The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal baseline scans. Eight participants with a diagnosis of probable MCI-LB and a normal baseline scan consented to a follow-up scan between 2 and 4 years after baseline. All eight repeat scans remained normal; however, in three cases uptake decreased by more than 10%. The mean change in uptake between baseline and repeat was −5.2% (range: −23.8% to +7.0%). The interpolated mean annual change in uptake was −1.6%.

Precolumbian Maya graffiti is challenging to document because it is complex, multilayered, and difficult to see with the naked eye. In the Maya Lowlands, precolumbian graffiti occurs as etched palimpsests on parts of substructures such as stucco walls of residences, palaces, and temples that are frequently only accessible through dark and narrow tunnel excavations. Experienced iconographers or epigraphers with advanced drawing skills are the most qualified researchers to accurately record, analyze, and interpret precolumbian Maya graffiti. Because these scholars have a vast knowledge of conventions and styles from multiple time periods and sites, they are less likely to document the complex and seemingly chaotic incisions incorrectly. But as with many specialists in Maya archaeology, iconographers and epigraphers are not always available to collaborate in the field. This raises the question, how might an archaeologist without advanced training in iconography accurately record graffiti in subterranean excavations? Advances in digital applications of archaeological field recording have opened new avenues for documenting graffiti. One of these is Reflectance Transformation Imaging (RTI), a method that uses a moving light source and photography in order to visualize, interact with, and analyze a three-dimensional object in a two-dimensional image. With practice, RTI images can easily be produced in the field and later shared with specialists for the purposes of analysis and interpretation. Performed on a series of 20 unique graffiti from the Maya archaeological site of Holtun (two examples are presented here), RTI shows promise as a viable technique for documenting and preserving graffiti as cultural heritage.

This paper considers the structure and priorities of the Carthaginian state in its imperial endeavours in both North Africa and across the Mediterranean, focusing especially on the well-documented period of the Punic Wars (264–146 BC.). It suggests that Carthaginian constitutional structures, in particular the split between civil shofetim (‘judges’) and military rabbim (‘generals’), impacted the strategic outlook and marginal bellicosity of the city, making it less competitive against its primary peer-rival in the Western Mediterranean, Rome.

For a pseudo-Anosov flow $\varphi $ without perfect fits on a closed $3$-manifold, Agol–Guéritaud produce a veering triangulation $\tau $ on the manifold M obtained by deleting the singular orbits of $\varphi $. We show that $\tau $ can be realized in M so that its 2-skeleton is positively transverse to $\varphi $, and that the combinatorially defined flow graph $\Phi $ embedded in M uniformly codes the orbits of $\varphi $ in a precise sense. Together with these facts, we use a modified version of the veering polynomial, previously introduced by the authors, to compute the growth rates of the closed orbits of $\varphi $ after cutting M along certain transverse surfaces, thereby generalizing the work of McMullen in the fibered setting. These results are new even in the case where the transverse surface represents a class in the boundary of a fibered cone of M. Our work can be used to study the flow $\varphi $ on the original closed manifold. Applications include counting growth rates of closed orbits after cutting along closed transverse surfaces, defining a continuous, convex entropy function on the ‘positive’ cone in $H^1$ of the cut-open manifold, and answering a question of Leininger about the closure of the set of all stretch factors arising as monodromies within a single fibered cone of a $3$-manifold. This last application connects to the study of endperiodic automorphisms of infinite-type surfaces and the growth rates of their periodic points.

The military punishment of decimatio, the cudgelling by lot of one in ten men in a disgraced unit, often described as a cornerstone of Roman military discipline, was never practised during the third and second centuries BC. The punishment was possibly used as an extraordinary measure a couple of times in the fifth and fourth centuries BC. It soon fell into total desuetude but was cultivated as a rhetorical construct that proclaimed theoretical powers commanders no longer dared effect. It was only revived, or rather reinvented, during the Late Republic, a violent moment that saw the confluence of antiquarian enthusiasm with military dynasts whose unrestrained powers allowed them to manifest what had previously been an aristocratic talking point.

New occurrences of flask-shaped and envelope-bearing microfossils, including the predominantly Cambrian taxon Granomarginata, are reported from new localities, as well as from earlier in time (Ediacaran) than previously known. The stratigraphic range of Granomarginata extends into the Cambrian System, where it had a cosmopolitan distribution. This newly reported Ediacaran record includes areas from Norway (Baltica), Newfoundland (Avalonia) and Namibia (adjacent to the Kalahari Craton), and puts the oldest global occurrence of Granomarginata in the Indreelva Member (< 563 Ma) of the Stáhpogieddi Formation on the Digermulen Peninsula, Arctic Norway. Although Granomarginata is rare within the assemblage, these new occurrences together with previously reported occurrences from India and Poland, suggest a potentially widespread palaeogeographic distribution of Granomarginata through the middle–late Ediacaran interval. A new flask-shaped microfossil Lagoenaforma collaris gen. et sp. nov. is also reported in horizons containing Granomarginata from the Stáhpogieddi Formation in Norway and the Dabis Formation in Namibia, and flask-shaped fossils are also found in the Gibbett Hill Formation in Newfoundland. The Granomarginata–Lagoenaforma association, in addition to a low-diversity organic-walled microfossil assemblage, occurs in the strata postdating the Shuram carbon isotope excursion, and may eventually be of use in terminal Ediacaran biostratigraphy. These older occurrences of Granomarginata add to a growing record of body fossil taxa spanning the Ediacaran–Cambrian boundary.

Electroencephalographic (EEG) abnormalities are greater in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB) than in MCI due to Alzheimer’s disease (MCI-AD) and may anticipate the onset of dementia. We aimed to assess whether quantitative EEG (qEEG) slowing would predict a higher annual hazard of dementia in MCI across these etiologies. MCI patients (n = 92) and healthy comparators (n = 31) provided qEEG recording and underwent longitudinal clinical and cognitive follow-up. Associations between qEEG slowing, measured by increased theta/alpha ratio, and clinical progression from MCI to dementia were estimated with a multistate transition model to account for death as a competing risk, while controlling for age, cognitive function, and etiology classified by an expert consensus panel.

Over a mean follow-up of 1.5 years (SD = 0.5), 14 cases of incident dementia and 5 deaths were observed. Increased theta/alpha ratio on qEEG was associated with increased annual hazard of dementia (hazard ratio = 1.84, 95% CI: 1.01–3.35). This extends previous findings that MCI-LB features early functional changes, showing that qEEG slowing may anticipate the onset of dementia in prospectively identified MCI.

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

Diets varying in SFA and MUFA content can impact glycaemic control; however, whether underlying differences in genetic make-up can influence blood glucose responses to these dietary fatty acids is unknown. We examined the impact of dietary oils varying in SFA/MUFA content on changes in blood glucose levels (primary outcome) and whether these changes were modified by variants in the stearoyl-CoA desaturase (SCD) gene (secondary outcome). Obese men and women participating in the randomised, crossover, isoenergetic, controlled-feeding Canola Oil Multicenter Intervention Trial II consumed three dietary oils for 6 weeks, with washout periods of ˜6 weeks between each treatment. Diets studied included a high SFA/low MUFA Control oil (36·6 % SFA/28·2 % MUFA), a conventional canola oil (6·2 % SFA/63·1 % MUFA) and a high-oleic acid canola oil (5·8 % SFA/74·7 % MUFA). No differences in fasting blood glucose were observed following the consumption of the dietary oils. However, when stratified by SCD genotypes, significant SNP-by-treatment interactions on blood glucose response were found with additive models for rs1502593 (P = 0·01), rs3071 (P = 0·02) and rs522951 (P = 0·03). The interaction for rs3071 remained significant (P = 0·005) when analysed with a recessive model, where individuals carrying the CC genotype showed an increase (0·14 (sem 0·09) mmol/l) in blood glucose levels with the Control oil diet, but reductions in blood glucose with both MUFA oil diets. Individuals carrying the AA and AC genotypes experienced reductions in blood glucose in response to all three oils. These findings identify a potential new target for personalised nutrition approaches aimed at improving glycaemic control.

The literature on nineteenth-century Newcastle city region is a narrative of industrial progress premised upon technological prowess. But there is another story to be told about the transformation of a relatively small northern town into a conurbation with the attributes of a modern city. This second process of ‘rounding out’ the city with social, cultural and political institutions to accompany the economic prowess is relatively under-reported. In this study, we follow 1,621 individuals and compare their record of being mentioned in the literature to their participation in 343 local institutions. The focus is directed towards those who are much more visible in the literature compared to institutional membership – ‘narrative heroes’ – and those with the reverse pattern, much more to be found in institutions than in the literature – civic builders. The two sets of individuals are discussed and reasons for their contrasting positions are suggested.

Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.