We report a high-power ultra-narrow fiber-coupled diode laser using a Faraday anomalous dispersion optical filter (FADOF) as an external cavity element. An external cavity suitable for both the fiber-coupled package and FADOF configuration has been proposed. Using a 87Rb-based FADOF as the frequency-selective element, we realized a 103 W continuous laser output with a uniform circular beam. The center wavelength was precisely locked at the D2 line of the Rb resonance, and the bandwidth was narrowed from 1.8 nm (free-running, full width at half maximum (FWHM)) to 0.013 nm (6.9 GHz, FWHM). The side mode suppression ratio reached 31 dB. Such diode lasers with precise wavelength and high spectral brightness have critical applications in many fields, such as high-energy gas laser pumping, spin-exchange optical pumping, Raman spectroscopy and nonlinear optics.

Melting and solidification in periodically time-modulated thermal convection are relevant for numerous natural and engineering systems, for example, glacial melting under periodic sun radiation and latent thermal energy storage under periodically pulsating heating. It is highly relevant for the estimation of melt rate and melt efficiency management. However, even the dynamics of a solid–liquid interface shape subjected to a simple sinusoidal heating has not yet been investigated in detail. In this paper, we offer a better understanding of the modulation frequency dependence of the melting and solidification front. We numerically investigate periodic melting and solidification in turbulent convective flow with the solid above and the melted liquid below, and sinusoidal heating at the bottom plate with the mean temperature equal to the melting temperature. We investigate how the periodic heating can prevent the full solidification, and the resulting flow structures and the quasi-equilibrium interface height. We further study the dependence on the heating modulation frequency. As the frequency decreases, we found two distinct regimes, which are ‘partially solid’ and ‘fully solid’. In the fully solid regime, the liquid freezes completely, and the effect of the modulation is limited. In the partially solid regime, the solid partially melts, and a steady or unsteady solid–liquid interface forms depending on the frequency. The interface height can be derived based on the energy balance through the interface. In the partially solid regime, the interface height oscillates periodically, following the frequency of modulation. Here, we propose a perturbation approach that can predict the dependency of the oscillation amplitude on the modulation frequency.

Escherichia albertii is an emerging foodborne enteropathogen associated with infectious diarrhoea in humans. In February 2023, an outbreak of acute gastroenteric cases was reported in a junior high school located in Hangzhou, Zhejiang province, China. Twenty-two investigated patients presented diarrhoea (22/22, 100%), abdominal pain (21/22, 95.5%), nausea (6/22, 27.3%), and vomiting (3/22, 13.6%). E. albertii strains were successfully isolated from anal swabs collected from six patients. Each isolate was classified as sequence type ST2686, harboured eae-β gene, and carried both cdtB-I and cdtB-II subtypes, being serotyped as EAOg32:EAHg4 serotype. A comprehensive whole-genome phylogenetic analysis revealed that the six isolates formed a distinct cluster, separate from other strains. These isolates exhibited minimal genetic variation, differing from one another by 0 to 1 single nucleotide polymorphism, suggesting a common origin from a single clone. To the best of our knowledge, this represented the first reported outbreak of gastroenteritis attributed to E. albertii outside of Japan on a global scale.

The potential threshold for dietary energy intake (DEI) that might prevent protein-energy wasting (PEW) in chronic kidney disease (CKD) is uncertain. The subjects were non-dialysis CKD patients aged ≥ 14 years who were hospitalised from September 2019 to July 2022. PEW was measured by subjective global assessment. DEI and dietary protein intake (DPI) were obtained by 3-d diet recalls. Patients were divided into adequate DEI group and inadequate DEI group according to DEI ≥ 30 or < 30 kcal/kg/d. Logistic regression analysis and restricted cubic spline were used in this study. We enrolled 409 patients, with 53·8 % had hypertension and 18·6 % had diabetes. The DEI and DPI were 27·63 (sd 5·79) kcal/kg/d and 1·00 (0·90, 1·20) g/kg/d, respectively. 69·2 % of participants are in the inadequate DEI group. Malnutrition occurred in 18·6 % of patients. Comparing with patients in the adequate DEI group, those in the inadequate DEI group had significantly lower total lymphocyte count, serum cholesterol and LDL-cholesterol and a higher prevalence of PEW. For every 1 kcal/kg/d increase in DEI, the incidence of PEW was reduced by 12·0 % (OR: 0·880, 95 % CI: 0·830, 0·933, P < 0·001). There was a nonlinear curve relationship between DEI and PEW (overall P < 0·001), and DEI ≥ 27·6 kcal/kg/d may have a preventive effect on PEW in CKD. Low DPI was also significantly associated with malnutrition, but not when DEI was adequate. Decreased energy intake may be a more important factor of PEW in CKD than protein intake.

Iceberg melting is a critical factor for climate change. However, the shape of an iceberg is an often neglected aspect of its melting process. Our study investigates the influence of different ice shapes and ambient flow velocities on melt rates by conducting direct numerical simulations of a simplified system of bluff body flow. Our study focuses on the ellipsoidal shape, with the aspect ratio as the control parameter. We found the shape plays a crucial role in the melting process, resulting in significant variations in the melt rate between different shapes. Without flow, the optimal shape for a minimal melt rate is the disk (two-dimensional) or sphere (three-dimensional), due to the minimal surface area. However, as the ambient flow velocity increases, the optimal shape changes with the aspect ratio. We find that ice with an elliptical shape (when the long axis is aligned with the flow direction) can melt up to 10 % slower than a circular shape when exposed to flowing water. Following the approach considered by Huang et al. (J. Fluid Mech., vol. 765, 2015, R3) for dissolving bodies, we provide a quantitative theoretical explanation for this optimal shape, based on the combined contributions from both surface-area effects and convective-heat-transfer effects. Our findings provide insight into the interplay between phase transitions and ambient flows, contributing to our understanding of the iceberg melting process and highlighting the need to consider the aspect-ratio effect in estimates of iceberg melt rates.

In preparation for an experiment with a laser-generated intense proton beam at the Laser Fusion Research Center at Mianyang to investigate the 11B(p,α)2α reaction, we performed a measurement at very low proton energy between 140 keV and 172 keV using the high-voltage platform at the Institute of Modern Physics, Lanzhou. The aim of the experiment was to test the ability to use CR-39 track detectors for cross-section measurements and to remeasure the cross-section of this reaction close to the first resonance using the thick target approach. We obtained the cross-section σ = 45.6 ± 12.5 mb near 156 keV. Our result confirms the feasibility of CR-39 type track detector for nuclear reaction measurement also in low-energy regions.

The effects of magnetic vortex acceleration (MVA) are investigated with two-dimensional particle-in-cell (PIC) simulations by laser interaction with near-critical density (NCD) plasma inside a hollow conical plasma. Energetic and collimated proton beams can be accelerated by a longitudinal charge-separation field. Energetic protons with a peak energy of 220 MeV are produced in PIC simulations. Compared with a uniform NCD plasma, both the cutoff energy and collimation of proton beams are improved remarkably. Furthermore, the influence of different gap sizes of cone tip is taken into account. For optimizing magnetic vortex acceleration, the gap size of the cone tip is suggested to match the focal spot size of laser pulse.

Energy loss of protons with 90 and 100 keV energies penetrating through a hydrogen plasma target has been measured, where the electron density of the plasma is about 1016 cm−3 and the electron temperature is about 1-2 eV. It is found that the energy loss of protons in the plasma is obviously larger than that in cold gas and the experimental results based on the Bethe model calculations can be demonstrated by the variation of effective charge of protons in the hydrogen plasma. The effective charge remains 1 for 100 keV protons, while the value for 90 keV protons decreases to be about 0.92. Moreover, two empirical formulae are employed to extract the effective charge.

In vitro fertilization (IVF) and embryo transfer and intracytoplasmic sperm injection (ICSI) have allowed millions of infertile couples to achieve pregnancy. As an essential part of IVF/ICSI enabling the retrieval of a high number of oocytes in one cycle, controlled ovarian stimulation (COS) treatment mainly composes of the standard long gonadotrophin-releasing hormone agonist (GnRH-a) protocol and the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol. However, the effectiveness of GnRH-ant protocol is still debated because of inconsistent conclusions and insufficient subgroup analyses. This systematic review and meta-analysis included a total of 52 studies, encompassing 5193 participants in the GnRH-ant group and 4757 in the GnRH-a group. The findings of this study revealed that the GnRH-ant protocol is comparable with the long GnRH-a protocol when considering live birth as the primary outcome, and it is a favourable protocol with evidence reducing the incidence of ovarian hyperstimulation syndrome in women undergoing IVF/ICSI, especially in women with polycystic ovary syndrome. Further research is needed to compare the subsequent cumulative live birth rate between the two protocols among the general and poor ovarian response patients since those patients have a lower clinical pregnancy rate, fewer oocytes retrieved or fewer high-grade embryos in the GnRH-ant protocol.

It is now generally believed that elderly may have slightly higher dietary protein requirements than those of the young-middle-aged adults. We have previously conducted related studies by the indicator amino acid oxidation (IAAO) technique, but more research data are needed to revise the protein requirements of the elderly. The main objective was to reevaluate the dietary protein requirements of healthy Chinese adults (65–80 years) without sarcopenia by using the IAAO technique. Nine healthy adult men and seven healthy adult women participated in the study, with protein intakes ranging from 0·1 to 1·8 g/(kg·d). Diets that delivered energy at a 1·5 resting energy expenditure were isocaloric. The amounts of phenylalanine and tyrosine needed to remain constant for each protein dosage. By applying a nonlinear mixed-effects model analysis on the F13CO2 data, which revealed a breakpoint in F13CO2 in response to graded protein intakes, the mean protein requirement was calculated. The mean estimated average requirement (EAR) for healthy elderly Chinese adults without sarcopenia was determined to be 0·94 g/(kg·d). The protein recommended nutrient intake (RNI) determined using various derivation approaches ranged from 1·13 to 1·36 g/(kg·d). The EAR for Chinese adults without sarcopenia aged 65–80 years in this study is 6·8 % higher than the current recommended EAR (0·88 g/(kg·d)). The RNI derived using various derivation approaches are all greater than the current RNI (0·98 g/(kg·d)). This trial was registered with the Chinese clinical trial registry as ChiCTR2200061382.

Acanthocephalans of the order Polymorphida mainly parasitic in birds and mammals, are of veterinary, medical and economic importance. However, the evolutionary relationships of its 3 families (Centrorhynchidae, Polymorphidae and Plagiorhynchidae) remain under debate. Additionally, some species of Polymorphida (i.e. Bolbosoma spp. and Corynosoma spp.) are recognized as zoonotic parasites, associated with human acanthocephaliasis, but the mitochondrial genomes for representatives of Bolbosoma and Corynosoma have not been reported so far. In the present study, the complete mitochondrial genomes B. nipponicum and C. villosum (Acanthocephala: Polymorphidae) are reported for the first time, which are 14 296 and 14 241 bp in length, respectively, and both contain 36 genes [including 12 PCGs, 22 tRNA genes and 2 rRNA genes] and 2 non-coding regions (NCR1 and NCR2). The gene arrangement of some tRNAs in the mitogenomes of B. nipponicum and C. villosum differs from that found in all other acanthocephalans, except Polymorphus minutus. Phylogenetic results based on concatenated amino acid (AA) sequences of the 12 protein-coding genes (PCGs) strongly supported that the family Polymorphidae is a sister to the Centrorhynchidae rather than the Plagiorhynchidae, and also confirmed the sister relationship of the genera Bolbosoma and Corynosoma in the Polymorphidae based on the mitogenomic data for the first time. Our present findings further clarified the phylogenetic relationships of the 3 families Plagiorhynchidae, Centrorhynchidae and Polymorphidae, enriched the mitogenome data of the phylum Acanthocephala (especially the order Polymorphida), and provided the resource of genetic data for diagnosing these 2 pathogenic parasites of human acanthocephaliasis.

This work studies the three-dimensional flow dynamics around a rotating circular cylinder of finite length, whose axis is positioned perpendicular to the streamwise direction. Direct numerical simulations and global stability analyses are performed within a parameter range of Reynolds number $Re=DU_\infty /\nu <500$ (based on cylinder diameter $D$, uniform incoming flow velocity $U_\infty$), length-to-diameter ratio ${\small \text{AR}}=L/D\leq 2$ and dimensionless rotation rate $\alpha =D\varOmega /2U_\infty \leq 2$ (where $\varOmega$ is rotation rate). By solving Navier–Stokes equations, we investigated the wake patterns and explored the phase diagrams of the lift and drag coefficients. For a cylinder with ${\small \text{AR}}=1$, we found that when the rotation effect is weak ($0\leq \alpha \lesssim 0.3$), the wake pattern is similar to the unsteady wake past the non-rotating finite-length cylinder, but with a new linear unstable mode competing to dominate the saturation state of the wake. The flow becomes stable for $0.3\lesssim \alpha \lesssim 0.9$ when $Re<360$. When the rotation effect is strong ($\alpha \gtrsim 0.9$), new low-frequency wake patterns with stronger oscillations emerge. Generally, the rotation effect first slightly decreases and then sharply increases the $Re$ threshold of the flow instability when $\alpha$ is relatively small, but significantly decreases the threshold at high $\alpha$ ($0.9<\alpha \leq 2$). Furthermore, the stability analyses based on the time-averaged flows and on the steady solutions demonstrate the existence of multiple unstable modes undergoing Hopf bifurcation, greatly influenced by the rotation effect. The shapes of these global eigenmodes are presented and compared, as well as their structural sensitivity, visualising the flow region important for the disturbance development with rotation. This research contributes to our understanding of the complex bluff-body wake dynamics past this critical configuration.

In the context of China's rising global role, the question of where its academia is moving to becomes a matter of concern. Embedded in the literature on academic (de)colonization and intellectual pluralism, research was conducted by Chinese educational scholars on the status quo of educational studies on and in mainland China within the world system of knowledge production. We report its major findings in order to respond to continuing struggles within the contemporary Chinese academic society and between global “centres” and “peripheries.” Drawing on semi-structured interviews conducted with both overseas ethnic Chinese and non-Chinese education researchers, as well as bibliographic and content analyses among relevant academic publications, its findings indicate the growing but still limited global impact of educational studies on/in China especially theoretically and epistemologically, tensions between “centres” and “peripheries” within the world knowledge system, as well as tensions between internationalization and local knowledge. Suggestions for future directions have been concluded based on empirical data.

Diode-pumped rare gas lasers are potential candidates for high-energy and high-beam quality laser systems. Currently, most investigations are focused on metastable Ar lasers. The Kr system has the unique advantages of higher quantum efficiency and lower discharge requirements for comparison. In this paper, a diode-pumped metastable Kr laser was demonstrated for the first time. Using a repetitively pulsed discharge at a Kr/He pressure of up to approximately 1500 Torr, metastable Kr atoms of more than 1013 cm–3 were generated. Under diode pumping, the laser realized a dual-wavelength output with an average output power of approximately 100 mW and an optical conversion efficiency of approximately 10% with respect to the absorbed pump power. A kinetics study involving population distribution and evolution was conducted to analyze the laser performance.

The presence of salt in seawater strongly affects the melt rate and the shape evolution of ice, both of utmost relevance in ice–ocean interactions and thus for the climate. To get a better quantitative understanding of the physical mechanics at play in ice melting in salty water, we numerically investigate the lateral melting of an ice block in stably stratified saline water. The developing ice shape from our numerical results shows good agreement with the experiments and theory from Huppert & Turner (J. Fluid Mech., vol. 100, 1980, pp. 367–384). Furthermore, we find that the melt rate of ice depends non-monotonically on the mean ambient salinity: it first decreases for increasing salt concentration until a local minimum is attained, and then increases again. This non-monotonic behaviour of the ice melt rate is due to the competition among salinity-driven buoyancy, temperature-driven buoyancy and salinity-induced stratification. We develop a theoretical model based on the force balance which gives a prediction of the salt concentration for which the melt rate is minimal, and is consistent with our data. Our findings give insight into the interplay between phase transitions and double-diffusive convective flows.

HIV-1 molecular surveillance provides a new approach to explore transmission risks and targeted interventions. From January to June 2021, 663 newly reported HIV-1 cases were recruited in Zhaotong City, Yunnan Province, China. The distribution characteristics of HIV-1 subtypes and HIV-1 molecular network were analysed. Of 542 successfully subtyped samples, 12 HIV-1 strains were identified. The main strains were CRF08_BC (47.0%, 255/542), CRF01_AE (17.0%, 92/542), CRF07_BC (17.0%, 92/542), URFs (8.7%, 47/542), and CRF85_BC (6.5%, 35/542). CRF08_BC was commonly detected among Zhaotong natives, illiterates, and non-farmers and was mostly detected in Zhaoyang County. CRF01_AE was frequently detected among married and homosexual individuals and mostly detected in Weixin and Zhenxiong counties. Among the 516 pol sequences, 187 (36.2%) were clustered. Zhaotong natives, individuals aged ≥60 years, and illiterate individuals were more likely to be found in the network. Assortativity analysis showed that individuals were more likely to be genetically associated when stratified by age, education level, occupation, and reporting area. The genetic diversity of HIV-1 reflects the complexity of local HIV epidemics. Molecular network analyses revealed the subpopulations to focus on and the characteristics of the risk networks. The results will help optimise local prevention and control strategies.

Spherical robots (SRs) have the characteristics of nonholonomic constraints, underactuation, nonchain, and strong coupling, which increase the difficulty of modeling and motion control compared with traditional robots. In this study, we develop an adaptive motion control scheme for a nonholonomic SR, in which an omnidirectional dynamic model is carried out by using the Euler–Lagrange method to describe the omnidirectional motion of the SR more accurately. Furthermore, to facilitate the design of the motion controller, the dynamic model is simplified to obtain the state space expression of the SR. Aiming at the problem of poor control effect caused by the change of system model parameters which are influenced by dynamic model reduction, an adaptive motion control law of SR is designed based on MRAC. And the coefficient adjustment of the controller is obtained by the Lyapunov method, with the guaranteed stability of the closed-loop system. Finally, the controller designed in this thesis is compared with four controllers including linear quadratic regulator, Fuzzy PID, PSO-ADRC, and hierarchical SMC. The experimental comparison proves that the control scheme proposed in this study still has good control ability when the motion parameters are disturbed.