This chapter explores the ways in which the trilogy takes up and alters Jean Baudrillard's concept of the genetic/digital code. Within Simulacra and Simulation the code functions as a point of intersection for a number of Baudrillard's ideas and arguments. The chapter addresses some key aspects of its presentation. Baudrillard's conception of the code incorporates aspects of the genetic and the digital. Baudrillard's characterisation of the code as a monistic single substance has clear resonances within The Matrix Trilogy. The Matrix Reloaded offers a key shift in the trilogy's take up of the code in that it presents two different underlying codes. Baudrillard's characterisation of the code also draws on the pathology of two different diseases: viruses and cancer. Baudrillard offers an extended comparison of the code and cancer, arguing that both are ultimately reliant on single cellular elements that are multiplied through a process of perfect replication.