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The construct of second language (L2) utterance fluency is typically operationalized through various individual temporal features. However, in natural speech, fluency (or disfluency) is often characterized by the clustering of multiple temporal features, collectively revealing the speaker’s effort in speech production or disfluency recovery. In this study, we explore the co-occurrence patterns of disfluency features in L2 speech and their associations with speakers’ L2 oral proficiency. We initially segmented all speech samples into analysis of speech (AS)-units. Within each AS-unit, six individual fluency features were manually coded, standardized, and subsequently subjected to a hierarchical-based k-means cluster analysis to examine their co-occurrence patterns. The results revealed four distinct disfluency clusters. A subsequent qualitative analysis of disfluencies in each cluster revealed distinct distributional patterns, disfluency makeup, and communicative functions. Additionally, the proportions of different disfluency clusters were significantly influenced by speakers’ proficiency level, first language background, and their interaction. These findings carry implications for L2 speaking research in general, shedding light on the intricate nature of speech fluency and presenting an alternative approach to the operationalization of this multidimensional construct.
This paper develops a theoretical framework to examine the technology adoption decisions of insurers and their impact on market share, considering heterogeneous customers and two representative insurers. Intuitively, when technology accessibility is observable, an insurer’s access to a new technology increases its market share, no matter whether it adopts the technology or not. However, when technology accessibility is unobservable, the insurer’s access to the new technology has additional side effects on its market share. First, the insurer may apply the available technology even if it increases costs and premiums, thereby decreasing market share. Second, the unobservable technology accessibility leads customers to expect that all insurers might have access to the new technology and underestimate the premium of those without access. This also decreases the market share of an insurer with access to the new technology. Our findings help explain the unclear relationship between technology adoption and the market share of insurance companies in practice.
This paper provides an overview of the current status of ultrafast and ultra-intense lasers with peak powers exceeding 100 TW and examines the research activities in high-energy-density physics within China. Currently, 10 high-intensity lasers with powers over 100 TW are operational, and about 10 additional lasers are being constructed at various institutes and universities. These facilities operate either independently or are combined with one another, thereby offering substantial support for both Chinese and international research and development efforts in high-energy-density physics.
In scientific collaborations, technologies have broadened access to scarce scientific and engineering resources. While broader access is often applauded, little attention has been focused on the problem of efficient and equitable resource allocation. This paper presents laboratory experiments designed to compare different allocation mechanisms for access to joint research facilities. Specifically, we study the Vickrey-Clarke-Groves (VCG) auction, a simultaneous ascending auction (the Resource Allocation Design, RAD), and a mechanism based on submitted rankings (Knapsack). Experimental results show that RAD and VCG are both more efficient than Knapsack, while Knapsack achieves a more equal distribution of resources than RAD or VCG. The findings highlight the need for systematic exploration of allocation mechanisms within collaboratories.
The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns in the ERN and whether the abnormal FC in the ERN can serve as a therapeutic response signature remain unclear.
Methods
A large functional magnetic resonance imaging dataset comprising 709 patients with MDD and 725 healthy controls (HCs) recruited across five sites was analyzed. Using a seed-based FC approach, we first investigated the group differences in whole-brain resting-state FC of the 14 ERN seeds between participants with and without MDD. Furthermore, an independent sample (45 MDD patients) was used to evaluate the relationship between the aforementioned abnormal FC in the ERN and symptom improvement after 8 weeks of antidepressant monotherapy.
Results
Compared to the HCs, patients with MDD exhibited aberrant FC between 7 ERN seeds and several cortical and subcortical areas, including the bilateral middle temporal gyrus, bilateral occipital gyrus, right thalamus, calcarine cortex, middle frontal gyrus, and the bilateral superior temporal gyrus. In an independent sample, these aberrant FCs in the ERN were negatively correlated with the reduction rate of the HAMD17 score among MDD patients.
Conclusions
These results might extend our understanding of the neurobiological underpinnings underlying unadaptable or inflexible emotional processing in MDD patients and help to elucidate the mechanisms of therapeutic response.
Western Zhou Dynasty (ca. 1046–771 BC) was established soon after conquering the Shang Dynasty (ca. 1600–1046 BC) and brought about the earliest enfeoffment system in Chinese history. Yan was one of the vassal states of the same clan as Zhou. According to historical records, the capital of Yan state was located near Yan mountain, which is now known as the Liulihe site in the Fangshan District, Beijing. This study carries out the high-precision dating of two newly discovered Western Zhou Dynasty noble tombs at the Liulihe site. The man in tomb M1902 participated in the groundbreaking ceremony of Yan’s capital according to inscriptions on the bronze vessel found in this tomb. Samples of different materials, especially different parts of human skeletons from the tombs, were selected to form a sample series in chronological order. Wiggle-matching models were established in OxCal program based on the growth and development time of different teeth and bones of human skeletons. More accurate ages were acquired for the death of the individuals. The results indicate that the most probable distribution range of the death date of the individual in M1902 is about 1045–1010 BC. The radiocarbon dates of M1902 give important chronological information about the founding of Yan state, and they are very close to those of the year in which King Wu of Zhou conquered the Shang Dynasty.
A high-energy pulsed vacuum ultraviolet (VUV) solid-state laser at 177 nm with high peak power by the sixth harmonic of a neodymium-doped yttrium aluminum garnet (Nd:YAG) amplifier in a KBe2BO3F2 prism-coupled device was demonstrated. The ultraviolet (UV) pump laser is a 352 ps pulsed, spatial top-hat super-Gaussian beam at 355 nm. A high energy of a 7.12 mJ VUV laser at 177 nm is obtained with a pulse width of 255 ps, indicating a peak power of 28 MW, and the conversion efficiency is 9.42% from 355 to 177 nm. The measured results fitted well with the theoretical prediction. It is the highest pulse energy and highest peak power ever reported in the VUV range for any solid-state lasers. The high-energy, high-peak-power, and high-spatial-uniformity VUV laser is of great interest for ultra-fine machining and particle-size measurements using UV in-line Fraunhofer holography diagnostics.
Background: Mild behavioral impairment (MBI) in older people refers to a group of syndromes that are characterized primarily by clusters of neuropsychiatric symptoms without severe cognitive impairment, which is a high-risk population for dementia. Patients often experience a variety of symptoms and exhibit high heterogeneity in symptomatology across different individuals. Classifying the psychotic symptom characteristics of MBI patients aids in the implementation of precise interventions for the next steps.
Objectives: To explore the symptom characteristics of older people with MBI and to classify them based on their symptoms.
Methods: Using a multi-stage sampling Methods, the MBI-Checklist was employed to investigate symptom characteristics in 255 older people with MBI from 32 nursing homes in Fujian Province. Latent Class Analysis (LCA) was then employed to categorize these individuals based on their symptom profiles.
Results: The neuropsychiatric symptoms clusters in older people with MBI often present as a combination of lack of motivation and emotional dysregulation, lack of motivation and impulse control disorders, or emotional dysregulation and impulse control disorders; presentation of a single symptom cluster is relatively less common, accounting for 45.49%. Older people with MBI can be divided into 2 latent classes (P < 0.05) based on symptom characteristics. According to the conditional probability of each class, they were named the “high- level group’’ [211 (82.69%)] and the “low-level group’’[44 (17.31%)].
Discussion: As individuals with MBI are at high risk for developing dementia, early intervention can effectively delay or reduce the occurrence of dementia. Future interventions should be personalized based on the specific symptom characteristics of this population.
This study aimed to investigate the effects of esketamine (Esk) combined with dexmedetomidine (Dex) on postoperative delirium (POD) and quality of recovery (QoR) in elderly patients undergoing thoracoscopic radical lung cancer surgery.
Methods
In this prospective, randomized, and controlled study, 172 elderly patients undergoing thoracoscopic radical lung cancer surgery were divided into two groups: the Esk + Dex group (n = 86) and the Dex group a (n = 86). The primary outcome was the incidence of POD within 7 days after surgery and the overall Quality of Recovery−15 (QoR − 15) scores within 3 days after surgery. Secondary outcomes included postoperative adverse reactions, extubation time, PACU stay, and hospitalization time. Serum levels of IL-6, IL-10, S100β protein, NSE, CD3+, CD4+, and CD8+ were detected from T0 to T5.
Results
Compared with the Dex group, the incidence of POD in the Esk + Dex group was significantly lower at 7 days after surgery (14.6% vs 30.9%; P = 0.013). The QoR − 15 score was significantly increased 3 days after surgery (P < 0.01). Levels of IL-6 and CD8+ were significantly decreased, and IL − 10 levels were significantly increased at T1-T2 (P < 0.05). At T1-T4, NSE levels were significantly decreased, while CD3+ and CD4+/CD8+ values were significantly increased (P < 0.01). At T1-T5, serum S100β protein concentration decreased significantly, and CD4+ value increased significantly (P < 0.01). The incidence of nausea/vomiting and hyperalgesia decreased significantly 48 hours after surgery (P < 0.01). The duration of extubation, PACU stay, and postoperative hospitalization were significantly shortened.
Conclusions
Esketamine combined with dexmedetomidine can significantly reduce the POD incidence and improve the QoR in patients undergoing thoracoscopic radical lung cancer surgery, which may be related to the improvement of cellular immune function.
Interface-resolved direct numerical simulations (DNS) of clustered settling suspensions in a periodic domain are performed to study the filtered drag force for clustered particle-laden flows. Our results show that, for the homogeneous system, the filtered drag is independent of the filter size, whereas for the clustered particle-laden flows, the averaged drag becomes smaller than the homogeneous drag at the filter size above 4 particle diameters. The drag reduction saturates at the filter size being comparable to the cluster size in the horizontal direction in our simulations. A new correlation is proposed to account for the mesoscale effect on the filtered drag force by using drift velocity and variance of the solid volume fraction, based on the modification of existing subgrid drag models for the inhomogeneous system. The existing models for the drift velocity and the variance of the solid volume fraction are assessed using our DNS data. A new model for the drift velocity and the variance of the solid volume fraction is proposed, based on the combination and modification of the previous models. All mesoscale models considered can predict well the filtered drag with comparable accuracy, and are superior to the homogeneous drag model for the clustered system. Our models with the same parameter values obtained from the large-scale system can also predict well the filtered drag for smaller computational domain sizes.
Hydrogen sulfide (H2S) has been shown to play a significant role in oxidative stress across various tissues and cells; however, its role in sperm function remains poorly understood. This study aimed to investigate the protective effect of GYY4137, a slow-releasing H2S compound, on sperm damage induced by H2O2. We assessed the effects of GYY4137 on motility, viability, lipid peroxidation and caspase-3 activity in human spermatozoa in vitro following oxidative damage mediated by H2O2. Spermatozoa from 25 healthy men were selected using a density gradient centrifugation method and cultured in the presence or absence of 10 μM H2O2, followed by incubation with varying concentrations of GYY4137 (0.625–2.5 μM). After 24 h of incubation, sperm motility, viability, lipid peroxidation, and caspase-3 activity were evaluated. The results indicated that H2O2 adversely affected sperm parameters, reducing motility and viability, while increasing oxidative stress, as evidenced by elevated lipid peroxidation and caspase-3 activity. GYY4137 provided dose-dependent protection against H2O2-induced oxidative stress (OS). We concluded that supplementation with GYY4137 may offer antioxidant protection during in vitro sperm preparation for assisted reproductive technology.
Species of epiphytic microbiota are closely associated with the fermentation performance of natural forage silage. This study aimed to evaluate the dynamic microbial communities, fermentation parameters, and aerobic stability of Napier grass silage from the same variety and growth period but harvested from three different regions (NGP1, NGP2, and NGP3). After 60 days of ensiling, triplicate silos were opened for sampling and testing aerobic stability. The epiphytic microbiota with higher relative abundances in fresh Napier grass (NGP1, NGP2, and NGP3) were Weissella, Enterobacter, and Lactococcus, respectively. After 60 days of ensiling, NGP3 exhibited higher fermentation quality, indicated by higher lactic acid (LA) concentration and lower pH than that of NGP1 and NGP2. The NH3–N content of all treatments was lower than 100 g/kg total nitrogen. Compared with NGP1 and NGP2 silage, NGP3 silage exhibited a sharp rise in pH and LA consumption during air exposure. After 7 days of air exposure, NGP3 had higher ethanol concentrations and pH. Ruminiclostridium_5, Pediococcus, and Lactobacillus predominated in NGP1, NGP2, and NGP3 silages, respectively, whereas Candida and Monascus predominated in air-exposed NGP3 silage. The bacterial co-occurrence networks from fresh samples to ensiling and air exposure became more complex; however, NGP3 had a higher negative correlation with co-occurrence after air exposure. Different regions had significant effects on the fermentation patterns, bacterial communities, and aerobic stability of Napier grass silage. This was mainly due to variable epiphytic microbiota. Higher fermentation quality of Napier grass silage may also result in accelerated spoilage due to air exposure. Candida and Monascus were primarily responsible for the lower dry matter recovery and higher ethanol contents and air exposure spoilage of Napier grass silage.
The flow-induced vibrations (FIVs) of two identical tandem square cylinders with mass ratio m* = 3.5 at Reynolds number Re = 150 are investigated through two-dimensional direct numerical simulation (DNS) and linear stability analysis over a parameter range of spacing ratio 1.5 ≤ L* ≤ 5 and reduced velocity 3 ≤ Ur ≤ 34. Three kinds of FIV responses, namely vortex-induced vibration (VIV), biased oscillation (BO) and galloping (GA), are identified. The FIVs are then further classified into the branches of initial VIV (IV), resonant VIV (RV and RV′), flutter-induced VIV (FV), desynchronized VIV (DV), VIV developing from GA (GV), transitional state between VIV and GA (TR), BO and GA based on the characteristics of the vibration responses. The transitions among different FIV branches are examined by combining the DNS with linear stability analysis, where the transition boundaries among the VIV, BO and GA branches over the concerned parameters are identified on the branch maps. The transition from IV to RV or RV′ is found to be related to the unstable wake mode, while the FV, transiting from RV or RV′, is induced by the unstable structural factor in the wake-structure mode. The structural instability is considered as the physical origin of GA, whereas the mode competition between unstable wake and structure leads to DV, GV and TR, and thus delays the appearance of GA. The transition from DV to BO with biased equilibrium position, accompanied by the even-order harmonic frequencies, is essentially induced by the symmetry breaking bifurcation.
Large-scale outbreaks of the dinoflagellate Karenia mikimotoi caused substantial mortality of abalone, Haliotis discus hannai in Fujian, China in 2012, resulting in 20 billion in economic losses to abalone industries. However, the mechanism behind the mortality, especially the reaction of abalone to this microalgal toxicity, which possibly differed significantly from the former ‘fish killer’ strain in the South China Sea (SCS). Our study revealed that K. mikimotoi FJ-strain exhibited a four-fold higher haemolytic toxicity than the SCS-strain during the late exponential phase. At the microalgal cell density of 3 × 107 cell L−1, the FJ-strain caused abalone mortality of 67% in 48 h, with decreased granulocyte–hyalinocyts ratio and phagocytic activity by 58.96% and 75.64%, respectively, increased haemocyte viability by 4.8-fold and severe gill damage. The toxic effect only worked for the haemolytic toxicity from active algal cells, which were probably produced under the contact of algal cells and abalone gills. However, under exposure to the SCS-strain, more than 80% of individuals survived under aeration. The results indicated that FJ-strain was a new K. mikimotoi ecotype with stronger toxicity. It evoked severe effects, with complete abalone mortality within 24 h under the cascading effect of non-aeration (dissolved oxygen declined to 2.0 mg L−1), when exposed to K. mikimotoi FJ-strain at the above density. Thus, apart from the microalgal toxicity, DO depletion exacerbated the mortality of abalone in the experiment. The massive abalone mortalities in Fujian were probably caused by the combination of microalgal toxic effects and oxygen depletion, leading to immunological depression and histopathological disruption.
BOUT++ turbulence simulations were performed to investigate the impact of turbulence spreading on the edge localized mode (ELM) size and divertor heat flux width $({\lambda _q})$ broadening in small ELM regimes. This study is motivated by EAST experiments. BOUT++ linear simulations of a pedestal radial electric field (Er) scan show that the dominant toroidal number mode (n) shifts from high-n to low-n, with a narrow mode spectrum, and the maximum linear growth rate increases as the pedestal Er well deepens. The nonlinear simulations show that as the net E × B pedestal flow increases, the pressure fluctuation level and its inward penetration beyond the top of the pedestal both increase. This leads to a transition from small ELMs to large ELMs. Both inward and outward turbulence spreading are sensitive to the scrape-off-layer (SOL) plasma profiles. The inward turbulence spreading increases for the steep SOL profiles, leading to increasing pedestal energy loss in the small ELM regime. The SOL width $({\lambda _q})$ is significantly broadened progressing from the ELM-free to small ELM regime, due to the onset of strong radial turbulent transport. The extent of the SOL width $({\lambda _q})$ broadening depends strongly on outward turbulence spreading. The fluctuation energy intensity flux ${\varGamma _\varepsilon }$ at the separatrix can be enhanced by increasing either pedestal Er flow shear or local SOL pressure gradient. The ${\lambda _q}$ is broadened as the fluctuation energy intensity flux ${\varGamma _\varepsilon }$ at the last close flux surface (LCFS) increases. Local SOL E × B flow shear will restrain outward turbulence spreading and the associated heat flux width broadening. Operating in H-mode with small ELMs has the potential to solve two critical problems: reducing the ELM size and broadening the SOL width.
For graphs $G$ and $H$, the Ramsey number $r(G,H)$ is the smallest positive integer $N$ such that any red/blue edge colouring of the complete graph $K_N$ contains either a red $G$ or a blue $H$. A book $B_n$ is a graph consisting of $n$ triangles all sharing a common edge.
Recently, Conlon, Fox, and Wigderson conjectured that for any $0\lt \alpha \lt 1$, the random lower bound $r(B_{\lceil \alpha n\rceil },B_n)\ge (\sqrt{\alpha }+1)^2n+o(n)$ is not tight. In other words, there exists some constant $\beta \gt (\sqrt{\alpha }+1)^2$ such that $r(B_{\lceil \alpha n\rceil },B_n)\ge \beta n$ for all sufficiently large $n$. This conjecture holds for every $\alpha \lt 1/6$ by a result of Nikiforov and Rousseau from 2005, which says that in this range $r(B_{\lceil \alpha n\rceil },B_n)=2n+3$ for all sufficiently large $n$.
We disprove the conjecture of Conlon, Fox, and Wigderson. Indeed, we show that the random lower bound is asymptotically tight for every $1/4\leq \alpha \leq 1$. Moreover, we show that for any $1/6\leq \alpha \le 1/4$ and large $n$, $r(B_{\lceil \alpha n\rceil }, B_n)\le \left (\frac 32+3\alpha \right ) n+o(n)$, where the inequality is asymptotically tight when $\alpha =1/6$ or $1/4$. We also give a lower bound of $r(B_{\lceil \alpha n\rceil }, B_n)$ for $1/6\le \alpha \lt \frac{52-16\sqrt{3}}{121}\approx 0.2007$, showing that the random lower bound is not tight, i.e., the conjecture of Conlon, Fox, and Wigderson holds in this interval.
Development of an effective sorbent for diesel fuel spill remediation remains an important challenge in the field of synthesis due to the potential capacity of sorbents to efficiently purify contaminated sites. Fly ash, a coal combustion by-product, was used as a raw material to synthesize two inexpensive zeolites (SZ-1 and SZ-2) for oil spill remediation using an alkali fusion approach prior to hydrothermal treatment. The sorbents were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and N2 adsorption/desorption. Diesel fuel sorption was used to examine the potential capacity of the synthetic zeolites to sorb oil and other petroleum products. Diesel fuel viscosity and density were determined at room temperature using a viscometer and a pycnometer, respectively. The synthetic zeolites exhibited a higher diesel fuel sorption capacity than fly ash. The SZ-1 zeolite sorbed approximately 1.43 g·g−1 and SZ-2 sorbed approximately 1.9 g·g−1. The sorption was mainly a physical process and mesopore filling seemed to play the dominant role. Sorbent textures were, therefore, vital for the sorption of petroleum products.