Soybean consultants from Arkansas, Louisiana, Mississippi, and Tennessee were surveyed by direct mail and by on-farm visits in fall 2011 to assess weed management practices and the prevalence of weed species in midsouth U.S. soybean. These consultants represented 15, 21, 5, and 10% of total soybean planted in Arkansas, Louisiana, Mississippi, and Tennessee, respectively, in 2011. Collectively, 93% of the total scouted area in these four states was planted with glyphosate-resistant (RR) soybean. The adoption of glufosinate-resistant (LL) soybean was greatest in Arkansas (12%), followed by Tennessee (4%), Mississippi (2%), and Louisiana (< 1%). Only 17% of the RR soybean was treated solely with glyphosate, compared with 35% of LL soybean treated solely with glufosinate. Across four states, average cost of herbicides in RR and LL soybean systems was US$78 and US$91 ha−1, respectively. Collectively across states, total scouted area under conventional tillage was 42%, stale seedbed was 37%, and no-tillage was 21%. Palmer amaranth and morningglories were the most problematic weeds in all four states. Additionally, barnyardgrass and horseweed were the third most problematic weeds of Arkansas and Tennessee, respectively, and Italian ryegrass was the third most problematic weed in Louisiana and Mississippi. Glyphosate-resistant Palmer amaranth infested fewer fields in Louisiana (16% of fields) than it did in the remaining three states (54% collectively). Average Palmer amaranth hand-weeding costs in the midsouth was US$59 ha−1. Three-fourths of the midsouth consultants stipulated the need for continued research and education focused on management of glyphosate-resistant and glyphosate-tolerant weed species.