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Influenced by human activities, microplastics (MPs) are widely distributed in terrestrial ecosystems. However, their ecotoxicity remains unclear. Therefore, we assessed the ecotoxicity of polyamide microplastics (PA-MPs) by investigating their toxic effects on the model insect, the silkworms Bombyx mori (Lepidoptera: Bombycidae). In this study, fifth-instar silkworm larvae were fed mulberry leaves treated with PA-MPs for 120 hours, but no changes in mortality rates were observed. However, the body weight, pupal weight, cocoon weight, egg laying amount, and cocoon shell weight in F0 generation silkworms were significantly reduced. This indicates that PA-MPs have sublethal effects on silkworms. To further investigate the effects of PA-MPs on the offspring of silkworms, we applied the age-stage, two-sex life table analysis. We found that in the PA-MPs treatment group, the duration of the larval and pupal stages of F1 generation silkworms was significantly prolonged, while the lifespan of the adults and total longevity were shortened. Meanwhile, the life history parameters (sxj, exj, lx, fxj, lxmx, and vxj values) and population parameters (R0, λ, r, and T) of F1 generation silkworms in the PA-MPs treatment group were also lower than control. This indicates that PA-MPs have transgenerational effects, affecting the growth, development, and reproduction of F1 generation silkworms. Our research findings demonstrate the sublethal and transgenerational effects of PA-MPs on silkworms, providing evidence for their ecotoxicity.
Traditional radiometric tracking navigation increasingly fails to meet the demands of deep space exploration. In contrast, optical navigation enables interplanetary spacecraft to navigate autonomously with higher precision. The effectiveness of image processing algorithms plays a crucial role in determining the accuracy of optical navigation systems. This paper presents a robust centroid extraction method based on a hybrid genetic algorithm. First, noise interference is effectively reduced by leveraging proximity information. Second, a fitness evaluation mechanism is introduced to assess model performance throughout the iterative process. Third, an annealing mutation operator is incorporated to prevent premature convergence to local optima. Finally, extensive comparative testing demonstrates that the proposed method offers substantial improvements in both accuracy and robustness, thereby substantially improving the reliability of the navigation system under complex conditions.
Rhopalosiphum padi is an important grain pest, causing severe losses during crop production. As a systemic insecticide, flonicamid can control piercing-sucking pests efficiently. In our study, the lethal effects of flonicamid on the biological traits of R. padi were investigated via a life table approach. Flonicamid is highly efficiently toxic to R. padi, with an LC50 of 9.068 mg L−1. The adult longevity and fecundity of the R. padi F0 generation were markedly reduced under the LC25 and LC50 concentrations of flonicamid exposure. In addition, negative transgenerational effects on R. padi were observed under exposure to lethal concentrations of flonicamid, with noticeable decreases in the reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation under the LC25 concentration of flonicamid. Furthermore, the third nymph stage (N3), preadult stage, duration of the adult pre-reproductive period, duration of the total pre-reproductive period, reproductive period, adult longevity, total longevity, and total fecundity of the F1 generation were significantly lower under treatment with the LC50 concentration of flonicamid. The life table parameters were subsequently analysed, revealing that the intrinsic rate of increase (rm) and the net reproductive rate (R0) were significantly lower but that the finite rate of increase (λ) and the mean generation time (T) were not significantly different under the LC25 and LC50 concentrations of flonicamid. These data are beneficial for grain aphid control and are critical for exploring the role of flonicamid in the integrated management of this key pest.
We demonstrated a high-power, high-energy regenerative amplifier (RA) based on Yb-doped CaGdAlO4 (Yb:CALGO) crystal, which achieves a maximum average power exceeding 50 W at a repetition rate greater than 50 kHz, and a maximum pulse energy of approximately 7 mJ at a repetition rate of up to 5 kHz. After compression, 130 fs pulses with a peak power of nearly 45 GW are achieved. To the best of our knowledge, this represents the highest average power and pulse energy reported for a Yb:CALGO RA. The RA cavity is specifically designed to maintain excellent stability and output beam quality under a pumping power of 380 W, resulting in a continuous-wave output power exceeding 70 W. For the seeder, a fiber laser utilizing a nonlinear amplification process, which yields a broadband spectrum to support approximately 80 fs pulses, is employed for the high-peak-power pulse generation.
Antidepressants’ effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims
To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method
We performed a cohort study based on the QResearch database. We included people with a newly recorded diagnosis of depression, exposed to licensed antidepressants in the UK. We assessed all-cause dropouts (acceptability), dropouts for adverse events (tolerability), occurrence of at least one adverse event (safety), and response and remission on the Patient Health Questionnaire (PHQ)-9 (effectiveness) at 2 and 12 months. Logistic regressions were used to compute adjusted-odds ratio (aOR) with 99% CIs, assessing the associations between exposure to each antidepressant against fluoxetine (comparator) and outcomes of interest. We compared estimates from the real world with RCTs using ratio-of-odds ratio (ROR) with 95% CI.
Results
A total of 673 177 depressed people were studied: females 57.1%, mean age 42.8 (s.d. 17.7) years, mean baseline PHQ-9 17.1 (s.d. 5.0) (moderately severe depression). At 2 months, antidepressant acceptability was 61.4%, tolerability 94.4%, safety 54.5%, PHQ-9 decreased to 12.3 (s.d. 6.5). At 12 months, acceptability was 12.3%, tolerability 87.5%, safety 28.8%, PHQ-9 12.9 (s.d. 6.8). In the short and long term, tricyclics, mirtazapine and trazodone were worse than fluoxetine for most outcomes; citalopram had better acceptability than fluoxetine (aOR 0.95; 99% CI 0.92, 0.97), sertraline had lower tolerability (aOR 1.12; 99% CI 1.06, 1.18), and both citalopram and sertraline had lower safety (aOR 1.17 and 1.25, respectively). In the long term, citalopram had better acceptability (aOR 0.78; 99% CI 0.76, 0.81) and effectiveness (aOR 1.12 for both response and remission), but worse tolerability (aOR 1.09; 99% CI 1.06, 1.13) and safety (aOR 1.12; 99% CI 1.08, 1.16). Observational and randomised data were similar for citalopram and sertraline, while there was some difference for drugs less prescribed in the real world.
Conclusions
Antidepressants showed low acceptability, moderate-to-high tolerability and safety, and small-to-moderate effectiveness in the real world. Real-world and RCT estimates showed similar findings only when the analyses were carried out using large datasets; otherwise, the results diverged.
Negative relationships between the parental age and offspring life history traits have been widely observed across diverse animal taxa. However, there is a lack of studies examining the influence of parental age on offspring performance using mites, particularly phytoseiid predators as subjects. This study explored the influence of maternal age on offspring life history traits in Amblyseius herbicolus (Chant) (Acari: Mesostigmata), a phytoseiid predatory mite reproducing through thelytokous parthenogenesis. We hypothesised that increased maternal age negatively impacts offspring traits, including developmental duration, body size, fecundity and lifespan. Amblyseius herbicolus was reared under controlled laboratory conditions, and the life history traits of offspring from mothers of varying ages were analysed using linear mixed-effect models. Our results showed that the increase in maternal age significantly reduced individual egg volume, but did not significantly affect offspring developmental duration, body size, fecundity or lifespan. These findings indicate that while older A. herbicolus females produced smaller eggs, the subsequent performance (i.e. body size, fecundity and lifespan) of offspring remained largely unaffected, suggesting possible compensatory mechanisms in the offspring or alternative maternal provisioning strategies. The results of this study offer useful insights into the reproductive strategies of phytoseiid predators and asexually reproducing species, enhancing our understanding of how maternal age affects offspring fitness. Further studies can examine how offspring of A. herbicolus from mothers of different ages perform under adverse environmental conditions.
Over the past several decades, more research focuses have been made on the inflammation/immune hypothesis of schizophrenia. Building upon synaptic plasticity hypothesis, inflammation may contribute the underlying pathophysiology of schizophrenia. Yet, pinpointing the specific inflammatory agents responsible for schizophrenia remains a complex challenge, mainly due to medication and metabolic status. Multiple lines of evidence point to a wide-spread genetic association across genome underlying the phenotypic variations of schizophrenia.
Method
We collected the latest genome-wide association analysis (GWAS) summary data of schizophrenia, cytokines, and longitudinal change of brain. We utilized the omnigenic model which takes into account all genomic SNPs included in the GWAS of trait, instead of traditional Mendelian randomization (MR) methods. We conducted two round MR to investigate the inflammatory triggers of schizophrenia and the resulting longitudinal changes in the brain.
Results
We identified seven inflammation markers linked to schizophrenia onset, which all passed the Bonferroni correction for multiple comparisons (bNGF, GROA(CXCL1), IL-8, M-CSF, MCP-3 (CCL7), TNF-β, CRP). Moreover, CRP were found to significantly influence the linear rate of brain morphology changes, predominantly in the white matter of the cerebrum and cerebellum.
Conclusion
With an omnigenic approach, our study sheds light on the immune pathology of schizophrenia. Although these findings need confirmation from future studies employing different methodologies, our work provides substantial evidence that pervasive, low-level neuroinflammation may play a pivotal role in schizophrenia, potentially leading to notable longitudinal changes in brain morphology.
Hippocampal disruptions represent potential neuropathological biomarkers in depressed adolescents with cognitive dysfunctions. Given heterogeneous outcomes of whole-hippocampus analyses, we investigated subregional abnormalities in depressed adolescents and their associations with symptom severity and cognitive dysfunctions.
Methods
MethodsSeventy-nine first-episode depressive patients (ag = 15.54 ± 1.83) and 71 healthy controls (age = 16.18 ± 2.85) were included. All participants underwent T1 and T2 imaging, completed depressive severity assessments, and performed cognitive assessments on memory, emotional recognition, cognitive control, and attention. Freesurfer was used to segment each hippocampus into 12 subfields. Multivariable analyses of variance were performed to identify overall and disease severity-related abnormalities in patients. LASSO regression was also conducted to explore the associations between hippocampal subfields and patients’ cognitive abilities.
Results
Depressed adolescents showed decreases in dentate gyrus, CA1, CA2/3, CA4, fimbria, tail, and molecular layer. Analyses of overall symptom severity, duration, self-harm behavior, and suicidality suggested that severity-related decreases mainly manifested in CA regions and involved surrounding subfields with disease severity increases. LASSO regression indicated that hippocampal subfield abnormalities had the strongest associations with memory impairments, with CA regions and dentate gyrus showing the highest weights.
Conclusions
Hippocampal abnormalities are widespread in depressed adolescents and such abnormalities may spread from CA regions to surrounding areas as the disease progresses. Abnormalities in CA regions and dentate gyrus among these subfields primarily link with memory impairments in patients. These results demonstrate that hippocampal subsections may serve as useful biomarkers of depression progression in adolescents, offering new directions for early clinical intervention.
All-fiber coherent beam combiners based on the self-imaging effect can achieve a near-perfect single laser beam, which can provide a promising way to overcome the power limitation of a single-fiber laser. One of the key points is combining efficiency, which is determined by various mismatches during fabrication. A theoretical model has been built, and the mismatch error is analyzed numerically for the first time. The mismatch errors have been numerically studied with the beam quality and combining efficiency being chosen as the evaluation criteria. The tolerance of each mismatch error for causing 1% loss is calculated to guide the design of the beam combiners. The simulation results are consistent with the experimental results, which show that the mismatch error of the square-core fiber is the main cause of the efficiency loss. The results can provide useful guidance for the fabrication of all-fiber coherent beam combiners.
Retropharyngeal lymphadenectomy is challenging. This study investigated a minimally invasive approach to salvage retropharyngeal lymphadenectomy in patients with nasopharyngeal carcinoma.
Methods
An anatomical study of four fresh cadaveric heads was conducted to demonstrate the relevant details of retropharyngeal lymphadenectomy using the endoscopic transoral medial pterygomandibular fold approach. Six patients with nasopharyngeal cancer with retropharyngeal lymph node recurrence, who underwent retropharyngeal lymphadenectomy with the endoscopic transoral medial pterygomandibular fold technique at the Eye and ENT Hospital of Fudan University from July to December 2021, were included in this study.
Results
The anatomical study demonstrated that the endoscopic transoral medial pterygomandibular fold approach offers a short path and minimally invasive approach to the retropharyngeal space. The surgical procedure was well tolerated by all patients, with no significant post-operative complications.
Conclusion
The endoscopic transoral medial pterygomandibular fold approach is safe and efficient for retropharyngeal lymphadenectomy.
The prevalence of depression is increasing among students in higher education due to academic stress and interpersonal relationships. Although medication is the main form of intervention, medication alone may not achieve the desired results. Recently, cohesion education based on educational psychology has received attention and is considered as a possible effective non-pharmacological treatment.
Subjects and Methods
Three hundred college and university students who had been diagnosed with depression were selected for the study. They were randomly divided into three groups: a medication group, a cohesion education combined with medication group, and a control group. Among them, cohesion education covered teamwork, group activity organisation, and interactive communication skills, which lasted for six months, once a week for two hours. All groups received conventional medication for depression. Students were assessed for depressive symptoms before, during and after the intervention using the Hamilton Depression Rating Scale (HDRS).
Results
HDRS scores in the cohesive education combined medication group were significantly lower than those in the medication and control groups at the end of the study. In addition, students in the combined treatment group generally reported that their interpersonal relationships improved and their teamwork skills increased.
Conclusions
Cohesive education based on educational psychology combined with medication has significant efficacy for students with depression in colleges and universities. This combined treatment not only helps to reduce students’ depressive symptoms, but also improves their interpersonal relationships and teamwork skills.
Acknowledgement
2016 Middle-aged and Youth Research Project of Fujian Provincial Department of Education (No. JAS160604).
Biochar is increasingly used in crop production as a fertilizer; however, its effects on nutrient cycling and stoichiometry in rice paddy soil–plant systems are unclear. We tested for effects of contrasting rates of biochar on soil and rice plant organ carbon (C), nitrogen (N), and phosphorus (P) concentrations and stoichiometry and soil physicochemical properties in early and late paddies. Overall, biochar reduced soil bulk density by an average of 7.4%, while application at 10, 20, and 40 t ha−1 increased soil C and N concentrations in early paddies by 31.6, 41.3, and 104.2%, respectively, and by 8.0, 5.0, and 21.8%, respectively; in late paddies, there were increases of 23.0, 94.1, and 117.0%, respectively, and 6.7, 15.4, and 18.0%, respectively (P < 0.05). Following biochar application at 10, 20, and 40 t ha−1, soil concentration of P decreased in early paddies by 10.9, 19.0, and 13.9%, respectively, and increased in late paddies by 4.3, 16.4, and 20.1%, respectively. Biochar increased ratios of soil C:N and C:P in early and late paddies (P < 0.05), and there was no effect on concentration and stoichiometry of soil available nutrients. Biochar reduced rice plant organ concentration of N and P in early rice and increased leaf N:P ratios. Despite the biochar application improved nutrient status in plant–soil system, we did not observe a significant increase in yield (P > 0.05). According to the N:P value of leaves between treatments, it was found that biochar alleviated the current situation of N limitation in paddy fields during the mature period and transformed the N limitation of early rice into a joint limitation of N and P. These results show that the addition of biochar to subtropical paddy soils leads to a short-term reduction in soil bulk density and increases in soil C and N concentrations and soil fertility. Thus, biochar applied at optimal rates is likely to improve the sustainability of subtropical paddy rice production.
To comprehensively study the physical properties of inductively coupled plasma (ICP), a finite element method (FEM) simulation model of ICP is developed using the well-established COMSOL software. To benchmark the validation of the FEM model, two key physical parameters, the electron density and the electron temperature of the ICP plasma, are precisely measured by the state-of-the-art laser Thomson scattering diagnostic approach. For low-pressure plasma such as ICP, the local pressure in the generator tube is difficult to measure directly. The local gas pressure in the ICP tube has been calibrated by comparing the experimental and simulation results of the maximum electron density. And on this basis, the electron density and electron temperature of ICP under the same gas pressure and absorbed power have been compared by experiments and simulations. The good agreement between the experimental and simulation data of these two key physical parameters fully verifies the validity of the ICP FEM simulation model. The experimental verification of the ICP FEM simulation model lays a foundation for further study of the distribution of various physical quantities and their variation with pressure and absorption power, which is beneficial for improving the level of ICP-related processes.
Maritime cybersecurity has attracted increasing attention in industrial and academic scope, which may be relevant to the increasing cyber-incidents in the maritime shipping industry. This paper presents a critical review of publications related to cybersecurity in the maritime transportation industry, to explore the current research status and gaps, as wells as to guide new probe avenues by employing bibliometric approaches. With the advantage of bibliometric methods, the research focus and evolution are conformed and visualised. Representative papers are reviewed together to demonstrate maritime cyber-threats recognition and categories, as well as potential consequence assessment and risk mitigation actions recommendation. This paper also created a detailed database that is comprised of attack form, occurring time, targets, purpose, as well as potential results and cost, which has been included in the Appendix and is fully portable and extendible.
The objective was to evaluate the association between serum carotenoid levels and respiratory morbidity and mortality in a nationally representative sample of US adults. We assessed the association of serum carotenoid levels with respiratory morbidity and mortality using logistic regression and proportional hazards regression models. Meanwhile, a series of confounders were controlled in regression models and restricted cubic spline, which included age, sex, race, marriage, education, income, drinking, smoking, regular exercise, BMI, daily energy intake, vitamin E, vitamin C, fruit intake, vegetable intake, diabetes, hypertension, asthma, emphysema and chronic bronchitis. Compared with participants in the lowest tertiles, participants in the highest tertiles of serum total carotenoids, β-cryptoxanthin and lutein/zeaxanthin levels had a significantly lower prevalence of emphysema (ORtotal carotenoids = 0·61, 95% CI: 0·41–0·89, ORβ-cryptoxanthin = 0·67, 95% CI: 0·49–0·92), chronic bronchitis (ORβ-cryptoxanthin = 0·66, 95% CI: 0·50–0·87) and asthma (Q2: ORlutein/zeaxanthin = 0·78, 95% CI: 0·62–0·97); participants in the highest tertiles of total carotenoids, α-carotene, lutein/zeaxanthin and lycopene had a lower risk of respiratory mortality (hazard ratio (HR)total carotenoids = 0·62, 95% CI: 0·42–0·90, HRα-carotene = 0·54, 95% CI: 0·36–0·82, HRlutein/zeaxanthin = 0·48, 95% CI: 0·33–0·71, HRlycopene = 0·66, 95% CI: 0·45–0·96) than those in the lowest tertiles. Higher serum total carotenoids and β-cryptoxanthin levels is associated with decreased prevalence of emphysema and chronic bronchitis, and higher serum total carotenoids, α-carotene, lutein/zeaxanthin and lycopene levels had a lower mortality of respiratory disease.
One of the most common harmful mites in edible fungi is Histiostoma feroniarum Dufour (Acaridida: Histiostomatidae), a fungivorous astigmatid mite that feeds on hyphae and fruiting bodies, thereby transmitting pathogens. This study examined the effects of seven constant temperatures and 10 types of mushrooms on the growth and development of H. feroniarum, as well as its host preference. Developmental time for the total immature stages was significantly affected by the type of mushroom species, ranging from 4.3 ± 0.4 days (reared on Pleurotus eryngii var. tuoliensis Mou at 28°C) to 17.1 ± 2.3 days (reared on Auricularia polytricha Sacc. at 19°C). The temperature was a major factor in the formation of facultative heteromorphic deutonymphs (hypopi). The mite entered the hypopus stage when the temperature dropped to 16°C or rose above 31°C. The growth and development of this mite were significantly influenced by the type of species and variety of mushrooms. Moreover, the fungivorous astigmatid mite preferred to feed on the ‘Wuxiang No. 1’ strain of Lentinula edodes (Berk.) Pegler and the ‘Gaowenxiu’ strain of P. pulmonarius (Fr.) Quél., with a shorter development period compared with that of feeding on other strains. These results therefore quantify the effect of host type and temperature on fungivorous astigmatid mite growth and development rates, and provide a reference for applying mushroom cultivar resistance to biological pest control.
Slowed information processing speed (IPS) is the core contributor to cognitive impairment in patients with late-life depression (LLD). The hippocampus is an important link between depression and dementia, and it may be involved in IPS slowing in LLD. However, the relationship between a slowed IPS and the dynamic activity and connectivity of hippocampal subregions in patients with LLD remains unclear.
Methods
One hundred thirty-four patients with LLD and 89 healthy controls were recruited. Sliding-window analysis was used to assess whole-brain dynamic functional connectivity (dFC), dynamic fractional amplitude of low-frequency fluctuations (dfALFF) and dynamic regional homogeneity (dReHo) for each hippocampal subregion seed.
Results
Cognitive impairment (global cognition, verbal memory, language, visual–spatial skill, executive function and working memory) in patients with LLD was mediated by their slowed IPS. Compared with the controls, patients with LLD exhibited decreased dFC between various hippocampal subregions and the frontal cortex and decreased dReho in the left rostral hippocampus. Additionally, most of the dFCs were negatively associated with the severity of depressive symptoms and were positively associated with various domains of cognitive function. Moreover, the dFC between the left rostral hippocampus and middle frontal gyrus exhibited a partial mediation effect on the relationships between the scores of depressive symptoms and IPS.
Conclusions
Patients with LLD exhibited decreased dFC between the hippocampus and frontal cortex, and the decreased dFC between the left rostral hippocampus and right middle frontal gyrus was involved in the underlying neural substrate of the slowed IPS.
Time preference reversal refers to systematic inconsistencies between preferences and bids for intertemporal options. From the two eye-tracking studies (N1 = 60, N2 = 110), we examined the underlying mechanisms of time preference reversal. We replicated the reversal effect in which individuals facing a pair of intertemporal options choose the smaller-sooner option but assign a higher value to the larger-later one. Results revealed that the mean fixation duration and the proportion of gaze time on the outcome attribute varied across the choice and bid tasks. In addition, time preference reversals correlated with individual differences in maximizing tendencies. Findings support the contingent weighting hypothesis and strategy compatibility hypothesis and allow for improved theoretical understanding of the potential mechanisms and processes involved in time preference reversals.