthen understanding by clarifying the relationship between nutritional status and low HRQoL in patients with decompensated cirrhosis. Consecutive inpatients with cirrhosis attending our department within a tertiary hospital were studied. Generic health profiles and malnutrition risk were evaluated by the EuroQol-5D (EQ-5D) and Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT) score, respectively. Multiple linear regression analysis was used to determine association of malnutrition risk with low HRQoL. In this cohort of 364 patients with median age of 64 years and 49·5 % male, 55·5 % of the study population reported impairment pertinent to HRQoL in at least one dimension in terms of the EQ-5D. Moreover, malnutrition risk (RFH-NPT score: β coefficient = −0·114, P = 0·038) was proved to be independently associated with poor HRQoL in multiple analysis, after adjustment for significant variables like age, BMI and markers of decompensation. Notably, we found that health dimensions representing physical function (i.e. mobility, self-care and usual activities) are substantially affected, while malnourished patients reported less frequencies of complaints in other domain such as anxiety/depression. In conclusion, the risk of malnutrition assessed by the RFH-NPT score is independently associated with low HRQoL. It is operational to improve HRQoL by identifying patients at high malnutrition risk and providing timely nutrition treatment.
Huang Xiaowu 黃小午 (b. 1948), a Jiangsu Company laosheng 老生, studied with “chuan” generation (chuan zi bei 傳字輩) performers, including Zhou Chuanying 周傳瑛 and Zheng Chuanjian 鄭傳鑑 [all Appendix H]. His wife Wang Weijian 王維艱 is among the leading performers of laodan 老旦 roles of her generation.
Synopsis
The Palace of Lasting Life (Changsheng dian 長生殿) [Appendix F] is a chuanqi 傳奇 script by Hong Sheng 洪昇 (1645–1704) [Appendix G], completed in 1688. Also translated as The Palace of Eternal Youth and The Palace of Eternal Life, it deals with the familiar story of the doomed love between the Tang emperor Minghuang 唐明皇 (that is, the Xuanzong 玄宗 emperor Li Longji 李隆基, r. 685–762 CE) and Precious Consort Yang (Yang Guifei 楊貴妃; personal name Yang Yuhuan 楊玉環, 719–756 CE). The story of their love and its consequences already had a long tradition in fiction, verse, and drama before Hong's work. Whereas some of those treatments portray Yang as unfaithful and Minghuang as culpable for the An Lushan 安禄山 rebellion (755–763 CE) as a result of neglecting his responsibilities, Hong presents both figures sympathetically. One of the highlights of Qing drama and the kunqu stage, The Palace of Lasting Life is often cited “for its exceptional musicality, that is, for the marvelous fit between the words and the tune patterns Hong Sheng employed” (Zeitlin 2006, 458). The chuanqi script by Hong consists of 50 scenes, early performances of which reportedly lasted “three days and nights.” Both historically and at present, a more common way to perform this content would be to mix these scenes with highlights from other plays. From the mid-1980s onward, sequential kunqu 崑曲 versions of one or more sessions (for example, on consecutive evenings) have proven popular, including five-scene (1986) and four-session, 44-scene versions in Shanghai (2007) (Yang 2018, 29, 48–49, 63, 205).
Wang Shiyu 汪世瑜 (b. 1941), a sheng 生 of the Zhejiang Troupe, studied with “chuan” generation actors (chuan zi bei 傳字輩), including Zhou Chuanying 周傳瑛 [both Appendix H]. A 1986 winner of the Plum Blossom Prize (Meihua jiang 梅花獎), he is especially well known for his jinsheng 巾生 roles, including Pan Bizheng 潘必正 in this play and Liu Mengmei 柳夢梅 in The Peony Pavilion [Appendix F].
Synopsis
The Jade Hairpin (Yuzan ji 玉簪記) [Appendix F] is a sixteenth-century chuanqi 傳奇, and one of the most popular kunqu 崑曲 plays. Several scenes are in regular repertoire and evening-length versions have also become fairly common. Credited to an otherwise obscure author, Gao Lian 高濂 [Appendix G], the play concerns the story of the young scholar Pan Bizheng who, while residing at the Abbey of Female Chastity (Nüzhen guan 女貞觀), meets the novice nun Chen Miaochang 陳妙常. Chen has sought refuge from the war at the abbey, of which Pan Bizheng's aunt is the abbess. The plot follows their courtship, parting, and reunion. An intriguing first encounter occurs in “Talk over Tea” (“Chaxu” 茶叙). This is followed by a nocturnal musical meeting which is the subject of this lecture, “The Stirring Zither” (“Qintiao” 琴挑). This scene marks the beginning of their courtship. In “The Sick Visit” (“Wenbing” 問病) Pan has caught a cold and is lovesick for Chen, and they seek to convey their affection without the notice of his aunt. In “Stealing the Poem” (“Toushi” 偷詩) Pan discovers evidence of Chen's love for him in poem of hers, and in “Autumn River” (“Qiujiang” 秋江) she hires a boat to catch up with him after his aunt has sent him down the river to take the imperial examinations. Chen does catch up with him and they exchange love pledges (including the hairpin of the title), but have to part.
Hou Shaokui 侯少奎 (b. 1939) is a Northern Company actor and the son of Hou Yongkui 侯永奎 [Appendix H]. Best known for powerful martial roles, including Lord Guan 關公 (Guan Yu 關羽) in this scene as well as the wusheng 武生 Lin Chong 林沖 in “Fleeing by Night” (“Yeben” 夜奔), Hou won the Plum Blossom Prize (Meihua jiang 梅花獎) in its second installment in 1985. His autobiography provides rich materials on twentieth-century northern kunqu history and practice (Hou Shaokui and Hu Mingming 2007).
Synopsis
“Sword Meeting” (“Daohui” 刀會) is the fourth and final act of the zaju play The Great King Guan Attends a Meeting with a Single Sword (Guan Dawang du fu dandaohui 關大王獨赴單刀會), more usually known as Single Sword Meeting (Dandaohui 單刀會), by the great fourteenthcentury playwright Guan Hanqing 關漢卿 [Appendix G]. “Sword Meeting” is perhaps the best-known kunqu scene to directly derive from northern “variety plays” (zaju 雜劇). The lyrics of the version performed were adjusted to be singable for kunqu, though the qupai 曲牌 and their sequence are largely the same as in the zaju script. Two early versions of the full play are translated in Wilt L. Idema and Stephen H. West (2012).
The play's hero is the Three Kingdoms figure Guan Yu, better known as Lord Guan. This scene depicts a meeting between major figures from two of these Three Kingdoms, the states of Wu 吳 and of Shu 蜀. After the Battle of Red Cliffs (Chibi zhi zhan 赤壁 之戰) in the winter of 208–209 ce, Wu and Shu formed an alliance against Wei 魏. Liu Bei 劉備 (161–223 CE), emperor of Shu, temporarily borrowed Nanjun 南郡, part of Jingzhou 荆州, from Wu as a base to resist the aggression of Wei. However, Liu Bei later refused to return Nanjun when Wu claimed sovereignty, and sent Lord Guan, one of the most important Shu generals, to defend it.
The Zhu Maichen story originates as a case of ‘female-initiated divorce' in an ancient Chinese biography, before later becoming a familiar late imperial narrative. In the last hundred years, it has featured as a prominent part of the narrative heritage available for operatic reworking. The absence of a canonical authorial version gives more space for playwrights and performers to incorporate their current perspectives of gender and sexuality into various renditions. We have seen a continuance of older patterns where the wife is demonised for her desire to divorce, as well as productions tending to reconsider the travails of the wife. The Hokkien-language genre liyuanxi draws on local narrative versions to arrive at a happy ending, enabling Zhu to remarry his wife, while a new jingju (Beijing opera) version at the turn of century even enables the disillusioned wife to liberate herself from the hypocritic Confucian family. Yet in liyuanxi the wife is taken back, having retained chastity during their parting, while in jingju the wife's materialistic motivations led to criticism in the press. The female-initiated divorce thus provides no escape for Zhu Maichen's wife, who is condemned even when tragedy is averted or the narrative’s patriarchal morality subverted.
Fibronectin type III domain-containing protein 5 (FNDC5) is a transmembrane protein and the precursor of irisin, which serves as a systemic exerkine/myokine with multiple origins. Since its discovery in 2012, this hormone-like polypeptide has rapidly evolved to a component significantly involved in a gamut of metabolic dysregulations and various liver diseases. After a decade of extensive investigation on FNDC5/irisin, we are still surrounded by lots of open questions regarding its diagnostic and therapeutic values. In this review, we first concentrated on the structure–function relationship of FNDC5/irisin. Next, we comprehensively summarised the current knowledge and research findings regarding pathogenic roles/therapeutic applications of FNDC5/irisin in the context of non-alcoholic fatty liver disease, fibrosis, liver injury due to multiple detrimental insults, hepatic malignancy and intrahepatic cholestasis of pregnancy. Moreover, the prominent molecules involved in the underlying mechanisms and signalling pathways were highlighted. As a result, emerging evidence reveals FNDC5/irisin may act as a proxy for diagnosing liver disease pathology, a sensitive biomarker for assessing damage severity, a predisposing factor for surveilling illness progression and a treatment option with protective/preventive impact, all of which are highly dependent on disease grading and contextually pathological features.
Listeriosis is a rare but serious foodborne disease caused by Listeria monocytogenes. This matched case–control study (1:1 ratio) aimed to identify the risk factors associated with food consumption and food-handling habits for the occurrence of sporadic listeriosis in Beijing, China. Cases were defined as patients from whom Listeria was isolated, in addition to the presence of symptoms, including fever, bacteraemia, sepsis and other clinical manifestations corresponding to listeriosis, which were reported via the Beijing Foodborne Disease Surveillance System. Basic patient information and possible risk factors associated with food consumption and food-handling habits were collected through face-to-face interviews. One hundred and six cases were enrolled from 1 January 2018 to 31 December 2020, including 52 perinatal cases and 54 non-perinatal cases. In the non-perinatal group, the consumption of Chinese cold dishes increased the risk of infection by 3.43-fold (95% confidence interval 1.27–9.25, χ2 = 5.92, P = 0.02). In the perinatal group, the risk of infection reduced by 95.2% when raw and cooked foods were well-separated (χ2 = 5.11, P = 0.02). These findings provide important scientific evidence for preventing infection by L. monocytogenes and improving the dissemination of advice regarding food safety for vulnerable populations.